• Structural basis for translocation by AddAB helicase-nuclease and its arrest at χ sites. 

  Krajewski, WW; Fu, X; Wilkinson, M; Cronin, NB; Dillingham, MS; Wigley, DB (2014-04)

  In bacterial cells, processing of double-stranded DNA breaks for repair by homologous recombination is dependent upon the recombination hotspot sequence χ (Chi) and is catalysed by either an AddAB- or RecBCD-type ...
• Multicenter phase II trial of temozolomide in patients with glioblastoma multiforme at first relapse 

  Brada, M; Hoang-Xuan, K; Rampling, R; Dietrich, PY; Dirix, LY; Macdonald, D; Heimans, JJ; Zonnenberg, BA; Bravo-Marques, JM; Henriksson, R; Stupp, R; Yue, N; Bruner, J; Dugan, M; Rao, S; Zaknoen, S (KLUWER ACADEMIC PUBL, 2001-02)

  Background: Recurrent glioblastoma multiforme (GBM) is resistant to most therapeutic endeavors, with low response rates and survival rarely exceeding six months. There are no clearly established chemotherapeutic regimens ...
• Nested allosteric interactions in the cytoplasmic chaperonin containing TCP-1 

  Kafri, G; Willison, KR; Horovitz, A (2001-02)

  Initial rates of ATP hydrolysis by the chaperonin containing TCP-1 (CCT) from bovine testis were measured as a function of ATP concentration. Two allosteric transitions are observed: one at relatively low concentrations ...
• Radiotherapy for brain metastases 

  Hoskin, PJ; Brada, M; Radioth, SWP (SPRINGER-VERLAG LONDON LTD, 2001)
• Resolution of alpha-hydroxytamoxifen; R-isomer forms more DNA adducts in rat liver cells 

  Osborne, MR; Hewer, A; Phillips, DH (AMER CHEMICAL SOC, 2001-07)

  The genotoxic tamoxifen metabolite alpha -hydroxytamoxifen has been resolved into R- and S-enantiomers. This was achieved by preparing its ester with S-camphanic acid, chromatographic separation into two diastereoisomers, ...
• N-acetyltransferases, sulfotransferases and heterocyclic amine activation in the breast 

  Williams, JA; Stone, EM; Fakis, G; Johnson, N; Cordell, JA; Meinl, W; Glatt, H; Sim, E; Phillips, DH (LIPPINCOTT WILLIAMS & WILKINS, 2001-07)
• Morphological transformation of C3H/M2 mouse fibroblasts by, and genotoxicity of, extracts of human milk 

  Pfau, W; Martin, FL; Cole, KJ; Weaver, G; Marquardt, H; Phillips, DH; Grover, PL (2001)

  Breast cancer may be initiated by environmental/dietary agents and human milk may act as an ex vivo indicator of in vivo exposure of mammary epithelial cells to genotoxins. Extracts of human milk from UK-resident women ...
• Analysis of the Interaction between the Eukaryotic Chaperonin CCT and Its Substrates Actin and Tubulin 

  Llorca, O; Martín-Benito, J; Gómez-Puertas, P; Ritco-Vonsovici, M; Willison, KR; Carrascosa, JL; Valpuesta, JM (2001)

  Twomechanisms have thus far been characterized for the assistance by chaperonins of the folding of other proteins. The first and best described is that of the prokaryotic chaperonin GroEL, which interacts with a large ...
• The ‘sequential allosteric ring’ mechanism in the eukaryotic chaperonin-assisted folding of actin and tubulin 

  Llorca, O; Martin-Benito, J; Grantham, J; Ritco-Vonsovici, M; Willison, KR; Carrascosa, JL; Valpuesta, JM (2001-08-01)

  Folding to completion of actin and tubulin in the eukaryotic cytosol requires their interaction with cytosolic chaperonin CCT [chaperonin containing tailless complex polypeptide 1 (TCP-1)]. Three-dimensional reconstructions ...
• Point Mutations in a Hinge Linking the Small and Large Domains of β-Actin Result in Trapped Folding Intermediates Bound to Cytosolic Chaperonin CCT 

  McCormack, EA; Llorca, O; Carrascosa, JL; Valpuesta, J-M; Willison, KR (2001)

  The30-Å cryo-EM-derived structure of apo-CCT–α-actin shows actin opened up across its nucleotide-binding cleft and binding to either of two CCT subunit pairs, CCTβ–CCTδ or CCTϵ–CCTδ, in a similar 1:4 arrangement. The two ...
• Mutational Screen Identifies Critical Amino Acid Residues of β-Actin Mediating Interaction between Its Folding Intermediates and Eukaryotic Cytosolic Chaperonin CCT 

  McCormack, EA; Rohman, MJ; Willison, KR (2001)

  Thethree-dimensional reconstruction of apo-CCT-α-actin by cryoelectron microscopy shows that actin binds either the CCTβ–CCTδ or the CCTϵ–CCTδ subunit pairs of the chaperonin in an open and apparently quasi-native conformation. ...
• Effectiveness and cost-effectiveness of double reading of mammograms in breast cancer screening: findings of a systematic review 

  Dinnes, J; Moss, S; Melia, J; Blanks, R; Song, F; Kleijnen, J (CHURCHILL LIVINGSTONE, 2001-12)

  There is a lack of direct evidence on the effectiveness of double reading of breast screening mammograms within the context of national screening programmes even though about half of the countries that use mammography ...
• Psychosocial issues in cancer 

  Watson, M (INDIAN ACAD SCIENCES, 2001-09-10)

  There are many dimensions to psychosocial, issues in cancer; two of which are focused here and relate to (i) the question of whether psychological factors play any role in cancer prognosis, and (ii) the quality of triage ...
• Genotoxicity of human breast milk from different countries 

  Martin, FL; Cole, KJ; Weaver, G; Hong, GS; Lam, BC; Balaram, P; Grover, PL; Phillips, DH (OXFORD UNIV PRESS, 2001-09)

  Dietary and/or environmental factors appear to play a key role in the international variations that exist in breast cancer incidence. The genotoxicity of breast milk extracts is being examined as a possible indicator of ...
• Molecular genetics of solid tumours: translating research into clinical practice. What we could do now: breast cancer 

  Lakhani, SR (2001-10)

  Breast cancer is a common solid malignancy in women. Over the past decade, much progress has been made in understanding the biology of breast cancer. The use of molecular and immunohistochemical techniques is providing ...
• Association between carcinogen-DNA adducts in white blood cells and lung cancer risk in the physicians health study 

  Tang, DL; Phillips, DH; Stampfer, M; Mooney, LA; Hsu, YZ; Cho, S; Tsai, WY; Ma, J; Cole, KJ; Ni She, M; Perera, FP (AMER ASSOC CANCER RESEARCH, 2001-09-15)

  In this matched case-control study nested within the prospective Physicians’ Health Study, we evaluated whether DNA damage in blood samples collected at enrollment significantly predicted risk, consistent with our hypothesis ...
• Mutability of p53 hotspot codons to benzo(a)pyrene diol epoxide (BPDE) and the frequency of p53 mutations in nontumorous human lung 

  Hussain, SP; Amstad, P; Raja, K; Sawyer, M; Hofseth, L; Shields, PG; Hewer, A; Phillips, DH; Ryberg, D; Haugen, A; Harriss, CC (2001-09-01)

  p53 mutations are common in lung cancer. In smoking-associated lung cancer, the occurrence of G:C to TA transversions at hotspot codons, e.g., 157, 248, 249, and 273, has been linked to the presence of carcinogenic chemicals ...
• Analyses of DNA adducts formed by ochratoxin A and aristolochic acid in patients with Chinese herbs nephropathy. 

  Arlt, VM; Pfohl-Leszkowicz, A; Cosyns, J; Schmeiser, HH (2001-07)

  Chinese herbs nephropathy (CHN), a unique type of nephropathy has been associated with the intake of weight-reducing pills containing the Chinese herb Aristolochia fangchi. Moreover, an association between the use of A. ...
• Mutagens in human breast lipid and milk: The search for environmental agents that initiate breast cancer 

  Phillips, DH; Martin, FL; Williams, JA; Wheat, LMC; Nolan, L; Cole, KJ; Grover, PL (2002)

  Epidemiological studies indicate the involvement of environmental factors in the etiology of breast cancer, but have not provided clear indications of the nature of the agents responsible. Several environmental carcinogens ...
• An investigation into the number of appointment changes and queries arising as a result of extending breast screening to older women in the United Kingdom 

  Brown, J; Garvican, L; Moss, S (BRITISH MED JOURNAL PUBL GROUP, 2002)

  Objective: To compare the number of telephone queries and appointment changes requested by women aged 65-69 with women aged 50-64. Setting: Department of Health funded demonstration study of extending breast screening to ...

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