Recent submissions

  • Baseline Surveillance in Li-Fraumeni Syndrome Using Whole-Body Magnetic Resonance Imaging: A Meta-analysis. 

    Ballinger, ML; Best, A; Mai, PL; Khincha, PP; Loud, JT; Peters, JA; Achatz, MI; Chojniak, R; Balieiro da Costa, A; Santiago, KM; Garber, J; O'Neill, AF; Eeles, RA; Evans, DG; Bleiker, E; Sonke, GS; Ruijs, M; Loo, C; Schiffman, J; Naumer, A; Kohlmann, W; Strong, LC; Bojadzieva, J; Malkin, D; Rednam, SP; Stoffel, EM; Koeppe, E; Weitzel, JN; Slavin, TP; Nehoray, B; Robson, M; Walsh, M; Manelli, L; Villani, A; Thomas, DM; Savage, SA (2017-08-03)
    Importance: Guidelines for clinical management in Li-Fraumeni syndrome, a multiple-organ cancer predisposition condition, are limited. Whole-body magnetic resonance imaging (WBMRI) may play a role in surveillance of this ...
  • DESNT: A Poor Prognosis Category of Human Prostate Cancer. 

    Luca, B-A; Brewer, DS; Edwards, DR; Edwards, S; Whitaker, HC; Merson, S; Dennis, N; Cooper, RA; Hazell, S; Warren, AY; CancerMap Group; Eeles, R; Lynch, AG; Ross-Adams, H; Lamb, AD; Neal, DE; Sethia, K; Mills, RD; Ball, RY; Curley, H; Clark, J; Moulton, V; Cooper, CS (2017-03-06)
    BACKGROUND: A critical problem in the clinical management of prostate cancer is that it is highly heterogeneous. Accurate prediction of individual cancer behaviour is therefore not achievable at the time of diagnosis leading ...
  • Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study. 

    Telomeres Mendelian Randomization Collaboration; Haycock, PC; Burgess, S; Nounu, A; Zheng, J; Okoli, GN; Bowden, J; Wade, KH; Timpson, NJ; Evans, DM; Willeit, P; Aviv, A; Gaunt, TR; Hemani, G; Mangino, M; Ellis, HP; Kurian, KM; Pooley, KA; Eeles, RA; Lee, JE; Fang, S; Chen, WV; Law, MH; Bowdler, LM; Iles, MM; Yang, Q; Worrall, BB; Markus, HS; Hung, RJ; Amos, CI; Spurdle, AB; Thompson, DJ; O'Mara, TA; Wolpin, B; Amundadottir, L; Stolzenberg-Solomon, R; Trichopoulou, A; Onland-Moret, NC; Lund, E; Duell, EJ; Canzian, F; Severi, G; Overvad, K; Gunter, MJ; Tumino, R; Svenson, U; van Rij, A; Baas, AF; Bown, MJ; Samani, NJ; van t'Hof, FNG; Tromp, G; Jones, GT; Kuivaniemi, H; Elmore, JR; Johansson, M; Mckay, J; Scelo, G; Carreras-Torres, R; Gaborieau, V; Brennan, P; Bracci, PM; Neale, RE; Olson, SH; Gallinger, S; Li, D; Petersen, GM; Risch, HA; Klein, AP; Han, J; Abnet, CC; Freedman, ND; Taylor, PR; Maris, JM; Aben, KK; Kiemeney, LA; Vermeulen, SH; Wiencke, JK; Walsh, KM; Wrensch, M; Rice, T; Turnbull, C; Litchfield, K; Paternoster, L; Standl, M; Abecasis, GR; SanGiovanni, JP; Li, Y; Mijatovic, V; Sapkota, Y; Low, S-K; Zondervan, KT; Montgomery, GW; Nyholt, DR; van Heel, DA; Hunt, K; Arking, DE; Ashar, FN; Sotoodehnia, N; Woo, D; Rosand, J; Comeau, ME; Brown, WM; Silverman, EK; Hokanson, JE; Cho, MH; Hui, J; Ferreira, MA; Thompson, PJ; Morrison, AC; Felix, JF; Smith, NL; Christiano, AM; Petukhova, L; Betz, RC; Fan, X; Zhang, X; Zhu, C; Langefeld, CD; Thompson, SD; Wang, F; Lin, X; Schwartz, DA; Fingerlin, T; Rotter, JI; Cotch, MF; Jensen, RA; Munz, M; Dommisch, H; Schaefer, AS; Han, F; Ollila, HM; Hillary, RP; Albagha, O; Ralston, SH; Zeng, C; Zheng, W; Shu, X-O; Reis, A; Uebe, S; Hüffmeier, U; Kawamura, Y; Otowa, T; Sasaki, T; Hibberd, ML; Davila, S; Xie, G; Siminovitch, K; Bei, J-X; Zeng, Y-X; Försti, A; Chen, B; Landi, S; Franke, A; Fischer, A; Ellinghaus, D; Flores, C; Noth, I; Ma, S-F; Foo, JN; Liu, J; Kim, J-W; Cox, DG; Delattre, O; Mirabeau, O; Skibola, CF; Tang, CS; Garcia-Barcelo, M; Chang, K-P; Su, W-H; Chang, Y-S; Martin, NG; Gordon, S; Wade, TD; Lee, C; Kubo, M; Cha, P-C; Nakamura, Y; Levy, D; Kimura, M; Hwang, S-J; Hunt, S; Spector, T; Soranzo, N; Manichaikul, AW; Barr, RG; Kahali, B; Speliotes, E; Yerges-Armstrong, LM; Cheng, C-Y; Jonas, JB; Wong, TY; Fogh, I; Lin, K; Powell, JF; Rice, K; Relton, CL; Martin, RM; Davey Smith, G (2017-05-01)
    Importance: The causal direction and magnitude of the association between telomere length and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility of observational studies to confounding ...
  • Height, selected genetic markers and prostate cancer risk: results from the PRACTICAL consortium. 

    Lophatananon, A; Stewart-Brown, S; Kote-Jarai, Z; Olama, AAA; Garcia, SB; Neal, DE; Hamdy, FC; Donovan, JL; Giles, GG; Fitzgerald, LM; Southey, MC; Pharoah, P; Pashayan, N; Gronberg, H; Wiklund, F; Aly, M; Stanford, JL; Brenner, H; Dieffenbach, AK; Arndt, V; Park, JY; Lin, H-Y; Sellers, T; Slavov, C; Kaneva, R; Mitev, V; Batra, J; Spurdle, A; Clements, JA; APCB BioResource; PRACTICAL consortium; Easton, D; Eeles, RA; Muir, K (2017-08-22)
    BACKGROUND: Evidence on height and prostate cancer risk is mixed, however, recent studies with large data sets support a possible role for its association with the risk of aggressive prostate cancer. METHODS: We analysed ...
  • Quantifying the Genetic Correlation between Multiple Cancer Types. 

    Lindström, S; Finucane, H; Bulik-Sullivan, B; Schumacher, FR; Amos, CI; Hung, RJ; Rand, K; Gruber, SB; Conti, D; Permuth, JB; Lin, H-Y; Goode, EL; Sellers, TA; Amundadottir, LT; Stolzenberg-Solomon, R; Klein, A; Petersen, G; Risch, H; Wolpin, B; Hsu, L; Huyghe, JR; Chang-Claude, J; Chan, A; Berndt, S; Eeles, R; Easton, D; Haiman, CA; Hunter, DJ; Neale, B; Price, AL; Kraft, P; PanScan, GECCO and the GAME-ON Network: CORECT, DRIVE, ELLIPSE, FOCI, and TRICL-ILCCO (2017-09)
    Background: Many cancers share specific genetic risk factors, including both rare high-penetrance mutations and common SNPs identified through genome-wide association studies (GWAS). However, little is known about the ...
  • Identification of ABC Transporter Interaction of a Novel Cyanoquinoline Radiotracer and Implications for Tumour Imaging by Positron Emission Tomography. 

    Slade, RL; Pisaneschi, F; Nguyen, QD; Smith, G; Carroll, L; Beckley, A; Kaliszczak, MA; Aboagye, EO (2016-01)
    The epidermal growth factor receptor (EGFR) is overexpressed in many cancers including lung, ovarian, breast, head and neck and brain. Mutation of this receptor has been shown to play a crucial role in the response of ...
  • A general [ 18 F]AlF radiochemistry procedure on two automated synthesis platforms 

    Allott, L; Da Pieve, C; Turton, DR; Smith, G (2017)
  • Assessment of MLC tracking performance during hypofractionated prostate radiotherapy using real-time dose reconstruction. 

    Fast, MF; Kamerling, CP; Ziegenhein, P; Menten, MJ; Bedford, JL; Nill, S; Oelfke, U (2016-02)
    By adapting to the actual patient anatomy during treatment, tracked multi-leaf collimator (MLC) treatment deliveries offer an opportunity for margin reduction and healthy tissue sparing. This is assumed to be especially ...
  • Using dual-energy x-ray imaging to enhance automated lung tumor tracking during real-time adaptive radiotherapy. 

    Menten, MJ; Fast, MF; Nill, S; Oelfke, U (2015-12)
    Real-time, markerless localization of lung tumors with kV imaging is often inhibited by ribs obscuring the tumor and poor soft-tissue contrast. This study investigates the use of dual-energy imaging, which can generate ...
  • Tumour auto-contouring on 2d cine MRI for locally advanced lung cancer: A comparative study. 

    Fast, MF; Eiben, B; Menten, MJ; Wetscherek, A; Hawkes, DJ; McClelland, JR; Oelfke, U (2017-10-10)
    BACKGROUND AND PURPOSE: Radiotherapy guidance based on magnetic resonance imaging (MRI) is currently becoming a clinical reality. Fast 2d cine MRI sequences are expected to increase the precision of radiation delivery by ...
  • Treating locally advanced lung cancer with a 1.5T MR-Linac - Effects of the magnetic field and irradiation geometry on conventionally fractionated and isotoxic dose-escalated radiotherapy. 

    Bainbridge, HE; Menten, MJ; Fast, MF; Nill, S; Oelfke, U; McDonald, F (2017-10-04)
    PURPOSE: This study investigates the feasibility and potential benefits of radiotherapy with a 1.5T MR-Linac for locally advanced non-small cell lung cancer (LA NSCLC) patients. MATERIAL AND METHODS: Ten patients with LA ...
  • MRI-guided lung SBRT: Present and future developments. 

    Menten, MJ; Wetscherek, A; Fast, MF (2017-02-24)
    Stereotactic body radiotherapy (SBRT) is rapidly becoming an alternative to surgery for the treatment of early-stage non-small cell lung cancer patients. Lung SBRT is administered in a hypo-fractionated, conformal manner, ...
  • Gold nanorod reshaping in vitro and in vivo using a continuous wave laser. 

    Harris-Birtill, D; Singh, M; Zhou, Y; Shah, A; Ruenraroengsak, P; Gallina, ME; Hanna, GB; Cass, AEG; Porter, AE; Bamber, J; Elson, DS (2017)
    Gold nanorods (GNRs) are increasingly being investigated for cancer theranostics as they possess features which lend themselves in equal measures as contrast agents and catalysts for photothermal therapy. Their optical ...
  • Value of combining dynamic contrast enhanced ultrasound and optoacoustic tomography for hypoxia imaging. 

    Shah, A; Bush, N; Box, G; Eccles, S; Bamber, J (2017-12)
    Optoacoustic imaging (OAI) can detect haemoglobin and assess its oxygenation. However, the lack of a haemoglobin signal need not indicate a lack of perfusion. This study uses a novel method to assist the co-registration ...
  • Growth trajectories, breast size, and breast-tissue composition in a British pre-birth cohort of young women 

    Denholm, R; De Stavola, B; Hipwell, J; Doran, SJ; Busana, M; Jeffreys, M; Leach, MO; Hawkes, D; dos-Santos-Silva, I
  • Subversion of NK-cell and TNFα Immune Surveillance Drives Tumor Recurrence. 

    Kottke, T; Evgin, L; Shim, KG; Rommelfanger, D; Boisgerault, N; Zaidi, S; Diaz, RM; Thompson, J; Ilett, E; Coffey, M; Selby, P; Pandha, H; Harrington, K; Melcher, A; Vile, R (2017-10-15)
    Understanding how incompletely cleared primary tumors transition from minimal residual disease (MRD) into treatment-resistant, immune-invisible recurrences has major clinical significance. We show here that this transition ...
  • Oncolytic Herpes Simplex Virus Inhibits Pediatric Brain Tumor Migration and Invasion. 

    Cockle, JV; Brüning-Richardson, A; Scott, KJ; Thompson, J; Kottke, T; Morrison, E; Ismail, A; Carcaboso, AM; Rose, A; Selby, P; Conner, J; Picton, S; Short, S; Vile, R; Melcher, A; Ilett, E (2017-06-16)
    Pediatric high-grade glioma (pHGG) and diffuse intrinsic pontine glioma (DIPG) are invasive tumors with poor survival. Oncolytic virotherapy, initially devised as a direct cytotoxic treatment, is now also known to act via ...
  • Cationic lipid-based nanoparticles mediate functional delivery of acetate to tumor cells in vivo leading to significant anticancer effects. 

    Brody, LP; Sahuri-Arisoylu, M; Parkinson, JR; Parkes, HG; So, PW; Hajji, N; Thomas, EL; Frost, GS; Miller, AD; Bell, JD (2017)
    Metabolic reengineering using nanoparticle delivery represents an innovative therapeutic approach to normalizing the deregulation of cellular metabolism underlying many diseases, including cancer. Here, we demonstrated a ...
  • Warthin Tumor-Like Mucoepidermoid Carcinoma. 

    Heatley, N; Harrington, KJ; Thway, K (2017-08-01)
    Mucoepidermoid carcinoma (MEC) shows a wide morphologic spectrum, including epithelium with oncocytic or squamous metaplastic changes overlying a prominent cystic architecture, as well as tumor-associated lymphoid tissue. ...

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