Browsing by author "Nill, Simeon"
Now showing items 1-20 of 61
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A comprehensive model for heat-induced radio-sensitisation.
Brüningk, SC; Ijaz, J; Rivens, I; Nill, S; Ter Haar, G; et al. (TAYLOR & FRANCIS LTD, 2017-07-05)Combined radiotherapy (RT) and hyperthermia (HT) treatments may improve treatment outcome by heat induced radio-sensitisation. We propose an empirical cell survival model (AlphaR model) to describe this multimodality ... -
A dosimetric comparison of real-time adaptive and non-adaptive radiotherapy: A multi-institutional study encompassing robotic, gimbaled, multileaf collimator and couch tracking.
Colvill, E; Booth, J; Nill, S; Fast, M; Bedford, J; et al. (ELSEVIER IRELAND LTD, 2016-04-01)PURPOSE: A study of real-time adaptive radiotherapy systems was performed to test the hypothesis that, across delivery systems and institutions, the dosimetric accuracy is improved with adaptive treatments over non-adaptive ... -
A kernel-based dose calculation algorithm for kV photon beams with explicit handling of energy and material dependencies.
Reinhart, AM; Fast, MF; Ziegenhein, P; Nill, S; Oelfke, U (BRITISH INST RADIOLOGY, 2017-01-01)OBJECTIVE: Mimicking state-of-the-art patient radiotherapy with high-precision irradiators for small animals is expected to advance the understanding of dose-effect relationships and radiobiology in general. We work on the ... -
A novel probabilistic approach to generating PTV with partial voxel contributions.
Tsang, HS; Kamerling, CP; Ziegenhein, P; Nill, S; Oelfke, U (IOP PUBLISHING LTD, 2017-06-21)Radiotherapy treatment planning for use with high-energy photon beams currently employs a binary approach in defining the planning target volume (PTV). We propose a margin concept that takes the beam directions into account, ... -
A phase space model of a Versa HD linear accelerator for application to Monte Carlo dose calculation in a real-time adaptive workflow
Bedford, JL; Nilawar, R; Nill, S; Oelfke, U (Elsevier, 2022-05-24) -
A phase space model of a Versa HD linear accelerator for application to Monte Carlo dose calculation in a real-time adaptive workflow.
Bedford, JL; Nilawar, R; Nill, S; Oelfke, U (WILEY, 2022-09-01)PURPOSE: This study aims to develop and validate a simple geometric model of the accelerator head, from which a particle phase space can be calculated for application to fast Monte Carlo dose calculation in real-time ... -
Adaptive Radiotherapy Enabled by MRI Guidance.
Hunt, A; Hansen, VN; Oelfke, U; Nill, S; Hafeez, S (ELSEVIER SCIENCE LONDON, 2018-11-01)Adaptive radiotherapy (ART) strategies systematically monitor variations in target and neighbouring structures to inform treatment-plan modification during radiotherapy. This is necessary because a single plan designed ... -
An Inter-observer Study to Determine Radiotherapy Planning Target Volumes for Recurrent Gynaecological Cancer Comparing Magnetic Resonance Imaging Only With Computed Tomography-Magnetic Resonance Imaging
Bernstein, D; Taylor, A; Nill, S; Imseeh, G; Kothari, G; et al. -
An Inter-observer Study to Determine Radiotherapy Planning Target Volumes for Recurrent Gynaecological Cancer Comparing Magnetic Resonance Imaging Only With Computed Tomography-Magnetic Resonance Imaging.
Bernstein, D; Taylor, A; Nill, S; Imseeh, G; Kothari, G; et al. (ELSEVIER SCIENCE LONDON, 2021-02-24)AIMS: Target delineation uncertainty is arguably the largest source of geometric uncertainty in radiotherapy. Several factors can affect it, including the imaging modality used for delineation. It is accounted for by ... -
Assessment of MLC tracking performance during hypofractionated prostate radiotherapy using real-time dose reconstruction.
Fast, MF; Kamerling, CP; Ziegenhein, P; Menten, MJ; Bedford, JL; et al. (IOP PUBLISHING LTD, 2016-02-21)By adapting to the actual patient anatomy during treatment, tracked multi-leaf collimator (MLC) treatment deliveries offer an opportunity for margin reduction and healthy tissue sparing. This is assumed to be especially ... -
Automatic reconstruction of the delivered dose of the day using MR-linac treatment log files and online MR imaging.
Menten, MJ; Mohajer, JK; Nilawar, R; Bertholet, J; Dunlop, A; et al. (ELSEVIER IRELAND LTD, 2020-01-10)BACKGROUND AND PURPOSE: Anatomical changes during external beam radiotherapy prevent the accurate delivery of the intended dose distribution. Resolving the delivered dose, which is currently unknown, is crucial to link ... -
Beam selection for stereotactic ablative radiotherapy using Cyberknife with multileaf collimation.
Bedford, JL; Ziegenhein, P; Nill, S; Oelfke, U (ELSEVIER SCI LTD, 2018-12-20)The Cyberknife system (Accuray Inc., Sunnyvale, CA) enables radiotherapy using stereotactic ablative body radiotherapy (SABR) with a large number of non-coplanar beam orientations. Recently, a multileaf collimator has also ... -
Characterization of small PRESAGE (R) samples for measurements near the dosimeter edges
Costa, F; Doran, S; Adamovics, J; Nill, S; Hanson, IM; et al. (IOP PUBLISHING LTD, 2019-01-01) -
Combining radiation with hyperthermia: a multiscale model informed by in vitro experiments.
Brüningk, S; Powathil, G; Ziegenhein, P; Ijaz, J; Rivens, I; et al. (ROYAL SOC, 2018-01-01)Combined radiotherapy and hyperthermia offer great potential for the successful treatment of radio-resistant tumours through thermo-radiosensitization. Tumour response heterogeneity, due to intrinsic, or micro-environmentally ... -
Comparison of the dose escalation potential for two hypofractionated radiotherapy regimens for locally advanced pancreatic cancer.
Bertholet, J; Hunt, A; Dunlop, A; Bird, T; Mitchell, RA; et al. (ELSEVIER IRELAND LTD, 2019-03-08)OBJECTIVES: To determine the potential for dose escalation to a biological equivalent dose BED10 ≅ 100 Gy in hypofractionated radiotherapy for locally advanced pancreatic cancer (LAPC). MATERIALS AND METHODS: Ten unselected ... -
Consistent and invertible deformation vector fields for a breathing anthropomorphic phantom: a post-processing framework for the XCAT phantom.
Eiben, B; Bertholet, J; Menten, MJ; Nill, S; Oelfke, U; et al. (IOP PUBLISHING LTD, 2020-08-13)Breathing motion is challenging for radiotherapy planning and delivery. This requires advanced four-dimensional (4D) imaging and motion mitigation strategies and associated validation tools with known deformations. Numerical ... -
Daily adaptive radiotherapy for patients with prostate cancer using a high field MR-linac: Initial clinical experiences and assessment of delivered doses compared to a C-arm linac.
Dunlop, A; Mitchell, A; Tree, A; Barnes, H; Bower, L; et al. (ELSEVIER IRELAND LTD, 2020-07-01)INTRODUCTION: MR-guided adapted radiotherapy (MRgART) using a high field MR-linac has recently become available. We report the estimated delivered fractional dose of the first five prostate cancer patients treated at our ... -
Development of a methodology to study the effect of magnetic field on dose distributions in an MR-linac, using PRESAGE (R) and Monte Carlo calculations
Costa, F; Doran, S; Nill, S; Duane, S; Shipley, D; et al. (IOP PUBLISHING LTD, 2017-01-01) -
Dose verification of dynamic MLC-tracked radiotherapy using small PRESAGE (R) 3D dosimeters and a motion phantom
Costa, F; Menten, MJ; Doran, S; Adamovics, J; Hanson, IM; et al. (IOP PUBLISHING LTD, 2019-01-01) -
Dosimetric accuracy of delivering SBRT using dynamic arcs on Cyberknife.
Bedford, JL; Nill, S; Oelfke, U (WILEY, 2020-04-01)PURPOSE: Several studies have demonstrated potential improvements in treatment time through the use of dynamic arcs for delivery of stereotactic body radiation therapy (SBRT) on Cyberknife. However, the delivery system has ...