Now showing items 1-20 of 54

    • Association analysis identifies 65 new breast cancer risk loci. 

      Michailidou, K; Lindström, S; Dennis, J; Beesley, J; Hui, S; Kar, S; Lemaçon, A; Soucy, P; Glubb, D; Rostamianfar, A; Bolla, MK; Wang, Q; Tyrer, J; Dicks, E; Lee, A; Wang, Z; Allen, J; Keeman, R; Eilber, U; French, JD; Qing Chen, X; Fachal, L; McCue, K; McCart Reed, AE; Ghoussaini, M; Carroll, JS; Jiang, X; Finucane, H; Adams, M; Adank, MA; Ahsan, H; Aittomäki, K; Anton-Culver, H; Antonenkova, NN; Arndt, V; Aronson, KJ; Arun, B; Auer, PL; Bacot, F; Barrdahl, M; Baynes, C; Beckmann, MW; Behrens, S; Benitez, J; Bermisheva, M; Bernstein, L; Blomqvist, C; Bogdanova, NV; Bojesen, SE; Bonanni, B; Børresen-Dale, A-L; Brand, JS; Brauch, H; Brennan, P; Brenner, H; Brinton, L; Broberg, P; Brock, IW; Broeks, A; Brooks-Wilson, A; Brucker, SY; Brüning, T; Burwinkel, B; Butterbach, K; Cai, Q; Cai, H; Caldés, T; Canzian, F; Carracedo, A; Carter, BD; Castelao, JE; Chan, TL; David Cheng, T-Y; Seng Chia, K; Choi, J-Y; Christiansen, H; Clarke, CL; NBCS Collaborators; Collée, M; Conroy, DM; Cordina-Duverger, E; Cornelissen, S; Cox, DG; Cox, A; Cross, SS; Cunningham, JM; Czene, K; Daly, MB; Devilee, P; Doheny, KF; Dörk, T; Dos-Santos-Silva, I; Dumont, M; Durcan, L; Dwek, M; Eccles, DM; Ekici, AB; Eliassen, AH; Ellberg, C; Elvira, M; Engel, C; Eriksson, M; Fasching, PA; Figueroa, J; Flesch-Janys, D; Fletcher, O; Flyger, H; Fritschi, L; Gaborieau, V; Gabrielson, M; Gago-Dominguez, M; Gao, Y-T; Gapstur, SM; García-Sáenz, JA; Gaudet, MM; Georgoulias, V; Giles, GG; Glendon, G; Goldberg, MS; Goldgar, DE; González-Neira, A; Grenaker Alnæs, GI; Grip, M; Gronwald, J; Grundy, A; Guénel, P; Haeberle, L; Hahnen, E; Haiman, CA; Håkansson, N; Hamann, U; Hamel, N; Hankinson, S; Harrington, P; Hart, SN; Hartikainen, JM; Hartman, M; Hein, A; Heyworth, J; Hicks, B; Hillemanns, P; Ho, DN; Hollestelle, A; Hooning, MJ; Hoover, RN; Hopper, JL; Hou, M-F; Hsiung, C-N; Huang, G; Humphreys, K; Ishiguro, J; Ito, H; Iwasaki, M; Iwata, H; Jakubowska, A; Janni, W; John, EM; Johnson, N; Jones, K; Jones, M; Jukkola-Vuorinen, A; Kaaks, R; Kabisch, M; Kaczmarek, K; Kang, D; Kasuga, Y; Kerin, MJ; Khan, S; Khusnutdinova, E; Kiiski, JI; Kim, S-W; Knight, JA; Kosma, V-M; Kristensen, VN; Krüger, U; Kwong, A; Lambrechts, D; Le Marchand, L; Lee, E; Lee, MH; Lee, JW; Neng Lee, C; Lejbkowicz, F; Li, J; Lilyquist, J; Lindblom, A; Lissowska, J; Lo, W-Y; Loibl, S; Long, J; Lophatananon, A; Lubinski, J; Luccarini, C; Lux, MP; Ma, ESK; MacInnis, RJ; Maishman, T; Makalic, E; Malone, KE; Kostovska, IM; Mannermaa, A; Manoukian, S; Manson, JE; Margolin, S; Mariapun, S; Martinez, ME; Matsuo, K; Mavroudis, D; McKay, J; McLean, C; Meijers-Heijboer, H; Meindl, A; Menéndez, P; Menon, U; Meyer, J; Miao, H; Miller, N; Taib, NAM; Muir, K; Mulligan, AM; Mulot, C; Neuhausen, SL; Nevanlinna, H; Neven, P; Nielsen, SF; Noh, D-Y; Nordestgaard, BG; Norman, A; Olopade, OI; Olson, JE; Olsson, H; Olswold, C; Orr, N; Pankratz, VS; Park, SK; Park-Simon, T-W; Lloyd, R; Perez, JIA; Peterlongo, P; Peto, J; Phillips, K-A; Pinchev, M; Plaseska-Karanfilska, D; Prentice, R; Presneau, N; Prokofyeva, D; Pugh, E; Pylkäs, K; Rack, B; Radice, P; Rahman, N; Rennert, G; Rennert, HS; Rhenius, V; Romero, A; Romm, J; Ruddy, KJ; Rüdiger, T; Rudolph, A; Ruebner, M; Rutgers, EJT; Saloustros, E; Sandler, DP; Sangrajrang, S; Sawyer, EJ; Schmidt, DF; Schmutzler, RK; Schneeweiss, A; Schoemaker, MJ; Schumacher, F; Schürmann, P; Scott, RJ; Scott, C; Seal, S; Seynaeve, C; Shah, M; Sharma, P; Shen, C-Y; Sheng, G; Sherman, ME; Shrubsole, MJ; Shu, X-O; Smeets, A; Sohn, C; Southey, MC; Spinelli, JJ; Stegmaier, C; Stewart-Brown, S; Stone, J; Stram, DO; Surowy, H; Swerdlow, A; Tamimi, R; Taylor, JA; Tengström, M; Teo, SH; Beth Terry, M; Tessier, DC; Thanasitthichai, S; Thöne, K; Tollenaar, RAEM; Tomlinson, I; Tong, L; Torres, D; Truong, T; Tseng, C-C; Tsugane, S; Ulmer, H-U; Ursin, G; Untch, M; Vachon, C; van Asperen, CJ; Van Den Berg, D; van den Ouweland, AMW; van der Kolk, L; van der Luijt, RB; Vincent, D; Vollenweider, J; Waisfisz, Q; Wang-Gohrke, S; Weinberg, CR; Wendt, C; Whittemore, AS; Wildiers, H; Willett, W; Winqvist, R; Wolk, A; Wu, AH; Xia, L; Yamaji, T; Yang, XR; Har Yip, C; Yoo, K-Y; Yu, J-C; Zheng, W; Zheng, Y; Zhu, B; Ziogas, A; Ziv, E; ABCTB Investigators; ConFab/AOCS Investigators; Lakhani, SR; Antoniou, AC; Droit, A; Andrulis, IL; Amos, CI; Couch, FJ; Pharoah, PDP; Chang-Claude, J; Hall, P; Hunter, DJ; Milne, RL; García-Closas, M; Schmidt, MK; Chanock, SJ; Dunning, AM; Edwards, SL; Bader, GD; Chenevix-Trench, G; Simard, J; Kraft, P; Easton, DF (2017-11)
      Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as BRCA1, and many common, mostly non-coding variants. However, much of the genetic contribution to breast cancer risk remains unknown. ...
    • Association of Body Mass Index and Age With Subsequent Breast Cancer Risk in Premenopausal Women. 

      Premenopausal Breast Cancer Collaborative Group; Schoemaker, MJ; Nichols, HB; Wright, LB; Brook, MN; Jones, ME; O'Brien, KM; Adami, H-O; Baglietto, L; Bernstein, L; Bertrand, KA; Boutron-Ruault, M-C; Braaten, T; Chen, Y; Connor, AE; Dorronsoro, M; Dossus, L; Eliassen, AH; Giles, GG; Hankinson, SE; Kaaks, R; Key, TJ; Kirsh, VA; Kitahara, CM; Koh, W-P; Larsson, SC; Linet, MS; Ma, H; Masala, G; Merritt, MA; Milne, RL; Overvad, K; Ozasa, K; Palmer, JR; Peeters, PH; Riboli, E; Rohan, TE; Sadakane, A; Sund, M; Tamimi, RM; Trichopoulou, A; Ursin, G; Vatten, L; Visvanathan, K; Weiderpass, E; Willett, WC; Wolk, A; Yuan, J-M; Zeleniuch-Jacquotte, A; Sandler, DP; Swerdlow, AJ (2018-11-01)
      Importance: The association between increasing body mass index (BMI; calculated as weight in kilograms divided by height in meters squared) and risk of breast cancer is unique in cancer epidemiology in that a crossover ...
    • Association of Body Mass Index and Age With Subsequent Breast Cancer Risk in Premenopausal Women. 

      Premenopausal Breast Cancer Collaborative Group; Schoemaker, MJ; Nichols, HB; Wright, LB; Brook, MN; Jones, ME; O'Brien, KM; Adami, H-O; Baglietto, L; Bernstein, L; Bertrand, KA; Boutron-Ruault, M-C; Braaten, T; Chen, Y; Connor, AE; Dorronsoro, M; Dossus, L; Eliassen, AH; Giles, GG; Hankinson, SE; Kaaks, R; Key, TJ; Kirsh, VA; Kitahara, CM; Koh, W-P; Larsson, SC; Linet, MS; Ma, H; Masala, G; Merritt, MA; Milne, RL; Overvad, K; Ozasa, K; Palmer, JR; Peeters, PH; Riboli, E; Rohan, TE; Sadakane, A; Sund, M; Tamimi, RM; Trichopoulou, A; Ursin, G; Vatten, L; Visvanathan, K; Weiderpass, E; Willett, WC; Wolk, A; Yuan, J-M; Zeleniuch-Jacquotte, A; Sandler, DP; Swerdlow, AJ (2018-11-08)
      Importance:The association between increasing body mass index (BMI; calculated as weight in kilograms divided by height in meters squared) and risk of breast cancer is unique in cancer epidemiology in that a crossover ...
    • Association of genetic susceptibility variants for type 2 diabetes with breast cancer risk in women of European ancestry. 

      Zhao, Z; Wen, W; Michailidou, K; Bolla, MK; Wang, Q; Zhang, B; Long, J; Shu, X-O; Schmidt, MK; Milne, RL; García-Closas, M; Chang-Claude, J; Lindstrom, S; Bojesen, SE; Ahsan, H; Aittomäki, K; Andrulis, IL; Anton-Culver, H; Arndt, V; Beckmann, MW; Beeghly-Fadiel, A; Benitez, J; Blomqvist, C; Bogdanova, NV; Børresen-Dale, A-L; Brand, J; Brauch, H; Brenner, H; Burwinkel, B; Cai, Q; Casey, G; Chenevix-Trench, G; Couch, FJ; Cox, A; Cross, SS; Czene, K; Dörk, T; Dumont, M; Fasching, PA; Figueroa, J; Flesch-Janys, D; Fletcher, O; Flyger, H; Fostira, F; Gammon, M; Giles, GG; Guénel, P; Haiman, CA; Hamann, U; Harrington, P; Hartman, M; Hooning, MJ; Hopper, JL; Jakubowska, A; Jasmine, F; John, EM; Johnson, N; Kabisch, M; Khan, S; Kibriya, M; Knight, JA; Kosma, V-M; Kriege, M; Kristensen, V; Le Marchand, L; Lee, E; Li, J; Lindblom, A; Lophatananon, A; Luben, R; Lubinski, J; Malone, KE; Mannermaa, A; Manoukian, S; Margolin, S; Marme, F; McLean, C; Meijers-Heijboer, H; Meindl, A; Miao, H; Muir, K; Neuhausen, SL; Nevanlinna, H; Neven, P; Olson, JE; Perkins, B; Peterlongo, P; Phillips, K-A; Pylkäs, K; Rudolph, A; Santella, R; Sawyer, EJ; Schmutzler, RK; Schoemaker, M; Shah, M; Shrubsole, M; Southey, MC; Swerdlow, AJ; Toland, AE; Tomlinson, I; Torres, D; Truong, T; Ursin, G; Van Der Luijt, RB; Verhoef, S; Wang-Gohrke, S; Whittemore, AS; Winqvist, R; Pilar Zamora, M; Zhao, H; Dunning, AM; Simard, J; Hall, P; Kraft, P; Pharoah, P; Hunter, D; Easton, DF; Zheng, W (2016-05)
      Type 2 diabetes (T2D) has been reported to be associated with an elevated risk of breast cancer. It is unclear, however, whether this association is due to shared genetic factors.We constructed a genetic risk score (GRS) ...
    • Brain and Salivary Gland Tumors and Mobile Phone Use: Evaluating the Evidence from Various Epidemiological Study Designs. 

      Röösli, M; Lagorio, S; Schoemaker, MJ; Schüz, J; Feychting, M (2019-04)
      Mobile phones (MPs) are the most relevant source of radiofrequency electromagnetic field (RF-EMF) exposure to the brain and the salivary gland. Whether this exposure implies a cancer risk has been addressed in several ...
    • BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer. 

      Shimelis, H; Mesman, RLS; Von Nicolai, C; Ehlen, A; Guidugli, L; Martin, C; Calléja, FMGR; Meeks, H; Hallberg, E; Hinton, J; Lilyquist, J; Hu, C; Aalfs, CM; Aittomäki, K; Andrulis, I; Anton-Culver, H; Arndt, V; Beckmann, MW; Benitez, J; Bogdanova, NV; Bojesen, SE; Bolla, MK; Borresen-Dale, A-L; Brauch, H; Brennan, P; Brenner, H; Broeks, A; Brouwers, B; Brüning, T; Burwinkel, B; Chang-Claude, J; Chenevix-Trench, G; Cheng, C-Y; Choi, J-Y; Collée, JM; Cox, A; Cross, SS; Czene, K; Darabi, H; Dennis, J; Dörk, T; Dos-Santos-Silva, I; Dunning, AM; Fasching, PA; Figueroa, J; Flyger, H; García-Closas, M; Giles, GG; Glendon, G; Guénel, P; Haiman, CA; Hall, P; Hamann, U; Hartman, M; Hogervorst, FB; Hollestelle, A; Hopper, JL; Ito, H; Jakubowska, A; Kang, D; Kosma, V-M; Kristensen, V; Lai, K-N; Lambrechts, D; Marchand, LL; Li, J; Lindblom, A; Lophatananon, A; Lubinski, J; Machackova, E; Mannermaa, A; Margolin, S; Marme, F; Matsuo, K; Miao, H; Michailidou, K; Milne, RL; Muir, K; Neuhausen, SL; Nevanlinna, H; Olson, JE; Olswold, C; Oosterwijk, JJC; Osorio, A; Peterlongo, P; Peto, J; Pharoah, PDP; Pylkäs, K; Radice, P; Rashid, MU; Rhenius, V; Rudolph, A; Sangrajrang, S; Sawyer, EJ; Schmidt, MK; Schoemaker, MJ; Seynaeve, C; Shah, M; Shen, C-Y; Shrubsole, M; Shu, X-O; Slager, S; Southey, MC; Stram, DO; Swerdlow, A; Teo, SH; Tomlinson, I; Torres, D; Truong, T; van Asperen, CJ; van der Kolk, LE; Wang, Q; Winqvist, R; Wu, AH; Yu, J-C; Zheng, W; Zheng, Y; Leary, J; Walker, L; Foretova, L; Fostira, F; Claes, KBM; Varesco, L; Moghadasi, S; Easton, DF; Spurdle, A; Devilee, P; Vrieling, H; Monteiro, ANA; Goldgar, DE; Carreira, A; Vreeswijk, MPG; Couch, FJ; for kConFab/AOCS Investigators; for NBCS Collaborators (2017-06)
      Breast cancer risks conferred by many germline missense variants in the BRCA1 and BRCA2 genes, often referred to as variants of uncertain significance (VUS), have not been established. In this study, associations between ...
    • Breast Cancer Risk After Recent Childbirth: A Pooled Analysis of 15 Prospective Studies. 

      Nichols, HB; Schoemaker, MJ; Cai, J; Xu, J; Wright, LB; Brook, MN; Jones, ME; Adami, H-O; Baglietto, L; Bertrand, KA; Blot, WJ; Boutron-Ruault, M-C; Dorronsoro, M; Dossus, L; Eliassen, AH; Giles, GG; Gram, IT; Hankinson, SE; Hoffman-Bolton, J; Kaaks, R; Key, TJ; Kitahara, CM; Larsson, SC; Linet, M; Merritt, MA; Milne, RL; Pala, V; Palmer, JR; Peeters, PH; Riboli, E; Sund, M; Tamimi, RM; Tjønneland, A; Trichopoulou, A; Ursin, G; Vatten, L; Visvanathan, K; Weiderpass, E; Wolk, A; Zheng, W; Weinberg, CR; Swerdlow, AJ; Sandler, DP (2019-01)
      Background:Parity is widely recognized as protective for breast cancer, but breast cancer risk may be increased shortly after childbirth. Whether this risk varies with breastfeeding, family history of breast cancer, or ...
    • Breast cancer risk in relation to history of preeclampsia and hyperemesis gravidarum: Prospective analysis in the Generations Study. 

      Wright, LB; Schoemaker, MJ; Jones, ME; Ashworth, A; Swerdlow, AJ (2018-03-08)
      Preeclampsia and hyperemesis are pregnancy complications associated with altered sex hormone levels. Previous studies suggest preeclampsia may be associated with a decreased risk of subsequent breast cancer and hyperemesis ...
    • Breast cancer risk in relation to history of preeclampsia and hyperemesis gravidarum: Prospective analysis in the Generations Study. 

      Wright, LB; Schoemaker, MJ; Jones, ME; Ashworth, A; Swerdlow, AJ (2018-08)
      Preeclampsia and hyperemesis gravidarum are pregnancy complications associated with altered sex hormone levels. Previous studies suggest preeclampsia may be associated with a decreased risk of subsequent breast cancer and ...
    • Breast cancer risk prediction in women aged 35-50 years: impact of including sex hormone concentrations in the Gail model. 

      Clendenen, TV; Ge, W; Koenig, KL; Afanasyeva, Y; Agnoli, C; Brinton, LA; Darvishian, F; Dorgan, JF; Eliassen, AH; Falk, RT; Hallmans, G; Hankinson, SE; Hoffman-Bolton, J; Key, TJ; Krogh, V; Nichols, HB; Sandler, DP; Schoemaker, MJ; Sluss, PM; Sund, M; Swerdlow, AJ; Visvanathan, K; Zeleniuch-Jacquotte, A; Liu, M (2019-03-19)
      BACKGROUND:Models that accurately predict risk of breast cancer are needed to help younger women make decisions about when to begin screening. Premenopausal concentrations of circulating anti-Müllerian hormone (AMH), a ...
    • Childhood body size and pubertal timing in relation to adult mammographic density phenotype. 

      Schoemaker, MJ; Jones, ME; Allen, S; Hoare, J; Ashworth, A; Dowsett, M; Swerdlow, AJ (2017-02-07)
      BACKGROUND:An earlier age at onset of breast development and longer time between pubertal stages has been implicated in breast cancer risk. It is not clear whether associations of breast cancer risk with puberty or predictors ...
    • Circulating anti-Müllerian hormone and breast cancer risk: A study in ten prospective cohorts. 

      Ge, W; Clendenen, TV; Afanasyeva, Y; Koenig, KL; Agnoli, C; Brinton, LA; Dorgan, JF; Eliassen, AH; Falk, RT; Hallmans, G; Hankinson, SE; Hoffman-Bolton, J; Key, TJ; Krogh, V; Nichols, HB; Sandler, DP; Schoemaker, MJ; Sluss, PM; Sund, M; Swerdlow, AJ; Visvanathan, K; Liu, M; Zeleniuch-Jacquotte, A (2018-06)
      A strong positive association has been observed between circulating anti-Müllerian hormone (AMH), a biomarker of ovarian reserve, and breast cancer risk in three prospective studies. Confirming this association is important ...
    • Circulating Vitamin D and Colorectal Cancer Risk: An International Pooling Project of 17 Cohorts. 

      McCullough, ML; Zoltick, ES; Weinstein, SJ; Fedirko, V; Wang, M; Cook, NR; Eliassen, AH; Zeleniuch-Jacquotte, A; Agnoli, C; Albanes, D; Barnett, MJ; Buring, JE; Campbell, PT; Clendenen, TV; Freedman, ND; Gapstur, SM; Giovannucci, EL; Goodman, GG; Haiman, CA; Ho, GYF; Horst, RL; Hou, T; Huang, W-Y; Jenab, M; Jones, ME; Joshu, CE; Krogh, V; Lee, I-M; Lee, JE; Männistö, S; Le Marchand, L; Mondul, AM; Neuhouser, ML; Platz, EA; Purdue, MP; Riboli, E; Robsahm, TE; Rohan, TE; Sasazuki, S; Schoemaker, MJ; Sieri, S; Stampfer, MJ; Swerdlow, AJ; Thomson, CA; Tretli, S; Tsugane, S; Ursin, G; Visvanathan, K; White, KK; Wu, K; Yaun, S-S; Zhang, X; Willett, WC; Gail, MH; Ziegler, RG; Smith-Warner, SA (2018-06-14)
      Background: Experimental and epidemiological studies suggest a protective role for vitamin D in colorectal carcinogenesis, but evidence is inconclusive. Circulating 25-hydroxyvitamin D (25(OH)D) concentrations that minimize ...
    • Circulating Vitamin D and Colorectal Cancer Risk: An International Pooling Project of 17 Cohorts. 

      McCullough, ML; Zoltick, ES; Weinstein, SJ; Fedirko, V; Wang, M; Cook, NR; Eliassen, AH; Zeleniuch-Jacquotte, A; Agnoli, C; Albanes, D; Barnett, MJ; Buring, JE; Campbell, PT; Clendenen, TV; Freedman, ND; Gapstur, SM; Giovannucci, EL; Goodman, GG; Haiman, CA; Ho, GYF; Horst, RL; Hou, T; Huang, W-Y; Jenab, M; Jones, ME; Joshu, CE; Krogh, V; Lee, I-M; Lee, JE; Männistö, S; Le Marchand, L; Mondul, AM; Neuhouser, ML; Platz, EA; Purdue, MP; Riboli, E; Robsahm, TE; Rohan, TE; Sasazuki, S; Schoemaker, MJ; Sieri, S; Stampfer, MJ; Swerdlow, AJ; Thomson, CA; Tretli, S; Tsugane, S; Ursin, G; Visvanathan, K; White, KK; Wu, K; Yaun, S-S; Zhang, X; Willett, WC; Gail, MH; Ziegler, RG; Smith-Warner, SA (2019-02)
      BACKGROUND:Experimental and epidemiological studies suggest a protective role for vitamin D in colorectal carcinogenesis, but evidence is inconclusive. Circulating 25-hydroxyvitamin D (25(OH)D) concentrations that minimize ...
    • Comparative validation of breast cancer risk prediction models and projections for future risk stratification. 

      Choudhury, PP; Wilcox, AN; Brook, MN; Zhang, Y; Ahearn, T; Orr, N; Coulson, P; Schoemaker, MJ; Jones, ME; Gail, MH; Swerdlow, AJ; Chatterjee, N; Garcia-Closas, M (2019-06-04)
      External validation of risk models is critical for risk stratified breast cancer prevention. We used the Individualized Coherent Absolute Risk Estimation (iCARE) as a flexible tool for risk model development, comparative ...
    • Domestic light at night and breast cancer risk: a prospective analysis of 105 000 UK women in the Generations Study. 

      Johns, LE; Jones, ME; Schoemaker, MJ; McFadden, E; Ashworth, A; Swerdlow, AJ (2018-02)
      BACKGROUND:Circadian disruption caused by exposure to light at night (LAN) has been proposed as a risk factor for breast cancer and a reason for secular increases in incidence. Studies to date have largely been ecological ...
    • E-cadherin breast tumor expression, risk factors and survival: Pooled analysis of 5,933 cases from 12 studies in the Breast Cancer Association Consortium. 

      Horne, HN; Oh, H; Sherman, ME; Palakal, M; Hewitt, SM; Schmidt, MK; Milne, RL; Hardisson, D; Benitez, J; Blomqvist, C; Bolla, MK; Brenner, H; Chang-Claude, J; Cora, R; Couch, FJ; Cuk, K; Devilee, P; Easton, DF; Eccles, DM; Eilber, U; Hartikainen, JM; Heikkilä, P; Holleczek, B; Hooning, MJ; Jones, M; Keeman, R; Mannermaa, A; Martens, JWM; Muranen, TA; Nevanlinna, H; Olson, JE; Orr, N; Perez, JIA; Pharoah, PDP; Ruddy, KJ; Saum, K-U; Schoemaker, MJ; Seynaeve, C; Sironen, R; Smit, VTHBM; Swerdlow, AJ; Tengström, M; Thomas, AS; Timmermans, AM; Tollenaar, RAEM; Troester, MA; van Asperen, CJ; van Deurzen, CHM; Van Leeuwen, FF; Van't Veer, LJ; García-Closas, M; Figueroa, JD (2018-04-26)
      E-cadherin (CDH1) is a putative tumor suppressor gene implicated in breast carcinogenesis. Yet, whether risk factors or survival differ by E-cadherin tumor expression is unclear. We evaluated E-cadherin tumor immunohistochemistry ...
    • Epigenome-wide association study for lifetime estrogen exposure identifies an epigenetic signature associated with breast cancer risk. 

      Johansson, A; Palli, D; Masala, G; Grioni, S; Agnoli, C; Tumino, R; Giurdanella, MC; Fasanelli, F; Sacerdote, C; Panico, S; Mattiello, A; Polidoro, S; Jones, ME; Schoemaker, MJ; Orr, N; Tomczyk, K; Johnson, N; Fletcher, O; Perduca, V; Baglietto, L; Dugué, P-A; Southey, MC; Giles, GG; English, DR; Milne, RL; Severi, G; Ambatipudi, S; Cuenin, C; Chajès, V; Romieu, I; Herceg, Z; Swerdlow, AJ; Vineis, P; Flanagan, JM (2019-04-30)
      BACKGROUND:It is well established that estrogens and other hormonal factors influence breast cancer susceptibility. We hypothesized that a woman's total lifetime estrogen exposure accumulates changes in DNA methylation, ...
    • Etiology of hormone receptor positive breast cancer differs by levels of histologic grade and proliferation. 

      Abubakar, M; Chang-Claude, J; Ali, HR; Chatterjee, N; Coulson, P; Daley, F; Blows, F; Benitez, J; Milne, RL; Brenner, H; Stegmaier, C; Mannermaa, A; Rudolph, A; Sinn, P; Couch, FJ; Devilee, P; Tollenaar, RAEM; Seynaeve, C; Figueroa, J; Lissowska, J; Hewitt, S; Hooning, MJ; Hollestelle, A; Foekens, R; Koppert, LB; kConFab Investigators; Bolla, MK; Wang, Q; Jones, ME; Schoemaker, MJ; Keeman, R; Easton, DF; Swerdlow, AJ; Sherman, ME; Schmidt, MK; Pharoah, PD; Garcia-Closas, M (2018-08)
      Limited epidemiological evidence suggests that the etiology of hormone receptor positive (HR+) breast cancer may differ by levels of histologic grade and proliferation. We pooled risk factor and pathology data on 5,905 HR+ ...