• Autoinhibition Mechanism of the Ubiquitin-Conjugating Enzyme UBE2S by Autoubiquitination. 

  Liess, AKL; Kucerova, A; Schweimer, K; Yu, L; Roumeliotis, TI; Diebold, M; Dybkov, O; Sotriffer, C; Urlaub, H; Choudhary, JS; Mansfeld, J; Lorenz, S (2019-08)

  Ubiquitin-conjugating enzymes (E2s) govern key aspects of ubiquitin signaling. Emerging evidence suggests that the activities of E2s are modulated by posttranslational modifications; the structural underpinnings, however, ...
• Immune Cell Associations with Cancer Risk. 

  Palomero, L; Galván-Femenía, I; de Cid, R; Espín, R; Barnes, DR; Cimba; Blommaert, E; Gil-Gil, M; Falo, C; Stradella, A; Ouchi, D; Roso-Llorach, A; Violan, C; Peña-Chilet, M; Dopazo, J; Extremera, AI; García-Valero, M; Herranz, C; Mateo, F; Mereu, E; Beesley, J; Chenevix-Trench, G; Roux, C; Mak, T; Brunet, J; Hakem, R; Gorrini, C; Antoniou, AC; Lázaro, C; Pujana, MA (2020-07)

  Proper immune system function hinders cancer development, but little is known about whether genetic variants linked to cancer risk alter immune cells. Here, we report 57 cancer risk loci associated with differences in ...
• The complete structure of the human TFIIH core complex. 

  Greber, BJ; Toso, DB; Fang, J; Nogales, E (2019-03-12)

  Transcription factor IIH (TFIIH) is a heterodecameric protein complex critical for transcription initiation by RNA polymerase II and nucleotide excision DNA repair. The TFIIH core complex is sufficient for its repair ...
• The cryoelectron microscopy structure of the human CDK-activating kinase 

  Greber, BJ; Perez-Bertoldi, JM; Lim, K; Iavarone, AT; Toso, DB; Nogales, E

  <jats:p>The human CDK-activating kinase (CAK), a complex composed of cyclin-dependent kinase (CDK) 7, cyclin H, and MAT1, is a critical regulator of transcription initiation and the cell cycle. It acts by phosphorylating ...
• CRC COVID: Colorectal cancer services during COVID-19 pandemic. Study protocol for service evaluation. 

  Courtney, A; Howell, A-M; Daulatzai, N; Savva, N; Warren, O; Mills, S; Rasheed, S; Milind, G; Tekkis, N; Gardiner, M; Dai, T; Safar, B; Efron, JE; Darzi, A; Tekkis, P; Kontovounisios, C (2020-01)

  Introduction:COVID-19 has had an impact on the provision of colorectal cancer care. The aim of the CRC COVID study is to describe the changes in colorectal cancer services in the UK and USA in response to the pandemic and ...
• Public perceptions on data sharing: key insights from the UK and the USA. 

  Ghafur, S; Van Dael, J; Leis, M; Darzi, A; Sheikh, A (2020-09)
• Distinct Levels of Reactive Oxygen Species Coordinate Metabolic Activity with Beta-cell Mass Plasticity. 

  Ahmed Alfar, E; Kirova, D; Konantz, J; Birke, S; Mansfeld, J; Ninov, N (2017-06-26)

  The pancreatic beta-cells control glucose homeostasis by secreting insulin in response to nutrient intake. The number of beta-cells is under tight metabolic control, as this number increases with higher nutrient intake. ...
• Review: The HSP90 molecular chaperone—an enigmatic ATPase 

  Pearl, LH (Wiley, 2016-08)
• Critical Appraisal of Programmed Death Ligand 1 Reflex Diagnostic Testing: Current Standards and Future Opportunities. 

  Humphries, MP; McQuaid, S; Craig, SG; Bingham, V; Maxwell, P; Maurya, M; McLean, F; Sampson, J; Higgins, P; Greene, C; James, J; Salto-Tellez, M (2019-01)

  INTRODUCTION:Patient suitability to anti-programmed death ligand 1 (PD-L1) immune checkpoint inhibition is key to the treatment of NSCLC. We present, applied to PD-L1 testing: a comprehensive cross-validation of two ...
• LUBAC determines chemotherapy resistance in squamous cell lung cancer. 

  Ruiz, EJ; Diefenbacher, ME; Nelson, JK; Sancho, R; Pucci, F; Chakraborty, A; Moreno, P; Annibaldi, A; Liccardi, G; Encheva, V; Mitter, R; Rosenfeldt, M; Snijders, AP; Meier, P; Calzado, MA; Behrens, A (2019-02)

  Lung squamous cell carcinoma (LSCC) and adenocarcinoma (LADC) are the most common lung cancer subtypes. Molecular targeted treatments have improved LADC patient survival but are largely ineffective in LSCC. The tumor ...
• Recommendations for determining HPV status in patients with oropharyngeal cancers under TNM8 guidelines: a two-tier approach. 

  Craig, SG; Anderson, LA; Schache, AG; Moran, M; Graham, L; Currie, K; Rooney, K; Robinson, M; Upile, NS; Brooker, R; Mesri, M; Bingham, V; McQuaid, S; Jones, T; McCance, DJ; Salto-Tellez, M; McDade, SS; James, JA (2019-04)

  BACKGROUND:TNM8 staging for oropharyngeal squamous cell carcinomas (OPSCC) surrogates p16 immunohistochemistry for HPV testing. Patients with p16+ OPSCC may lack HPV aetiology. Here, we evaluate the suitability of TNM8 ...
• A Machine Learning Platform to Optimize the Translation of Personalized Network Models to the Clinic. 

  Salvucci, M; Rahman, A; Resler, AJ; Udupi, GM; McNamara, DA; Kay, EW; Laurent-Puig, P; Longley, DB; Johnston, PG; Lawler, M; Wilson, R; Salto-Tellez, M; Van Schaeybroeck, S; Rafferty, M; Gallagher, WM; Rehm, M; Prehn, JHM (2019-04)

  PURPOSE:Dynamic network models predict clinical prognosis and inform therapeutic intervention by elucidating disease-driven aberrations at the systems level. However, the personalization of model predictions requires the ...
• Immune activation by DNA damage predicts response to chemotherapy and survival in oesophageal adenocarcinoma. 

  Turkington, RC; Knight, LA; Blayney, JK; Secrier, M; Douglas, R; Parkes, EE; Sutton, EK; Stevenson, L; McManus, D; Halliday, S; McCavigan, AM; Logan, GE; Walker, SM; Steele, CJ; Perner, J; Bornschein, J; MacRae, S; Miremadi, A; McCarron, E; McQuaid, S; Arthur, K; James, JA; Eatock, MM; O'Neill, R; Noble, F; Underwood, TJ; Harkin, DP; Salto-Tellez, M; Fitzgerald, RC; Kennedy, RD; Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Study Group (2019-11)

  OBJECTIVE:Current strategies to guide selection of neoadjuvant therapy in oesophageal adenocarcinoma (OAC) are inadequate. We assessed the ability of a DNA damage immune response (DDIR) assay to predict response following ...
• NUQA: Estimating Cancer Spatial and Temporal Heterogeneity and Evolution through Alignment-Free Methods. 

  Roddy, AC; Jurek-Loughrey, A; Souza, J; Gilmore, A; O'Reilly, PG; Stupnikov, A; Gonzalez de Castro, D; Prise, KM; Salto-Tellez, M; McArt, DG (2019-12)

  Longitudinal next-generation sequencing of cancer patient samples has enhanced our understanding of the evolution and progression of various cancers. As a result, and due to our increasing knowledge of heterogeneity, such ...
• Systematic evaluation of PAXgene® tissue fixation for the histopathological and molecular study of lung cancer. 

  Southwood, M; Krenz, T; Cant, N; Maurya, M; Gazdova, J; Maxwell, P; McGready, C; Moseley, E; Hughes, S; Stewart, P; Salto-Tellez, M; Groelz, D; Rassl, D; STRATfix Consortium (2020-01)

  Whilst adequate for most existing pathological tests, formalin is generally considered a poor DNA preservative and use of alternative fixatives may prove advantageous for molecular testing of tumour material; an increasingly ...
• Exercise reduces immune suppression and breast cancer progression in a preclinical model. 

  Wennerberg, E; Lhuillier, C; Rybstein, MD; Dannenberg, K; Rudqvist, N-P; Koelwyn, GJ; Jones, LW; Demaria, S (2020-01-28)

  Exercise is associated with favorable changes in circulating immune cells and improved survival in early-stage breast cancer patients, but the mechansims remain to be fully elucidated. Preclinical studies indicate that ...
• Cep55 promotes cytokinesis of neural progenitors but is dispensable for most mammalian cell divisions. 

  Tedeschi, A; Almagro, J; Renshaw, MJ; Messal, HA; Behrens, A; Petronczki, M (2020-04-08)

  In mammalian cell lines, the endosomal sorting complex required for transport (ESCRT)-III mediates abscission, the process that physically separates daughter cells and completes cell division. Cep55 protein is regarded as ...
• Gastrointestinal tissue-based molecular biomarkers: a practical categorisation based on the 2019 World Health Organization classification of epithelial digestive tumours. 

  Quezada-Marín, JI; Lam, AK; Ochiai, A; Odze, RD; Washington, KM; Fukayama, M; Rugge, M; Klimstra, DS; Nagtegaal, ID; Tan, P-H; Arends, MJ; Goldblum, JR; Cree, IA; Salto-Tellez, M (2020-09)

  Molecular biomarkers have come to constitute one of the cornerstones of oncological pathology. The method of classification not only directly affects the manner in which patients are diagnosed and treated, but also guides ...
• Improving the Diagnostic Accuracy of the PD-L1 Test with Image Analysis and Multiplex Hybridization. 

  Humphries, MP; Bingham, V; Abdullahi Sidi, F; Craig, SG; McQuaid, S; James, J; Salto-Tellez, M (2020-04-29)

  Targeting of the programmed cell death protein (PD-1)/programmed death-ligand 1 (PD-L1) axis with checkpoint inhibitors has changed clinical practice in non-small cell lung cancer (NSCLC). However, clinical assessment ...
• The adaptive immune and immune checkpoint landscape of neoadjuvant treated esophageal adenocarcinoma using digital pathology quantitation. 

  Humphries, MP; Craig, SG; Kacprzyk, R; Fisher, NC; Bingham, V; McQuaid, S; Murray, GI; McManus, D; Turkington, RC; James, J; Salto-Tellez, M (2020-06)

  BACKGROUND:Limited studies examine the immune landscape in Esophageal Adenocarcinoma (EAC). We aim to identify novel associations, which may inform immunotherapy treatment stratification. METHODS:Three hundred twenty-nine ...

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