• Circulating tumor DNA markers for early progression on fulvestrant with or without palbociclib in ER+ advanced breast cancer 

  O’Leary, B; Cutts, RJ; Huang, X; Hrebien, S; Liu, Y; André, F; Loibl, S; Loi, S; Garcia-Murillas, I; Cristofanilli, M; Bartlett, CH; Turner, NC

  <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>There are no established molecular biomarkers for patients with breast cancer receiving combination endocrine and CDK4/6 inhibitor ...
• Alternative catalytic residues in the active site of Esco acetyltransferases. 

  Ajam, T; De, I; Petkau, N; Whelan, G; Pena, V; Eichele, G (2020-06-17)

  Cohesin is a protein complex whose core subunits, Smc1, Smc3, Scc1, and SA1/SA2 form a ring-like structure encircling the DNA. Cohesins play a key role in the expression, repair, and segregation of eukaryotic genomes. ...
• The Ku-binding motif is a conserved module for recruitment and stimulation of non-homologous end-joining proteins. 

  Grundy, GJ; Rulten, SL; Arribas-Bosacoma, R; Davidson, K; Kozik, Z; Oliver, AW; Pearl, LH; Caldecott, KW (2016-04-11)

  The Ku-binding motif (KBM) is a short peptide module first identified in APLF that we now show is also present in Werner syndrome protein (WRN) and in Modulator of retrovirus infection homologue (MRI). We also identify a ...
• How to develop a meaningful radiomic signature for clinical use in oncologic patients. 

  Papanikolaou, N; Matos, C; Koh, DM (2020-05)

  During the last decade, there is an increasing usage of quantitative methods in Radiology in an effort to reduce the diagnostic variability associated with a subjective manner of radiological interpretation. Combined ...
• Diagnostic accuracy of whole-body MRI versus standard imaging pathways for metastatic disease in newly diagnosed colorectal cancer: the prospective Streamline C trial. 

  Taylor, SA; Mallett, S; Beare, S; Bhatnagar, G; Blunt, D; Boavida, P; Bridgewater, J; Clarke, CS; Duggan, M; Ellis, S; Glynne-Jones, R; Goh, V; Groves, AM; Hameeduddin, A; Janes, SM; Johnston, EW; Koh, D-M; Miles, A; Morris, S; Morton, A; Navani, N; O'Donohue, J; Oliver, A; Padhani, AR; Pardoe, H; Patel, U; Punwani, S; Quinn, L; Rafiee, H; Reczko, K; Rockall, AG; Shahabuddin, K; Sidhu, HS; Teague, J; Thaha, MA; Train, M; van Ree, K; Wijeyekoon, S; Halligan, S; Streamline investigators (2019-07)

  BACKGROUND:Whole-body MRI (WB-MRI) could be an alternative to multimodality staging of colorectal cancer, but its diagnostic accuracy, effect on staging times, number of tests needed, cost, and effect on treatment decisions ...
• Whole-body magnetic resonance imaging (WB-MRI) for cancer screening in asymptomatic subjects of the general population: review and recommendations. 

  Zugni, F; Padhani, AR; Koh, D-M; Summers, PE; Bellomi, M; Petralia, G (2020-05-11)

  BACKGROUND:The number of studies describing the use of whole-body magnetic resonance imaging (WB-MRI) for screening of malignant tumours in asymptomatic subjects is increasing. Our aim is to review the methodologies used ...
• How clinical imaging can assess cancer biology. 

  García-Figueiras, R; Baleato-González, S; Padhani, AR; Luna-Alcalá, A; Vallejo-Casas, JA; Sala, E; Vilanova, JC; Koh, D-M; Herranz-Carnero, M; Vargas, HA (2019-03-04)

  Human cancers represent complex structures, which display substantial inter- and intratumor heterogeneity in their genetic expression and phenotypic features. However, cancers usually exhibit characteristic structural, ...
• Patient preferences for whole-body MRI or conventional staging pathways in lung and colorectal cancer: a discrete choice experiment. 

  Miles, A; Taylor, SA; Evans, REC; Halligan, S; Beare, S; Bridgewater, J; Goh, V; Janes, S; Navani, N; Oliver, A; Morton, A; Rockall, A; Clarke, CS; Morris, S; STREAMLINE investigators (2019-07)

  OBJECTIVES:To determine the importance placed by patients on attributes associated with whole-body MRI (WB-MRI) and standard cancer staging pathways and ascertain drivers of preference. METHODS:Patients recruited to two ...
• Diagnostic accuracy of whole-body MRI versus standard imaging pathways for metastatic disease in newly diagnosed non-small-cell lung cancer: the prospective Streamline L trial. 

  Taylor, SA; Mallett, S; Ball, S; Beare, S; Bhatnagar, G; Bhowmik, A; Boavida, P; Bridgewater, J; Clarke, CS; Duggan, M; Ellis, S; Glynne-Jones, R; Goh, V; Groves, AM; Hameeduddin, A; Janes, SM; Johnston, EW; Koh, D-M; Lock, S; Miles, A; Morris, S; Morton, A; Navani, N; Oliver, A; O'Shaughnessy, T; Padhani, AR; Prezzi, D; Punwani, S; Quinn, L; Rafiee, H; Reczko, K; Rockall, AG; Russell, P; Sidhu, HS; Strickland, N; Tarver, K; Teague, J; Halligan, S; Streamline investigators (2019-06)

  BACKGROUND:Whole-body magnetic resonance imaging (WB-MRI) could be an alternative to multi-modality staging of non-small-cell lung cancer (NSCLC), but its diagnostic accuracy, effect on staging times, number of tests needed, ...
• Embryonal Rhabdomyosarcoma of the Ovary and Fallopian Tube: Rare Neoplasms Associated With Germline and Somatic DICER1 Mutations. 

  McCluggage, WG; Apellaniz-Ruiz, M; Chong, A-L; Hanley, KZ; Velázquez Vega, JE; McVeigh, TP; Foulkes, WD (2020-06)

  DICER1 mutations (somatic or germline) are associated with a variety of uncommon neoplasms including cervical and genitourinary embryonal rhabdomyosarcoma (ERMS). We report a primary ovarian and 2 primary fallopian tube ...
• "I was seen by a radiologist, but unfortunately I can't remember the name and I still have questions. What should I do?" Radiologists should give thoughts to improve service professionalism and patient esteem. 

  Gutzeit, A; Fischmann, A; Forstner, R; Goette, R; Herzog, B; Kurtz, C; Hebler, C; Ladinger, A; Froehlich, JM; Blautzik, J; Kolokythas, O; Matoori, S; Kos, S; Reischauer, C; Schefer, H; Dubsky, P; Gampenrieder, SP; Hergan, K; Gaissmaier, W; Koh, D-M; Meissnitzer, M (2020-02-13)

  BACKGROUND:The aim of the study is to investigate how well patients remember the radiologist's name after a radiological examination, and whether giving the patient a business card improves the patient's perception of the ...
• Whole-body MRI compared with standard pathways for staging metastatic disease in lung and colorectal cancer: the Streamline diagnostic accuracy studies. 

  Taylor, SA; Mallett, S; Miles, A; Morris, S; Quinn, L; Clarke, CS; Beare, S; Bridgewater, J; Goh, V; Janes, S; Koh, D-M; Morton, A; Navani, N; Oliver, A; Padhani, A; Punwani, S; Rockall, A; Halligan, S (2019-12)

  BACKGROUND:Whole-body magnetic resonance imaging is advocated as an alternative to standard pathways for staging cancer. OBJECTIVES:The objectives were to compare diagnostic accuracy, efficiency, patient acceptability, ...
• PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2B(Glu2). 

  Grundy, GJ; Polo, LM; Zeng, Z; Rulten, SL; Hoch, NC; Paomephan, P; Xu, Y; Sweet, SM; Thorne, AW; Oliver, AW; Matthews, SJ; Pearl, LH; Caldecott, KW (2016-08-17)

  PARP3 is a member of the ADP-ribosyl transferase superfamily that we show accelerates the repair of chromosomal DNA single-strand breaks in avian DT40 cells. Two-dimensional nuclear magnetic resonance experiments reveal ...
• Consensus report from the 8th International Forum for Liver Magnetic Resonance Imaging. 

  Zech, CJ; Ba-Ssalamah, A; Berg, T; Chandarana, H; Chau, G-Y; Grazioli, L; Kim, M-J; Lee, JM; Merkle, EM; Murakami, T; Ricke, J; B Sirlin, C; Song, B; Taouli, B; Yoshimitsu, K; Koh, D-M (2020-01)

  OBJECTIVES:The 8th International Forum for Liver Magnetic Resonance Imaging (MRI), held in Basel, Switzerland, in October 2017, brought together clinical and academic radiologists from around the world to discuss developments ...
• The articles.ELM resource: simplifying access to protein linear motif literature by annotation, text-mining and classification. 

  Palopoli, N; Iserte, JA; Chemes, LB; Marino-Buslje, C; Parisi, G; Gibson, TJ; Davey, NE (2020-01)

  Modern biology produces data at a staggering rate. Yet, much of these biological data is still isolated in the text, figures, tables and supplementary materials of articles. As a result, biological information created at ...
• Genomic Evolution of Breast Cancer Metastasis and Relapse. 

  Yates, LR; Knappskog, S; Wedge, D; Farmery, JHR; Gonzalez, S; Martincorena, I; Alexandrov, LB; Van Loo, P; Haugland, HK; Lilleng, PK; Gundem, G; Gerstung, M; Pappaemmanuil, E; Gazinska, P; Bhosle, SG; Jones, D; Raine, K; Mudie, L; Latimer, C; Sawyer, E; Desmedt, C; Sotiriou, C; Stratton, MR; Sieuwerts, AM; Lynch, AG; Martens, JW; Richardson, AL; Tutt, A; Lønning, PE; Campbell, PJ (2017-08)

  Patterns of genomic evolution between primary and metastatic breast cancer have not been studied in large numbers, despite patients with metastatic breast cancer having dismal survival. We sequenced whole genomes or a panel ...
• Fast, Quantitative and Variant Enabled Mapping of Peptides to Genomes. 

  Schlaffner, CN; Pirklbauer, GJ; Bender, A; Choudhary, JS (2017-08)

  Current tools for visualization and integration of proteomics with other omics datasets are inadequate for large-scale studies and capture only basic sequence identity information. Furthermore, the frequent reformatting ...
• HECTD3 Mediates an HSP90-Dependent Degradation Pathway for Protein Kinase Clients 

  Li, Z; Zhou, L; Prodromou, C; Savic, V; Pearl, LH (Elsevier BV, 2017-06)
• RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex. 

  Martino, F; Pal, M; Muñoz-Hernández, H; Rodríguez, CF; Núñez-Ramírez, R; Gil-Carton, D; Degliesposti, G; Skehel, JM; Roe, SM; Prodromou, C; Pearl, LH; Llorca, O (2018-04-16)

  The R2TP/Prefoldin-like co-chaperone, in concert with HSP90, facilitates assembly and cellular stability of RNA polymerase II, and complexes of PI3-kinase-like kinases such as mTOR. However, the mechanism by which this ...
• Quantitative Dual-Isotope Planar Imaging of Thorium-227 and Radium-223 Using Defined Energy Windows 

  Murray

View more