Recent submissions

  • Genetics of high risk myeloma 

    Shah, V (2021-03-31)
    Despite significant progress in therapy in the last two decades, the outlook for multiple myeloma (MM) patients is still poor as the disease remains incurable and only 33% of patients survive for up to 10 years after ...
  • JunD, not c-Jun, is the AP-1 transcription factor required for Ras-induced lung cancer. 

    Ruiz, EJ; Lan, L; Diefenbacher, ME; Riising, EM; Da Costa, C; Chakraborty, A; Hoeck, JD; Spencer-Dene, B; Kelly, G; David, J-P; Nye, E; Downward, J; Behrens, A (2021-07-08)
    The AP-1 transcription factor c-Jun is required for Ras-driven tumorigenesis in many tissues and is considered as a classical proto-oncogene. To determine the requirement for c-Jun in a mouse model of K-RasG12D-induced ...
  • Pharmacotherapy for liposarcoma: current and emerging synthetic treatments. 

    Chamberlain, F; Benson, C; Thway, K; Huang, P; Jones, RL; Gennatas, S (2021-04-21)
    Liposarcomas are rare tumors arising from adipocytic tissue and accounting for approximately 15-20% of all soft tissue sarcomas. Liposarcoma can be further classified into histopathological subtypes with variable ...
  • Genomic Classification and Clinical Outcome in Rhabdomyosarcoma: A Report From an International Consortium. 

    Shern, JF; Selfe, J; Izquierdo, E; Patidar, R; Chou, H-C; Song, YK; Yohe, ME; Sindiri, S; Wei, J; Wen, X; Rudzinski, ER; Barkauskas, DA; Lo, T; Hall, D; Linardic, CM; Hughes, D; Jamal, S; Jenney, M; Chisholm, J; Brown, R; Jones, K; Hicks, B; Angelini, P; George, S; Chesler, L; Hubank, M; Kelsey, A; Gatz, SA; Skapek, SX; Hawkins, DS; Shipley, JM; Khan, J
    <h4>Purpose</h4>Rhabdomyosarcoma is the most common soft tissue sarcoma of childhood. Despite aggressive therapy, the 5-year survival rate for patients with metastatic or recurrent disease remains poor, and beyond ...
  • Local excision and treatment of early node-negative anal squamous cell carcinomas in a highly HIV prevalent population. 

    Brogden, DRL; Kontovounisios, C; Chong, I; Tait, D; Warren, OJ; Bower, M; Tekkis, P; Mills, SC
    <h4>Background</h4>Anal squamous cell carcinoma (ASCC) is an uncommon cancer associated with human immunodeficiency virus (HIV) infection. There has been increasing interest in providing organ-sparing treatment in small ...
  • Frequency and Prognostic Impact of <i>ALK</i> Amplifications and Mutations in the European Neuroblastoma Study Group (SIOPEN) High-Risk Neuroblastoma Trial (HR-NBL1). 

    Bellini, A; Pötschger, U; Bernard, V; Lapouble, E; Baulande, S; Ambros, PF; Auger, N; Beiske, K; Bernkopf, M; Betts, DR; Bhalshankar, J; Bown, N; de Preter, K; Clément, N; Combaret, V; Font de Mora, J; George, SL; Jiménez, I; Jeison, M; Marques, B; Martinsson, T; Mazzocco, K; Morini, M; Mühlethaler-Mottet, A; Noguera, R; Pierron, G; Rossing, M; Taschner-Mandl, S; Van Roy, N; Vicha, A; Chesler, L; Balwierz, W; Castel, V; Elliott, M; Kogner, P; Laureys, G; Luksch, R; Malis, J; Popovic-Beck, M; Ash, S; Delattre, O; Valteau-Couanet, D; Tweddle, DA; Ladenstein, R; Schleiermacher, G (2021-06-11)
    <h4>Purpose</h4>In neuroblastoma (NB), the ALK receptor tyrosine kinase can be constitutively activated through activating point mutations or genomic amplification. We studied <i>ALK</i> genetic alterations in high-risk ...
  • A phospho-proteomic study of cetuximab resistance in KRAS/NRAS/BRAF(V600) wild-type colorectal cancer 

    Georgiou, A; Stewart, A; Vlachogiannis, G; Pickard, L; Valeri, N; Cunningham, D; Whittaker, SR; Banerji, U (SPRINGER, 2021-08-30)
  • Ductal Ngn3-expressing progenitors contribute to adult β cell neogenesis in the pancreas 

    Gribben, C; Lambert, C; Messal, HA; Hubber, E-L; Rackham, C; Evans, I; Heimberg, H; Jones, P; Sancho, R; Behrens, A
  • Biological Role of MYCN in Medulloblastoma: Novel Therapeutic Opportunities and Challenges Ahead. 

    Shrestha, S; Morcavallo, A; Gorrini, C; Chesler, L
    The constitutive and dysregulated expression of the transcription factor MYCN has a central role in the pathogenesis of the paediatric brain tumour medulloblastoma, with an increased expression of this oncogene correlating ...
  • Histamine signaling and metabolism identify potential biomarkers and therapies for lymphangioleiomyomatosis. 

    Herranz, C; Mateo, F; Baiges, A; Ruiz de Garibay, G; Junza, A; Johnson, SR; Miller, S; García, N; Capellades, J; Gómez, A; Vidal, A; Palomero, L; Espín, R; Extremera, AI; Blommaert, E; Revilla-López, E; Saez, B; Gómez-Ollés, S; Ancochea, J; Valenzuela, C; Alonso, T; Ussetti, P; Laporta, R; Xaubet, A; Rodríguez-Portal, JA; Montes-Worboys, A; Machahua, C; Bordas, J; Menendez, JA; Cruzado, JM; Guiteras, R; Bontoux, C; La Motta, C; Noguera-Castells, A; Mancino, M; Lastra, E; Rigo-Bonnin, R; Perales, JC; Viñals, F; Lahiguera, A; Zhang, X; Cuadras, D; van Moorsel, CHM; van der Vis, JJ; Quanjel, MJR; Filippakis, H; Hakem, R; Gorrini, C; Ferrer, M; Ugun-Klusek, A; Billett, E; Radzikowska, E; Casanova, Á; Molina-Molina, M; Roman, A; Yanes, O; Pujana, MA (2021-08-11)
    Inhibition of mTOR is the standard of care for lymphangioleiomyomatosis (LAM). However, this therapy has variable tolerability and some patients show progressive decline of lung function despite treatment. LAM diagnosis ...
  • PARP1 Inhibitor Combined With Oxaliplatin Efficiently Suppresses Oxaliplatin Resistance in Gastric Cancer-Derived Organoids via Homologous Recombination and the Base Excision Repair Pathway 

    Li, H; Wang, C; Lan, L; Wu, W; Evans, I; Ruiz, EJ; Yan, L; Zhou, Z; Oliveira, JM; Reis, RL; Hu, Z; Chen, W; Behrens, A; He, Y; Zhang, C
    <jats:p>Oxaliplatin (OXA) resistance in the treatment of different types of cancer is an important and complex problem. The culture of tumor organoids derived from gastric cancer can help us to provide a deeper understanding ...
  • MicroRNAs as biomarkers of response to HER2 inhibitors in gastro-oesophageal cancers 

    Lote, H (2021-01-31)
    Trastuzumab in combination with chemotherapy represents the standard of care in HER2-positive advanced gastro-oesophageal cancer (GOC), but development of resistance limits response. MicroRNAs (miRs) modulate key pathways ...
  • Targeting therapeutic vulnerabilities associated with EWS fusion proteins in Ewing sarcoma 

    Romo Morales, A (2021-01-31)
    Ewing sarcoma (ES) is a are and aggressive bone tumour affecting children and young adults and that requires better therapeutic options to improve patient outcomes. ES is characterised by chromosomal rearrangements producing ...
  • Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance. 

    Zatreanu, D; Robinson, HMR; Alkhatib, O; Boursier, M; Finch, H; Geo, L; Grande, D; Grinkevich, V; Heald, RA; Langdon, S; Majithiya, J; McWhirter, C; Martin, NMB; Moore, S; Neves, J; Rajendra, E; Ranzani, M; Schaedler, T; Stockley, M; Wiggins, K; Brough, R; Sridhar, S; Gulati, A; Shao, N; Badder, LM; Novo, D; Knight, EG; Marlow, R; Haider, S; Callen, E; Hewitt, G; Schimmel, J; Prevo, R; Alli, C; Ferdinand, A; Bell, C; Blencowe, P; Bot, C; Calder, M; Charles, M; Curry, J; Ekwuru, T; Ewings, K; Krajewski, W; MacDonald, E; McCarron, H; Pang, L; Pedder, C; Rigoreau, L; Swarbrick, M; Wheatley, E; Willis, S; Wong, AC; Nussenzweig, A; Tijsterman, M; Tutt, A; Boulton, SJ; Higgins, GS; Pettitt, SJ; Smith, GCM; Lord, CJ (2021-06-17)
    To identify approaches to target DNA repair vulnerabilities in cancer, we discovered nanomolar potent, selective, low molecular weight (MW), allosteric inhibitors of the polymerase function of DNA polymerase Polθ, including ...
  • The PTEN and ATM axis controls the G1/S cell cycle checkpoint and tumorigenesis in HER2-positive breast cancer. 

    Bassi, C; Fortin, J; Snow, BE; Wakeham, A; Ho, J; Haight, J; You-Ten, A; Cianci, E; Buckler, L; Gorrini, C; Stambolic, V; Mak, TW (2021-05-31)
    The tumor suppressor PTEN is disrupted in a large proportion of cancers, including in HER2-positive breast cancer, where its loss is associated with resistance to therapy. Upon genotoxic stress, ataxia telangiectasia mutated ...
  • Epithelioid hemangioendothelioma, an ultra-rare cancer: a consensus paper from the community of experts. 

    Stacchiotti, S; Miah, AB; Frezza, AM; Messiou, C; Morosi, C; Caraceni, A; Antonescu, CR; Bajpai, J; Baldini, E; Bauer, S; Biagini, R; Bielack, S; Blay, JY; Bonvalot, S; Boukovinas, I; Bovee, JVMG; Boye, K; Brodowicz, T; Callegaro, D; De Alava, E; Deoras-Sutliff, M; Dufresne, A; Eriksson, M; Errani, C; Fedenko, A; Ferraresi, V; Ferrari, A; Fletcher, CDM; Garcia Del Muro, X; Gelderblom, H; Gladdy, RA; Gouin, F; Grignani, G; Gutkovich, J; Haas, R; Hindi, N; Hohenberger, P; Huang, P; Joensuu, H; Jones, RL; Jungels, C; Kasper, B; Kawai, A; Le Cesne, A; Le Grange, F; Leithner, A; Leonard, H; Lopez Pousa, A; Martin Broto, J; Merimsky, O; Merriam, P; Miceli, R; Mir, O; Molinari, M; Montemurro, M; Oldani, G; Palmerini, E; Pantaleo, MA; Patel, S; Piperno-Neumann, S; Raut, CP; Ravi, V; Razak, ARA; Reichardt, P; Rubin, BP; Rutkowski, P; Safwat, AA; Sangalli, C; Sapisochin, G; Sbaraglia, M; Scheipl, S; Schöffski, P; Strauss, D; Strauss, SJ; Sundby Hall, K; Tap, WD; Trama, A; Tweddle, A; van der Graaf, WTA; Van De Sande, MAJ; Van Houdt, W; van Oortmerssen, G; Wagner, AJ; Wartenberg, M; Wood, J; Zaffaroni, N; Zimmermann, C; Casali, PG; Dei Tos, AP; Gronchi, A (2021-06-02)
    Epithelioid hemangioendothelioma (EHE) is an ultra-rare, translocated, vascular sarcoma. EHE clinical behavior is variable, ranging from that of a low-grade malignancy to that of a high-grade sarcoma and it is marked by a ...
  • Chromosome 1q21 abnormalities refine outcome prediction in patients with multiple myeloma - a meta-analysis of 2,596 trial patients. 

    Weinhold, N; Salwender, HJ; Cairns, DA; Raab, MS; Waldron, G; Blau, IW; Bertsch, U; Hielscher, T; Morgan, GJ; Jauch, A; Davies, FE; Hänel, M; Cook, G; Scheid, C; Houlston, R; Goldschmidt, H; Jackson, G; Kaiser, MF (2021-06-03)
    Not available.
  • The genomic landscape of teenage and young adult T‐cell acute lymphoblastic leukemia 

    Mansur, MB; Furness, CL; Nakjang, S; Enshaei, A; Alpar, D; Colman, SM; Minto, L; Irving, J; Poole, BV; Noronha, EP; Savola, S; Iqbal, S; Gribben, J; Pombo‐de‐Oliveira, MS; Ford, TM; Greaves, MF; Delft, FW
  • Impairment of a distinct cancer-associated fibroblast population limits tumour growth and metastasis. 

    Jungwirth, U; van Weverwijk, A; Evans, RJ; Jenkins, L; Vicente, D; Alexander, J; Gao, Q; Haider, S; Iravani, M; Isacke, CM (2021-06-10)
    Profiling studies have revealed considerable phenotypic heterogeneity in cancer-associated fibroblasts (CAFs) present within the tumour microenvironment, however, functional characterisation of different CAF subsets is ...
  • Droplet digital PCR-based detection of circulating tumor DNA from pediatric high grade and diffuse midline glioma patients. 

    Izquierdo, E; Proszek, P; Pericoli, G; Temelso, S; Clarke, M; Carvalho, DM; Mackay, A; Marshall, LV; Carceller, F; Hargrave, D; Lannering, B; Pavelka, Z; Bailey, S; Entz-Werle, N; Grill, J; Vassal, G; Rodriguez, D; Morgan, PS; Jaspan, T; Mastronuzzi, A; Vinci, M; Hubank, M; Jones, C (2021-01-27)
    <h4>Background</h4>The use of liquid biopsy is of potential high importance for children with high grade (HGG) and diffuse midline gliomas (DMG), particularly where surgical procedures are limited, and invasive biopsy ...

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