Cancer Biology
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Recent submissions
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Dicentric Dose Estimates for Patients Undergoing Radiotherapy in the RTGene Study to Assess Blood Dosimetric Models and the New Bayesian Method for Gradient Exposure.
(2018-09-20)The RTGene study was focused on the development and validation of new transcriptional biomarkers for prediction of individual radiotherapy patient responses to ionizing radiation. In parallel, for validation purposes, this ... -
Feasibility study of combined dynamic imaging and lymphaticovenous anastomosis surgery for breast cancer-related lymphoedema.
(2018-10-08)BACKGROUND: Breast cancer-related lymphoedema (BCRL) presents a significant healthcare burden and adversely affects quality of life of breast cancer survivors. A prospective feasibility study was performed on lymphaticovenous ... -
Real time fluorescence imaging of PLC gamma translocation and its interaction with the epidermal growth factor receptor
(2001-04-30)The translocation of fluorescently tagged PLC gamma and requirements for this process in cells stimulated with EGF were analyzed using real time fluorescence microscopy applied for the first time to monitor growth factor ... -
Rescue of retroviral envelope fusion deficiencies by cationic liposomes
Background Retroviral particles that are inappropriately enveloped can transduce target cells if pre-associated with cationic liposomes. This study optimises and addresses the mechanism of liposome-enhanced gene delivery, ... -
Retroviral hybrid LTR vector strategy: functional analysis of LTR elements and generation of endothelial cell specificity
(NATURE PUBLISHING GROUP, 2004-05)Transcriptional targeting is an important aspect of developing gene therapy vectors in order to restrict transgene expression to selected target cells. One approach, when using retroviral vectors, is to replace viral ... -
Dose-limiting Urinary Toxicity With Pembrolizumab Combined With Weekly Hypofractionated Radiation Therapy in Bladder Cancer.
(2018-08-01)There is currently significant interest in the potential benefits of combining radiation and immune checkpoint blockade (ICB) to stimulate both regional and distant abscopal immune responses. In melanoma and lung cancer, ... -
Transcriptional targeting of acute hypoxia in the tumour stroma is a novel and viable strategy for cancer gene therapy
(2005-07)Deregulated tumour growth and neovascularization result in an inadequate tumour blood supply, leading to areas of chronic hypoxia and necrosis. Irregular vascular structure and abnormal tumour physiology also cause erratic ... -
Inactivation of murine leukaemia virus by exposure to visible light
(2005-10-25)Prolonged storage of murine leukaemia virus in ambient light leads to a loss of infectivity. Particle integrity and envelope incorporation are unaffected; rather, the defect is functional and intrinsic to the viral core. ... -
Dishevelled (Dvl-2) activates canonical Wnt signalling in the absence of cytoplasmic puncta
(COMPANY OF BIOLOGISTS LTD, 2005-11-15)Dishevelled family proteins are multidomain intracellular transducers of Wnt signals. Ectopically expressed mammalian Dishevelled 2 (Dvl-2) activates downstream signalling and localises to cytoplasmic puncta. It has been ... -
Oncolytic Immunotherapy for Bladder Cancer Using Coxsackie A21 Virus.
(2018-06-29)As a clinical setting in which local live biological therapy is already well established, non-muscle invasive bladder cancer (NMIBC) presents intriguing opportunities for oncolytic virotherapy. Coxsackievirus A21 (CVA21) ... -
PATRIOT: A phase I study to assess the tolerability, safety and biological effects of a specific ataxia telangiectasia and Rad3-related (ATR) inhibitor (AZD6738) as a single agent and in combination with palliative radiation therapy in patients with solid tumours.
(2018-08)PATRIOT is a phase I study of the ATR inhibitor, AZD6738, as monotherapy, and in combination with palliative radiotherapy. Here, we describe the protocol for this study, which opened in 2014 and is currently recruiting and ... -
Tumor-Secreted LOXL2 Activates Fibroblasts through FAK Signaling
(AMER ASSOC CANCER RESEARCH, 2013-11)Cancer-associated fibroblasts enhance cancer progression when activated by tumor cells through mechanisms not yet fully understood. Blocking mammary tumor cell-derived lysyl oxidase-like 2 (LOXL2) significantly inhibited ... -
Exploiting vulnerabilities in cancer signalling networks to combat targeted therapy resistance
(Portland Press, 2018-08-02)Drug resistance remains one of the greatest challenges facing precision oncology today. Despite the vast array of resistance mechanisms that cancer cells employ to subvert the effects of targeted therapy, a deep understanding ... -
Exploiting vulnerabilities in cancer signalling networks to combat targeted therapy resistance
(Portland Press, 2018-08-02)Drug resistance remains one of the greatest challenges facing precision oncology today. Despite the vast array of resistance mechanisms that cancer cells employ to subvert the effects of targeted therapy, a deep understanding ... -
Exploiting vulnerabilities in cancer signalling networks to combat targeted therapy resistance.
(2018-08-02)Drug resistance remains one of the greatest challenges facing precision oncology today. Despite the vast array of resistance mechanisms that cancer cells employ to subvert the effects of targeted therapy, a deep understanding ... -
Desmoid fibromatosis through the patients' eyes: time to change the focus and organisation of care?
(2018-08-28)PURPOSE: Desmoid fibromatosis (DF) is a rare, unpredictable disease with no established, evidence-based treatments. Individual management is based on consensus algorithms. This study aimed to examine the specific health-related ... -
Randomised phase II trial of hyperbaric oxygen therapy in patients with chronic arm lymphoedema after radiotherapy for cancer.
(2010-10)BACKGROUND: A non-randomised phase II study suggested a therapeutic effect of hyperbaric oxygen (HBO) therapy on arm lymphoedema following adjuvant radiotherapy for early breast cancer, justifying further investigation in ... -
Alterations in the phosphoproteomic profile of cells expressing a non-functional form of the SHP2 phosphatase.
(2016-09)The phosphatase SHP-2 plays an essential role in growth factor signaling and mutations in its locus is the cause of congenital and acquired pathologies. Mutations of SHP-2 are known to affect the activation of the RAS ... -
Combined ATR and DNA-PK Inhibition Radiosensitizes Tumor Cells Independently of Their p53 Status.
(2018)Head and neck squamous cell carcinoma (HNSCC) is a significant cause of cancer deaths. Cisplatin-based chemoradiotherapy is a standard of care for locally advanced disease. ATR and DNA-PK inhibition (DNA-PKi) are actively ...
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