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dc.contributor.authorCockle, JV
dc.contributor.authorCorley, EA
dc.contributor.authorZebian, B
dc.contributor.authorHettige, S
dc.contributor.authorVaidya, SJ
dc.contributor.authorAngelini, P
dc.contributor.authorStone, J
dc.contributor.authorLeitch, RJ
dc.contributor.authorAlbanese, A
dc.contributor.authorMandeville, HC
dc.contributor.authorCarceller, F
dc.contributor.authorMarshall, LV
dc.coverage.spatialSwitzerland
dc.date.accessioned2024-04-30T15:54:23Z
dc.date.available2024-04-30T15:54:23Z
dc.date.issued2023-10-10
dc.identifierARTN 1178553
dc.identifier.citationFrontiers in Oncology, 2023, 13 pp. 1178553 -
dc.identifier.issn2234-943X
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/6212
dc.identifier.eissn2234-943X
dc.identifier.eissn2234-943X
dc.identifier.doi10.3389/fonc.2023.1178553
dc.identifier.doi10.3389/fonc.2023.1178553
dc.description.abstractPediatric diencephalic tumors represent a histopathologically and molecularly diverse group of neoplasms arising in the central part of the brain and involving eloquent structures, including the hypothalamic-pituitary axis (HPA), optic pathway, thalamus, and pineal gland. Presenting symptoms can include significant neurological, endocrine, or visual manifestations which may be exacerbated by injudicious intervention. Upfront multidisciplinary assessment and coordinated management is crucial from the outset to ensure best short- and long-term functional outcomes. In this review we discuss the clinical and pathological features of the neoplastic entities arising in this location, and their management. We emphasize a clear move towards 'function preserving' diagnostic and therapeutic approaches with novel toxicity-sparing strategies, including targeted therapies.
dc.formatElectronic-eCollection
dc.format.extent1178553 -
dc.languageeng
dc.language.isoeng
dc.publisherFRONTIERS MEDIA SA
dc.relation.ispartofFrontiers in Oncology
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectLangerhans cell histiocytosis
dc.subjectcraniopharyngioma
dc.subjectfunctional outcomes
dc.subjectgerm cell tumor
dc.subjectglioma
dc.subjectmolecularly targeted therapies
dc.subjectpediatric diencephalic tumors
dc.titleNovel therapeutic approaches for pediatric diencephalic tumors: improving functional outcomes.
dc.typeJournal Article
dcterms.dateAccepted2023-07-06
dc.date.updated2024-04-16T14:46:12Z
rioxxterms.versionVoR
rioxxterms.versionofrecord10.3389/fonc.2023.1178553
rioxxterms.licenseref.startdate2023-10-10
rioxxterms.typeJournal Article/Review
pubs.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/37886179
pubs.organisational-groupICR
pubs.organisational-groupICR/Primary Group
pubs.organisational-groupICR/Primary Group/ICR Divisions
pubs.organisational-groupICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-groupICR/Primary Group/Royal Marsden Clinical Units
pubs.organisational-groupICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Paediatric and Adolescent Radiotherapy
pubs.publication-statusPublished online
pubs.publisher-urlhttp://dx.doi.org/10.3389/fonc.2023.1178553
pubs.volume13
icr.researchteamPaed & Adolesc Radiother
dc.contributor.icrauthorAngelini, Paola
icr.provenanceDeposited by Henry Mandeville on 2024-04-16. Deposit type is initial. No. of files: 1. Files: Novel therapeutic approaches for pediatric diencephalic tumors improving functional outcomes.pdf


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Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/