• Adult soft tissue myoepithelial carcinoma: treatment outcomes and efficacy of chemotherapy. 

  Chamberlain, F; Cojocaru, E; Scaranti, M; Noujaim, J; Constantinou, A; Thway, K; Fisher, C; Messiou, C; Strauss, DC; Miah, A; Zaidi, S; Benson, C; Gennatas, S; Jones, RL (2019-12-27)

  Soft tissue myoepithelial carcinomas are a rare, malignant subgroup of myoepithelial tumours mostly arising in the extremities with equal predilection for women and men. The mainstay of management of localised disease is ...
• Discovery of Rare Phenotypes in Cellular Images Using Weakly Supervised Deep Learning 

  Sailem, H; Arias-Garcia, M; Bakal, C; Zisserman, A; Rittscher, J (IEEE, 2017-01-01)
• Immunomodulatory activity of IR700-labelled affibody targeting HER2. 

  Mączyńska, J; Da Pieve, C; Burley, TA; Raes, F; Shah, A; Saczko, J; Harrington, KJ; Kramer-Marek, G (2020-10-20)

  There is an urgent need to develop therapeutic approaches that can increase the response rate to immuno-oncology agents. Photoimmunotherapy has recently been shown to generate anti-tumour immunological responses by releasing ...
• CHD7 and 53BP1 regulate distinct pathways for the re-ligation of DNA double-strand breaks. 

  Rother, MB; Pellegrino, S; Smith, R; Gatti, M; Meisenberg, C; Wiegant, WW; Luijsterburg, MS; Imhof, R; Downs, JA; Vertegaal, ACO; Huet, S; Altmeyer, M; van Attikum, H (2020-11-13)

  Chromatin structure is dynamically reorganized at multiple levels in response to DNA double-strand breaks (DSBs). Yet, how the different steps of chromatin reorganization are coordinated in space and time to differentially ...
• HOX genes promote cell proliferation and are potential therapeutic targets in adrenocortical tumours. 

  Francis, JC; Gardiner, JR; Renaud, Y; Chauhan, R; Weinstein, Y; Gomez-Sanchez, C; Lefrançois-Martinez, A-M; Bertherat, J; Val, P; Swain, A (2020-11-20)

  <h4>Background</h4>Understanding the pathways that drive adrenocortical carcinoma (ACC) is essential to the development of more effective therapies. This study investigates the role of the transcription factor HOXB9 and ...
• WDHD1 is essential for the survival of PTEN-inactive triple-negative breast cancer. 

  Ertay, A; Liu, H; Liu, D; Peng, P; Hill, C; Xiong, H; Hancock, D; Yuan, X; Przewloka, MR; Coldwell, M; Howell, M; Skipp, P; Ewing, RM; Downward, J; Wang, Y (2020-11-21)

  Triple-negative breast cancer (TNBC) is the most aggressive type of breast cancer that lacks the oestrogen receptor, progesterone receptor and human epidermal growth factor receptor 2, making it difficult to target ...
• Squeezing through the microcirculation: survival adaptations of circulating tumour cells to seed metastasis. 

  Perea Paizal, J; Au, SH; Bakal, C (2021-01)

  During metastasis, tumour cells navigating the vascular circulatory system-circulating tumour cells (CTCs)-encounter capillary beds, where they start the process of extravasation. Biomechanical constriction forces exerted ...
• Clustering of Tir during enteropathogenic E. coli infection triggers calcium influx-dependent pyroptosis in intestinal epithelial cells. 

  Zhong, Q; Roumeliotis, TI; Kozik, Z; Cepeda-Molero, M; Fernández, LÁ; Shenoy, AR; Bakal, C; Frankel, G; Choudhary, JS (2020-12-30)

  Clustering of the enteropathogenic Escherichia coli (EPEC) type III secretion system (T3SS) effector translocated intimin receptor (Tir) by intimin leads to actin polymerisation and pyroptotic cell death in macrophages. ...
• Metastatic Soft Tissue Sarcomas in Adolescents and Young Adults: A Specialist Center Experience. 

  Younger, E; Husson, O; Asare, B; Benson, C; Judson, I; Miah, A; Zaidi, S; Dunlop, A; Al-Muderis, O; van Houdt, WJ; Jones, RL; van der Graaf, WTA (2020-05-05)

  Purpose: Soft tissue sarcomas (STS) account for 8% of all cancers in adolescents and young adults (AYAs). Metastatic STS contribute significantly to disease-related mortality in this age group; however, data are limited ...
• Advanced Prostate Cancer with ATM Loss: PARP and ATR Inhibitors. 

  Neeb, A; Herranz, N; Arce-Gallego, S; Miranda, S; Buroni, L; Yuan, W; Athie, A; Casals, T; Carmichael, J; Rodrigues, DN; Gurel, B; Rescigno, P; Rekowski, J; Welti, J; Riisnaes, R; Gil, V; Ning, J; Wagner, V; Casanova-Salas, I; Cordoba, S; Castro, N; Fenor de la Maza, MD; Seed, G; Chandran, K; Ferreira, A; Figueiredo, I; Bertan, C; Bianchini, D; Aversa, C; Paschalis, A; Gonzalez, M; Morales-Barrera, R; Suarez, C; Carles, J; Swain, A; Sharp, A; Gil, J; Serra, V; Lord, C; Carreira, S; Mateo, J; de Bono, JS (2020-11-08)

  <h4>Background</h4>Deleterious ATM alterations are found in metastatic prostate cancer (PC); PARP inhibition has antitumour activity against this subset, but only some ATM loss PCs respond.<h4>Objective</h4>To characterise ...
• Structural basis for the inhibition of cGAS by nucleosomes. 

  Kujirai, T; Zierhut, C; Takizawa, Y; Kim, R; Negishi, L; Uruma, N; Hirai, S; Funabiki, H; Kurumizaka, H (2020-10)

  The cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS) senses invasion of pathogenic DNA and stimulates inflammatory signaling, autophagy, and apoptosis. Organization of host DNA into nucleosomes was ...
• Targeting Bromodomain and Extra-Terminal (BET) Family Proteins in Castration-Resistant Prostate Cancer (CRPC). 

  Welti, J; Sharp, A; Yuan, W; Dolling, D; Nava Rodrigues, D; Figueiredo, I; Gil, V; Neeb, A; Clarke, M; Seed, G; Crespo, M; Sumanasuriya, S; Ning, J; Knight, E; Francis, JC; Hughes, A; Halsey, WS; Paschalis, A; Mani, RS; Raj, GV; Plymate, SR; Carreira, S; Boysen, G; Chinnaiyan, AM; Swain, A; de Bono, JS; International SU2C/PCF Prostate Cancer Dream Team (2018-07)

  <b>Purpose:</b> Persistent androgen receptor (AR) signaling drives castration-resistant prostate cancer (CRPC) and confers resistance to AR-targeting therapies. Novel therapeutic strategies to overcome this are urgently ...
• The melanoma-specific graded prognostic assessment does not adequately discriminate prognosis in a modern population with brain metastases from malignant melanoma. 

  Wilkins, A; Furness, A; Corbett, RW; Bloomfield, A; Porta, N; Morris, S; Ali, Z; Larkin, J; Harrington, K (2015-11)

  The melanoma-specific graded prognostic assessment (msGPA) assigns patients with brain metastases from malignant melanoma to 1 of 4 prognostic groups. It was largely derived using clinical data from patients treated in the ...
• Dimerization regulates the human APC/C-associated ubiquitin-conjugating enzyme UBE2S. 

  Liess, AKL; Kucerova, A; Schweimer, K; Schlesinger, D; Dybkov, O; Urlaub, H; Mansfeld, J; Lorenz, S (2020-10-20)

  At the heart of protein ubiquitination cascades, ubiquitin-conjugating enzymes (E2s) form reactive ubiquitin-thioester intermediates to enable efficient transfer of ubiquitin to cellular substrates. The precise regulation ...
• UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs. 

  Gozdecka, M; Meduri, E; Mazan, M; Tzelepis, K; Dudek, M; Knights, AJ; Pardo, M; Yu, L; Choudhary, JS; Metzakopian, E; Iyer, V; Yun, H; Park, N; Varela, I; Bautista, R; Collord, G; Dovey, O; Garyfallos, DA; De Braekeleer, E; Kondo, S; Cooper, J; Göttgens, B; Bullinger, L; Northcott, PA; Adams, D; Vassiliou, GS; Huntly, BJP (2018-06)

  The histone H3 Lys27-specific demethylase UTX (or KDM6A) is targeted by loss-of-function mutations in multiple cancers. Here, we demonstrate that UTX suppresses myeloid leukemogenesis through noncatalytic functions, a ...
• Interferon-driven alterations of the host's amino acid metabolism in the pathogenesis of typhoid fever. 

  Blohmke, CJ; Darton, TC; Jones, C; Suarez, NM; Waddington, CS; Angus, B; Zhou, L; Hill, J; Clare, S; Kane, L; Mukhopadhyay, S; Schreiber, F; Duque-Correa, MA; Wright, JC; Roumeliotis, TI; Yu, L; Choudhary, JS; Mejias, A; Ramilo, O; Shanyinde, M; Sztein, MB; Kingsley, RA; Lockhart, S; Levine, MM; Lynn, DJ; Dougan, G; Pollard, AJ (2016-05-23)

  Enteric fever, caused by Salmonella enterica serovar Typhi, is an important public health problem in resource-limited settings and, despite decades of research, human responses to the infection are poorly understood. In ...
• Resolving Affinity Purified Protein Complexes by Blue Native PAGE and Protein Correlation Profiling. 

  Pardo, M; Bode, D; Yu, L; Choudhary, JS (2017-04)

  Most proteins act in association with others; hence, it is crucial to characterize these functional units in order to fully understand biological processes. Affinity purification coupled to mass spectrometry (AP-MS) has ...
• Multiple short windows of calcium-dependent protein kinase 4 activity coordinate distinct cell cycle events during <i>Plasmodium</i> gametogenesis. 

  Fang, H; Klages, N; Baechler, B; Hillner, E; Yu, L; Pardo, M; Choudhary, J; Brochet, M (2017-05-08)

  Malaria transmission relies on the production of gametes following ingestion by a mosquito. Here, we show that Ca²⁺-dependent protein kinase 4 controls three processes essential to progress from a single haploid ...
• Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity. 

  Thomas, DC; Clare, S; Sowerby, JM; Pardo, M; Juss, JK; Goulding, DA; van der Weyden, L; Storisteanu, D; Prakash, A; Espéli, M; Flint, S; Lee, JC; Hoenderdos, K; Kane, L; Harcourt, K; Mukhopadhyay, S; Umrania, Y; Antrobus, R; Nathan, JA; Adams, DJ; Bateman, A; Choudhary, JS; Lyons, PA; Condliffe, AM; Chilvers, ER; Dougan, G; Smith, KGC (2017-04)

  The phagocyte respiratory burst is crucial for innate immunity. The transfer of electrons to oxygen is mediated by a membrane-bound heterodimer, comprising gp91<i>phox</i> and p22<i>phox</i> subunits. Deficiency of either ...
• Myst2/Kat7 histone acetyltransferase interaction proteomics reveals tumour-suppressor Niam as a novel binding partner in embryonic stem cells. 

  Pardo, M; Yu, L; Shen, S; Tate, P; Bode, D; Letney, BL; Quelle, DE; Skarnes, W; Choudhary, JS (2017-08-15)

  MYST histone acetyltransferases have crucial functions in transcription, replication and DNA repair and are hence implicated in development and cancer. Here we characterise Myst2/Kat7/Hbo1 protein interactions in mouse ...

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