Risk factors for adenocarcinoma and squamous cell carcinoma of the cervix in women aged 20-44 years: the UK National Case-Control Study of Cervical Cancer
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Date
2003-12-01ICR Author
Author
Green, J
Berrington de Gonzalez, A
Sweetland, S
Beral, V
Chilvers, C
Crossley, B
Deacon, J
Hermon, C
Jha, P
Mant, D
Peto, J
Pike, M
Vessey, MP
Type
Journal Article
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Show full item recordAbstract
We report results on risk factors for invasive squamous cell and adenocarcinomas of the cervix in women aged 20-44 years from the UK National Case-Control Study of Cervical Cancer, including 180 women with adenocarcinoma, 39 1 women with squamous cell carcinoma and 923 population controls. The risk of both squamous cell and adenocarcinoma was strongly related to the lifetime number of sexual partners, and, independently, to age at first intercourse. The risk of both types of cervical cancer increased with increasing duration of use of oral contraceptives, and this effect was most marked in current and recent users of oral contraceptives. The risk of squamous cell carcinoma was associated with high parity and the risk of both squarrous cell and adenocarcinoma increased with early age at first birth. Long duration smoking (20 or more years) was associated with a two-fold increase in the risk of squamous cell carcinoma, but smoking was not associated with the risk of adenocarcinoma. Further studies are needed to confirm the suggestion from this and other studies of differences in risk related to smoking between squamous cell and adenocarcinomas of the cervix.
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Language
eng
License start date
2003-12-01
Citation
BRITISH JOURNAL OF CANCER, 2003, 89 pp. 2078 - 2086