• A blood transcriptome-based analysis of disease progression, immune regulation, and symptoms in coronavirus-infected patients. 

  Sadanandam, A; Bopp, T; Dixit, S; Knapp, DJHF; Emperumal, CP; Vergidis, P; Rajalingam, K; Melcher, A; Kannan, N (2020-12-08)

  COVID-19 patients show heterogeneity in clinical presentation and outcomes that makes pandemic control and strategy difficult; optimizing management requires a systems biology approach of understanding the disease. Here ...
• Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD. 

  Hewitt, G; Borel, V; Segura-Bayona, S; Takaki, T; Ruis, P; Bellelli, R; Lehmann, LC; Sommerova, L; Vancevska, A; Tomas-Loba, A; Zhu, K; Cooper, C; Fugger, K; Patel, H; Goldstone, R; Schneider-Luftman, D; Herbert, E; Stamp, G; Brough, R; Pettitt, S; Lord, CJ; West, SC; Ahel, I; Ahel, D; Chapman, JR; Deindl, S; Boulton, SJ (2020-12-15)

  Chromatin is a barrier to efficient DNA repair, as it hinders access and processing of certain DNA lesions. ALC1/CHD1L is a nucleosome-remodeling enzyme that responds to DNA damage, but its precise function in DNA repair ...
• Phase I Trial of DNA Methyltransferase Inhibitor Guadecitabine Combined with Cisplatin and Gemcitabine for Solid Malignancies Including Urothelial Carcinoma (SPIRE). 

  Crabb, SJ; Danson, S; Catto, JWF; Hussain, S; Chan, D; Dunkley, D; Downs, N; Marwood, E; Day, L; Saunders, G; Light, M; Whitehead, A; Ellis, D; Sarwar, N; Enting, D; Birtle, A; Johnson, B; Huddart, R; Griffiths, G (2021-01-20)

  <h4>Purpose</h4>Preclinical data indicate that DNA methyltransferase inhibition will circumvent cisplatin resistance in various cancers.<h4>Patient and methods</h4>SPIRE comprised a dose-escalation phase for incurable ...
• Treatment outcomes for small cell carcinoma of the bladder: results from a UK patient retrospective cohort study. 

  Chau, C; Rimmer, Y; Choudhury, A; Leaning, D; Law, A; Enting, D; Lim, JH; Hafeez, S; Khoo, V; Huddart, R; Mitchell, D; Henderson, DR; McGrane, J; Beresford, M; Vasudev, N; Beesley, S; Hilman, S; Manetta, C; Sriram, R; Sharma, A; Eswar, C; Treece, S; Vilarino-Varela, M; Varughese, M; H Glen; Pintus, E; Crabb, S (2021-02-06)

  <h4>Background</h4>Small cell carcinoma of the bladder (SCCB) is rare, accounting for under 1% of all bladder carcinomas. It is aggressive and outcomes are poor due to early metastatic spread. Owing to its rarity, there ...
• Clinical and co-clinical genomics of paediatric solid tumours with a special focus in DIPG 

  Izquierdo Delgado, E (2020-07-31)

  Cure rates for paediatric solid cancers have not improved in the last decade. Delivering precision medicine to stratify patients based on their molecular profiling is a key goal to support existing and upcoming adaptive ...
• Intuitive Gaze-Control of a Robotized Flexible Endoscope 

  Vrielink, TJCO; Puyal, JG-B; Kogkas, A; Darzi, A; Mylonas, G (IEEE, 2018-01-01)
• Hypofractionated Stereotactic Ablative Radiotherapy for Recurrent or Oligometastatic Tumours in Children and Young Adults. 

  Chandy, E; Taylor, H; Gaito, S; Wells, E; Jones, C; Meehan, C; Burland, H; Stone, J; Snowball, C; Mashru, J; Riddell, C; Hon, Y; Welsh, L; Saran, F; Mandeville, H

  <h4>Aims</h4>Cancer remains a leading cause of death in children and adolescents in the developed world. Despite advances in oncological management, rates of primary treatment failure remain significant. Radiation of ...
• Optimizing the Timing of Salvage Postprostatectomy Radiotherapy and the Use of Concurrent Hormonal Therapy for Prostate Cancer. 

  Kishan, AU; Tendulkar, RD; Tran, PT; Parker, CC; Nguyen, PL; Stephenson, AJ; Carrie, C (2018-05-15)

  <h4>Context</h4>Currently, salvage radiotherapy (SRT) is the only known curative intervention for men with recurrent disease following prostatectomy. Critical issues in the optimal selection and management of men being ...
• Abiraterone in "High-" and "Low-risk" Metastatic Hormone-sensitive Prostate Cancer. 

  Hoyle, AP; Ali, A; James, ND; Cook, A; Parker, CC; de Bono, JS; Attard, G; Chowdhury, S; Cross, WR; Dearnaley, DP; Brawley, CD; Gilson, C; Ingleby, F; Gillessen, S; Aebersold, DM; Jones, RJ; Matheson, D; Millman, R; Mason, MD; Ritchie, AWS; Russell, M; Douis, H; Parmar, MKB; Sydes, MR; Clarke, NW; STAMPEDE Investigators

  <h4>Background</h4>Abiraterone acetate received licencing for use in only "high-risk" metastatic hormone-naïve prostate cancer (mHNPC) following the LATITUDE trial findings. However, a "risk"-related effect was not seen ...
• What Type of Prostate Cancer Is Systematically Overlooked by Multiparametric Magnetic Resonance Imaging? An Analysis from the PROMIS Cohort. 

  Norris, JM; Carmona Echeverria, LM; Bott, SRJ; Brown, LC; Burns-Cox, N; Dudderidge, T; El-Shater Bosaily, A; Frangou, E; Freeman, A; Ghei, M; Henderson, A; Hindley, RG; Kaplan, RS; Kirkham, A; Oldroyd, R; Parker, C; Persad, R; Punwani, S; Rosario, DJ; Shergill, IS; Stavrinides, V; Winkler, M; Whitaker, HC; Ahmed, HU; Emberton, M

  <h4>Background</h4>All risk stratification strategies in cancer overlook a spectrum of disease. The Prostate MR Imaging Study (PROMIS) provides a unique opportunity to explore cancers that are overlooked by multiparametric ...
• Prostate radiotherapy in newly diagnosed metastatic prostate cancer. 

  Ali, A; Parker, CC; Clarke, NW

  <h4>Purpose of review</h4>The aim of this article is to review the role of prostate radiotherapy in the multimodal management of newly diagnosed metastatic hormone naïve prostate cancer.<h4>Recent findings</h4>Two randomized ...
• Prostate cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. 

  Parker, C; Castro, E; Fizazi, K; Heidenreich, A; Ost, P; Procopio, G; Tombal, B; Gillessen, S; ESMO Guidelines Committee. Electronic address: [email protected]
• False Positive Multiparametric Magnetic Resonance Imaging Phenotypes in the Biopsy-naïve Prostate: Are They Distinct from Significant Cancer-associated Lesions? Lessons from PROMIS. 

  Stavrinides, V; Syer, T; Hu, Y; Giganti, F; Freeman, A; Karapanagiotis, S; Bott, SRJ; Brown, LC; Burns-Cox, N; Dudderidge, TJ; Bosaily, AE-S; Frangou, E; Ghei, M; Henderson, A; Hindley, RG; Kaplan, RS; Oldroyd, R; Parker, C; Persad, R; Rosario, DJ; Shergill, IS; Echeverria, LMC; Norris, JM; Winkler, M; Barratt, D; Kirkham, A; Punwani, S; Whitaker, HC; Ahmed, HU; Emberton, M; PROMIS group

  <h4>Background</h4>False positive multiparametric magnetic resonance imaging (mpMRI) phenotypes prompt unnecessary biopsies. The Prostate MRI Imaging Study (PROMIS) provides a unique opportunity to explore such phenotypes ...
• Bevacizumab as adjuvant treatment of colon cancer: updated results from the S-AVANT phase III study by the GERCOR Group. 

  André, T; Vernerey, D; Im, SA; Bodoky, G; Buzzoni, R; Reingold, S; Rivera, F; McKendrick, J; Scheithauer, W; Ravit, G; Fountzilas, G; Yong, WP; Isaacs, R; Österlund, P; Liang, JT; Creemers, GJ; Rakez, M; Van Cutsem, E; Cunningham, D; Tabernero, J; de Gramont, A

  <h4>Background</h4>The bevacizumab-Avastin® adjuVANT (AVANT) study did not meet its primary end point of improving disease-free survival (DFS) with the addition of bevacizumab to oxaliplatin-based chemotherapy in stage III ...
• Adult soft tissue myoepithelial carcinoma: treatment outcomes and efficacy of chemotherapy. 

  Chamberlain, F; Cojocaru, E; Scaranti, M; Noujaim, J; Constantinou, A; Thway, K; Fisher, C; Messiou, C; Strauss, DC; Miah, A; Zaidi, S; Benson, C; Gennatas, S; Jones, RL (2019-12-27)

  Soft tissue myoepithelial carcinomas are a rare, malignant subgroup of myoepithelial tumours mostly arising in the extremities with equal predilection for women and men. The mainstay of management of localised disease is ...
• Genomic and transcriptomic heterogeneity in metaplastic carcinomas of the breast. 

  Piscuoglio, S; Ng, CKY; Geyer, FC; Burke, KA; Cowell, CF; Martelotto, LG; Natrajan, R; Popova, T; Maher, CA; Lim, RS; Bruijn, ID; Mariani, O; Norton, L; Vincent-Salomon, A; Weigelt, B; Reis-Filho, JS

  Metaplastic breast cancer (MBC) is a rare special histologic type of triple-negative breast cancer, characterized by the presence of neoplastic cells showing differentiation towards squamous epithelium and/or mesenchymal ...
• Free-View, 3D Gaze-Guided, Assistive Robotic System for Activities of Daily Living 

  Wang, M-Y; Kogkas, AA; Darzi, A; Mylonas, GP (IEEE, 2018-01-01)
• Effect of bariatric surgery on long-term cardiovascular outcomes: a nationwide nested cohort study. 

  Moussa, O; Ardissino, M; Heaton, T; Tang, A; Khan, O; Ziprin, P; Darzi, A; Collins, P; Purkayastha, S

  AIMS :This study aims to evaluate the long-term effect of bariatric surgery on cardiovascular outcomes of patients with obesity. METHODS AND RESULTS :A nested cohort study was carried out within the Clinical Practice ...
• Capturing Global Spatial Context for Accurate Cell Classification in Skin Cancer Histology 

  Zormpas-Petridis, K; Failmezger, H; Roxanis, I; Blackledge, M; Jamin, Y; Yuan, Y (SPRINGER INTERNATIONAL PUBLISHING AG, 2018-01-01)
• Discovery of Rare Phenotypes in Cellular Images Using Weakly Supervised Deep Learning 

  Sailem, H; Arias-Garcia, M; Bakal, C; Zisserman, A; Rittscher, J (IEEE, 2017-01-01)

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