• Regulation of miR-483-3p by the O-linked N-acetylglucosamine transferase links chemosensitivity to glucose metabolism in liver cancer cells. 

  Pepe, F; Pagotto, S; Soliman, S; Rossi, C; Lanuti, P; Braconi, C; Mariani-Costantini, R; Visone, R; Veronese, A (2017-05-08)

  The miR-483-3p is upregulated in several tumors, including liver tumors, where it inhibits TP53-dependent apoptosis by targeting the pro-apoptotic gene BBC3/PUMA. The transcriptional regulation of the miR-483-3p could be ...
• Is breast seroma after tumour resection associated with patient-reported breast appearance change following radiotherapy? Results from the IMPORT HIGH (CRUK/06/003) trial 

  Bhattacharya, I; Haviland, JS; Gulliford, S; Harris, E; Bliss, J; Kirby, A
• Over-expression of the miR-483-3p overcomes the miR-145/TP53 pro-apoptotic loop in hepatocellular carcinoma. 

  Lupini, L; Pepe, F; Ferracin, M; Braconi, C; Callegari, E; Pagotto, S; Spizzo, R; Zagatti, B; Lanuti, P; Fornari, F; Ghasemi, R; Mariani-Costantini, R; Bolondi, L; Gramantieri, L; Calin, GA; Sabbioni, S; Visone, R; Veronese, A; Negrini, M (2016-05)

  The miR-145-5p, which induces TP53-dependent apoptosis, is down-regulated in several tumors, including hepatocellular carcinomas (HCCs), but some HCCs show physiological expression of this miR. Here we demonstrate that in ...
• MicroRNA 31-3p expression and benefit from anti-EGFR inhibitors in metastatic colorectal cancer patients enrolled in the prospective phase II PROSPECT-C trial. 

  Anandappa, G; Lampis, A; Cunningham, D; Khan, KH; Kouvelakis, K; Vlachogiannis, G; Hedayat, S; Tunariu, N; Rao, S; Watkins, D; Starling, N; Braconi, C; Darvish Damavandi, M; Lote, H; Thomas, J; Peckitt, C; Kalaitzaki, E; Khan, N; Fotiadis, N; Rugge, M; Begum, R; Rana, I; Bryant, A; Hahne, JC; Chau, I; Fassan, M; Valeri, N (2019-04-05)

  PURPOSE: Anti-Epidermal Growth Factor Receptor (EGFR) monoclonal antibodies (mABs) are effective in the treatment of metastatic colorectal cancer (mCRC) patients. RAS status and tumour location (sidedness) are predictive ...
• miR-224 Is Significantly Upregulated and Targets Caspase-3 and Caspase-7 During Colorectal Carcinogenesis. 

  Fassan, M; Cui, R; Gasparini, P; Mescoli, C; Guzzardo, V; Vicentini, C; Munari, G; Loupakis, F; Lonardi, S; Braconi, C; Scarpa, M; D'Angelo, E; Pucciarelli, S; Angriman, I; Agostini, M; D'Incá, R; Farinati, F; Gafà, R; Lanza, G; Frankel, WL; Croce, CM; Valeri, N; Rugge, M (2019-02)

  miR-224 has recently emerged as a driver oncomiR in sporadic colorectal carcinogenesis, but its pathogenetic role is still controversial. A large phenotypical and molecularly characterized series of preinvasive and invasive ...
• A disease-specific quality of life questionnaire for primary aldosteronism. 

  Velema, M; de Nooijer, A; Hermus, A; Timmers, HJLM; Lenders, J; Husson, O; Deinum, J (2019-03-01)

  OBJECTIVE: To develop a primary aldosteronism (PA) disease-specific Health-Related Quality of Life (HRQoL) questionnaire. METHODS: We included newly diagnosed patients with PA (n=26), and patients with PA after adrenalectomy ...
• Noncoding RNA in Cholangiocarcinoma. 

  Salati, M; Braconi, C (2019-02)

  Cholangiocarcinomas (CCAs) are tumors with a dismal prognosis. Early diagnosis is a key challenge because of the lack of specific symptoms, and the curability rate is low due to the difficulty in achieving a radical resection ...
• BEECH: A dose-finding run-in followed by a randomised phase 2 study assessing the efficacy of AKT inhibitor capivasertib (AZD5363) combined with paclitaxel in patients with oestrogen receptor-positive advanced or metastatic breast cancer, and in a PIK3CA mutant sub-population. 

  Turner, NC; Alarcón, E; Armstrong, AC; Philco, M; López Chuken, YA; Sablin, M-P; Tamura, K; Gómez Villanueva, A; Pérez-Fidalgo, JA; Cheung, SYA; Corcoran, C; Cullberg, M; Davies, BR; de Bruin, EC; Foxley, A; Lindemann, JPO; Maudsley, R; Moschetta, M; Outhwaite, E; Pass, M; Rugman, P; Schiavon, G; Oliveira, M (2019-03-12)

  BACKGROUND: BEECH investigated the efficacy of capivasertib (AZD5363), an oral inhibitor of AKT isoforms 1-3, in combination with first-line weekly paclitaxel for advanced or metastatic oestrogen receptor-positive (ER+)/human ...
• Realising the potential of magnetic resonance image guided radiotherapy in gynaecological and rectal cancer. 

  White, IM; Scurr, E; Wetscherek, A; Brown, G; Sohaib, A; Nill, S; Oelfke, U; Dearnaley, D; Lalondrelle, S; Bhide, S (2019-04-01)

  Computerised tomography based radiotherapy workflow is limited by poor soft tissue definition in the pelvis and reliance on rigid registration methods. Current image guided radiotherapy and adaptive radiotherapy models ...
• PET-PANC: multicentre prospective diagnostic accuracy and health economic analysis study of the impact of combined modality 18fluorine-2-fluoro-2-deoxy-d-glucose positron emission tomography with computed tomography scanning in the diagnosis and management of pancreatic cancer. 

  Ghaneh, P; Hanson, R; Titman, A; Lancaster, G; Plumpton, C; Lloyd-Williams, H; Yeo, ST; Edwards, RT; Johnson, C; Abu Hilal, M; Higginson, AP; Armstrong, T; Smith, A; Scarsbrook, A; McKay, C; Carter, R; Sutcliffe, RP; Bramhall, S; Kocher, HM; Cunningham, D; Pereira, SP; Davidson, B; Chang, D; Khan, S; Zealley, I; Sarker, D; Al Sarireh, B; Charnley, R; Lobo, D; Nicolson, M; Halloran, C; Raraty, M; Sutton, R; Vinjamuri, S; Evans, J; Campbell, F; Deeks, J; Sanghera, B; Wong, W-L; Neoptolemos, JP

  BACKGROUND: Pancreatic cancer diagnosis and staging can be difficult in 10-20% of patients. Positron emission tomography (PET)/computed tomography (CT) adds precise anatomical localisation to functional data. The use of ...
• Improving fiducial and prostate capsule visualization for radiotherapy planning using MRI. 

  Pathmanathan, AU; Schmidt, MA; Brand, DH; Kousi, E; van As, NJ; Tree, AC (2019-03)

  BACKGROUND AND PURPOSE: Intraprostatic fiducial markers (FM) improve the accuracy of radiotherapy (RT) delivery. Here we assess geometric integrity and contouring consistency using a T2*-weighted (T2*W) sequence alone, ...
• Combined ultrasound and cone beam CT improves target segmentation for image guided radiation therapy in uterine cervix cancer. 

  Mason, SA; White, IM; O'Shea, T; McNair, HA; Alexander, S; Kalaitzaki, E; Bamber, JC; Harris, EJ; Lalondrelle, S (2019-03-11)

  PURPOSE: Adaptive radiation therapy strategies could account for interfractional uterine motion observed in cervix cancer patients, but the current CBCT-based treatment workflow is limited by poor soft tissue contrast. The ...
• Dissecting mechanisms of resistance to targeted drug combination therapy in human colorectal cancer. 

  Clarke, PA; Roe, T; Swabey, K; Hobbs, SM; McAndrew, C; Tomlin, K; Westwood, I; Burke, R; van Montfort, R; Workman, P (2019-03-25)

  Genomic alterations in cancer cells result in vulnerabilities that clinicians can exploit using molecularly targeted drugs, guided by knowledge of the tumour genotype. However, the selective activity of these drugs exerts ...
• Psychosocial morbidity in TP53 mutation carriers: is whole-body cancer screening beneficial? 

  McBride, KA; Ballinger, ML; Schlub, TE; Young, M-A; Tattersall, MHN; Kirk, J; Eeles, R; Killick, E; Walker, LG; Shanley, S; Thomas, DM; Mitchell, G (2017-07)

  Germline TP53 mutation carriers are at high risk of developing a range of cancers. Effective cancer risk management is an important issue for these individuals. We assessed the psychosocial impact in TP53 mutation carriers ...
• Prostate Cancer Germline Variations and Implications for Screening and Treatment. 

  Dias, A; Kote-Jarai, Z; Mikropoulos, C; Eeles, R (2018-09-04)

  Prostate cancer (PCa) is a highly heritable disease, and rapid evolution of sequencing technologies has enabled marked progression of our understanding of its genetic inheritance. A complex polygenic model that involves ...
• Efficacy and Cardiotoxic Safety Profile of Raltitrexed in Fluoropyrimidines-Pretreated or High-Risk Cardiac Patients With GI Malignancies: Large Single-Center Experience. 

  Khan, K; Rane, JK; Cunningham, D; Rao, S; Watkins, D; Starling, N; Kalaitzaki, E; Forster, M; Braconi, C; Valeri, N; Gerlinger, M; Chau, I (2019-03)

  BACKGROUND: Gastrointestinal (GI) cancer patients may not be considered for therapy with fluoropyrimidines (FPs) because of previous cardiovascular (CV) toxicity or preexisting risk factors; such patients may benefit from ...
• Dosimetry and Gastrointestinal Toxicity Relationships in a Phase II Trial of Pelvic Lymph Node Radiotherapy in Advanced Localised Prostate Cancer. 

  Ferreira, MR; Thomas, K; Truelove, L; Khan, A; Parker, C; Dearnaley, DP; Gulliford, S (2019-03-19)

  AIMS: Pelvic lymph node (PLN) radiotherapy for high-risk prostate cancer is limited by late gastrointestinal toxicity. Application of rectal and bowel constraints may reduce risks of side-effects. We evaluated associations ...
• Accountability in the NHS: the impact on cancer care. 

  Macklin-Doherty, A (2018)

  Accountability of service delivery is becoming increasingly complex and never has this been more apparent than in the field of Oncology. Cancer care has an unrivalled level of complexity not only in the heterogeneity of ...
• Breast cancer risk prediction in women aged 35-50 years: impact of including sex hormone concentrations in the Gail model. 

  Clendenen, TV; Ge, W; Koenig, KL; Afanasyeva, Y; Agnoli, C; Brinton, LA; Darvishian, F; Dorgan, JF; Eliassen, AH; Falk, RT; Hallmans, G; Hankinson, SE; Hoffman-Bolton, J; Key, TJ; Krogh, V; Nichols, HB; Sandler, DP; Schoemaker, MJ; Sluss, PM; Sund, M; Swerdlow, AJ; Visvanathan, K; Zeleniuch-Jacquotte, A; Liu, M (2019-03-19)

  BACKGROUND: Models that accurately predict risk of breast cancer are needed to help younger women make decisions about when to begin screening. Premenopausal concentrations of circulating anti-Müllerian hormone (AMH), a ...
• Cut-and-Run: A Distinct Mechanism by which V(D)J Recombination Causes Genome Instability. 

  Kirkham, CM; Scott, JNF; Wang, X; Smith, AL; Kupinski, AP; Ford, AM; Westhead, DR; Stockley, PG; Tuma, R; Boyes, J (2019-03-18)

  V(D)J recombination is essential to generate antigen receptor diversity but is also a potent cause of genome instability. Many chromosome alterations that result from aberrant V(D)J recombination involve breaks at single ...

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