Browsing Other ICR Research by issue date
Now showing items 1-20 of 612
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Rheo-optics of concentrated kaolinite suspensions
(ELSEVIER SCIENCE BV, 1996-06-14) -
PRH represses transcription in hematopoietic cells by at least two independent mechanisms
(2001-01-26)PRH (proline-rich homeodomain protein) is strongly expressed in the hematopoietic compartment, Here we show that PRH is a repressor of transcription in hematopoietic cells. A fragment of PRH that includes the homeodomain ... -
Structure-based design of selective and potent G quadruplex-mediated telomerase inhibitors
(2001-04-24)The telomerase enzyme is a potential therapeutic target in many human cancers. A series of potent inhibitors has been designed by computer modeling, which exploit the unique structural features of quadruplex DNA, These ... -
Stabilisation of TG-and AG-containing antiparrallel DNA triplexes by triplex-binding ligands
(2001-05-01)Stabilisation of TG-and AG-containing antiparrallel DNA triplexes by triplex-binding ligands. We have used DNase I footprinting to examine the interaction of several tripler-binding ligands with antiparallel TG- and AG- ... -
Demonstration of correlations between clinical and physical image quality measures in chest and lumbar spine screen-film radiography
(BRITISH INST RADIOLOGY, 2001-06)The ability to predict clinical image quality from physical measures is useful for optimization in diagnostic radiology. In this work, clinical and physical assessments of image quality are compared and correlations between ... -
A mutation in the Gsk3-binding domain of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon and eyes to diencephalon
(2001-06-01)Zebrafish embryos homozygous for the masterblind (mb1) mutation exhibit a striking phenotype in which the eyes and telencephalon are reduced or absent and diencephalic fates expand to the front of the brain. Here we show ... -
Short tandem repeat profiling provides an international reference standard for human cell lines
(NATL ACAD SCIENCES, 2001-07-03)Cross-contamination between cell lines is a longstanding and frequent cause of scientific misrepresentation. Estimates from national testing services indicate that up to 36% of cell lines are of a different origin or species ... -
High levels of the MDM2 oncogene in paediatric rhabdomyosarcoma cell lines may confer multidrug resistance
(2001-11-30)The MDM2 protein is known to be overexpressed in some sarcomas including rhabdomyosarcoma. However, the extent to which the MDM2 protein influences sensitivity to chemotherapeutic drugs is unclear. We have analysed this ... -
Effect of manipulation of primary tumour vascularity on metastases in an adenocarcinoma model
(2002-01-07)One explanation for the clinical association between tumour vascularity and probability of metastasis is that increased primary tumour vascularity enhances haematogenous dissemination by offering greater opportunity for ... -
Protein and drug interactions in the minor groove of DNA
(2002-03-01)Interactions between proteins, drugs, water and B-DNA minor groove have been analyzed in crystal structures of 60 protein-DNA and 14 drug-DNA complexes. It was found that only purine N3, pyrimidine O2, guanine N2 and ... -
Neuroblastoma in monozygotic twins - a case of probable twin to twin metastasis (vol 85, pg 493, 2001)
(NATURE PUBLISHING GROUP, 2002-05-20) -
Deregulation of the Egfr/Ras signaling pathway induces age-related brain degeneration in the Drosophila mutant vap
(2003-01)Ras signaling has been shown to play an important role in promoting cell survival in many different tissues. Here we show that upregulation of Ras activity in adult Drosophila neurons induces neuronal cell death, as evident ... -
Loss of P16(INK4a) results in increased glucocorticoid receptor activity during fibrosarcoma development
(NATL ACAD SCIENCES, 2003-03-18)‘Glucocorticoids inhibit proliferation of many cell types, but the relationship between the glucocorticoid receptor (GR) and the proteins regulating cell cycle progression is not fully understood. We previously found that ... -
Glucocorticoids inhibit apoptosis during fibrosarcoma development by transcriptionally activating Bcl-x(L)
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2003-05-16)Glucocorticoids influence many physiological processes, and in particular apoptosis, often with opposite effects depending on the cell type examined. We found that during fibrosarcoma development there is a strong increase ... -
Kaposi’s sarcoma-associated herpesvirus-infected primary effusion lymphoma has a gene expression profile
(2003-09-02)Kaposi’s sarcoma-associated herpesvirus is associated with three human tumors: Kaposi’s sarcoma, and the B cell lymphomas, plasmablastic lymphoma associated with multicentric Castleman’s disease, and primary effusion ... -
Kinetic energy of He atoms in liquid He-4-He-3 mixtures
(AMER PHYSICAL SOC, 2003-12)Deep inelastic neutron scattering measurements on liquid He-3-He-4 mixtures in the normal phase have been performed on the VESUVIO spectrometer at the ISIS pulsed neutron source at exchanged wave vectors of about qsimilar ... -
Risk factors for adenocarcinoma and squamous cell carcinoma of the cervix in women aged 20-44 years: the UK National Case-Control Study of Cervical Cancer
(2003-12-01)We report results on risk factors for invasive squamous cell and adenocarcinomas of the cervix in women aged 20-44 years from the UK National Case-Control Study of Cervical Cancer, including 180 women with adenocarcinoma, ... -
Variation in RNA expression and genomic DNA content acquired during cell culture
(NATURE PUBLISHING GROUP, 2004-02-26)Specific chromosomal abnormalities are increasingly recognised to be associated with particular tumour subtypes. These cytogenetic abnormalities define the sites of specific genes, the alteration of which is implicated in ... -
Cervical HPV infection and neoplasia in a large population-based prospective study: the Manchester cohort
(NATURE PUBLISHING GROUP, 2004-08-31)Cytology and histology records and cervical samples for HPV assay were obtained from a prospective cohort of 49 655 women attending clinics for routine cervical cytology in or near Manchester between 1988 and 1993. The ... -
The expected burden of mesothelioma mortality in Great Britain from 2002 to 2050
(NATURE PUBLISHING GROUP, 2005-02-14)The British mesothelioma register contains all deaths from 1968 to 2001 where mesothelioma was mentioned on the death certificate. These data were used to predict the future burden of mesothelioma mortality in Great Britain. ...