Browsing Other ICR Research by title
Now showing items 1-20 of 756
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14-3-3 Proteins Interact with a Hybrid Prenyl-Phosphorylation Motif to Inhibit G Proteins
(2013-04)Signaling through G proteins normally involves conformational switching between GTP- and GDP-bound states. Several Rho GTPases are also regulated by RhoGDI binding and sequestering in the cytosol. Rnd proteins are atypical ... -
6p abnormalities and TNF-α over-expression in retinoblastoma cell line
(2001)Retinoblastoma is the most common primary intra-ocular tumor in childhood. It has been established that recurrent cytogenetic abnormalities are the hallmark of mostly all malignant tumors. Recurrent atypical cytogenetic ... -
The ability to accumulate deoxyuridine triphosphate and cellular response to thymidylate synthase (TS) inhibition
(2001-08)The ability to accumulate deoxyuridine triphosphate and cellular response to thymidylate synthase (TS) inhibition. Thymidylate synthase (TS) is an important enzyme catalysing the reductive methylation of dUMP to dTMP that ... -
Abnormal constitutional karyotypes in patients with neuroblastoma: a report of four new cases and review of 47 others in the literature
(2003)Anomalies of constitutional karyotype, which have led to the discovery of oncogenes and tumor-suppressor genes in embryonal tumors such as retinoblastoma and Wilms tumor, have, until recently, rarely been reported until ... -
Abnormalities of the p53 Tumour Suppressor Gene in Mature B-cell Neoplasms
(Taylor & Francis, 2001)The p53 gene, located on the short arm of human chromosome 17 at 17p13, codes for a 393 aminoacid phosphoprotein, which acts as a transcription factor and is involved in the control of many different cellular processes. ... -
Access to clinical trials for adolescents with soft tissue sarcomas: Enrollment in European pediatric Soft tissue sarcoma Study Group (EpSSG) protocols.
(2017-06)BACKGROUND: Adolescents with cancer are enrolled in clinical trials at far lower rates than children. This report compares the number of adolescents (15-19-year-olds) and children (0-14-year-olds) enrolled in the protocols ... -
Activation of Aurora-A Kinase by Protein Partner Binding and Phosphorylation Are Independent and Synergistic
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2012-01-06)Protein kinases are activated by phosphorylation and by the binding of activator proteins. The interplay of these two factors is incompletely understood. We applied energetic analysis to this question and characterized the ... -
Acute myeloid leukemia xenograft success prediction: Saving time.
(2018-03)Xenograft assay allows functional analysis of leukemia-initiating cells of acute myeloid leukemia primary samples. However, 40% of samples derived from patients with better outcomes fail to engraft in immunodeficient mouse ... -
Adherence to Guidelines for Adult (Non-GIST) Soft Tissue Sarcoma in the Netherlands: A Plea for Dedicated Sarcoma Centers.
(2017-10)INTRODUCTION: Optimal management of soft tissue sarcoma (STS) remains a challenge. A nationwide survey assessed the quality of STS care in the Netherlands, thereby aiming to identify potentialities for improvement through ... -
Adjuvant chemotherapy may improve disease-free survival in patients with mrEMVI-positive rectal cancer following chemoradiation.
(2016-09-27)MRI-detected extramural venous invasion (mrEMVI) is a poor prognostic factor in rectal cancer. Pre-operative chemoradiotherapy (CRT) can cause regression in the severity of EMVI and subsequently improve survival whereas ... -
Advanced roles in cancer nursing
(2017-05-25) -
Age does not influence efficacy of ramucirumab in advanced gastric cancer: Subgroup analyses of REGARD and RAINBOW.
(2018-04)BACKGROUND AND AIM: REGARD and RAINBOW were global, phase 3, randomized, double-blind trials of second-line ramucirumab for metastatic gastric or gastroesophageal junction adenocarcinoma. Exploratory subgroup analyses were ... -
Aggressive haematological malignancies
(2017-10)
