Recent submissions

  • Evaluating Imaging Biomarkers of Acquired Resistance to Targeted EGFR Therapy in Xenograft Models of Human Head and Neck Squamous Cell Carcinoma. 

    Baker, LCJ; Sikka, A; Price, JM; Boult, JKR; Lepicard, EY; Box, G; Jamin, Y; Spinks, TJ; Kramer-Marek, G; Leach, MO; Eccles, SA; Box, C; Robinson, SP (2018)
    Background: Overexpression of EGFR is a negative prognostic factor in head and neck squamous cell carcinoma (HNSCC). Patients with HNSCC who respond to EGFR-targeted tyrosine kinase inhibitors (TKIs) eventually develop ...
  • Development of a methodology to study the effect of magnetic field on dose distributions in an MR-linac, using PRESAGE (R) and Monte Carlo calculations 

    Costa, F; Doran, S; Nill, S; Duane, S; Shipley, D; Billas, I; Adamovics, J; Oelfke, U; IOP (2017)
  • Tumor-Secreted LOXL2 Activates Fibroblasts through FAK Signaling 

    Barker, HE; Bird, D; Lang, G; Erler, JT (AMER ASSOC CANCER RESEARCH, 2013-11)
    Cancer-associated fibroblasts enhance cancer progression when activated by tumor cells through mechanisms not yet fully understood. Blocking mammary tumor cell-derived lysyl oxidase-like 2 (LOXL2) significantly inhibited ...
  • Focal amplification of the androgen receptor gene in hormone-naive human prostate cancer 

    Merson, S; Yang, ZH; Brewer, D; Olmos, D; Eichholz, A; McCarthy, F; Fisher, G; Kovacs, G; Berney, DM; Foster, CS; Moller, H; Scardino, P; Cuzick, J; Cooper, CS; Clark, JP; Grp, TP (NATURE PUBLISHING GROUP, 2014-03-18)
    Background: Androgen receptor (AR)-gene amplification, found in 20-30% of castration-resistant prostate cancer (CRPCa) is proposed to develop as a consequence of hormone-deprivation therapy and be a prime cause of treatment ...
  • Performance characteristics of the novel PETRRA positron camera 

    Otta, RJ; Flower, M; Erlandsson, K; Reader, A; Duxbury, D; Bateman, J; Stephenson, R; Spill, E (ELSEVIER SCIENCE BV, 2002-01-21)
    The PETRRA positron camera consists of two 60 cm x 40 cm annihilation photon detectors mounted on a rotating gantry. Each detector contains large BaF2 scintillators interfaced to large area multiwire proportional chambers ...
  • Towards the evaluation of the relevant degrees of freedom in nonlinear partial differential equations 

    Degenhard, A; Rodriguez-Laguna, J (SPRINGER, 2002-03)
    We investigate an operator renormalization group method to extract and describe the relevant degrees of freedom in the evolution of partial differential equations. The proposed renormalization group approach is formulated ...
  • Tumor to cervical spinal cord standardized uptake ratio (SUR) improves the reproducibility of 18F-FDG-PET based tumor segmentation in head and neck squamous cell carcinoma in a multicenter setting. 

    van den Bosch, S; Dijkema, T; Philippens, MEP; Terhaard, CHJ; Hoebers, FJP; Kaanders, JHAM; Oyen, WJG (2018-07-10)
    BACKGROUND: In quantitative FDG-PET data analysis, normalization of the standardized uptake value (SUV) with an internal image-derived standard improves its reproducibility. In this study, the cervical spinal cord is ...
  • Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci. 

    Schumacher, FR; Al Olama, AA; Berndt, SI; Benlloch, S; Ahmed, M; Saunders, EJ; Dadaev, T; Leongamornlert, D; Anokian, E; Cieza-Borrella, C; Goh, C; Brook, MN; Sheng, X; Fachal, L; Dennis, J; Tyrer, J; Muir, K; Lophatananon, A; Stevens, VL; Gapstur, SM; Carter, BD; Tangen, CM; Goodman, PJ; Thompson, IM; Batra, J; Chambers, S; Moya, L; Clements, J; Horvath, L; Tilley, W; Risbridger, GP; Gronberg, H; Aly, M; Nordström, T; Pharoah, P; Pashayan, N; Schleutker, J; Tammela, TLJ; Sipeky, C; Auvinen, A; Albanes, D; Weinstein, S; Wolk, A; Håkansson, N; West, CML; Dunning, AM; Burnet, N; Mucci, LA; Giovannucci, E; Andriole, GL; Cussenot, O; Cancel-Tassin, G; Koutros, S; Beane Freeman, LE; Sorensen, KD; Orntoft, TF; Borre, M; Maehle, L; Grindedal, EM; Neal, DE; Donovan, JL; Hamdy, FC; Martin, RM; Travis, RC; Key, TJ; Hamilton, RJ; Fleshner, NE; Finelli, A; Ingles, SA; Stern, MC; Rosenstein, BS; Kerns, SL; Ostrer, H; Lu, Y-J; Zhang, H-W; Feng, N; Mao, X; Guo, X; Wang, G; Sun, Z; Giles, GG; Southey, MC; MacInnis, RJ; FitzGerald, LM; Kibel, AS; Drake, BF; Vega, A; Gómez-Caamaño, A; Szulkin, R; Eklund, M; Kogevinas, M; Llorca, J; Castaño-Vinyals, G; Penney, KL; Stampfer, M; Park, JY; Sellers, TA; Lin, H-Y; Stanford, JL; Cybulski, C; Wokolorczyk, D; Lubinski, J; Ostrander, EA; Geybels, MS; Nordestgaard, BG; Nielsen, SF; Weischer, M; Bisbjerg, R; Røder, MA; Iversen, P; Brenner, H; Cuk, K; Holleczek, B; Maier, C; Luedeke, M; Schnoeller, T; Kim, J; Logothetis, CJ; John, EM; Teixeira, MR; Paulo, P; Cardoso, M; Neuhausen, SL; Steele, L; Ding, YC; De Ruyck, K; De Meerleer, G; Ost, P; Razack, A; Lim, J; Teo, S-H; Lin, DW; Newcomb, LF; Lessel, D; Gamulin, M; Kulis, T; Kaneva, R; Usmani, N; Singhal, S; Slavov, C; Mitev, V; Parliament, M; Claessens, F; Joniau, S; Van den Broeck, T; Larkin, S; Townsend, PA; Aukim-Hastie, C; Dominguez, MG; Castelao, JE; Martinez, ME; Roobol, MJ; Jenster, G; van Schaik, RHN; Menegaux, F; Truong, T; Koudou, YA; Profile Study; Xu, J; Khaw, K-T; Cannon-Albright, L; Pandha, H; Michael, A; Thibodeau, SN; McDonnell, SK; Schaid, DJ; Lindstrom, S; Turman, C; Ma, J; Hunter, DJ; Riboli, E; Siddiq, A; Canzian, F; Kolonel, LN; Le Marchand, L; Hoover, RN; Machiela, MJ; Cui, Z; Kraft, P; Australian Prostate Cancer BioResource (APCB); IMPACT Study; Canary PASS Investigators; Breast and Prostate Cancer Cohort Consortium (BPC3); PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium; Cancer of the Prostate in Sweden (CAPS); Prostate Cancer Genome-wide Association Study of Uncommon Susceptibility Loci (PEGASUS); Genetic Associations and Mechanisms in Oncology (GAME-ON)/Elucidating Loci Involved in Prostate Cancer Susceptibility (ELLIPSE) Consortium; Amos, CI; Conti, DV; Easton, DF; Wiklund, F; Chanock, SJ; Henderson, BE; Kote-Jarai, Z; Haiman, CA; Eeles, RA (2018-06-11)
    Genome-wide association studies (GWAS) and fine-mapping efforts to date have identified more than 100 prostate cancer (PrCa)-susceptibility loci. We meta-analyzed genotype data from a custom high-density array of 46,939 ...
  • Assessing response to treatment in breast cancer using magnetic resonance. 

    Leach, MO (2002-09)
    Magnetic resonance imaging provides a range of powerful techniques for assessing breast cancer. Contrast enhanced MRI has been shown to provide a sensitive method for assessing primary breast cancer, with increasing emphasis ...
  • Multiple spin echoes for the evaluation of trabecular bone quality 

    Capuani, S; Alessandri, FM; Bifone, A; Maraviglia, B (ELSEVIER SCIENCE BV, 2002-03)
    We report a simple and efficient MR method for the evaluation of trabecular bone quality. This technique is based on detection and imaging of Multiple Spin-Echoes (MSE). a manifestation of the dipolar field generated by ...
  • Scaling images using their background ratio. An application in statistical comparisons of images 

    Kalemis, A; Binnie, D; Bailey, DL; Flower, MA; Ott, RJ (IOP PUBLISHING LTD, 2003-06-07)
    Comparison of two medical images often requires image scaling as a preprocessing step. This is usually done with the scaling-to-the-mean or scaling-to-the-maximum techniques which, under certain circumstances, in quantitative ...
  • Performance of the PETRRA positron camera: reduction of scatter and randoms 

    Ott, RJ; Flower, MA; Divoli, A; Binnie, D (ELSEVIER SCIENCE BV, 2003-11-01)
    The PETRRA positron camera consists of two 60 x 40 cm(2) detectors mounted on a rotating gantry. The detectors each contain 1 cm thick BaF2 crystals interfaced to a MWPC filled with tetrakis dimethylamino ethylene (TMAE) ...
  • The evaluation of a large-area hybrid photodiode for PET applications 

    Ott, RJ; White, L; Duxbury, D; Fowler, R; Herbert, D; Ramsden, D (ELSEVIER SCIENCE BV, 2003-11-01)
    A large-area hybrid photodiode interfaced to scintillating crystals is being evaluated to determine its application as part of a positron camera dedicated to imaging the breast, positron emission mammography (PEM). The ...
  • The high resolution gamma imager (HRGI): a CCD based camera for medical imaging 

    Lees, JE; Fraser, GW; Keay, A; Bassford, D; Ott, R; Ryder, W (ELSEVIER SCIENCE BV, 2003-11-01)
    We describe the High Resolution Gamma Imager (HRGI): a Charge Coupled Device (CCD) based camera for imaging small volumes of radionuclide uptake in tissues. The HRGI is a collimated, scintillator-coated, low cost, high ...
  • Statistical pixelwise inference models for planar data analysis: an application to gamma-camera uniformity monitoring 

    Kalemis, A; Bailey, DL; Flower, MA; Lord, SK; Ott, RJ (IOP PUBLISHING LTD, 2004-07-21)
    In this paper two tests based on statistical models are presented and used to assess, quantify and provide positional information of the existence of bias and/or variations between planar images acquired at different times ...
  • Externally triggered gating of nuclear medicine acquisitions: a useful method for partitioning data 

    Bailey, DL; Kalemis, A (IOP PUBLISHING LTD, 2005-04-07)
    Physiological gating in nuclear medicine image acquisition was introduced over 30 years ago to subdivide data from the beating heart into short time frames to minimize motion blurring and permit evaluation of contractile ...
  • The PETRRA positron camera: design, characterization and results of a physical evaluation 

    Divoli, A; Flower, MA; Erlandsson, K; Reader, AJ; Evans, N; Meriaux, S; Ott, RJ; Stephenson, R; Bateman, JE; Duxbury, DM; Spill, EJ (IOP PUBLISHING LTD, 2005-09-07)
    The PETRRA positron camera is a large-area (600 mm x 400 mm sensitive area) prototype system that has been developed through a collaboration between the Rutherford Appleton Laboratory and the Institute of Cancer Research/Royal ...
  • Characterization of trabecular bone by dipolar demagnetizing field MRI 

    Capuani, S; Curzi, F; Alessandri, FM; Maraviglia, B; Bifone, A (JOHN WILEY & SONS INC, 2001-10)
    A multiple spin-echo (MSE) sequence has been applied for the first time to study trabecular bone ex vivo. The second echo generated by the demagnetizing field presents discrete drops in signal intensity for certain values ...
  • Desmoid fibromatosis through the patients’ eyes: Time to change the focus and organisation of care? 

    Husson, O; Younger, E; Dunlop, A; Dean, L; Strauss, D; Benson, C; Hayes, A; Miah, A; van Houdt, W; Zaidi, S; Smith, M; Williams, J; Jones, R; van der Graaf, W

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