The Emerging Role of LPA as an Oncometabolite.
Date
2024-04-04Author
Karalis, T
Poulogiannis, G
Type
Journal Article
Metadata
Show full item recordAbstract
Lysophosphatidic acid (LPA) is a phospholipid that displays potent signalling activities that are regulated in both an autocrine and paracrine manner. It can be found both extra- and intracellularly, where it interacts with different receptors to activate signalling pathways that regulate a plethora of cellular processes, including mitosis, proliferation and migration. LPA metabolism is complex, and its biosynthesis and catabolism are under tight control to ensure proper LPA levels in the body. In cancer patient specimens, LPA levels are frequently higher compared to those of healthy individuals and often correlate with poor responses and more aggressive disease. Accordingly, LPA, through promoting cancer cell migration and invasion, enhances the metastasis and dissemination of tumour cells. In this review, we summarise the role of LPA in the regulation of critical aspects of tumour biology and further discuss the available pre-clinical and clinical evidence regarding the feasibility and efficacy of targeting LPA metabolism for effective anticancer therapy.
Collections
Subject
cancer metabolism
lysophosphatidic acid
oncometabolite
phospholipid
Humans
Neoplasms
Signal Transduction
Cell Movement
Lysophospholipids
Research team
Signalling Cancer Metab
Language
eng
Date accepted
2024-04-01
License start date
2024-04-04
Citation
Cells, 2024, 13 (7), pp. 629 -
Publisher
MDPI