Browsing ICR Divisions by issue date
Now showing items 1-20 of 4577
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Rheo-optics of concentrated kaolinite suspensions
(ELSEVIER SCIENCE BV, 1996-06-14) -
Applications of microarray technology in breast cancer research
(BIOMED CENTRAL LTD, 2001)Microarrays provide a versatile platform for utilizing information from the Human Genome Project to benefit human health. This article reviews the ways in which microarray technology may be used in breast cancer research. ... -
PRH represses transcription in hematopoietic cells by at least two independent mechanisms
(2001-01-26)PRH (proline-rich homeodomain protein) is strongly expressed in the hematopoietic compartment, Here we show that PRH is a repressor of transcription in hematopoietic cells. A fragment of PRH that includes the homeodomain ... -
Structure-based design of selective and potent G quadruplex-mediated telomerase inhibitors
(2001-04-24)The telomerase enzyme is a potential therapeutic target in many human cancers. A series of potent inhibitors has been designed by computer modeling, which exploit the unique structural features of quadruplex DNA, These ... -
Real time fluorescence imaging of PLC gamma translocation and its interaction with the epidermal growth factor receptor
(2001-04-30)The translocation of fluorescently tagged PLC gamma and requirements for this process in cells stimulated with EGF were analyzed using real time fluorescence microscopy applied for the first time to monitor growth factor ... -
Stabilisation of TG-and AG-containing antiparrallel DNA triplexes by triplex-binding ligands
(2001-05-01)Stabilisation of TG-and AG-containing antiparrallel DNA triplexes by triplex-binding ligands. We have used DNase I footprinting to examine the interaction of several tripler-binding ligands with antiparallel TG- and AG- ... -
Demonstration of correlations between clinical and physical image quality measures in chest and lumbar spine screen-film radiography
(BRITISH INST RADIOLOGY, 2001-06)The ability to predict clinical image quality from physical measures is useful for optimization in diagnostic radiology. In this work, clinical and physical assessments of image quality are compared and correlations between ... -
A mutation in the Gsk3-binding domain of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon and eyes to diencephalon
(2001-06-01)Zebrafish embryos homozygous for the masterblind (mb1) mutation exhibit a striking phenotype in which the eyes and telencephalon are reduced or absent and diencephalic fates expand to the front of the brain. Here we show ... -
Short tandem repeat profiling provides an international reference standard for human cell lines
(NATL ACAD SCIENCES, 2001-07-03)Cross-contamination between cell lines is a longstanding and frequent cause of scientific misrepresentation. Estimates from national testing services indicate that up to 36% of cell lines are of a different origin or species ... -
Nonperturbative real-space renormalization group scheme for the spin-1/2 XXX Heisenberg model
(AMER PHYSICAL SOC, 2001-11-01)In this paper we apply an analytical real-space renormalization group formulation which is based on numerical concepts of the density-matrix renormalization group, Within a rigorous mathematical framework we construct ... -
High levels of the MDM2 oncogene in paediatric rhabdomyosarcoma cell lines may confer multidrug resistance
(2001-11-30)The MDM2 protein is known to be overexpressed in some sarcomas including rhabdomyosarcoma. However, the extent to which the MDM2 protein influences sensitivity to chemotherapeutic drugs is unclear. We have analysed this ... -
Effect of manipulation of primary tumour vascularity on metastases in an adenocarcinoma model
(2002-01-07)One explanation for the clinical association between tumour vascularity and probability of metastasis is that increased primary tumour vascularity enhances haematogenous dissemination by offering greater opportunity for ... -
Protein and drug interactions in the minor groove of DNA
(2002-03-01)Interactions between proteins, drugs, water and B-DNA minor groove have been analyzed in crystal structures of 60 protein-DNA and 14 drug-DNA complexes. It was found that only purine N3, pyrimidine O2, guanine N2 and ... -
Translocation t(2;7)(p12;q21-22) with dysregulation of the CDK6 gene mapping to 7q21-22 in a non-Hodgkin’s lymphoma with leukemia
(2002-04)Background and Objectives. A female patient presented with splenomegaly and lymphocytosis with atypical lymphoid cell morphology, We identified t(2;7)(p12;q21) prompting studies of the translocation breakpoint and its ... -
Dominant negative knockout of p53 abolishes ErbB2-dependent apoptosis and permits growth acceleration in human breast cancer cells
(Springer Science and Business Media LLC, 2002-04-01)Dominant negative knockout of p53 abolishes ErbB2-dependent apoptosis and permits growth acceleration in human breast cancer cells. We previously reported that the FrbB2 oncoprotein prolongs and amplifies growth factor ... -
Neuroblastoma in monozygotic twins - a case of probable twin to twin metastasis (vol 85, pg 493, 2001)
(NATURE PUBLISHING GROUP, 2002-05-20) -
Characterization of sugar binding by the mannose receptor family member, Endo180.
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2002-12-27)Members of the mannose receptor family, the mannose receptor, the phospholipase A(2) receptor, DEC-205, and Endo180, contain multiple C-type lectin-like domains (CTLDs) within a single polypeptide. In addition, at their N ... -
Deregulation of the Egfr/Ras signaling pathway induces age-related brain degeneration in the Drosophila mutant vap
(2003-01)Ras signaling has been shown to play an important role in promoting cell survival in many different tissues. Here we show that upregulation of Ras activity in adult Drosophila neurons induces neuronal cell death, as evident ... -
Loss of P16(INK4a) results in increased glucocorticoid receptor activity during fibrosarcoma development
(NATL ACAD SCIENCES, 2003-03-18)‘Glucocorticoids inhibit proliferation of many cell types, but the relationship between the glucocorticoid receptor (GR) and the proteins regulating cell cycle progression is not fully understood. We previously found that ...