ICR Divisions
Browse by
Collections in this community
Recent submissions
-
Protein identification and quantification by two-dimensional infrared spectroscopy: Implications for an all-optical proteomic platform
(NATL ACAD SCIENCES, 2008-10-07)Electron-vibration-vibration two-dimensional coherent spectroscopy, a variant of 2DIR, is shown to be a useful tool to differentiate a set of 10 proteins based on their amino acid content. Two-dimensional vibrational ... -
Measuring interobserver variation in a pathology EQA scheme using weighted kappa for multiple readers
(B M J PUBLISHING GROUP, 2011-12)Background A Urological Pathology External Quality Assurance (EQA) Scheme in the UK has reported observer variation in the diagnosis and grading of adenocarcinoma in prostatic biopsies using basic kappa statistics, which ... -
Mixed-phenotype acute leukemia: clinical and laboratory features and outcome in 100 patients defined according to the WHO 2008 classification
(AMER SOC HEMATOLOGY, 2011-03-17)The features of 100 mixed-phenotype acute leukemias (MPALs), fulfilling WHO 2008 criteria, are documented. Myeloid and T-lineage features were demonstrated by cytoplasmic myeloperoxidase and CD3; B-lineage features were ... -
A single nucleotide polymorphism tags variation in the arylamine N-acetyltransferase 2 phenotype in populations of European background.
(2011-04)The arylamine N-acetyltransferase 2 (NAT2) slow acetylation phenotype is an established risk factor for urinary bladder cancer. We reported earlier on this risk association using NAT2 phenotypic categories inferred from ... -
A comparison of HPV DNA testing and liquid based cytology over three rounds of primary cervical screening: Extended follow up in the ARTISTIC trial
(ELSEVIER SCI LTD, 2011-04)Background: The additional sensitivity of HPV testing compared with cytology could permit extended cervical screening intervals. We wished to determine, through a further (third) round of screening in the ARTISTIC trial, ... -
Immunophenotyping of acute leukemia and lymphoproliferative disorders: a consensus proposal of the European LeukemiaNet Work Package 10
(NATURE PUBLISHING GROUP, 2011-04)The European LeukemiaNet (ELN), workpackage 10 (WP10) was designed to deal with diagnosis matters using morphology and immunophenotyping. This group aimed at establishing a consensus on the required reagents for proper ... -
A practical application of analysing weighted kappa for panels of experts and EQA schemes in pathology
(B M J PUBLISHING GROUP, 2011-03)Background Kappa statistics are frequently used to analyse observer agreement for panels of experts and External Quality Assurance (EQA) schemes and generally treat all disagreements as total disagreement. However, the ... -
Evaluating Imaging Biomarkers of Acquired Resistance to Targeted EGFR Therapy in Xenograft Models of Human Head and Neck Squamous Cell Carcinoma.
(2018)Background: Overexpression of EGFR is a negative prognostic factor in head and neck squamous cell carcinoma (HNSCC). Patients with HNSCC who respond to EGFR-targeted tyrosine kinase inhibitors (TKIs) eventually develop ... -
On the evolutionary origin of the chaperonins
(WILEY-BLACKWELL, 2011-04)An analysis of the apical domain of the Group-I and Group-II chaperonins shows that they have structural similarities to two different protein folds: a “swivel-domain” phosphotransferase and a thioredoxin-like peroxiredoxin. ... -
Protein coalitions in a core mammalian biochemical network linked by rapidly evolving proteins
(BIOMED CENTRAL LTD, 2011-05-25)Background: Cellular ATP levels are generated by glucose-stimulated mitochondrial metabolism and determine metabolic responses, such as glucose-stimulated insulin secretion (GSIS) from the beta-cells of pancreatic islets. ... -
Estimation of disease severity in the NHS cervical screening programme. Part I: artificial cut-off points and semi-quantitative solutions
(WILEY-BLACKWELL, 2011-06)Objective: Current cytology and histology classifications are based on ordered categories and have a strong emphasis on providing information that decides a woman’s management rather than the best estimate of disease ... -
Estimation of disease severity in the NHS cervical screening programme. Part II: quantitative methods of estimating disease severity and progression potential
(WILEY-BLACKWELL, 2011-06)Estimation of disease severity in the NHS cervical screening programme. Part II: quantitative methods of estimating disease severity and progression potential Objective: This is the second of a two-part paper exploring the ... -
Menopausal symptoms and bone health in women undertaking risk reducing bilateral salpingo-oophorectomy: significant bone health issues in those not taking HRT
(NATURE PUBLISHING GROUP, 2011-06-28)BACKGROUND: Women at high ovarian cancer risk, especially those with mutations in BRCA1/BRCA2, are encouraged to undergo bilateral risk-reducing salpingo-oophorectomy (BRRSPO) prior to the natural menopause. The decision ... -
FRACTIONATED STEREOTACTIC RADIOTHERAPY IN THE TREATMENT OF VESTIBULAR SCHWANNOMA (ACOUSTIC NEUROMA): PREDICTING THE RISK OF HYDROCEPHALUS
(ELSEVIER SCIENCE INC, 2011-07-15)Purpose: To determine the incidence and predictive factors for the development of hydrocephalus in patients with acoustic neuromas (AN) treated with fractionated stereotactic radiotherapy. Patients and Methods: Seventy-two ... -
Somnolence syndrome in patients receiving radical radiotherapy for primary brain tumours: A prospective study
(ELSEVIER IRELAND LTD, 2011-07)Background and purpose: To characterise the incidence, pattern and severity of post cranial radiotherapy somnolence and to identify factors predictive of frequency and severity. Materials and methods: Seventy consecutive ... -
Boronic acids-A novel class of bacterial mutagen
(ELSEVIER SCIENCE BV, 2011-09-18)Boronic acids and their esters are important building blocks in organic syntheses including those for drug substances and for which, as far as it can be determined, there are no published reports of testing for genotoxicity. ... -
Evaluation of the use of digital images for a national prostate core external quality assurance scheme
(WILEY-BLACKWELL, 2011-10)Aims: To evaluate the use of virtual images as an alternative to glass slides to expand the number of participants in the External Quality Assurance Scheme for prostatic biopsies. Methods and results: Benign and neoplastic ... -
False-positive screening results in the European randomized study of screening for prostate cancer
(ELSEVIER SCI LTD, 2011-12)Background: Screening for prostate cancer (PC) with prostate-specific antigen (PSA) has been shown to decrease mortality, but has adverse effects, such as false-positive (FP) screening results. We describe the frequency ...
RSS 1.0