• Targeting androgen receptor splicing in lethal prostate cancer 

  Paschalis, A (2021-04-30)

  Over the past decade, androgen receptor (AR) directed therapies such as abiraterone and enzalutamide have become the standard of care for treating advanced prostate cancer, improving both progression-free and overall ...
• Genetics of high risk myeloma 

  Shah, V (2021-03-31)

  Despite significant progress in therapy in the last two decades, the outlook for multiple myeloma (MM) patients is still poor as the disease remains incurable and only 33% of patients survive for up to 10 years after ...
• JunD, not c-Jun, is the AP-1 transcription factor required for Ras-induced lung cancer. 

  Ruiz, EJ; Lan, L; Diefenbacher, ME; Riising, EM; Da Costa, C; Chakraborty, A; Hoeck, JD; Spencer-Dene, B; Kelly, G; David, J-P; Nye, E; Downward, J; Behrens, A (2021-07-08)

  The AP-1 transcription factor c-Jun is required for Ras-driven tumorigenesis in many tissues and is considered as a classical proto-oncogene. To determine the requirement for c-Jun in a mouse model of K-RasG12D-induced ...
• Deficient adaptation to centrosome duplication defects in neural progenitors causes microcephaly and subcortical heterotopias. 

  González-Martínez, J; Cwetsch, AW; Martínez-Alonso, D; López-Sainz, LR; Almagro, J; Melati, A; Gómez, J; Pérez-Martínez, M; Megías, D; Boskovic, J; Gilabert-Juan, J; Graña-Castro, O; Pierani, A; Behrens, A; Ortega, S; Malumbres, M (2021-08-23)

  Congenital microcephaly (MCPH) is a neurodevelopmental disease associated with mutations in genes encoding proteins involved in centrosomal and chromosomal dynamics during mitosis. Detailed MCPH pathogenesis at the cellular ...
• Clinical outcomes of patients with corticosteroid refractory immune checkpoint inhibitor-induced enterocolitis treated with infliximab. 

  Alexander, JL; Ibraheim, H; Sheth, B; Little, J; Khan, MS; Richards, C; Hunter, N; Chauhan, D; Ratnakumaran, R; McHugh, K; Pinato, DJ; Nathan, P; Choy, J; Crusz, SM; Furness, A; Turajlic, S; Pickering, L; Larkin, J; Teare, JP; Papa, S; Speight, A; Sharma, A; Powell, N

  <h4>Introduction</h4>Immune checkpoint inhibitors (CPIs) have changed the treatment landscape for many cancers, but also cause severe inflammatory side effects including enterocolitis. CPI-induced enterocolitis is treated ...
• Clinical and immunologic implications of COVID-19 in patients with melanoma and renal cell carcinoma receiving immune checkpoint inhibitors. 

  Switzer, B; Haanen, J; Lorigan, PC; Puzanov, I; Turajlic, S

  The clinical and immunologic implications of the SARS-CoV-2 pandemic for patients with cancer receiving systemic anticancer therapy have introduced a multitude of clinical challenges and academic controversies. This review ...
• Features and Management of Late Relapse of Nonseminomatous Germ Cell Tumour. 

  Jay, APM; Aldiwani, M; O'Callaghan, ME; Pearce, AK; Huddart, RA; Mayer, E; Reid, AH; Nicol, DL

  <h4>Background</h4>Late relapse (LR) of nonseminomatous germ cell tumour (NSGCT) is uncommon, with limited data published. LR is defined as relapse occurring after a disease-free interval of 2 yr.<h4>Objective</h4>To review ...
• Pharmacotherapy for liposarcoma: current and emerging synthetic treatments. 

  Chamberlain, F; Benson, C; Thway, K; Huang, P; Jones, RL; Gennatas, S (2021-04-21)

  Liposarcomas are rare tumors arising from adipocytic tissue and accounting for approximately 15-20% of all soft tissue sarcomas. Liposarcoma can be further classified into histopathological subtypes with variable ...
• Real-world treatment outcomes with brigatinib in patients with pretreated ALK+ metastatic non-small cell lung cancer. 

  Popat, S; Brustugun, OT; Cadranel, J; Felip, E; Garassino, MC; Griesinger, F; Helland, Å; Hochmair, M; Pérol, M; Bent-Ennakhil, N; Kruhl, C; Novello, S

  <h4>Background</h4>The next-generation ALK inhibitor brigatinib is approved for use in patients with ALK inhibitor-naïve ALK-positive advanced NSCLC and in patients previously treated with crizotinib. A phase II trial ...
• Reconstructing single-cell karyotype alterations in colorectal cancer identifies punctuated and gradual diversification patterns. 

  Bollen, Y; Stelloo, E; van Leenen, P; van den Bos, M; Ponsioen, B; Lu, B; van Roosmalen, MJ; Bolhaqueiro, ACF; Kimberley, C; Mossner, M; Cross, WCH; Besselink, NJM; van der Roest, B; Boymans, S; Oost, KC; de Vries, SG; Rehmann, H; Cuppen, E; Lens, SMA; Kops, GJPL; Kloosterman, WP; Terstappen, LWMM; Barnes, CP; Sottoriva, A; Graham, TA; Snippert, HJG

  Central to tumor evolution is the generation of genetic diversity. However, the extent and patterns by which de novo karyotype alterations emerge and propagate within human tumors are not well understood, especially at ...
• The concerns of oncology professionals during the COVID-19 pandemic: results from the ESMO Resilience Task Force survey II. 

  Lim, KHJ; Murali, K; Kamposioras, K; Punie, K; Oing, C; O'Connor, M; Thorne, E; Amaral, T; Garrido, P; Lambertini, M; Devnani, B; Westphalen, CB; Morgan, G; Haanen, JBAG; Hardy, C; Banerjee, S

  <h4>Background</h4>The COVID-19 pandemic has resulted in significant changes to professional and personal lives of oncology professionals globally. The European Society for Medical Oncology (ESMO) Resilience Task Force ...
• The potential role of MR-guided adaptive radiotherapy in pediatric oncology: Results from a SIOPE-COG survey. 

  Seravalli, E; Kroon, PS; Buatti, JM; Hall, MD; Mandeville, HC; Marcus, KJ; Onal, C; Ozyar, E; Paulino, AC; Paulsen, F; Saunders, D; Tsang, DS; Wolden, SL; Janssens, GO

  <h4>Background and purpose</h4>Magnetic resonance guided radiotherapy (MRgRT) has been successfully implemented for several routine clinical applications in adult patients. The purpose of this study is to map the potential ...
• A systematic review and meta-analysis of the relationship between the radiation absorbed dose to the thyroid and response in patients treated with radioiodine for Graves’ disease 

  Taprogge, J; Flux, G; Murray, I; Gear, J; Carnegie-Peake, L; Gape, P
• Genomic and transcriptomic analyses of breast cancer primaries and matched metastases in AURORA, the Breast International Group (BIG) molecular screening initiative. 

  Aftimos, P; Oliveira, M; Irrthum, A; Fumagalli, D; Sotiriou, C; Nili Gal-Yam, E; Robson, ME; Ndozeng, J; Di Leo, A; Ciruelos, EM; de Azambuja, E; Viale, G; Scheepers, ED; Curigliano, G; Bliss, JM; Reis-Filho, JS; Colleoni, M; Balic, M; Cardoso, F; Albanell, J; Duhem, C; Marreaud, S; Romagnoli, D; Rojas, B; Gombos, A; Wildiers, H; Guerrero-Zotano, A; Hall, P; Bonetti, A; Larsson, KF; Degiorgis, M; Khodaverdi, S; Greil, R; Sverrisdottir, A; Paoli, M; Seyll, E; Loibl, S; Linderholm, B; Zoppoli, G; Davidson, NE; Johannsson, OT; Bedard, PL; Loi, S; Knox, S; Cameron, DA; Harbeck, N; Lasa Montoya, M; Brandão, M; Vingiani, A; Caballero, C; Hilbers, FS; Yates, LR; Benelli, M; Venet, D; Piccart, MJ (2021-06-28)

  AURORA aims to study the processes of relapse in metastatic breast cancer (MBC) by performing multi-omics profiling on paired primary tumors and early-course metastases. Among 381 patients (primary tumor and metastasis ...
• Activation and transcriptional profile of monocytes and CD8⁺ T cells are altered in checkpoint inhibitor-related hepatitis. 

  Gudd, CLC; Au, L; Triantafyllou, E; Shum, B; Liu, T; Nathwani, R; Kumar, N; Mukherjee, S; Dhar, A; Woollard, KJ; Yone, Y; Pinato, DJ; Thursz, MR; Goldin, RD; Gore, ME; Larkin, J; Khamri, W; Antoniades, CG; Turajlic, S; Possamai, LA

  <h4>Background & aims</h4>Checkpoint inhibitor-related hepatitis (CPI-Hep) is an emerging clinical challenge. We aimed to gain insights into the immunopathology of CPI-Hep by comprehensively characterising myeloid and ...
• CT-Based Pelvic T₁-Weighted MR Image Synthesis Using UNet, UNet++ and Cycle-Consistent Generative Adversarial Network (Cycle-GAN). 

  Kalantar, R; Messiou, C; Winfield, JM; Renn, A; Latifoltojar, A; Downey, K; Sohaib, A; Lalondrelle, S; Koh, D-M; Blackledge, MD

  <h4>Background</h4>Computed tomography (CT) and magnetic resonance imaging (MRI) are the mainstay imaging modalities in radiotherapy planning. In MR-Linac treatment, manual annotation of organs-at-risk (OARs) and clinical ...
• Roles of cancer associated fibroblasts in squamous cell carcinoma 

  Rullan, A (2021-03-31)

  Cancer associated fibroblasts (CAFs) play a key role in the tumour microenvironment (TME) of squamous cell carcinoma. Influenced by cues from cancer cells, CAFS remodel the extracellular matrix and secrete cytokines and ...
• Adjuvant Olaparib for Patients with <i>BRCA1</i>- or <i>BRCA2</i>-Mutated Breast Cancer. 

  Tutt, ANJ; Garber, JE; Kaufman, B; Viale, G; Fumagalli, D; Rastogi, P; Gelber, RD; de Azambuja, E; Fielding, A; Balmaña, J; Domchek, SM; Gelmon, KA; Hollingsworth, SJ; Korde, LA; Linderholm, B; Bandos, H; Senkus, E; Suga, JM; Shao, Z; Pippas, AW; Nowecki, Z; Huzarski, T; Ganz, PA; Lucas, PC; Baker, N; Loibl, S; McConnell, R; Piccart, M; Schmutzler, R; Steger, GG; Costantino, JP; Arahmani, A; Wolmark, N; McFadden, E; Karantza, V; Lakhani, SR; Yothers, G; Campbell, C; Geyer, CE; OlympiA Clinical Trial Steering Committee and Investigators (2021-06-03)

  <h4>Background</h4>Poly(adenosine diphosphate-ribose) polymerase inhibitors target cancers with defects in homologous recombination repair by synthetic lethality. New therapies are needed to reduce recurrence in patients ...
• Abemaciclib as initial therapy for advanced breast cancer: MONARCH 3 updated results in prognostic subgroups. 

  Johnston, S; O'Shaughnessy, J; Martin, M; Huober, J; Toi, M; Sohn, J; André, VAM; Martin, HR; Hardebeck, MC; Goetz, MP (2021-06-22)

  In MONARCH 3, continuous dosing of abemaciclib with an aromatase inhibitor (AI) conferred significant clinical benefit to postmenopausal women with HR+, HER2- advanced breast cancer. We report data for clinically prognostic ...
• The Evaluation of Health-Related Quality of Life Issues Experienced by Patients with Desmoid-Type Fibromatosis (The QUALIFIED Study)-A Protocol for an International Cohort Study. 

  Schut, A-RW; Timbergen, MJM; Lidington, E; Grünhagen, DJ; van der Graaf, WTA; Sleijfer, S; van Houdt, WJ; Bonenkamp, JJ; Younger, E; Dunlop, A; Jones, RL; Verhoef, C; Gennatas, S; Husson, O (2021-06-22)

  Sporadic desmoid-type fibromatosis (DTF) is a rare soft tissue tumour with an unpredictable clinical course. These tumours are incapable of metastasising, but their local aggressive tumour growth and tendency to recur ...

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