• Measuring interobserver variation in a pathology EQA scheme using weighted kappa for multiple readers 

  Wright, KC; Melia, J; Moss, S; Berney, DM; Coleman, D; Harnden, P (B M J PUBLISHING GROUP, 2011-12)

  Background A Urological Pathology External Quality Assurance (EQA) Scheme in the UK has reported observer variation in the diagnosis and grading of adenocarcinoma in prostatic biopsies using basic kappa statistics, which ...
• A single nucleotide polymorphism tags variation in the arylamine N-acetyltransferase 2 phenotype in populations of European background. 

  García-Closas, M; Hein, DW; Silverman, D; Malats, N; Yeager, M; Jacobs, K; Doll, MA; Figueroa, JD; Baris, D; Schwenn, M; Kogevinas, M; Johnson, A; Chatterjee, N; Moore, LE; Moeller, T; Real, FX; Chanock, S; Rothman, N (2011-04)

  The arylamine N-acetyltransferase 2 (NAT2) slow acetylation phenotype is an established risk factor for urinary bladder cancer. We reported earlier on this risk association using NAT2 phenotypic categories inferred from ...
• A comparison of HPV DNA testing and liquid based cytology over three rounds of primary cervical screening: Extended follow up in the ARTISTIC trial 

  Kitchener, HC; Gilham, C; Sargent, A; Bailey, A; Albrow, R; Roberts, C; Desai, M; Mather, J; Turner, A; Moss, S; Peto, J (ELSEVIER SCI LTD, 2011-04)

  Background: The additional sensitivity of HPV testing compared with cytology could permit extended cervical screening intervals. We wished to determine, through a further (third) round of screening in the ARTISTIC trial, ...
• A practical application of analysing weighted kappa for panels of experts and EQA schemes in pathology 

  Wright, KC; Harnden, P; Moss, S; Berney, DM; Melia, J (B M J PUBLISHING GROUP, 2011-03)

  Background Kappa statistics are frequently used to analyse observer agreement for panels of experts and External Quality Assurance (EQA) schemes and generally treat all disagreements as total disagreement. However, the ...
• On the evolutionary origin of the chaperonins 

  Dekker, C; Willison, KR; Taylor, WR (WILEY-BLACKWELL, 2011-04)

  An analysis of the apical domain of the Group-I and Group-II chaperonins shows that they have structural similarities to two different protein folds: a “swivel-domain” phosphotransferase and a thioredoxin-like peroxiredoxin. ...
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  Menopausal symptoms and bone health in women undertaking risk reducing bilateral salpingo-oophorectomy: significant bone health issues in those not taking HRT 

  Challberg, J; Ashcroft, L; Lalloo, F; Eckersley, B; Clayton, R; Hopwood, P; Selby, P; Howell, A; Evans, DG (NATURE PUBLISHING GROUP, 2011-06-28)

  BACKGROUND: Women at high ovarian cancer risk, especially those with mutations in BRCA1/BRCA2, are encouraged to undergo bilateral risk-reducing salpingo-oophorectomy (BRRSPO) prior to the natural menopause. The decision ...
• FRACTIONATED STEREOTACTIC RADIOTHERAPY IN THE TREATMENT OF VESTIBULAR SCHWANNOMA (ACOUSTIC NEUROMA): PREDICTING THE RISK OF HYDROCEPHALUS 

  Powell, C; Micallef, C; Gonsalves, A; Wharram, B; Ashley, S; Brada, M (ELSEVIER SCIENCE INC, 2011-07-15)

  Purpose: To determine the incidence and predictive factors for the development of hydrocephalus in patients with acoustic neuromas (AN) treated with fractionated stereotactic radiotherapy. Patients and Methods: Seventy-two ...
• Somnolence syndrome in patients receiving radical radiotherapy for primary brain tumours: A prospective study 

  Powell, C; Guerrero, D; Sardell, S; Cumins, S; Wharram, B; Traish, D; Gonsalves, A; Ashley, S; Brada, M (ELSEVIER IRELAND LTD, 2011-07)

  Background and purpose: To characterise the incidence, pattern and severity of post cranial radiotherapy somnolence and to identify factors predictive of frequency and severity. Materials and methods: Seventy consecutive ...
• Boronic acids-A novel class of bacterial mutagen 

  O Donovan, MR; Mee, CD; Fenner, S; Teasdale, A; Phillips, DH (ELSEVIER SCIENCE BV, 2011-09-18)

  Boronic acids and their esters are important building blocks in organic syntheses including those for drug substances and for which, as far as it can be determined, there are no published reports of testing for genotoxicity. ...
• Evaluation of the use of digital images for a national prostate core external quality assurance scheme 

  Harnden, P; Coleman, D; Moss, S; Kodikara, S; Griffin, NR; Melia, J (WILEY-BLACKWELL, 2011-10)

  Aims: To evaluate the use of virtual images as an alternative to glass slides to expand the number of participants in the External Quality Assurance Scheme for prostatic biopsies. Methods and results: Benign and neoplastic ...
• False-positive screening results in the European randomized study of screening for prostate cancer 

  Kilpelainen, TP; Tammela, TLJ; Roobol, M; Hugosson, J; Ciatto, S; Nelen, V; Moss, S; Maattanen, L; Auvinen, A (ELSEVIER SCI LTD, 2011-12)

  Background: Screening for prostate cancer (PC) with prostate-specific antigen (PSA) has been shown to decrease mortality, but has adverse effects, such as false-positive (FP) screening results. We describe the frequency ...
• Prognostic and predictive roles for circulating biomarkers in gastrointestinal cancer 

  De Mattos-Arruda, L; Olmos, D; Tabernero, J (FUTURE MEDICINE LTD, 2011-12)

  Circulating tumor cells (CTCs) and circulating free DNA (cfDNA) have been studied as promising prognostic and predictive tumor-derived biomarkers in the bloodstream of patients with gastrointestinal malignancies because ...
• Incidence of cervical intraepithelial neoplasia grade 2 or worse in colposcopy-negative/human papillomavirus-positive women with low-grade cytological abnormalities 

  Moss, S (2012-01)

  Objective To determine the risk of incident high-grade cervical intraepithelial neoplasia (CIN) in human papillomavirus (-HPV) positive women with low-grade cytological abnormalities who had a satisfactory normal colposcopy. ...
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  Prognostic signatures in breast cancer: correlation does not imply causation 

  Reis-Filho, J (2012)

  Testing the statistical associations between microarray-based gene expression signatures and patient outcome has become a popular approach to infer biological and clinical significance of laboratory observations. Venet and ...
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  Prognostic value of proliferation assay in the luminal, HER2-positive, and triple-negative biologic classes of breast cancer 

  Aleskandarany, MA; Green, AR; Benhasouna, AA; Barros, FF; Neal, K; Reis-Filho, JS; Ellis, IO; Rakha, EA (BIOMED CENTRAL LTD, 2012)

  Introduction: Although the prognostic significance of proliferation in early invasive breast cancer has been recognized for a long time, recent gene-expression profiling studies have reemphasized its biologic and prognostic ...
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  siRNA Knockdown of Ribosomal Protein Gene RPL19 Abrogates the Aggressive Phenotype of Human Prostate Cancer 

  Bee, A; Brewer, D; Beesley, C; Dodson, A; Forootan, S; Dickinson, T; Gerard, P; Lane, B; Yao, S; Cooper, CS; Djamgoz, MBA; Gosden, CM; Ke, Y; Foster, CS (PUBLIC LIBRARY SCIENCE, 2011-07-22)

  We provide novel functional data that posttranscriptional silencing of gene RPL19 using RNAi not only abrogates the malignant phenotype of PC-3M prostate cancer cells but is selective with respect to transcription and ...
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  HPV testing as a triage for borderline or mild dyskaryosis on cervical cytology: results from the Sentinel Sites study 

  Kelly, RS; Patnick, J; Kitchener, HC; Moss, SM; Grp, NHSCSPHPVSI (NATURE PUBLISHING GROUP, 2011-09-27)

  BACKGROUND: Earlier pilot studies of human papillomavirus (HPV) triage concluded that HPV triage was feasible and cost-effective. The aim of the present study was to study the impact of wider rollout of HPV triage for women ...
• Affinity chromatography and capillary electrophoresis for analysis of the yeast ribosomal proteins 

  Goyder, MS; Willison, KR; Klug, DR; deMello, AJ; Ces, O (KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY, 2012-04-30)

  We present a top down separation platform for yeast ribosomal proteins using affinity chromatography and capillary electrophoresis which is designed to allow deposition of proteins onto a substrate. FLAG tagged ribosomes ...
• Metabolic activation of diesel exhaust carcinogens in primary and immortalized human TP53 knock-in (Hupki) mouse embryo fibroblasts 

  Kucab, JE; Phillips, DH; Arlt, VM (WILEY-BLACKWELL, 2012-04)

  Approximately 50% of human tumors have a mutation in TP53. The pattern and spectra of TP53 mutations often differ between cancer types, perhaps due to different etiological factors. The Hupki (human TP53 knock-in) mouse ...
• Metformin Accelerates the Growth of BRAF(V600E)-Driven Melanoma by Upregulating VEGF-A 

  Martin, MJ; Hayward, R; Viros, A; Marais, R (AMER ASSOC CANCER RESEARCH, 2012-04)

  The antidiabetic drug metformin has antitumor activity in a variety of cancers because it blocks cell growth by inhibiting TORC1. Here, we show that melanoma cells that are driven by oncogenic BRAF are resistant to the ...

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