Other ICR Research
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Recent submissions
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Estimation of disease severity in the NHS cervical screening programme. Part I: artificial cut-off points and semi-quantitative solutions
(WILEY-BLACKWELL, 2011-06)Objective: Current cytology and histology classifications are based on ordered categories and have a strong emphasis on providing information that decides a woman’s management rather than the best estimate of disease ... -
Estimation of disease severity in the NHS cervical screening programme. Part II: quantitative methods of estimating disease severity and progression potential
(WILEY-BLACKWELL, 2011-06)Estimation of disease severity in the NHS cervical screening programme. Part II: quantitative methods of estimating disease severity and progression potential Objective: This is the second of a two-part paper exploring the ... -
Activation of Aurora-A Kinase by Protein Partner Binding and Phosphorylation Are Independent and Synergistic
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2012-01-06)Protein kinases are activated by phosphorylation and by the binding of activator proteins. The interplay of these two factors is incompletely understood. We applied energetic analysis to this question and characterized the ... -
A stable-isotope HPLC-MS/MS method to simplify storage of human whole blood samples for glutathione assay
(ELSEVIER SCIENCE BV, 2012-06-01)Background: Glutathione is the principal non-protein tripeptide thiol present in most mammalian cells and plays an important role in the redox status of biological systems. The accurate assessment of reduced glutathione ... -
The rationale for targeting the LOX family in cancer
(NATURE PUBLISHING GROUP, 2012-08)The therapeutic targeting of extracellular proteins is becoming hugely attractive in light of evidence implicating the tumour microenvironment as pivotal in all aspects of tumour initiation and progression. Members of the ... -
Treatment and outcome of Wilms’ tumour patients: an analysis of all cases registered in the UKW3 trial
(OXFORD UNIV PRESS, 2012-09)The randomised findings of the UKW3 trial were that preoperative chemotherapy was associated with a more advantageous stage distribution and reduction in therapy burden versus immediate nephrectomy without compromising ... -
Evidence of exposure to aristolochic acid in patients with urothelial cancer from a Balkan endemic nephropathy region of Romania
(WILEY-BLACKWELL, 2012-10)Recently, chronic Aristolochia poisoning was found responsible for the aetiology of Balkan endemic nephropathy (BEN) in Croatia, Serbia, and Bosnia, and diet was the likely route of exposure to aristolochic acid (AA). BEN, ... -
The Anaphase Promoting Complex Contributes to the Degradation of the S. cerevisiae Telomerase Recruitment Subunit Est1p
(PUBLIC LIBRARY SCIENCE, 2013-01-25)Telomerase is a multi-subunit enzyme that reverse transcribes telomere repeats onto the ends of linear eukaryotic chromosomes and is therefore critical for genome stability. S. cerevisiae telomerase activity is cell-cycle ... -
Does Body Contouring After Bariatric Weight Loss Enhance Quality of Life? A Systematic Review of QOL Studies.
(2018-08-02)Massive weight loss following bariatric surgery can result in excess tissue, manifesting as large areas of redundant skin that can be managed by body contouring surgery. This study aims to quantify the effects of body ... -
LOX-Mediated Collagen Crosslinking Is Responsible for Fibrosis-Enhanced Metastasis
(AMER ASSOC CANCER RESEARCH, 2013-03-15)Tumor metastasis is a highly complex, dynamic, and inefficient process involving multiple steps, yet it accounts for more than 90% of cancer-related deaths. Although it has long been known that fibrotic signals enhance ... -
A Kinetic Test Characterizes Kinase Intramolecular and Intermolecular Autophosphorylation Mechanisms
(AMER ASSOC ADVANCEMENT SCIENCE, 2013-07-02)Many protein kinases catalyze their own activation by autophosphorylation. The mechanism of this is generally considered to be intermolecular and similar to that used in substrate phosphorylation. We derived the kinetic ... -
Genetic Tracing via DNGR-1 Expression History Defines Dendritic Cells as a Hematopoietic Lineage
(CELL PRESS, 2013-08-15)Mononuclear phagocytes are classified as macrophages or dendritic cells (DCs) based on cell morphology, phenotype, or select functional properties. However, these attributes are not absolute and often overlap, leading to ... -
Optical photon transport in powdered-phosphor scintillators. Part II. Calculation of single-scattering transport parameters
(AMER ASSOC PHYSICISTS MEDICINE AMER INST PHYSICS, 2013-04)Purpose: Monte Carlo methods based on the Boltzmann transport equation (BTE) have previously been used to model light transport in powdered-phosphor scintillator screens. Physically motivated guesses or, alternatively, the ... -
Optical photon transport in powdered-phosphor scintillators. Part 1. Multiple-scattering and validity of the Boltzmann transport equation
(AMER ASSOC PHYSICISTS MEDICINE AMER INST PHYSICS, 2013-04)Purpose: In Part 1 of this two-part work, predictions for light transport in powdered-phosphor screens are made, based on three distinct approaches. Predictions of geometrical optics-based ray tracing through an explicit ... -
Unlocking the potential of retinoic acid in anticancer therapy
(NATURE PUBLISHING GROUP, 2014-11-25)All-trans-retinoic acid (ATRA) is a physiologically active metabolite of vitamin A. Its antitumour activities have been extensively studied in a variety of model systems and clinical trials; however, to date the only ... -
The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase
(NATURE PUBLISHING GROUP, 2015-06-04)Tumour metastasis is a complex process involving reciprocal interplay between cancer cells and host stroma at both primary and secondary sites, and is strongly influenced by microenvironmental factors such as hypoxia(1). ... -
Epstein-Barr virus and HLA-DPB1-*0301 in young adult Hodgkin’s disease: Evidence for inherited susceptibility to Epstein-Barr virus in cases that are EBV+ve
(AMER ASSOC CANCER RESEARCH, 2001-06)Cases of Hodgkin’s disease (HD) may be distinguished by whether they do [EBV-positive ((+ve)) cases] or do not [EBV-negative ((-ve)) cases] have evidence of EBV DNA in the Reed-Sternberg cells. Only one study has attempted ... -
An epidemiologic study of index and family infectious mononucleosis and adult Hodgkin’s disease (HD): Evidence for a specific association with EBV+ve HD in young adults
(WILEY-LISS, 2003-11-01)Infectious mononucleosis (IM) is an established risk factor for Hodgkin’s disease (HD). A substantial minority (33%) of cases of HD have. Epstein-Barr virus (EBV) DNA within the malignant cells (are EBV+ve). It is unclear ... -
Dose perturbations at high-Z interfaces in kilovoltage photon beams: comparison with Monte Carlo simulations and measurements
(PERGAMON-ELSEVIER SCIENCE LTD, 2002-06)Dose perturbations, backscatter dose perturbation factor (BSDF), and forward dose perturbation factor (FDPF) near high-Z material interfaces have been reported to be intense and significant in kilovoltage photon beams. ... -
Evaluation of the EGSnrc Monte Carlo code for interface dosimetry near high-Z media exposed to kilovolt and Co-60 photons
(IOP PUBLISHING LTD, 2002-05-21)High atomic number (Z) heterogeneities in tissue exposed to photons with energies of up to about 1 MeV can cause significant dose perturbations in their immediate vicinity. The recently released Monte Carlo (MC) code EGSnrc ...
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