Breast cancer risk in relation to history of preeclampsia and hyperemesis gravidarum: Prospective analysis in the Generations Study.
Date
2018-08-15Author
Wright, LB
Schoemaker, MJ
Jones, ME
Ashworth, A
Swerdlow, AJ
Type
Journal Article
Metadata
Show full item recordAbstract
Preeclampsia and hyperemesis gravidarum are pregnancy complications associated with altered sex hormone levels. Previous studies suggest preeclampsia may be associated with a decreased risk of subsequent breast cancer and hyperemesis with an increased risk, but the evidence remains unclear. We used data from the Generations Study, a large prospective study of women in the United Kingdom, to estimate relative risks of breast cancer in relation to a history of preeclampsia and hyperemesis using Cox regression adjusting for known breast cancer risk factors. During 7.5 years average follow-up of 82,053 parous women, 1,969 were diagnosed with invasive or in situ breast cancer. Women who had experienced preeclampsia during pregnancy had a significantly decreased risk of premenopausal breast cancer (hazard ratio (HR) =0.67, 95% confidence interval (CI): 0.49-0.90) and of HER2-enriched tumours (HR = 0.33, 95% CI: 0.12-0.91), but there was no association with overall (HR = 0.90, 95% CI: 0.80-1.02) or postmenopausal (HR = 0.97, 95% CI: 0.85-1.12) breast cancer risk. Risk reductions among premenopausal women were strongest within 20 years since the last pregnancy with preeclampsia. Hyperemesis was associated with a significantly increased risk of HER2-enriched tumours (HR = 1.76, 95% CI: 1.07-2.87), but not with other intrinsic subtypes or breast cancer risk overall. These results provide evidence that preeclampsia is associated with a decreased risk of premenopausal and HER2-enriched breast cancer and that hyperemesis, although not associated with breast cancer risk overall, may be associated with raised risk of HER2-enriched tumours.
Collections
Subject
Humans
Breast Neoplasms
Neoplasm Invasiveness
Pre-Eclampsia
Hyperemesis Gravidarum
Receptor, erbB-2
Proportional Hazards Models
Risk Factors
Follow-Up Studies
Prospective Studies
Pregnancy
Postmenopause
Premenopause
Adult
Middle Aged
Female
United Kingdom
Breast Carcinoma In Situ
Research team
Aetiological Epidemiology
Language
eng
Date accepted
2018-03-01
License start date
2018-08
Citation
International journal of cancer, 2018, 143 (4), pp. 782 - 792
Publisher
WILEY