• Deficient adaptation to centrosome duplication defects in neural progenitors causes microcephaly and subcortical heterotopias. 

  González-Martínez, J; Cwetsch, AW; Martínez-Alonso, D; López-Sainz, LR; Almagro, J; Melati, A; Gómez, J; Pérez-Martínez, M; Megías, D; Boskovic, J; Gilabert-Juan, J; Graña-Castro, O; Pierani, A; Behrens, A; Ortega, S; Malumbres, M (2021-08-23)

  Congenital microcephaly (MCPH) is a neurodevelopmental disease associated with mutations in genes encoding proteins involved in centrosomal and chromosomal dynamics during mitosis. Detailed MCPH pathogenesis at the cellular ...
• Clinical outcomes of patients with corticosteroid refractory immune checkpoint inhibitor-induced enterocolitis treated with infliximab. 

  Alexander, JL; Ibraheim, H; Sheth, B; Little, J; Khan, MS; Richards, C; Hunter, N; Chauhan, D; Ratnakumaran, R; McHugh, K; Pinato, DJ; Nathan, P; Choy, J; Crusz, SM; Furness, A; Turajlic, S; Pickering, L; Larkin, J; Teare, JP; Papa, S; Speight, A; Sharma, A; Powell, N

  <h4>Introduction</h4>Immune checkpoint inhibitors (CPIs) have changed the treatment landscape for many cancers, but also cause severe inflammatory side effects including enterocolitis. CPI-induced enterocolitis is treated ...
• Clinical and immunologic implications of COVID-19 in patients with melanoma and renal cell carcinoma receiving immune checkpoint inhibitors. 

  Switzer, B; Haanen, J; Lorigan, PC; Puzanov, I; Turajlic, S

  The clinical and immunologic implications of the SARS-CoV-2 pandemic for patients with cancer receiving systemic anticancer therapy have introduced a multitude of clinical challenges and academic controversies. This review ...
• Reconstructing single-cell karyotype alterations in colorectal cancer identifies punctuated and gradual diversification patterns. 

  Bollen, Y; Stelloo, E; van Leenen, P; van den Bos, M; Ponsioen, B; Lu, B; van Roosmalen, MJ; Bolhaqueiro, ACF; Kimberley, C; Mossner, M; Cross, WCH; Besselink, NJM; van der Roest, B; Boymans, S; Oost, KC; de Vries, SG; Rehmann, H; Cuppen, E; Lens, SMA; Kops, GJPL; Kloosterman, WP; Terstappen, LWMM; Barnes, CP; Sottoriva, A; Graham, TA; Snippert, HJG

  Central to tumor evolution is the generation of genetic diversity. However, the extent and patterns by which de novo karyotype alterations emerge and propagate within human tumors are not well understood, especially at ...
• The concerns of oncology professionals during the COVID-19 pandemic: results from the ESMO Resilience Task Force survey II. 

  Lim, KHJ; Murali, K; Kamposioras, K; Punie, K; Oing, C; O'Connor, M; Thorne, E; Amaral, T; Garrido, P; Lambertini, M; Devnani, B; Westphalen, CB; Morgan, G; Haanen, JBAG; Hardy, C; Banerjee, S

  <h4>Background</h4>The COVID-19 pandemic has resulted in significant changes to professional and personal lives of oncology professionals globally. The European Society for Medical Oncology (ESMO) Resilience Task Force ...
• A systematic review and meta-analysis of the relationship between the radiation absorbed dose to the thyroid and response in patients treated with radioiodine for Graves’ disease 

  Taprogge, J; Flux, G; Murray, I; Gear, J; Carnegie-Peake, L; Gape, P
• Roles of cancer associated fibroblasts in squamous cell carcinoma 

  Rullan, A (2021-03-31)

  Cancer associated fibroblasts (CAFs) play a key role in the tumour microenvironment (TME) of squamous cell carcinoma. Influenced by cues from cancer cells, CAFS remodel the extracellular matrix and secrete cytokines and ...
• Adjuvant Olaparib for Patients with <i>BRCA1</i>- or <i>BRCA2</i>-Mutated Breast Cancer. 

  Tutt, ANJ; Garber, JE; Kaufman, B; Viale, G; Fumagalli, D; Rastogi, P; Gelber, RD; de Azambuja, E; Fielding, A; Balmaña, J; Domchek, SM; Gelmon, KA; Hollingsworth, SJ; Korde, LA; Linderholm, B; Bandos, H; Senkus, E; Suga, JM; Shao, Z; Pippas, AW; Nowecki, Z; Huzarski, T; Ganz, PA; Lucas, PC; Baker, N; Loibl, S; McConnell, R; Piccart, M; Schmutzler, R; Steger, GG; Costantino, JP; Arahmani, A; Wolmark, N; McFadden, E; Karantza, V; Lakhani, SR; Yothers, G; Campbell, C; Geyer, CE; OlympiA Clinical Trial Steering Committee and Investigators (2021-06-03)

  <h4>Background</h4>Poly(adenosine diphosphate-ribose) polymerase inhibitors target cancers with defects in homologous recombination repair by synthetic lethality. New therapies are needed to reduce recurrence in patients ...
• High expression of vinculin predicts poor prognosis and distant metastasis and associates with influencing tumor-associated NK cell infiltration and epithelial-mesenchymal transition in gastric cancer. 

  Li, H; Wang, C; Lan, L; Behrens, A; Tomaschko, M; Ruiz, J; Su, Q; Zhao, G; Yuan, C; Xiao, X; Li, B; Yan, L; Wu, W; Li, W; Chen, J; He, Y; Zhang, C

  In the process of epithelial-mesenchymal transition (EMT), epithelial cancer cells transdifferentiate into mesenchymal-like cells with high motility and aggressiveness, resulting in the spread of tumor cells. Immune cells ...
• Identification of different side effects between PARP inhibitors and their polypharmacological multi-target rationale. 

  Sandhu, D; Antolin, AA; Cox, AR; Jones, AM (2021-07-30)

  <h4>Aims</h4>The aim of this study was to determine the differences and potential mechanistic rationale for observed adverse drug reactions (ADRs) between four approved PARP inhibitors (PARPi).<h4>Methods</h4>The Medicines ...
• Introduction to the National Cancer Imaging Translational Accelerator (NCITA): a UK-wide infrastructure for multicentre clinical translation of cancer imaging biomarkers. 

  McAteer, MA; O'Connor, JPB; Koh, DM; Leung, HY; Doran, SJ; Jauregui-Osoro, M; Muirhead, N; Brew-Graves, C; Plummer, ER; Sala, E; Ng, T; Aboagye, EO; Higgins, GS; Punwani, S (2021-07-27)

  The National Cancer Imaging Translational Accelerator (NCITA) is creating a UK national coordinated infrastructure for accelerated translation of imaging biomarkers for clinical use. Through the development of standardised ...
• Tumor-Infiltrating B Lymphocyte Profiling Identifies IgG-Biased, Clonally Expanded Prognostic Phenotypes In Triple-Negative Breast Cancer. 

  Harris, RJ; Cheung, A; Ng, JCF; Laddach, R; Chenoweth, AM; Crescioli, S; Fittall, M; Dominguez Rodriguez, D; Roberts, J; Levi, D; Liu, F; Alberts, E; Quist, J; Santaolalla, A; Pinder, SE; Gillett, C; Hammar, N; Irshad, S; Van Hemelrijck, M; Dunn-Walters, DK; Fraternali, F; Spicer, JF; Lacy, KE; Tsoka, S; Grigoriadis, A; Tutt, ANJ; Karagiannis, SN (2021-06-15)

  In breast cancer, humoral immune responses may contribute to clinical outcomes, especially in more immunogenic subtypes. Here we investigated B lymphocyte subsets, immunoglobulin expression, and clonal features in breast ...
• Endoscopic surveillance for bladder cancer: a systematic review of contemporary worldwide practices. 

  Russell, B; Kotecha, P; Thurairaja, R; Nair, R; Malde, S; Kumar, P; Khan, MS

  <h4>Background</h4>The aim of this systematic review was to identify the current endoscopic surveillance strategies in use across the world and to determine whether these were sufficient or if any recommendations for changes ...
• Has COVID-19 had a greater impact on female than male oncologists? Results of the ESMO Women for Oncology (W4O) Survey. 

  Garrido, P; Adjei, AA; Bajpai, J; Banerjee, S; Berghoff, AS; Choo, SP; Felip, E; Furness, AJS; Garralda, E; Haanen, J; Letsch, A; Linardou, H; Peters, S; Sessa, C; Tabernero, J; Tsang, J; Yang, JC-H; Garassino, MC

  <h4>Background</h4>European Society for Medical Oncology Women for Oncology (ESMO W4O) research has previously shown under-representation of female oncologists in leadership roles. As early reports suggested disproportionate ...
• Phase III, randomized trial of mirvetuximab soravtansine versus chemotherapy in patients with platinum-resistant ovarian cancer: primary analysis of FORWARD I. 

  Moore, KN; Oza, AM; Colombo, N; Oaknin, A; Scambia, G; Lorusso, D; Konecny, GE; Banerjee, S; Murphy, CG; Tanyi, JL; Hirte, H; Konner, JA; Lim, PC; Prasad-Hayes, M; Monk, BJ; Pautier, P; Wang, J; Berkenblit, A; Vergote, I; Birrer, MJ

  <h4>Background</h4>Mirvetuximab soravtansine (MIRV) is an antibody-drug conjugate comprising a folate receptor alpha (FRα)-binding antibody, cleavable linker, and the maytansinoid DM4, a potent tubulin-targeting agent. The ...
• Cytokine release syndrome in a patient with colorectal cancer after vaccination with BNT162b2. 

  Au, L; Fendler, A; Shepherd, STC; Rzeniewicz, K; Cerrone, M; Byrne, F; Carlyle, E; Edmonds, K; Del Rosario, L; Shon, J; Haynes, WA; Ward, B; Shum, B; Gordon, W; Gerard, CL; Xie, W; Joharatnam-Hogan, N; Young, K; Pickering, L; Furness, AJS; Larkin, J; Harvey, R; Kassiotis, G; Gandhi, S; Crick COVID-19 Consortium; Swanton, C; Fribbens, C; Wilkinson, KA; Wilkinson, RJ; Lau, DK; Banerjee, S; Starling, N; Chau, I; CAPTURE Consortium; Turajlic, S (2021-05-26)

  Patients with cancer are currently prioritized in coronavirus disease 2019 (COVID-19) vaccination programs globally, which includes administration of mRNA vaccines. Cytokine release syndrome (CRS) has not been reported ...
• Characteristics and predictors of acute and chronic post-COVID syndrome: A systematic review and meta-analysis. 

  Iqbal, FM; Lam, K; Sounderajah, V; Clarke, JM; Ashrafian, H; Darzi, A

  <h4>Background</h4>A significant proportion of individuals experience lingering and debilitating symptoms following acute COVID-19 infection. The National Institute for Health and Care Excellence (NICE) have coined the ...
• A novel gaze-controlled flexible robotized endoscope; preliminary trial and report. 

  Sivananthan, A; Kogkas, A; Glover, B; Darzi, A; Mylonas, G; Patel, N (2021-05-24)

  <h4>Background</h4>Interventional endoluminal therapy is rapidly advancing as a minimally invasive surgical technique. The expanding remit of endoscopic therapy necessitates precision control. Eye tracking is an emerging ...
• Grass-roots junior doctor communication network in response to the COVID-19 pandemic: a service evaluation. 

  Sivananthan, A; Machin, M; Zijlstra, G; Harris, A; Radhakrishnan, ST; Crook, P; Phillips, G; Denning, MC; Patel, N; Russell, G; Darzi, A; Kinross, J; Brown, R

  <h4>Background</h4>COVID-19 was declared a worldwide pandemic on 11 March 2020. Imperial College Healthcare NHS Trust provides 1412 inpatient beds staffed by 1200 junior doctors and faced a large burden of COVID-19 ...
• Prevalence of antibody positivity to SARS-CoV-2 following the first peak of infection in England: Serial cross-sectional studies of 365,000 adults. 

  Ward, H; Cooke, GS; Atchison, C; Whitaker, M; Elliott, J; Moshe, M; Brown, JC; Flower, B; Daunt, A; Ainslie, K; Ashby, D; Donnelly, CA; Riley, S; Darzi, A; Barclay, W; Elliott, P (2021-05-02)

  <h4>Background</h4>The time-concentrated nature of the first wave of the COVID-19 epidemic in England in March and April 2020 provides a natural experiment to measure changes in antibody positivity at the population level ...

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