Recent submissions

  • Features and Management of Late Relapse of Nonseminomatous Germ Cell Tumour. 

    Jay, APM; Aldiwani, M; O'Callaghan, ME; Pearce, AK; Huddart, RA; Mayer, E; Reid, AH; Nicol, DL
    <h4>Background</h4>Late relapse (LR) of nonseminomatous germ cell tumour (NSGCT) is uncommon, with limited data published. LR is defined as relapse occurring after a disease-free interval of 2 yr.<h4>Objective</h4>To review ...
  • The potential role of MR-guided adaptive radiotherapy in pediatric oncology: Results from a SIOPE-COG survey. 

    Seravalli, E; Kroon, PS; Buatti, JM; Hall, MD; Mandeville, HC; Marcus, KJ; Onal, C; Ozyar, E; Paulino, AC; Paulsen, F; Saunders, D; Tsang, DS; Wolden, SL; Janssens, GO
    <h4>Background and purpose</h4>Magnetic resonance guided radiotherapy (MRgRT) has been successfully implemented for several routine clinical applications in adult patients. The purpose of this study is to map the potential ...
  • CT-Based Pelvic T<sub>1</sub>-Weighted MR Image Synthesis Using UNet, UNet++ and Cycle-Consistent Generative Adversarial Network (Cycle-GAN). 

    Kalantar, R; Messiou, C; Winfield, JM; Renn, A; Latifoltojar, A; Downey, K; Sohaib, A; Lalondrelle, S; Koh, D-M; Blackledge, MD
    <h4>Background</h4>Computed tomography (CT) and magnetic resonance imaging (MRI) are the mainstay imaging modalities in radiotherapy planning. In MR-Linac treatment, manual annotation of organs-at-risk (OARs) and clinical ...
  • Antiviral antibody responses to systemic administration of an oncolytic RNA virus: the impact of standard concomitant anticancer chemotherapies. 

    Roulstone, V; Mansfield, D; Harris, RJ; Twigger, K; White, C; de Bono, J; Spicer, J; Karagiannis, SN; Vile, R; Pandha, H; Melcher, A; Harrington, K
    <h4>Background</h4>Oncolytic reovirus therapy for cancer induces a typical antiviral response to this RNA virus, including neutralizing antibodies. Concomitant treatment with cytotoxic chemotherapies has been hypothesized ...
  • Four-dimensional imaging for radiotherapy planning in children and teenagers 

    Lavan, N (2021-02-28)
    Respiratory-related organ motion (RROM) is a potential source of geometric uncertainty in RT planning and delivery. Approaches to mitigate its effects are well described in adults. For example, four-dimensional computed ...
  • Circulating tumour DNA in advanced thyroid cancer 

    Allin, D (2021-02-28)
    Conventional biomarkers currently used in thyroid cancer are not disease specific and fluctuate in advanced disease, making interpretation difficult. Circulating tumour DNA (ctDNA) has been shown to be a useful in other ...
  • Pulsed focused ultrasound can improve the anti-cancer effects of immune checkpoint inhibitors in murine pancreatic cancer. 

    Mouratidis, PXE; Costa, M; Rivens, I; Repasky, EE; Ter Haar, G (2021-07-07)
    Pulsed high-intensity focused ultrasound (pHIFU) uses acoustic pressure to physically disrupt tumours. The aim of this study was to investigate whether pHIFU can be used in combination with immune checkpoint inhibitors ...
  • Computational science-enabled radiological pathology for the non-invasive mapping of tumour heterogeneity in childhood neuroblastoma 

    Zormpas Petridis, K (2021-01-31)
    Neuroblastoma is a common childhood solid tumour that accounts for 15% of all cancer paediatric deaths. This thesis addresses key deficiencies in our ability to define, monitor and predict neuroblastoma heterogeneity for ...
  • Marital status and prostate cancer incidence: a pooled analysis of 12 case-control studies from the PRACTICAL consortium. 

    Salmon, C; Song, L; Muir, K; UKGPCS Collaborators; Pashayan, N; Dunning, AM; Batra, J; APCB BioResource (Australian Prostate Cancer BioResource); Chambers, S; Stanford, JL; Ostrander, EA; Park, JY; Lin, H-Y; Cussenot, O; Cancel-Tassin, G; Menegaux, F; Cordina-Duverger, E; Kogevinas, M; Llorca, J; Kaneva, R; Slavov, C; Razack, A; Lim, J; Gago-Dominguez, M; Castelao, JE; Kote-Jarai, Z; Eeles, RA; on behalf of the PRACTICAL Consortium; Parent, M-É (2021-07-18)
    While being in a committed relationship is associated with a better prostate cancer prognosis, little is known about how marital status relates to its incidence. Social support provided by marriage/relationship could promote ...
  • Combined Effect of a Polygenic Risk Score and Rare Genetic Variants on Prostate Cancer Risk. 

    Darst, BF; Sheng, X; Eeles, RA; Kote-Jarai, Z; Conti, DV; Haiman, CA
    Although prostate cancer is known to have a strong genetic basis and is influenced by both common and rare variants, the ability to investigate the combined effect of such genetic risk factors has been limited to date. We ...
  • The effect of sample size on polygenic hazard models for prostate cancer. 

    Karunamuni, RA; Huynh-Le, M-P; Fan, CC; Eeles, RA; Easton, DF; Kote-Jarai, Z; Amin Al Olama, A; Benlloch Garcia, S; Muir, K; Gronberg, H; Wiklund, F; Aly, M; Schleutker, J; Sipeky, C; Tammela, TLJ; Nordestgaard, BG; Key, TJ; Travis, RC; Neal, DE; Donovan, JL; Hamdy, FC; Pharoah, P; Pashayan, N; Khaw, K-T; Thibodeau, SN; McDonnell, SK; Schaid, DJ; Maier, C; Vogel, W; Luedeke, M; Herkommer, K; Kibel, AS; Cybulski, C; Wokolorczyk, D; Kluzniak, W; Cannon-Albright, L; Brenner, H; Schöttker, B; Holleczek, B; Park, JY; Sellers, TA; Lin, H-Y; Slavov, C; Kaneva, R; Mitev, V; Batra, J; Clements, JA; Spurdle, A; Australian Prostate Cancer BioResource (APCB); Teixeira, MR; Paulo, P; Maia, S; Pandha, H; Michael, A; Mills, IG; Andreassen, OA; Dale, AM; Seibert, TM; PRACTICAL Consortium
    We determined the effect of sample size on performance of polygenic hazard score (PHS) models in prostate cancer. Age and genotypes were obtained for 40,861 men from the PRACTICAL consortium. The dataset included 201,590 ...
  • The BARCODE1 Pilot: a feasibility study of using germline single nucleotide polymorphisms to target prostate cancer screening. 

    Benafif, S; Ni Raghallaigh, H; McGrowder, E; Saunders, EJ; Brook, MN; Saya, S; Rageevakumar, R; Wakerell, S; James, D; Chamberlain, A; Taylor, N; Hogben, M; Benton, B; D'Mello, L; Myhill, K; Mikropoulos, C; Bowen-Perkins, H; Rafi, I; Ferris, M; Beattie, A; Kuganolipava, S; Sevenoaks, T; Bower, J; Kumar, P; Hazell, S; deSouza, NM; Antoniou, A; Bancroft, E; Kote-Jarai, Z; Eeles, R (2021-07-02)
    <h4>Objectives</h4>To assess the feasibility and uptake of a community-based prostate cancer (PCa) screening programme selecting men according to their genetic risk of PCa. To assess the uptake of PCa screening investigations ...
  • Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction. 

    Conti, DV; Darst, BF; Moss, LC; Saunders, EJ; Sheng, X; Chou, A; Schumacher, FR; Olama, AAA; Benlloch, S; Dadaev, T; Brook, MN; Sahimi, A; Hoffmann, TJ; Takahashi, A; Matsuda, K; Momozawa, Y; Fujita, M; Muir, K; Lophatananon, A; Wan, P; Le Marchand, L; Wilkens, LR; Stevens, VL; Gapstur, SM; Carter, BD; Schleutker, J; Tammela, TLJ; Sipeky, C; Auvinen, A; Giles, GG; Southey, MC; MacInnis, RJ; Cybulski, C; Wokołorczyk, D; Lubiński, J; Neal, DE; Donovan, JL; Hamdy, FC; Martin, RM; Nordestgaard, BG; Nielsen, SF; Weischer, M; Bojesen, SE; Røder, MA; Iversen, P; Batra, J; Chambers, S; Moya, L; Horvath, L; Clements, JA; Tilley, W; Risbridger, GP; Gronberg, H; Aly, M; Szulkin, R; Eklund, M; Nordström, T; Pashayan, N; Dunning, AM; Ghoussaini, M; Travis, RC; Key, TJ; Riboli, E; Park, JY; Sellers, TA; Lin, H-Y; Albanes, D; Weinstein, SJ; Mucci, LA; Giovannucci, E; Lindstrom, S; Kraft, P; Hunter, DJ; Penney, KL; Turman, C; Tangen, CM; Goodman, PJ; Thompson, IM; Hamilton, RJ; Fleshner, NE; Finelli, A; Parent, M-É; Stanford, JL; Ostrander, EA; Geybels, MS; Koutros, S; Freeman, LEB; Stampfer, M; Wolk, A; Håkansson, N; Andriole, GL; Hoover, RN; Machiela, MJ; Sørensen, KD; Borre, M; Blot, WJ; Zheng, W; Yeboah, ED; Mensah, JE; Lu, Y-J; Zhang, H-W; Feng, N; Mao, X; Wu, Y; Zhao, S-C; Sun, Z; Thibodeau, SN; McDonnell, SK; Schaid, DJ; West, CML; Burnet, N; Barnett, G; Maier, C; Schnoeller, T; Luedeke, M; Kibel, AS; Drake, BF; Cussenot, O; Cancel-Tassin, G; Menegaux, F; Truong, T; Koudou, YA; John, EM; Grindedal, EM; Maehle, L; Khaw, K-T; Ingles, SA; Stern, MC; Vega, A; Gómez-Caamaño, A; Fachal, L; Rosenstein, BS; Kerns, SL; Ostrer, H; Teixeira, MR; Paulo, P; Brandão, A; Watya, S; Lubwama, A; Bensen, JT; Fontham, ETH; Mohler, J; Taylor, JA; Kogevinas, M; Llorca, J; Castaño-Vinyals, G; Cannon-Albright, L; Teerlink, CC; Huff, CD; Strom, SS; Multigner, L; Blanchet, P; Brureau, L; Kaneva, R; Slavov, C; Mitev, V; Leach, RJ; Weaver, B; Brenner, H; Cuk, K; Holleczek, B; Saum, K-U; Klein, EA; Hsing, AW; Kittles, RA; Murphy, AB; Logothetis, CJ; Kim, J; Neuhausen, SL; Steele, L; Ding, YC; Isaacs, WB; Nemesure, B; Hennis, AJM; Carpten, J; Pandha, H; Michael, A; De Ruyck, K; De Meerleer, G; Ost, P; Xu, J; Razack, A; Lim, J; Teo, S-H; Newcomb, LF; Lin, DW; Fowke, JH; Neslund-Dudas, C; Rybicki, BA; Gamulin, M; Lessel, D; Kulis, T; Usmani, N; Singhal, S; Parliament, M; Claessens, F; Joniau, S; Van den Broeck, T; Gago-Dominguez, M; Castelao, JE; Martinez, ME; Larkin, S; Townsend, PA; Aukim-Hastie, C; Bush, WS; Aldrich, MC; Crawford, DC; Srivastava, S; Cullen, JC; Petrovics, G; Casey, G; Roobol, MJ; Jenster, G; van Schaik, RHN; Hu, JJ; Sanderson, M; Varma, R; McKean-Cowdin, R; Torres, M; Mancuso, N; Berndt, SI; Van Den Eeden, SK; Easton, DF; Chanock, SJ; Cook, MB; Wiklund, F; Nakagawa, H; Witte, JS; Eeles, RA; Kote-Jarai, Z; Haiman, CA (2021-01-04)
    Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 ...
  • Diffusion-Weighted Magnetic Resonance Imaging (DW-MRI) of the normal bone marrow in children and effects of local and systemic cancer therapies 

    Pace, E (2021-01-31)
    Bone marrow, one of the largest organs in the body, is a highly proliferative tissue because of its dynamic function in providing the cellular elements of blood. In a paediatric population, the proportion of red marrow ...
  • On-treatment immune prognostic score for patients with relapsed and/or metastatic head and neck squamous cell carcinoma treated with immunotherapy. 

    Nenclares, P; Gunn, L; Soliman, H; Bover, M; Trinh, A; Leslie, I; Wong, KH; Melcher, A; Newbold, K; Nutting, CM; Ap Dafydd, D; Bhide, SA; Harrington, K
    <h4>Background</h4>Previous studies have suggested that inflammatory markers (neutrophil-to-lymphocyte ratio (NLR), lactate dehydrogenase (LDH) and fibrinogen) are prognostic biomarkers in patients with a variety of solid ...
  • Traceable reference dosimetry in MRI guided radiotherapy using alanine: calibration and magnetic field correction factors of ionisation chambers. 

    Billas, I; Bouchard, H; Oelfke, U; Duane, S (2021-05-28)
    MRIgRT falls outside the scope of existing CoPs, because do not consider the effects of the magnetic field on detector response and on absorbed dose to water. The aim of this study is to evaluate and demonstrate the traceable ...
  • Oncologically Relevant Findings Reporting and Data System (ONCO-RADS): Guidelines for the Acquisition, Interpretation, and Reporting of Whole-Body MRI for Cancer Screening. 

    Petralia, G; Koh, D-M; Attariwala, R; Busch, JJ; Eeles, R; Karow, D; Lo, GG; Messiou, C; Sala, E; Vargas, HA; Zugni, F; Padhani, AR (2021-06)
    Acknowledging the increasing number of studies describing the use of whole-body MRI for cancer screening, and the increasing number of examinations being performed in patients with known cancers, an international ...
  • Image-guided Adaptive Radiotherapy for Bladder Cancer. 

    Kong, V; Hansen, VN; Hafeez, S
    Technological advancement has facilitated patient-specific radiotherapy in bladder cancer. This has been made possible by developments in image-guided radiotherapy (IGRT). Particularly transformative has been the integration ...

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