Recent submissions

  • Adjuvant Therapy for Stage IB Germ Cell Tumors: One versus Two Cycles of BEP. 

    Huddart, RA; Reid, AM
    Testicular germ cell tumours are the commonest tumours of young men and are broadly managed either as pure seminomas or as 'nonseminomas'. The management of Stage 1 nonseminomatous germ cell tumours (NSGCTs), beyond surgical ...
  • In Vivo Validation of Elekta's Clarity Autoscan for Ultrasound-based Intrafraction Motion Estimation of the Prostate During Radiation Therapy. 

    Grimwood, A; McNair, HA; O'Shea, TP; Gilroy, S; Thomas, K; Bamber, JC; Tree, AC; Harris, EJ (2018-04-16)
    PURPOSE: Our purpose was to perform an in vivo validation of ultrasound imaging for intrafraction motion estimation using the Elekta Clarity Autoscan system during prostate radiation therapy. The study was conducted as ...
  • A Dosimetric Comparison of Breast Radiotherapy Techniques to Treat Locoregional Lymph Nodes Including the Internal Mammary Chain. 

    Ranger, A; Dunlop, A; Hutchinson, K; Convery, H; Maclennan, MK; Chantler, H; Twyman, N; Rose, C; McQuaid, D; Amos, RA; Griffin, C; deSouza, NM; Donovan, E; Harris, E; Coles, CE; Kirby, A
    AIMS: Radiotherapy target volumes in early breast cancer treatment increasingly include the internal mammary chain (IMC). In order to maximise survival benefits of IMC radiotherapy, doses to the heart and lung should be ...
  • Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants 

    Dadaev, T; Saunders, EJ; Newcombe, PJ; Anokian, E; Leongamornlert, DA; Brook, MN; Cieza-Borrella, C; Mijuskovic, M; Wakerell, S; Olama, AAA; Schumacher, FR; Berndt, SI; Benlloch, S; Ahmed, M; Goh, C; Sheng, X; Zhang, Z; Muir, K; Govindasami, K; Lophatananon, A; Stevens, VL; Gapstur, SM; Carter, BD; Tangen, CM; Goodman, P; Thompson, IM; Batra, J; Chambers, S; Moya, L; Clements, J; Horvath, L; Tilley, W; Risbridger, G; Gronberg, H; Aly, M; Nordström, T; Pharoah, P; Pashayan, N; Schleutker, J; Tammela, TLJ; Sipeky, C; Auvinen, A; Albanes, D; Weinstein, S; Wolk, A; Hakansson, N; West, C; Dunning, AM; Burnet, N; Mucci, L; Giovannucci, E; Andriole, G; Cussenot, O; Cancel-Tassin, G; Koutros, S; Freeman, LEB; Sorensen, KD; Orntoft, TF; Borre, M; Maehle, L; Grindedal, EM; Neal, DE; Donovan, JL; Hamdy, FC; Martin, RM; Travis, RC; Key, TJ; Hamilton, RJ; Fleshner, NE; Finelli, A; Ingles, SA; Stern, MC; Rosenstein, B; Kerns, S; Ostrer, H; Lu, Y-J; Zhang, H-W; Feng, N; Mao, X; Guo, X; Wang, G; Sun, Z; Giles, GG; Southey, MC; MacInnis, RJ; FitzGerald, LM; Kibel, AS; Drake, BF; Vega, A; Gómez-Caamaño, A; Fachal, L; Szulkin, R; Eklund, M; Kogevinas, M; Llorca, J; Castaño-Vinyals, G; Penney, KL; Stampfer, M; Park, JY; Sellers, TA; Lin, H-Y; Stanford, JL; Cybulski, C; Wokolorczyk, D; Lubinski, J; Ostrander, EA; Geybels, MS; Nordestgaard, BG; Nielsen, SF; Weisher, M; Bisbjerg, R; Røder, MA; Iversen, P; Brenner, H; Cuk, K; Holleczek, B; Maier, C; Luedeke, M; Schnoeller, T; Kim, J; Logothetis, CJ; John, EM; Teixeira, MR; Paulo, P; Cardoso, M; Neuhausen, SL; Steele, L; Ding, YC; De Ruyck, K; De Meerleer, G; Ost, P; Razack, A; Lim, J; Teo, S-H; Lin, DW; Newcomb, LF; Lessel, D; Gamulin, M; Kulis, T; Kaneva, R; Usmani, N; Slavov, C; Mitev, V; Parliament, M; Singhal, S; Claessens, F; Joniau, S; Van den Broeck, T; Larkin, S; Townsend, PA; Aukim-Hastie, C; Gago-Dominguez, M; Castelao, JE; Martinez, ME; Roobol, MJ; Jenster, G; van Schaik, RHN; Menegaux, F; Truong, T; Koudou, YA; Xu, J; Khaw, K-T; Cannon-Albright, L; Pandha, H; Michael, A; Kierzek, A; Thibodeau, SN; McDonnell, SK; Schaid, DJ; Lindstrom, S; Turman, C; Ma, J; Hunter, DJ; Riboli, E; Siddiq, A; Canzian, F; Kolonel, LN; Le Marchand, L; Hoover, RN; Machiela, MJ; Kraft, P; Freedman, M; Wiklund, F; Chanock, S; Henderson, BE; Easton, DF; Haiman, CA; Eeles, RA; Conti, DV; Kote-Jarai, Z
  • The psychosocial impact of undergoing prostate cancer screening for men with BRCA1/2 mutations. 

    Bancroft, EK; Saya, S; Page, EC; Myhill, K; Thomas, S; Pope, J; Chamberlain, A; Hart, R; Glover, W; Cook, J; Rosario, DJ; Helfand, BT; Selkirk, CH; Davidson, R; Longmuir, M; Eccles, DM; Gadea, N; Brewer, C; Barwell, J; Salinas, M; Greenhalgh, L; Tischkowitz, M; Henderson, A; Evans, DG; Buys, SS; IMPACT Study Steering Committee; IMPACT Collaborators; Eeles, RA; Aaronson, NK (2018-05-26)
    OBJECTIVES: To report the baseline results of a longitudinal psychosocial study that forms part of the IMPACT study, a multi-national investigation of targeted prostate cancer (PCa) screening among men with a known pathogenic ...
  • A paradox: urgent BRCA genetic testing. 

    Mitchell, G; Ardern-Jones, A; Kissin Mchir, M; Taylor, R; Eeles, RA (2001-01)
    Diagnostic or predictive testing for germline mutations in cancer predisposition genes is inherently slow as result of both genetic counselling and mutation analysis. The overall time taken for mutation testing is not ...
  • The UK national study of magnetic resonance imaging as a method of screening for breast cancer (MARIBS). 

    Leach, MO; Eeles, RA; Turnbull, LW; Dixon, AK; Brown, J; Hoff, RJ; Coulthard, A; Dixon, JM; Easton, DF; Evans, DG; Gilbert, FJ; Hawnaur, J; Hayes, C; Kessar, P; Lakhani, S; Liney, G; Moss, SM; Padhani, AP; Pointon, LJ; Sydenham, M; Walker, LG; Warren, RM; Haites, NE; Morrison, P; Cole, T; Rayter, Z; Donaldson, A; Shere, M; Rankin, J; Goudie, D; Steel, CM; Davidson, R; Chu, C; Ellis, I; Mackay, J; Hodgson, SV; Homfray, T; Douglas, F; Quarrell, OW; Eccles, DM; Gilbert, FG; Crothers, G; Walker, CP; Jones, A; Slack, N; Britton, P; Sheppard, DG; Walsh, J; Whitehouse, G; Teh, W; Rankin, S; Boggis, C; Potterton, J; McLean, L; Gordon, PA; Rubin, C (2002-09)
    The UK national study of magnetic resonance imaging as a method of screening for breast cancer (MARIBS) is in progress. The study design, accrual to date, and related research projects are described. Revised accrual rates ...
  • Guilt, blame and responsibility: men's understanding of their role in the transmission of BRCA1/2 mutations within their family. 

    Hallowell, N; Arden-Jones, A; Eeles, R; Foster, C; Lucassen, A; Moynihan, C; Watson, M
    Men and women who have a family history of breast and/or ovarian cancer may be offered a predictive genetic test to determine whether or not they carry the family specific BRCA1/2 mutation. The sons and daughters of mutation ...
  • Prostate cancer segregation analyses using 4390 families from UK and Australian population-based studies. 

    MacInnis, RJ; Antoniou, AC; Eeles, RA; Severi, G; Guy, M; McGuffog, L; Hall, AL; O'Brien, LT; Wilkinson, RA; Dearnaley, DP; Ardern-Jones, AT; Horwich, A; Khoo, VS; Parker, CC; Huddart, RA; McCredie, MR; Smith, C; Southey, MC; Staples, MP; English, DR; Hopper, JL; Giles, GG; Easton, DF (2010-01)
    Familial aggregation of prostate cancer is likely to be due to multiple susceptibility loci, perhaps acting in conjunction with shared lifestyle risk factors. Models that assume a single mode of inheritance may be unrealistic. ...
  • The potential value of microseminoprotein-beta as a prostate cancer biomarker and therapeutic target. 

    Whitaker, HC; Warren, AY; Eeles, R; Kote-Jarai, Z; Neal, DE (2010-02)
    BACKGROUND: Recent genome-wide association studies have shown an association of a SNP two base pairs upstream of the 5' UTR of the microseminoprotein-beta (MSMB) gene with an increased risk of developing the prostate cancer, ...
  • Dietary fat and early-onset prostate cancer risk. 

    Lophatananon, A; Archer, J; Easton, D; Pocock, R; Dearnaley, D; Guy, M; Kote-Jarai, Z; O'Brien, L; Wilkinson, RA; Hall, AL; Sawyer, E; Page, E; Liu, JF; Barratt, S; Rahman, AA; Eeles, R; Muir, K (2010-05)
    The UK incidence of prostate cancer has been increasing in men aged < 60 years. Migrant studies and global and secular variation in incidence suggest that modifiable factors, including a high-fat diet, may contribute to ...
  • Geometric and dosimetric evaluations of atlas-based segmentation methods of MR images in the head and neck region 

    Kieselmann, J; Kamerling, C; Burgos, N; Menten, M; Fuller, CD; Nill, S; Oelfke, U
  • Genome-wide linkage analysis of 1,233 prostate cancer pedigrees from the International Consortium for Prostate Cancer Genetics using novel sumLINK and sumLOD analyses. 

    Christensen, GB; Baffoe-Bonnie, AB; George, A; Powell, I; Bailey-Wilson, JE; Carpten, JD; Giles, GG; Hopper, JL; Severi, G; English, DR; Foulkes, WD; Maehle, L; Moller, P; Eeles, R; Easton, D; Badzioch, MD; Whittemore, AS; Oakley-Girvan, I; Hsieh, CL; Dimitrov, L; Xu, J; Stanford, JL; Johanneson, B; Deutsch, K; McIntosh, L; Ostrander, EA; Wiley, KE; Isaacs, SD; Walsh, PC; Isaacs, WB; Thibodeau, SN; McDonnell, SK; Hebbring, S; Schaid, DJ; Lange, EM; Cooney, KA; Tammela, TL; Schleutker, J; Paiss, T; Maier, C; Grönberg, H; Wiklund, F; Emanuelsson, M; Farnham, JM; Cannon-Albright, LA; Camp, NJ
    Prostate cancer (PC) is generally believed to have a strong inherited component, but the search for susceptibility genes has been hindered by the effects of genetic heterogeneity. The recently developed sumLINK and sumLOD ...
  • Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes. 

    Tubio, JM; Li, Y; Ju, YS; Martincorena, I; Cooke, SL; Tojo, M; Gundem, G; Pipinikas, CP; Zamora, J; Raine, K; Menzies, A; Roman-Garcia, P; Fullam, A; Gerstung, M; Shlien, A; Tarpey, PS; Papaemmanuil, E; Knappskog, S; Van Loo, P; Ramakrishna, M; Davies, HR; Marshall, J; Wedge, DC; Teague, JW; Butler, AP; Nik-Zainal, S; Alexandrov, L; Behjati, S; Yates, LR; Bolli, N; Mudie, L; Hardy, C; Martin, S; McLaren, S; O'Meara, S; Anderson, E; Maddison, M; Gamble, S; Foster, C; Warren, AY; Whitaker, H; Brewer, D; Eeles, R; Cooper, C; Neal, D; Lynch, AG; Visakorpi, T; Isaacs, WB; van't Veer, L; Caldas, C; Desmedt, C; Sotiriou, C; Aparicio, S; Foekens, JA; Eyfjörd, JE; Lakhani, SR; Thomas, G; Myklebost, O; Span, PN; Børresen-Dale, AL; Richardson, AL; Van de Vijver, M; Vincent-Salomon, A; Van den Eynden, GG; Flanagan, AM; Futreal, PA; Janes, SM; Bova, GS; Stratton, MR; McDermott, U; Campbell, PJ
    Long interspersed nuclear element-1 (L1) retrotransposons are mobile repetitive elements that are abundant in the human genome. L1 elements propagate through RNA intermediates. In the germ line, neighboring, nonrepetitive ...
  • Candidate genetic modifiers for breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers. 

    Peterlongo, P; Chang-Claude, J; Moysich, KB; Rudolph, A; Schmutzler, RK; Simard, J; Soucy, P; Eeles, RA; Easton, DF; Hamann, U; Wilkening, S; Chen, B; Rookus, MA; Schmidt, MK; van der Baan, FH; Spurdle, AB; Walker, LC; Lose, F; Maia, AT; Montagna, M; Matricardi, L; Lubinski, J; Jakubowska, A; Gómez Garcia, EB; Olopade, OI; Nussbaum, RL; Nathanson, KL; Domchek, SM; Rebbeck, TR; Arun, BK; Karlan, BY; Orsulic, S; Lester, J; Chung, WK; Miron, A; Southey, MC; Goldgar, DE; Buys, SS; Janavicius, R; Dorfling, CM; van Rensburg, EJ; Ding, YC; Neuhausen, SL; Hansen, TV; Gerdes, AM; Ejlertsen, B; Jønson, L; Osorio, A; Martínez-Bouzas, C; Benitez, J; Conway, EE; Blazer, KR; Weitzel, JN; Manoukian, S; Peissel, B; Zaffaroni, D; Scuvera, G; Barile, M; Ficarazzi, F; Mariette, F; Fortuzzi, S; Viel, A; Giannini, G; Papi, L; Martayan, A; Tibiletti, MG; Radice, P; Vratimos, A; Fostira, F; Garber, JE; Donaldson, A; Brewer, C; Foo, C; Evans, DG; Frost, D; Eccles, D; Brady, A; Cook, J; Tischkowitz, M; Adlard, J; Barwell, J; Walker, L; Izatt, L; Side, LE; Kennedy, MJ; Rogers, MT; Porteous, ME; Morrison, PJ; Platte, R; Davidson, R; Hodgson, SV; Ellis, S; Cole, T; Godwin, AK; Claes, K; Van Maerken, T; Meindl, A; Gehrig, A; Sutter, C; Engel, C; Niederacher, D; Steinemann, D; Plendl, H; Kast, K; Rhiem, K; Ditsch, N; Arnold, N; Varon-Mateeva, R; Wappenschmidt, B; Wang-Gohrke, S; Bressac-de Paillerets, B; Buecher, B; Delnatte, C; Houdayer, C; Stoppa-Lyonnet, D; Damiola, F; Coupier, I; Barjhoux, L; Venat-Bouvet, L; Golmard, L; Boutry-Kryza, N; Sinilnikova, OM; Caron, O; Pujol, P; Mazoyer, S; Belotti, M; Piedmonte, M; Friedlander, ML; Rodriguez, GC; Copeland, LJ; de la Hoya, M; Segura, PP; Nevanlinna, H; Aittomäki, K; van Os, TA; Meijers-Heijboer, HE; van der Hout, AH; Vreeswijk, MP; Hoogerbrugge, N; Ausems, MG; van Doorn, HC; Collée, JM; Olah, E; Diez, O; Blanco, I; Lazaro, C; Brunet, J; Feliubadalo, L; Cybulski, C; Gronwald, J; Durda, K; Jaworska-Bieniek, K; Sukiennicki, G; Arason, A; Chiquette, J; Teixeira, MR; Olswold, C; Couch, FJ; Lindor, NM; Wang, X; Szabo, CI; Offit, K; Corines, M; Jacobs, L; Robson, ME; Zhang, L; Joseph, V; Joseph, V; Berger, A; Singer, CF; Rappaport, C; Kaulich, DG; Pfeiler, G; Tea, MK; Phelan, CM; Greene, MH; Mai, PL; Rennert, G; Mulligan, AM; Glendon, G; Tchatchou, S; Andrulis, IL; Toland, AE; Bojesen, A; Pedersen, IS; Thomassen, M; Jensen, UB; Laitman, Y; Rantala, J; von Wachenfeldt, A; Ehrencrona, H; Askmalm, MS; Borg, Å; Kuchenbaecker, KB; McGuffog, L; Barrowdale, D; Healey, S; Lee, A; Pharoah, PD; Chenevix-Trench, G; Antoniou, AC; Friedman, E
    BRCA1 and BRCA2 mutation carriers are at substantially increased risk for developing breast and ovarian cancer. The incomplete penetrance coupled with the variable age at diagnosis in carriers of the same mutation suggests ...
  • Off-Target V(D)J Recombination Drives Lymphomagenesis and Is Escalated by Loss of the Rag2 C Terminus 

    Mijuskovic, Martina
    Genome-wide analysis of thymic lymphomas from Tp53(-/-) mice with wild-type or C-terminally truncated Rag2 revealed numerous off-target, RAG-mediated DNA rearrangements. A significantly higher fraction of these errors ...
  • A risk prediction algorithm based on family history and common genetic variants: application to prostate cancer with potential clinical impact. 

    Macinnis, RJ; Antoniou, AC; Eeles, RA; Severi, G; Al Olama, AA; McGuffog, L; Kote-Jarai, Z; Guy, M; O'Brien, LT; Hall, AL; Wilkinson, RA; Sawyer, E; Ardern-Jones, AT; Dearnaley, DP; Horwich, A; Khoo, VS; Parker, CC; Huddart, RA; Van As, N; McCredie, MR; English, DR; Giles, GG; Hopper, JL; Easton, DF
    Genome wide association studies have identified several single nucleotide polymorphisms (SNPs) that are independently associated with small increments in risk of prostate cancer, opening up the possibility for using such ...
  • 18F-fluorodeoxyglucose positron-emission tomography combined with computed tomography as a diagnostic tool in native valve endocarditis. 

    Kouijzer, IJE; Berrevoets, MAH; Aarntzen, EHJG; de Vries, J; van Dijk, APJ; Oyen, WJG; de Geus-Oei, L-F; Bleeker-Rovers, CP (2018-05-14)
    OBJECTIVE: The aim of the study was to investigate the value of F-fluorodeoxyglucose positron-emission tomography combined with computed tomography (F-FDG-PET/CT) in diagnosing native valve endocarditis (NVE). PATIENTS AND ...
  • Isolated limb perfusion with melphalan, tumour necrosis factor-alpha and oncolytic vaccinia virus improves tumour targeting and prolongs survival in a rat model of advanced extremity sarcoma. 

    Pencavel, TD; Wilkinson, MJ; Mansfield, DC; Khan, AA; Seth, R; Karapanagiotou, EM; Roulstone, V; Aguilar, RJ; Chen, NG; Szalay, AA; Hayes, AJ; Harrington, KJ (2015-02)
    Isolated limb perfusion (ILP) is a treatment for advanced extremity sarcoma and in-transit melanoma. Advancing this procedure by investigating the addition of novel agents, such as cancer-selective oncolytic viruses, may ...
  • Human Papillomavirus-Negative Pharyngeal Cancer. 

    Dillon, MT; Harrington, KJ (2015-10)
    Human papillomavirus-negative head and neck squamous cell carcinoma (HNSCC) carries a poor prognosis, and despite optimal treatment with chemoradiotherapy to the limit of tolerance, many patients will relapse. A number of ...

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