• Targeted Alpha Therapy, an Emerging Class of Cancer Agents: A Review. 

  Targeted Alpha Therapy Working Group; Parker, C; Lewington, V; Shore, N; Kratochwil, C; Levy, M; Lindén, O; Noordzij, W; Park, J; Saad, F (2018-09-20)

  Importance: Targeted alpha therapy attempts to deliver systemic radiation selectively to cancer cells while minimizing systemic toxic effects and may lead to additional treatment options for many cancer types. Observations: ...
• Adjuvant bevacizumab for melanoma patients at high risk of recurrence: survival analysis of the AVAST-M trial. 

  Corrie, PG; Marshall, A; Nathan, PD; Lorigan, P; Gore, M; Tahir, S; Faust, G; Kelly, CG; Marples, M; Danson, SJ; Marshall, E; Houston, SJ; Board, RE; Waterston, AM; Nobes, JP; Harries, M; Kumar, S; Goodman, A; Dalgleish, A; Martin-Clavijo, A; Westwell, S; Casasola, R; Chao, D; Maraveyas, A; Patel, PM; Ottensmeier, CH; Farrugia, D; Humphreys, A; Eccles, B; Young, G; Barker, EO; Harman, C; Weiss, M; Myers, KA; Chhabra, A; Rodwell, SH; Dunn, JA; Middleton, MR; AVAST-M Investigators (2018-08-01)

  Background: Bevacizumab is a recombinant humanised monoclonal antibody to vascular endothelial growth factor shown to improve survival in advanced solid cancers. We evaluated the role of adjuvant bevacizumab in melanoma ...
• Functional phosphorylation sites in the C-terminal region of the multivalent multifunctional transcriptional factor CTCF 

  Klenova, EM; Chernukhin, IV; El-Kady, A; Lee, RE; Pugacheva, EM; Loukinov, DI; Goodwin, GH; Delgado, D; Filippova, GN; Leon, J; Morse, HC; Neiman, PE; Lobanenkov, VV (2001-03)

  CTCF is a widely expressed and highly conserved multi-Zn-finger (ZF) nuclear factor. Binding to various CTCF target sites (CTSs) is mediated by combinatorial contributions of different ZFs. Different CTSs mediate distinct ...
• Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity 

  Gregson, SJ; Howard, PW; Hartley, JA; Brooks, NA; Adams, LJ; Jenkins, TC; Kelland, LR; Thurston, DE (2001-03-01)

  A novel sequence-selective pyrrolobenzodiazepine (PBD) dimer 5 (SJG-136) has been developed that comprises two C2-exo-methylene-substituted DC-81 (3) subunits tethered through their C8 positions via an inert propanedioxy ...
• ‘Dividing the desolation’: Clients views on the benefits of a cancer counselling service 

  Boulton, M; Boudioni, M; Mossman, J; Moynihan, G; Leydon, G; Ramirez, A

  This paper describes clients’ accounts of the benefits they derived from a short course of cancer counselling provided within a humanist framework. Three hundred and two clients who had attended at least one session of a ...
• Design and performance of a data acquisition system for VUB-PET 

  Bruyndonckx, P; Wang, YG; Tavernier, S; Carnochan, P (2001-02)

  A flexible and high-speed VME-based data acquisition system (DAQ) has been designed to process data from the University of Brussels (VUB) small-animal positron emission tomography (PET) system. The core tasks of the system ...
• Polymer-assisted solution-phase library synthesis of 4-alkoxy-2-hydroxy-3,5,6-trifluorobenzoic acids 

  Hardcastle, IR; Barber, AM; Marriott, JH; Jarman, M (2001)

  The efficient synthesis of a small library of 4-alkoxy-2-hydroxy-3,5,6-trifluorobenzoic acids is described via the fluoride mediated alkylation of 5,6,8-trifluoro-7-hydroxy-2-methyl-benzo[1,3]dioxin-4-one with a collection ...
• Synthesis and anti-melanoma activity of analogues of N-acetyl-4-S-cysteaminylphenol substituted with two methyl groups α to the nitrogen 

  Lant, N; McKeown, P; C Timoney, M; R Kelland, L; Rogers, P; J Robins, D
• Single nucleotide polymorphisms, metabolic activation and environmental carcinogenesis: why molecular epidemiologists should think about enzyme expression 

  Williams, JA (2001-02)

  This commentary was written to stimulate thoughts on, and consideration of, enzyme expression data in target organs when investigating possible associations between polymorphisms in carcinogen activation enzymes, ...
• Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I 

  Coleman, ML; Sahai, EA; Yeo, M; Bosch, M; Dewar, A; Olson, MF (MACMILLAN PUBLISHERS LTD, 2001-04)

  The execution phase of apoptosis is characterized by marked changes in cell morphology that include contraction and membrane blebbing. The actin-myosin system has been proposed to be the source of contractile force that ...
• Radiation response and cure rate of human colon adenocarcinoma spheroids of different size: the significance of hypoxia on tumor control modelling 

  Buffa, FM; West, C; Byrne, K; Moore, JV; Nahum, AE (2001)

  Purpose: To evaluate the adequacy of a Poisson tumor control probability (tcp) model and the impact of hypoxia on tumor cure. Methods and Materials: A human colon adenocarcinoma cell line, WiDr, was grown as multicellular ...
• Genotoxins and the initiation of sporadic breast cancer 

  Martin, FL (2001-03)

  Breast cancer is the most frequently diagnosed female malignancy world-wide. The aetiology of the majority of cases remains obscure and the only genotoxin as yet known to initiate breast cancer is ionizing radiation, High ...
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  Structure-based design of selective and potent G quadruplex-mediated telomerase inhibitors 

  Read, M; Harrison, RJ; Romagnoli, B; Tanious, FA; Gowan, SH; Reszka, AP; Wilson, WD; Kelland, LR; Neidle, S (2001-04-24)

  The telomerase enzyme is a potential therapeutic target in many human cancers. A series of potent inhibitors has been designed by computer modeling, which exploit the unique structural features of quadruplex DNA, These ...
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  High levels of the MDM2 oncogene in paediatric rhabdomyosarcoma cell lines may confer multidrug resistance 

  Cocker, HA; Hobbs, SM; Tiffin, N; Pritchard-Jones, K; Pinkerton, CR; Kelland, LR (2001-11-30)

  The MDM2 protein is known to be overexpressed in some sarcomas including rhabdomyosarcoma. However, the extent to which the MDM2 protein influences sensitivity to chemotherapeutic drugs is unclear. We have analysed this ...
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  A mutation in the Gsk3-binding domain of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon and eyes to diencephalon 

  Heisenberg, CP; Houart, C; Take-uchi, M; Rauch, GJ; Young, N; Coutinho, P; Masai, I; Caneparo, L; Concha, ML; Geisler, R; Dale, TC; Wilson, SW; Stemple, DL (2001-06-01)

  Zebrafish embryos homozygous for the masterblind (mb1) mutation exhibit a striking phenotype in which the eyes and telencephalon are reduced or absent and diencephalic fates expand to the front of the brain. Here we show ...
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  Short tandem repeat profiling provides an international reference standard for human cell lines 

  Masters, JR; Thomson, JA; Daly-Burns, B; Reid, YA; Dirks, WG; Packer, P; Toji, LH; Ohno, T; Tanabe, H; Arlett, CF; Kelland, LR; Harrison, M; Virmani, A; Ward, TH; Ayres, KL; Debenham, PG (NATL ACAD SCIENCES, 2001-07-03)

  Cross-contamination between cell lines is a longstanding and frequent cause of scientific misrepresentation. Estimates from national testing services indicate that up to 36% of cell lines are of a different origin or species ...
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  Stabilisation of TG-and AG-containing antiparrallel DNA triplexes by triplex-binding ligands 

  Neidle, S (2001-05-01)

  Stabilisation of TG-and AG-containing antiparrallel DNA triplexes by triplex-binding ligands. We have used DNase I footprinting to examine the interaction of several tripler-binding ligands with antiparallel TG- and AG- ...
• Modulation of both endogenous folates and thymidine enhance the therapeutic efficacy of thymidylate synthase inhibitors 

  van der Wilt, CL; Backus, HHJ; Smid, K; Comijn, L; Veerman, G; Wouters, D; Voorn, DA; Priest, DG; Bunni, MA; Mitchell, F; Jackman, AL; Jansen, G; Peters, GJ (AMER ASSOC CANCER RESEARCH, 2001-05-01)

  Plasma levels of folates and thymidine in mice are about 10-fold higher than in humans and may influence the therapeutic efficacy of thymidylate synthase (TS) Inhibitors, such as 5-fluorouracil (5FU) and the antifolates ...
• Polycythemia vera: analysis of DNA from blood granulocytes using comparative genomic hybridization 

  Gruszka-Westwood, Alicja (2001-05)

  Polycythemia vera: analysis of DNA from blood granulocytes using comparative genomic hybridization. Background and Objectives. The diagnosis of polycythemia vera (PV) is supported by the finding of an abnormal karyotype ...
• Series model volume effects in a population of non-identical patients: how low is low? 

  Nahum, A (2001-07)

  Series model volume effects in a population of non-identical patients: how low is low? Working with several mechanisms of critical local tissue damage, formulae are analytically derived that describe normal tissue complication ...

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