Now showing items 1-20 of 259

    • Accelerating Live Single-Cell Signalling Studies. 

      Cooper, S; Bakal, C (2017-05)
      The dynamics of signalling networks that couple environmental conditions with cellular behaviour can now be characterised in exquisite detail using live single-cell imaging experiments. Recent improvements in our abilities ...
    • Activation of the Aryl Hydrocarbon Receptor Interferes with Early Embryonic Development. 

      Gialitakis, M; Tolaini, M; Li, Y; Pardo, M; Yu, L; Toribio, A; Choudhary, JS; Niakan, K; Papayannopoulos, V; Stockinger, B (2017-11)
      The transcriptional program of early embryonic development is tightly regulated by a set of well-defined transcription factors that suppress premature expression of differentiation genes and sustain the pluripotent identity. ...
    • The Adequacy of Core Biopsy in the Assessment of Smooth Muscle Neoplasms of Soft Tissues: Implications for Treatment and Prognosis. 

      Schneider, N; Strauss, DC; Smith, MJ; Miah, AB; Zaidi, S; Benson, C; van Houdt, WJ; Jones, RL; Hayes, AJ; Fisher, C; Thway, K (2017-07)
      The grading of soft tissue sarcomas is one of the most important prognostic factors and determines patient management. Although grading of most adult-type soft tissue sarcomas on biopsies correlates highly with the final ...
    • Advances in mass spectrometry based strategies to study receptor tyrosine kinases. 

      Vyse, S; Desmond, H; Huang, PH (2017-03)
      Receptor tyrosine kinases (RTKs) are key transmembrane environmental sensors that are capable of transmitting extracellular information into phenotypic responses, including cell proliferation, survival and metabolism. ...
    • Affibody-Based PET Imaging to Guide EGFR-Targeted Cancer Therapy in Head and Neck Squamous Cell Cancer Models. 

      Burley, TA; Da Pieve, C; Martins, CD; Ciobota, DM; Allott, L; Oyen, WJG; Harrington, KJ; Smith, G; Kramer-Marek, G (2019-03)
      In head and neck squamous cell cancer, the human epidermal growth factor receptor 1 (EGFR) is the dominant signaling molecule among all members of the family. So far, cetuximab is the only approved anti-EGFR monoclonal ...
    • ALPK1 hotspot mutation as a driver of human spiradenoma and spiradenocarcinoma. 

      Rashid, M; van der Horst, M; Mentzel, T; Butera, F; Ferreira, I; Pance, A; Rütten, A; Luzar, B; Marusic, Z; de Saint Aubain, N; Ko, JS; Billings, SD; Chen, S; Abi Daoud, M; Hewinson, J; Louzada, S; Harms, PW; Cerretelli, G; Robles-Espinoza, CD; Patel, RM; van der Weyden, L; Bakal, C; Hornick, JL; Arends, MJ; Brenn, T; Adams, DJ (2019-05-17)
      Spiradenoma and cylindroma are distinctive skin adnexal tumors with sweat gland differentiation and potential for malignant transformation and aggressive behaviour. We present the genomic analysis of 75 samples from 57 ...
    • Alterations in the phosphoproteomic profile of cells expressing a non-functional form of the SHP2 phosphatase. 

      Corallino, S; Iwai, LK; Payne, LS; Huang, PH; Sacco, F; Cesareni, G; Castagnoli, L (2016-09)
      The phosphatase SHP-2 plays an essential role in growth factor signaling and mutations in its locus is the cause of congenital and acquired pathologies. Mutations of SHP-2 are known to affect the activation of the RAS ...
    • Analysis of Breast Cancer Cell Invasion Using an Organotypic Culture System. 

      Ranftl, RE; Calvo, F (2017-01)
      Metastasis is the main cause of cancer patient mortality. Local tumor invasion is a key step in metastatic dissemination whereby cancer cells dislodge from primary tumors, migrate through the peritumoral stroma and reach ...
    • Analysis of R-Ras signalling pathways 

      Paterson, H (2001-04)
      Analysis of R-Ras signalling pathways. R-Ras has a high degree of sequence homology to Ras and to other members of the Ras subfamily including Rap, TC21 and ill- Ras. Activated versions of Ras and TC21 are highly transforming ...
    • APOBEC3B-mediated corruption of the tumor cell immunopeptidome induces heteroclitic neoepitopes for cancer immunotherapy. 

      Driscoll, CB; Schuelke, MR; Kottke, T; Thompson, JM; Wongthida, P; Tonne, JM; Huff, AL; Miller, A; Shim, KG; Molan, A; Wetmore, C; Selby, P; Samson, A; Harrington, K; Pandha, H; Melcher, A; Pulido, JS; Harris, R; Evgin, L; Vile, RG (2020-02-07)
      APOBEC3B, an anti-viral cytidine deaminase which induces DNA mutations, has been implicated as a mediator of cancer evolution and therapeutic resistance. Mutational plasticity also drives generation of neoepitopes, which ...
    • ART DECO (CRUK/10/018): dose escalated vs standard dose IMRT in locally advanced head and neck cancer 

      Nutting, C; Morden, J; Bernstein, D; Beasley, M; Cosgrove, V; Fisher, S; Foran, B; Guerrero-Urbano, T; Gujral, D; Harrington, K; Junor, E; Mehanna, H; Miah, A; Palaniappan, N; Ramkumar, S; Sanghera, P; Sen, M; Sibtain, A; Soe, W; West, C; Piercey, D; Witts, S; Emson, M; Hall, E (2017-03)
    • Asparagine bioavailability governs metastasis in a model of breast cancer. 

      Knott, SRV; Wagenblast, E; Khan, S; Kim, SY; Soto, M; Wagner, M; Turgeon, M-O; Fish, L; Erard, N; Gable, AL; Maceli, AR; Dickopf, S; Papachristou, EK; D'Santos, CS; Carey, LA; Wilkinson, JE; Harrell, JC; Perou, CM; Goodarzi, H; Poulogiannis, G; Hannon, GJ (2018-02-07)
      Using a functional model of breast cancer heterogeneity, we previously showed that clonal sub-populations proficient at generating circulating tumour cells were not all equally capable of forming metastases at secondary ...
    • Assessment of fully-automated atlas-based segmentation of novel oral mucosal surface organ-at-risk. 

      Dean, JA; Welsh, LC; McQuaid, D; Wong, KH; Aleksic, A; Dunne, E; Islam, MR; Patel, A; Patel, P; Petkar, I; Phillips, I; Sham, J; Newbold, KL; Bhide, SA; Harrington, KJ; Gulliford, SL; Nutting, CM (2016-04)
      Current oral mucositis normal tissue complication probability models, based on the dose distribution to the oral cavity volume, have suboptimal predictive power. Improving the delineation of the oral mucosa is likely to ...
    • ATMIN Is a Tumor Suppressor Gene in Lung Adenocarcinoma. 

      Foster, H; Ruiz, EJ; Moore, C; Stamp, GWH; Nye, EL; Li, N; Pan, Y; He, Y; Downward, J; Behrens, A (2019-10)
      Tumor cells proliferate rapidly and thus are frequently subjected to replication stress and the risk of incomplete duplication of the genome. Fragile sites are replicated late, making them more vulnerable to damage when ...
    • ATR Inhibition Potentiates the Radiation-induced Inflammatory Tumor Microenvironment. 

      Dillon, MT; Bergerhoff, KF; Pedersen, M; Whittock, H; Crespo-Rodriguez, E; Patin, EC; Pearson, A; Smith, HG; Paget, JTE; Patel, RR; Foo, S; Bozhanova, G; Ragulan, C; Fontana, E; Desai, K; Wilkins, AC; Sadanandam, A; Melcher, A; McLaughlin, M; Harrington, KJ (2019-06)
      PURPOSE:ATR inhibitors (ATRi) are in early phase clinical trials and have been shown to sensitize to chemotherapy and radiotherapy preclinically. Limited data have been published about the effect of these drugs on the tumor ...
    • ATR Is a Therapeutic Target in Synovial Sarcoma. 

      Jones, SE; Fleuren, EDG; Frankum, J; Konde, A; Williamson, CT; Krastev, DB; Pemberton, HN; Campbell, J; Gulati, A; Elliott, R; Menon, M; Selfe, JL; Brough, R; Pettitt, SJ; Niedzwiedz, W; van der Graaf, WTA; Shipley, J; Ashworth, A; Lord, CJ (2017-12)
      Synovial sarcoma (SS) is an aggressive soft-tissue malignancy characterized by expression of SS18-SSX fusions, where treatment options are limited. To identify therapeutically actionable genetic dependencies in SS, we ...
    • Autophagy inhibition specifically promotes epithelial-mesenchymal transition and invasion in RAS-mutated cancer cells. 

      Wang, Y; Xiong, H; Liu, D; Hill, C; Ertay, A; Li, J; Zou, Y; Miller, P; White, E; Downward, J; Goldin, RD; Yuan, X; Lu, X (2019-05)
      Macroautophagy/autophagy inhibition is a novel anticancer therapeutic strategy, especially for tumors driven by mutant RAS. Here, we demonstrate that autophagy inhibition in RAS-mutated cells induces epithelial-mesenchymal ...
    • Autophagy inhibition-mediated epithelial-mesenchymal transition augments local myofibroblast differentiation in pulmonary fibrosis. 

      Hill, C; Li, J; Liu, D; Conforti, F; Brereton, CJ; Yao, L; Zhou, Y; Alzetani, A; Chee, SJ; Marshall, BG; Fletcher, SV; Hancock, D; Ottensmeier, CH; Steele, AJ; Downward, J; Richeldi, L; Lu, X; Davies, DE; Jones, MG; Wang, Y (2019-08-07)
      Idiopathic pulmonary fibrosis (IPF), the prototypic progressive fibrotic interstitial lung disease, is thought to be a consequence of repetitive micro-injuries to an ageing, susceptible alveolar epithelium. Ageing is a ...
    • The BAF and PRC2 Complex Subunits Dpf2 and Eed Antagonistically Converge on Tbx3 to Control ESC Differentiation. 

      Zhang, W; Chronis, C; Chen, X; Zhang, H; Spalinskas, R; Pardo, M; Chen, L; Wu, G; Zhu, Z; Yu, Y; Yu, L; Choudhary, J; Nichols, J; Parast, MM; Greber, B; Sahlén, P; Plath, K (2019-01)
      BAF complexes are composed of different subunits with varying functional and developmental roles, although many subunits have not been examined in depth. Here we show that the Baf45 subunit Dpf2 maintains pluripotency and ...