Recent submissions

  • Appraising the relevance of DNA copy number loss and gain in prostate cancer using whole genome DNA sequence data. 

    Camacho, N; Van Loo, P; Edwards, S; Kay, JD; Matthews, L; Haase, K; Clark, J; Dennis, N; Thomas, S; Kremeyer, B; Zamora, J; Butler, AP; Gundem, G; Merson, S; Luxton, H; Hawkins, S; Ghori, M; Marsden, L; Lambert, A; Karaszi, K; Pelvender, G; Massie, CE; Kote-Jarai, Z; Raine, K; Jones, D; Howat, WJ; Hazell, S; Livni, N; Fisher, C; Ogden, C; Kumar, P; Thompson, A; Nicol, D; Mayer, E; Dudderidge, T; Yu, Y; Zhang, H; Shah, NC; Gnanapragasam, VJ; CRUK-ICGC Prostate Group; Isaacs, W; Visakorpi, T; Hamdy, F; Berney, D; Verrill, C; Warren, AY; Wedge, DC; Lynch, AG; Foster, CS; Lu, YJ; Bova, GS; Whitaker, HC; McDermott, U; Neal, DE; Eeles, R; Cooper, CS; Brewer, DS (2017-09)
    A variety of models have been proposed to explain regions of recurrent somatic copy number alteration (SCNA) in human cancer. Our study employs Whole Genome DNA Sequence (WGS) data from tumor samples (n = 103) to comprehensively ...
  • Ambiguity in a masculine world: Being a BRCA1/2 mutation carrier and a man with prostate cancer. 

    Moynihan, C; Bancroft, EK; Mitra, A; Ardern-Jones, A; Castro, E; Page, EC; Eeles, RA (2017-11)
    OBJECTIVE: Increased risk of prostate cancer (PCa) is observed in men with BRCA1/BRCA2 mutations. Sex and gender are key determinants of health and disease although unequal care exists between the sexes. Stereotypical male ...
  • Uterine Cancer After Risk-Reducing Salpingo-oophorectomy Without Hysterectomy in Women With BRCA Mutations. 

    Shu, CA; Pike, MC; Jotwani, AR; Friebel, TM; Soslow, RA; Levine, DA; Nathanson, KL; Konner, JA; Arnold, AG; Bogomolniy, F; Dao, F; Olvera, N; Bancroft, EK; Goldfrank, DJ; Stadler, ZK; Robson, ME; Brown, CL; Leitao, MM; Abu-Rustum, NR; Aghajanian, CA; Blum, JL; Neuhausen, SL; Garber, JE; Daly, MB; Isaacs, C; Eeles, RA; Ganz, PA; Barakat, RR; Offit, K; Domchek, SM; Rebbeck, TR; Kauff, ND (2016-06-30)
    The link between BRCA mutations and uterine cancer is unclear. Therefore, although risk-reducing salpingo-oophorectomy (RRSO) is standard treatment among women with BRCA mutations (BRCA+ women), the role of concomitant ...
  • Germline variants in IL4, MGMT and AKT1 are associated with prostate cancer-specific mortality: An analysis of 12,082 prostate cancer cases. 

    FitzGerald, LM; Zhao, S; Leonardson, A; Geybels, MS; Kolb, S; Lin, DW; Wright, JL; Eeles, R; Kote-Jarai, Z; Govindasami, K; Giles, GG; Southey, MC; Schleutker, J; Tammela, TL; Sipeky, C; Penney, KL; Stampfer, MJ; Gronberg, H; Wiklund, F; Stattin, P; Hugosson, J; Karyadi, DM; Ostrander, EA; Feng, Z; Stanford, JL (2018-01-03)
    BACKGROUND: Prostate cancer (PCa) is a leading cause of mortality and genetic factors can influence tumour aggressiveness. Several germline variants have been associated with PCa-specific mortality (PCSM), but further ...
  • Prostate-specific antigen velocity in a prospective prostate cancer screening study of men with genetic predisposition. 

    Mikropoulos, C; Selkirk, CGH; Saya, S; Bancroft, E; Vertosick, E; Dadaev, T; Brendler, C; Page, E; Dias, A; Evans, DG; Rothwell, J; Maehle, L; Axcrona, K; Richardson, K; Eccles, D; Jensen, T; Osther, PJ; van Asperen, CJ; Vasen, H; Kiemeney, LA; Ringelberg, J; Cybulski, C; Wokolorczyk, D; Hart, R; Glover, W; Lam, J; Taylor, L; Salinas, M; Feliubadaló, L; Oldenburg, R; Cremers, R; Verhaegh, G; van Zelst-Stams, WA; Oosterwijk, JC; Cook, J; Rosario, DJ; Buys, SS; Conner, T; Domchek, S; Powers, J; Ausems, MG; Teixeira, MR; Maia, S; Izatt, L; Schmutzler, R; Rhiem, K; Foulkes, WD; Boshari, T; Davidson, R; Ruijs, M; Helderman-van den Enden, AT; Andrews, L; Walker, L; Snape, K; Henderson, A; Jobson, I; Lindeman, GJ; Liljegren, A; Harris, M; Adank, MA; Kirk, J; Taylor, A; Susman, R; Chen-Shtoyerman, R; Pachter, N; Spigelman, A; Side, L; Zgajnar, J; Mora, J; Brewer, C; Gadea, N; Brady, AF; Gallagher, D; van Os, T; Donaldson, A; Stefansdottir, V; Barwell, J; James, PA; Murphy, D; Friedman, E; Nicolai, N; Greenhalgh, L; Obeid, E; Murthy, V; Copakova, L; McGrath, J; Teo, S-H; Strom, S; Kast, K; Leongamornlert, DA; Chamberlain, A; Pope, J; Newlin, AC; Aaronson, N; Ardern-Jones, A; Bangma, C; Castro, E; Dearnaley, D; Eyfjord, J; Falconer, A; Foster, CS; Gronberg, H; Hamdy, FC; Johannsson, O; Khoo, V; Lubinski, J; Grindedal, EM; McKinley, J; Shackleton, K; Mitra, AV; Moynihan, C; Rennert, G; Suri, M; Tricker, K; IMPACT study collaborators; Moss, S; Kote-Jarai, Z; Vickers, A; Lilja, H; Helfand, BT; Eeles, RA (2018-01-04)
    BACKGROUND: Prostate-specific antigen (PSA) and PSA-velocity (PSAV) have been used to identify men at risk of prostate cancer (PrCa). The IMPACT study is evaluating PSA screening in men with a known genetic predisposition ...
  • Variations in the practice of molecular radiotherapy and implementation of dosimetry: results from a European survey. 

    Sjögreen Gleisner, K; Spezi, E; Solny, P; Gabina, PM; Cicone, F; Stokke, C; Chiesa, C; Paphiti, M; Brans, B; Sandström, M; Tipping, J; Konijnenberg, M; Flux, G (2017-12-04)
    BACKGROUND: Currently, the implementation of dosimetry in molecular radiotherapy (MRT) is not well investigated, and in view of the Council Directive (2013/59/Euratom), there is a need to understand the current availability ...
  • Dosimetry-based treatment planning for molecular radiotherapy: a summary of the 2017 report from the Internal Dosimetry Task Force. 

    Stokke, C; Gabiña, PM; Solný, P; Cicone, F; Sandström, M; Gleisner, KS; Chiesa, C; Spezi, E; Paphiti, M; Konijnenberg, M; Aldridge, M; Tipping, J; Wissmeyer, M; Brans, B; Bacher, K; Kobe, C; Flux, G (2017-11-21)
    BACKGROUND: The European directive on basic safety standards (Council directive 2013/59 Euratom) mandates dosimetry-based treatment planning for radiopharmaceutical therapies. The directive comes into operation February ...
  • ImmunoPET in pontine glioma : more than meets the eye ? 

    Oyen, WJG; Jones, C (2017-12-07)
  • Mendelian randomisation analysis provides no evidence for a relationship between adult height and testicular cancer risk. 

    Levy, M; Hall, D; Sud, A; Law, P; Litchfield, K; Dudakia, D; Haugen, TB; Karlsson, R; Reid, A; Huddart, RA; Grotmol, T; Wiklund, F; Houlston, RS; Turnbull, C (2017-09)
    Observational studies have suggested anthropometric traits, particularly increased height are associated with an elevated risk of testicular cancer (testicular germ cell tumour). However, there is an inconsistency between ...
  • Changes in multimodality functional imaging parameters early during chemoradiation predict treatment response in patients with locally advanced head and neck cancer. 

    Wong, KH; Panek, R; Dunlop, A; Mcquaid, D; Riddell, A; Welsh, LC; Murray, I; Koh, D-M; Leach, MO; Bhide, SA; Nutting, CM; Oyen, WJ; Harrington, KJ; Newbold, KL (2017-11-21)
    OBJECTIVE: To assess the optimal timing and predictive value of early intra-treatment changes in multimodality functional and molecular imaging (FMI) parameters as biomarkers for clinical remission in patients receiving ...
  • Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism. 

    Bilanges, B; Alliouachene, S; Pearce, W; Morelli, D; Szabadkai, G; Chung, Y-L; Chicanne, G; Valet, C; Hill, JM; Voshol, PJ; Collinson, L; Peddie, C; Ali, K; Ghazaly, E; Rajeeve, V; Trichas, G; Srinivas, S; Chaussade, C; Salamon, RS; Backer, JM; Scudamore, CL; Whitehead, MA; Keaney, EP; Murphy, LO; Semple, RK; Payrastre, B; Tooze, SA; Vanhaesebroeck, B (2017-11-27)
    Vps34 PI3K is thought to be the main producer of phosphatidylinositol-3-monophosphate, a lipid that controls intracellular vesicular trafficking. The organismal impact of systemic inhibition of Vps34 kinase activity is not ...
  • UK Consensus on Normal Tissue Dose Constraints for Stereotactic Radiotherapy. 

    Hanna, GG; Murray, L; Patel, R; Jain, S; Aitken, KL; Franks, KN; van As, N; Tree, A; Hatfield, P; Harrow, S; McDonald, F; Ahmed, M; Saran, FH; Webster, GJ; Khoo, V; Landau, D; Eaton, DJ; Hawkins, MA (2018-01)
    Six UK studies investigating stereotactic ablative radiotherapy (SABR) are currently open. Many of these involve the treatment of oligometastatic disease at different locations in the body. Members of all the trial management ...
  • Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility. 

    Sud, A; Thomsen, H; Law, PJ; Försti, A; Filho, MIDS; Holroyd, A; Broderick, P; Orlando, G; Lenive, O; Wright, L; Cooke, R; Easton, D; Pharoah, P; Dunning, A; Peto, J; Canzian, F; Eeles, R; Kote-Jarai, Z; Muir, K; Pashayan, N; PRACTICAL consortium; Hoffmann, P; Nöthen, MM; Jöckel, K-H; Strandmann, EPV; Lightfoot, T; Kane, E; Roman, E; Lake, A; Montgomery, D; Jarrett, RF; Swerdlow, AJ; Engert, A; Orr, N; Hemminki, K; Houlston, RS (2017-12-01)
    Several susceptibility loci for classical Hodgkin lymphoma have been reported. However, much of the heritable risk is unknown. Here, we perform a meta-analysis of two existing genome-wide association studies, a new genome-wide ...
  • Use of a Novel Nonparametric Version of DEPTH to Identify Genomic Regions Associated with Prostate Cancer Risk. 

    MacInnis, RJ; Schmidt, DF; Makalic, E; Severi, G; FitzGerald, LM; Reumann, M; Kapuscinski, MK; Kowalczyk, A; Zhou, Z; Goudey, B; Qian, G; Bui, QM; Park, DJ; Freeman, A; Southey, MC; Al Olama, AA; Kote-Jarai, Z; Eeles, RA; Hopper, JL; Giles, GG; UK Genetic Prostate Cancer Study Collaborators (2016-12)
    BACKGROUND: We have developed a genome-wide association study analysis method called DEPTH (DEPendency of association on the number of Top Hits) to identify genomic regions potentially associated with disease by considering ...
  • Equivalence of cell survival data for radiation dose and thermal dose in ablative treatments: analysis applied to essential tremor thalamotomy by focused ultrasound and gamma knife. 

    Schlesinger, D; Lee, M; Ter Haar, G; Sela, B; Eames, M; Snell, J; Kassell, N; Sheehan, J; Larner, JM; Aubry, J-F (2017-01-31)
    Thermal dose and absorbed radiation dose have historically been difficult to compare because different biological mechanisms are at work. Thermal dose denatures proteins and the radiation dose causes DNA damage in order ...
  • seXY: a tool for sex inference from genotype arrays. 

    Qian, DC; Busam, JA; Xiao, X; O'Mara, TA; Eeles, RA; Schumacher, FR; Phelan, CM; Amos, CI (2017-02-15)
    Motivation: Checking concordance between reported sex and genotype-inferred sex is a crucial quality control measure in genome-wide association studies (GWAS). However, limited insights exist regarding the true accuracy ...
  • Radiotherapy dose-distribution to the perirectal fat space (PRS) is related to gastrointestinal control-related complications 

    Gulliford, S; Ghose, S; Ebert, M; Kennedy, A; Dowling, J; Mitra, J; Joseph, D; Denham, J (2017-12)
  • Guidelines for Cleaning Transvaginal Ultrasound Transducers Between Patients. 

    Abramowicz, JS; Evans, DH; Fowlkes, JB; Maršal, K; terHaar, G; WFUMB Safety Committee
    The purpose of this article is to provide guidance regarding the cleaning and disinfection of transvaginal ultrasound probes. These recommendations are also applicable to transrectal probes.

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