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Genetic mechanisms in squamous cell carcinoma of the head and neck.
Genetic mechanisms in squamous cell carcinoma of the head and neck. This review aims to explore the genetic mechanisms involved in the development of squamous cell carcinoma of the head and neck (SCCHN). The epidemiology ... -
Bayesian disclosure risk assessment: predicting small frequencies in contingency tables
We propose an approach for assessing the risk of individual identification in the release of categorical data. This requires the accurate calculation of predictive probabilities for those cells in a contingency table which ... -
Comparative genomics in chicken and Pekin duck using FISH mapping and microarray analysis
(BIOMED CENTRAL LTD, 2009-08-05)Background: The availability of the complete chicken (Gallus gallus) genome sequence as well as a large number of chicken probes for fluorescent in-situ hybridization (FISH) and microarray resources facilitate comparative ... -
Genetic testing for cancer predisposition and implications for nursing practice: narrative review
P>Title. Genetic testing for cancer predisposition and implications for nursing practice:narrative review. Aim. This paper is a report of a review of literature on the psychological and social implications of genetic testing ... -
Impact of Radiotherapy When Added to Androgen-Deprivation Therapy for Locally Advanced Prostate Cancer: Long-Term Quality-of-Life Outcomes From the NCIC CTG PR3/MRC PR07 Randomized Trial
(2015-05-26)Purpose The NCIC CTG PR3/MRC PR07 randomized phase III trial compared androgen-deprivation therapy (ADT) alone versus ADT with radiotherapy (RT) for patients with locally advanced prostate cancer. This article reports the ... -
Chromosome 17p Homodisomy Is Associated With Better Outcome in 1p19q Non-Codeleted and IDH-Mutated Gliomas
Background. The 1p19q non-codeleted gliomas with IDH mutation, defined as "molecular astrocytomas," display frequent TP53 mutations and have an intermediate prognosis. We investigated the prognostic impact of copy ... -
Same-day genomic and epigenomic diagnosis of brain tumors using real-time nanopore sequencing
(2017-06-21)Molecular classification of cancer has entered clinical routine to inform diagnosis, prognosis, and treatment decisions. At the same time, new tumor entities have been identified that cannot be defined histologically. For ... -
Statistical analysis of pathogenicity of somatic mutations in cancer
(2006-08)Statistical analysis of pathogenicity of somatic mutations in cancer Recent large-scale sequencing studies have revealed that cancer genomes contain variable numbers of somatic point mutations distributed across many genes. ... -
Mutation analysis of 24 known cancer genes in the NCI-60 cell line set
(2006-11)The panel of 60 human cancer cell lines (the NCI-60) assembled by the National Cancer Institute for anticancer drug discovery is a widely used resource. The NCI-60 has been characterized pharmacologically and at the molecular ... -
Architectures of somatic genomic rearrangement in human cancer amplicons at sequence-level resolution
(2007-09)For decades, cytogenetic studies have demonstrated that somatically acquired structural rearrangements of the genome are a common feature of most classes of human cancer. However, the characteristics of these rearrangements ... -
Mutations in UPF3B, a member of the nonsense-mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardation
(2007-09)Nonsense- mediated mRNA decay ( NMD) is of universal biological significance(1-3). It has emerged as an important global RNA, DNA and translation regulatory pathway(4). By systematically sequencing 737 genes ( annotated ... -
Feedback circuit among INK4 tumor suppressors constrains human glioblastoma development
(2008-04)We have developed a nonheuristic genome topography scan (GTS) algorithm to characterize the patterns of genomic alterations in human glioblastoma (GBM), identifying frequent p18(INK4C) and p16(INK4A) codeletion. Functional ... -
A novel diffuse gastric cancer susceptibility variant in E-cadherin (CDH1) intron 2: A case control study in an Italian population
(2008-05)Background: Inherited genetic factors such as E-cadherin (CDH1) promoter variants are believed to influence the risk towards sporadic diffuse gastric cancer (DGC). Recently, a new regulatory region essential for CDH1 ... -
Subclonal phylogenetic structures in cancer revealed by ultra-deep sequencing
During the clonal expansion of cancer from an ancestral cell with an initiating oncogenic mutation to symptomatic neoplasm, the occurrence of somatic mutations (both driver and passenger) can be used to track the on-going ... -
Parallel RNAi screens across different cell lines identify generic and cell type-specific regulators of actin organization and cell morphology
Background: In recent years RNAi screening has proven a powerful tool for dissecting gene functions in animal cells in culture. However, to date, most RNAi screens have been performed in a single cell line, and results ... -
The cancer genome
(2009-04)All cancers arise as a result of changes that have occurred in the DNA sequence of the genomes of cancer cells. Over the past quarter of a century much has been learnt about these mutations and the abnormal genes that ... -
A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation
(2009-05)Large-scale systematic resequencing has been proposed as the key future strategy for the discovery of rare, disease-causing sequence variants across the spectrum of human complex disease. We have sequenced the coding exons ... -
Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer
(2009-05)Somatically acquired epigenetic changes are present in many cancers. Epigenetic regulation is maintained via post-translational modifications of core histones. Here, we describe inactivating somatic mutations in the histone ... -
A comprehensive catalogue of somatic mutations from a human cancer genome
(NATURE PUBLISHING GROUP, 2010-01)All cancers carry somatic mutations. A subset of these somatic alterations, termed driver mutations, confer selective growth advantage and are implicated in cancer development, whereas the remainder are passengers. Here ... -
A small-cell lung cancer genome with complex signatures of tobacco exposure
(NATURE PUBLISHING GROUP, 2010-01)Cancer is driven by mutation. Worldwide, tobacco smoking is the principal lifestyle exposure that causes cancer, exerting carcinogenicity through \ensuremath>60 chemicals that bind and mutate DNA. Using massively parallel ...
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