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Short tandem repeat profiling provides an international reference standard for human cell lines

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Date
2001-07-03
ICR Author
Kelland, Lloyd
Author
Masters, JR
Thomson, JA
Daly-Burns, B
Reid, YA
Dirks, WG
Packer, P
Toji, LH
Ohno, T
Tanabe, H
Arlett, CF
Kelland, LR
Harrison, M
Virmani, A
Ward, TH
Ayres, KL
Debenham, PG
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Type
Journal Article
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Abstract
Cross-contamination between cell lines is a longstanding and frequent cause of scientific misrepresentation. Estimates from national testing services indicate that up to 36% of cell lines are of a different origin or species to that claimed. To test a standard method of cell line authentication, 253 human cell lines from banks and research institutes worldwide were analyzed by short: tandem repeat profiling. The short tandem repeat profile is a simple numerical code that is reproducible between laboratories, is inexpensive, and can provide an international reference standard for every cell line. If DMA profiling of cell lines is accepted and demanded internationally, scientific misrepresentation because of cross-contamination can be largely eliminated.
URI
https://repository.icr.ac.uk/handle/internal/2865
DOI
https://doi.org/10.1073/pnas.121616198
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  • Other ICR Research
Language
eng
License start date
2001-07-03
Citation
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 pp. 8012 - 8017
Publisher
NATL ACAD SCIENCES

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