Novel therapeutic approaches for pediatric diencephalic tumors: improving functional outcomes.
Date
2023-10-10ICR Author
Author
Cockle, JV
Corley, EA
Zebian, B
Hettige, S
Vaidya, SJ
Angelini, P
Stone, J
Leitch, RJ
Albanese, A
Mandeville, HC
Carceller, F
Marshall, LV
Type
Journal Article
Metadata
Show full item recordAbstract
Pediatric diencephalic tumors represent a histopathologically and molecularly diverse group of neoplasms arising in the central part of the brain and involving eloquent structures, including the hypothalamic-pituitary axis (HPA), optic pathway, thalamus, and pineal gland. Presenting symptoms can include significant neurological, endocrine, or visual manifestations which may be exacerbated by injudicious intervention. Upfront multidisciplinary assessment and coordinated management is crucial from the outset to ensure best short- and long-term functional outcomes. In this review we discuss the clinical and pathological features of the neoplastic entities arising in this location, and their management. We emphasize a clear move towards 'function preserving' diagnostic and therapeutic approaches with novel toxicity-sparing strategies, including targeted therapies.
Collections
Subject
Langerhans cell histiocytosis
craniopharyngioma
functional outcomes
germ cell tumor
glioma
molecularly targeted therapies
pediatric diencephalic tumors
Research team
Paed & Adolesc Radiother
Language
eng
Date accepted
2023-07-06
License start date
2023-10-10
Citation
Frontiers in Oncology, 2023, 13 pp. 1178553 -
Publisher
FRONTIERS MEDIA SA