• Fibroblastic Reticular Cells Control Conduit Matrix Deposition during Lymph Node Expansion. 

  Martinez, VG; Pankova, V; Krasny, L; Singh, T; Makris, S; White, IJ; Benjamin, AC; Dertschnig, S; Horsnell, HL; Kriston-Vizi, J; Burden, JJ; Huang, PH; Tape, CJ; Acton, SE (2019-11)

  Lymph nodes (LNs) act as filters, constantly sampling peripheral cues. This is facilitated by the conduit network, a tubular structure of aligned extracellular matrix (ECM) fibrils ensheathed by fibroblastic reticular cells ...
• A decade of clinical development of PARP inhibitors in perspective. 

  Mateo, J; Lord, CJ; Serra, V; Tutt, A; Balmaña, J; Castroviejo-Bermejo, M; Cruz, C; Oaknin, A; Kaye, SB; de Bono, JS (2019-09)

  Genomic instability is a hallmark of cancer, and often is the result of altered DNA repair capacities in tumour cells. DNA damage repair defects are common in different cancer types; these alterations can also induce ...
• Multidisciplinary interventions in a specialist Drug Development Unit to improve family history documentation and onward referral of patients with advanced cancer to cancer genetics services. 

  Moss, CA; Cojocaru, E; Hanwell, J; Ward, S; Xu, W; van Zyl, M; O'Leary, L; de Bono, JS; Banerji, U; Kaye, SB; Minchom, A; George, AJ; Lopez, J; McVeigh, TP (2019-06)

  BACKGROUND:Molecular aberrations in cancer may represent therapeutic targets, and, if arising from the germline, may impact further cancer risk management in patients and their blood relatives. Annually, 600-700 patients ...
• Phase 2 study evaluating intermittent and continuous linsitinib and weekly paclitaxel in patients with recurrent platinum resistant ovarian epithelial cancer. 

  Oza, A; Kaye, S; Van Tornout, J; Sessa, C; Gore, M; Naumann, RW; Hirte, H; Colombo, N; Chen, J; Gorla, S; Poondru, S; Singh, M; Steinberg, J; Yuen, G; Banerjee, S (2018-05)

  BACKGROUND:Linsitinib, an oral, dual inhibitor of insulin-like growth factor-1 receptor and insulin receptor, in combination with weekly paclitaxel, may improve clinical outcomes compared with paclitaxel alone in patients ...
• Disruption of the Interaction of RAS with PI 3-Kinase Induces Regression of EGFR-Mutant-Driven Lung Cancer. 

  Murillo, MM; Rana, S; Spencer-Dene, B; Nye, E; Stamp, G; Downward, J (2018-12)

  RAS family GTPases contribute directly to the regulation of type I phosphoinositide 3-kinases (PI3Ks) via RAS-binding domains in the PI3K catalytic p110 subunits. Disruption of this domain of p110α impairs RAS-mutant-onc ...
• Publisher Correction: Cancer genetics, precision prevention and a call to action. 

  Turnbull, C; Sud, A; Houlston, RS (2019-01)

  In the version of this article originally published, there was an error in the second-to-last sentence of the abstract. In this sentence, the final phrase "to identify carriers of first-wave gene mutation carriers" should ...
• Structural basis for translocation by AddAB helicase-nuclease and its arrest at χ sites. 

  Krajewski, WW; Fu, X; Wilkinson, M; Cronin, NB; Dillingham, MS; Wigley, DB (2014-04)

  In bacterial cells, processing of double-stranded DNA breaks for repair by homologous recombination is dependent upon the recombination hotspot sequence χ (Chi) and is catalysed by either an AddAB- or RecBCD-type ...
• A first in man, dose-finding study of the mTORC1/mTORC2 inhibitor OSI-027 in patients with advanced solid malignancies. 

  Mateo, J; Olmos, D; Dumez, H; Poondru, S; Samberg, NL; Barr, S; Van Tornout, JM; Jie, F; Sandhu, S; Tan, DS; Moreno, V; LoRusso, PM; Kaye, SB; Schöffski, P (2016-04)

  The kinase activity of mTOR involves 2 multiprotein complexes, (mTORC1-mTORC2). Targeting mTORC1 with rapalogues induces compensatory feedback loops resulting in AKT/ERK activation, which may be abrogated by mTORC2 inhibition. ...
• Multicenter phase II trial of temozolomide in patients with glioblastoma multiforme at first relapse 

  Brada, M; Hoang-Xuan, K; Rampling, R; Dietrich, PY; Dirix, LY; Macdonald, D; Heimans, JJ; Zonnenberg, BA; Bravo-Marques, JM; Henriksson, R; Stupp, R; Yue, N; Bruner, J; Dugan, M; Rao, S; Zaknoen, S (KLUWER ACADEMIC PUBL, 2001-02)

  Background: Recurrent glioblastoma multiforme (GBM) is resistant to most therapeutic endeavors, with low response rates and survival rarely exceeding six months. There are no clearly established chemotherapeutic regimens ...
• Nested allosteric interactions in the cytoplasmic chaperonin containing TCP-1 

  Kafri, G; Willison, KR; Horovitz, A (2001-02)

  Initial rates of ATP hydrolysis by the chaperonin containing TCP-1 (CCT) from bovine testis were measured as a function of ATP concentration. Two allosteric transitions are observed: one at relatively low concentrations ...
• Radiotherapy for brain metastases 

  Hoskin, PJ; Brada, M; Radioth, SWP (SPRINGER-VERLAG LONDON LTD, 2001)
• Resolution of alpha-hydroxytamoxifen; R-isomer forms more DNA adducts in rat liver cells 

  Osborne, MR; Hewer, A; Phillips, DH (AMER CHEMICAL SOC, 2001-07)

  The genotoxic tamoxifen metabolite alpha -hydroxytamoxifen has been resolved into R- and S-enantiomers. This was achieved by preparing its ester with S-camphanic acid, chromatographic separation into two diastereoisomers, ...
• Clinical outcomes of adolescents and young adults with advanced solid tumours participating in phase I trials. 

  Sundar, R; McVeigh, T; Dolling, D; Petruckevitch, A; Diamantis, N; Ang, JE; Chenard-Poiriér, M; Collins, D; Lim, J; Ameratunga, M; Khan, K; Kaye, SB; Banerji, U; Lopez, J; George, AJ; de Bono, JS; van der Graaf, WT (2018-09)

  BACKGROUND:Adolescent and young adult (AYA) patients with advanced solid tumours are often considered for phase I clinical trials with novel agents. The outcome of AYAs in these trials have not been described before. AIM:To ...
• N-acetyltransferases, sulfotransferases and heterocyclic amine activation in the breast 

  Williams, JA; Stone, EM; Fakis, G; Johnson, N; Cordell, JA; Meinl, W; Glatt, H; Sim, E; Phillips, DH (LIPPINCOTT WILLIAMS & WILKINS, 2001-07)
• Morphological transformation of C3H/M2 mouse fibroblasts by, and genotoxicity of, extracts of human milk 

  Pfau, W; Martin, FL; Cole, KJ; Weaver, G; Marquardt, H; Phillips, DH; Grover, PL (2001)

  Breast cancer may be initiated by environmental/dietary agents and human milk may act as an ex vivo indicator of in vivo exposure of mammary epithelial cells to genotoxins. Extracts of human milk from UK-resident women ...
• Analysis of the Interaction between the Eukaryotic Chaperonin CCT and Its Substrates Actin and Tubulin 

  Llorca, O; Martín-Benito, J; Gómez-Puertas, P; Ritco-Vonsovici, M; Willison, KR; Carrascosa, JL; Valpuesta, JM (2001)

  Twomechanisms have thus far been characterized for the assistance by chaperonins of the folding of other proteins. The first and best described is that of the prokaryotic chaperonin GroEL, which interacts with a large ...
• The ‘sequential allosteric ring’ mechanism in the eukaryotic chaperonin-assisted folding of actin and tubulin 

  Llorca, O; Martin-Benito, J; Grantham, J; Ritco-Vonsovici, M; Willison, KR; Carrascosa, JL; Valpuesta, JM (2001-08-01)

  Folding to completion of actin and tubulin in the eukaryotic cytosol requires their interaction with cytosolic chaperonin CCT [chaperonin containing tailless complex polypeptide 1 (TCP-1)]. Three-dimensional reconstructions ...
• Point Mutations in a Hinge Linking the Small and Large Domains of β-Actin Result in Trapped Folding Intermediates Bound to Cytosolic Chaperonin CCT 

  McCormack, EA; Llorca, O; Carrascosa, JL; Valpuesta, J-M; Willison, KR (2001)

  The30-Å cryo-EM-derived structure of apo-CCT–α-actin shows actin opened up across its nucleotide-binding cleft and binding to either of two CCT subunit pairs, CCTβ–CCTδ or CCTϵ–CCTδ, in a similar 1:4 arrangement. The two ...
• Mutational Screen Identifies Critical Amino Acid Residues of β-Actin Mediating Interaction between Its Folding Intermediates and Eukaryotic Cytosolic Chaperonin CCT 

  McCormack, EA; Rohman, MJ; Willison, KR (2001)

  Thethree-dimensional reconstruction of apo-CCT-α-actin by cryoelectron microscopy shows that actin binds either the CCTβ–CCTδ or the CCTϵ–CCTδ subunit pairs of the chaperonin in an open and apparently quasi-native conformation. ...
• Effectiveness and cost-effectiveness of double reading of mammograms in breast cancer screening: findings of a systematic review 

  Dinnes, J; Moss, S; Melia, J; Blanks, R; Song, F; Kleijnen, J (CHURCHILL LIVINGSTONE, 2001-12)

  There is a lack of direct evidence on the effectiveness of double reading of breast screening mammograms within the context of national screening programmes even though about half of the countries that use mammography ...

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