Recent submissions

  • Transcriptome-wide association study of breast cancer risk by estrogen-receptor status. 

    Feng, H; Gusev, A; Pasaniuc, B; Wu, L; Long, J; Abu-Full, Z; Aittomäki, K; Andrulis, IL; Anton-Culver, H; Antoniou, AC; Arason, A; Arndt, V; Aronson, KJ; Arun, BK; Asseryanis, E; Auer, PL; Azzollini, J; Balmaña, J; Barkardottir, RB; Barnes, DR; Barrowdale, D; Beckmann, MW; Behrens, S; Benitez, J; Bermisheva, M; Białkowska, K; Blanco, A; Blomqvist, C; Boeckx, B; Bogdanova, NV; Bojesen, SE; Bolla, MK; Bonanni, B; Borg, A; Brauch, H; Brenner, H; Briceno, I; Broeks, A; Brüning, T; Burwinkel, B; Cai, Q; Caldés, T; Caligo, MA; Campbell, I; Canisius, S; Campa, D; Carter, BD; Carter, J; Castelao, JE; Chang-Claude, J; Chanock, SJ; Christiansen, H; Chung, WK; Claes, KBM; Clarke, CL; GEMO Study Collaborators; EMBRACE Collaborators; GC-HBOC study Collaborators; Couch, FJ; Cox, A; Cross, SS; Cybulski, C; Czene, K; Daly, MB; de la Hoya, M; De Leeneer, K; Dennis, J; Devilee, P; Diez, O; Domchek, SM; Dörk, T; Dos-Santos-Silva, I; Dunning, AM; Dwek, M; Eccles, DM; Ejlertsen, B; Ellberg, C; Engel, C; Eriksson, M; Fasching, PA; Fletcher, O; Flyger, H; Fostira, F; Friedman, E; Fritschi, L; Frost, D; Gabrielson, M; Ganz, PA; Gapstur, SM; Garber, J; García-Closas, M; García-Sáenz, JA; Gaudet, MM; Giles, GG; Glendon, G; Godwin, AK; Goldberg, MS; Goldgar, DE; González-Neira, A; Greene, MH; Gronwald, J; Guénel, P; Haiman, CA; Hall, P; Hamann, U; Hake, C; He, W; Heyworth, J; Hogervorst, FBL; Hollestelle, A; Hooning, MJ; Hoover, RN; Hopper, JL; Huang, G; Hulick, PJ; Humphreys, K; Imyanitov, EN; ABCTB Investigators; HEBON Investigators; BCFR Investigators; OCGN Investigators; Isaacs, C; Jakimovska, M; Jakubowska, A; James, P; Janavicius, R; Jankowitz, RC; John, EM; Johnson, N; Joseph, V; Jung, A; Karlan, BY; Khusnutdinova, E; Kiiski, JI; Konstantopoulou, I; Kristensen, VN; Laitman, Y; Lambrechts, D; Lazaro, C; Leroux, D; Leslie, G; Lester, J; Lesueur, F; Lindor, N; Lindström, S; Lo, W-Y; Loud, JT; Lubiński, J; Makalic, E; Mannermaa, A; Manoochehri, M; Manoukian, S; Margolin, S; Martens, JWM; Martinez, ME; Matricardi, L; Maurer, T; Mavroudis, D; McGuffog, L; Meindl, A; Menon, U; Michailidou, K; Kapoor, PM; Miller, A; Montagna, M; Moreno, F; Moserle, L; Mulligan, AM; Muranen, TA; Nathanson, KL; Neuhausen, SL; Nevanlinna, H; Nevelsteen, I; Nielsen, FC; Nikitina-Zake, L; Offit, K; Olah, E; Olopade, OI; Olsson, H; Osorio, A; Papp, J; Park-Simon, T-W; Parsons, MT; Pedersen, IS; Peixoto, A; Peterlongo, P; Peto, J; Pharoah, PDP; Phillips, K-A; Plaseska-Karanfilska, D; Poppe, B; Pradhan, N; Prajzendanc, K; Presneau, N; Punie, K; Pylkäs, K; Radice, P; Rantala, J; Rashid, MU; Rennert, G; Risch, HA; Robson, M; Romero, A; Saloustros, E; Sandler, DP; Santos, C; Sawyer, EJ; Schmidt, MK; Schmidt, DF; Schmutzler, RK; Schoemaker, MJ; Scott, RJ; Sharma, P; Shu, X-O; Simard, J; Singer, CF; Skytte, A-B; Soucy, P; Southey, MC; Spinelli, JJ; Spurdle, AB; Stone, J; Swerdlow, AJ; Tapper, WJ; Taylor, JA; Teixeira, MR; Terry, MB; Teulé, A; Thomassen, M; Thöne, K; Thull, DL; Tischkowitz, M; Toland, AE; Tollenaar, RAEM; Torres, D; Truong, T; Tung, N; Vachon, CM; van Asperen, CJ; van den Ouweland, AMW; van Rensburg, EJ; Vega, A; Viel, A; Vieiro-Balo, P; Wang, Q; Wappenschmidt, B; Weinberg, CR; Weitzel, JN; Wendt, C; Winqvist, R; Yang, XR; Yannoukakos, D; Ziogas, A; Milne, RL; Easton, DF; Chenevix-Trench, G; Zheng, W; Kraft, P; Jiang, X (2020-03)
    Previous transcriptome-wide association studies (TWAS) have identified breast cancer risk genes by integrating data from expression quantitative loci and genome-wide association studies (GWAS), but analyses of breast cancer ...
  • Infant high grade gliomas comprise multiple subgroups characterized by novel targetable gene fusions and favorable outcomes 

    Jones, C; Mackay, A; Izquierdo, E; Temelso, S; Carvalho, D; Molinari, V; Burford, A; Howell, L; Natrajan, R; Boult, J; Robinson, S
  • Intraductal patient-derived xenografts of estrogen receptor α-positive breast cancer recapitulate the histopathological spectrum and metastatic potential of human lesions. 

    Fiche, M; Scabia, V; Aouad, P; Battista, L; Treboux, A; Stravodimou, A; Zaman, K; RLS; Dormoy, V; Ayyanan, A; Sflomos, G; Brisken, C (2019-03)
    Estrogen receptor α-positive (ER-positive) or 'luminal' breast cancers were notoriously difficult to establish as patient-derived xenografts (PDXs). We and others recently demonstrated that the microenvironment is critical ...
  • Capivasertib Plus Paclitaxel Versus Placebo Plus Paclitaxel As First-Line Therapy for Metastatic Triple-Negative Breast Cancer: The PAKT Trial. 

    Schmid, P; Abraham, J; Chan, S; Wheatley, D; Brunt, AM; Nemsadze, G; Baird, RD; Park, YH; Hall, PS; Perren, T; Stein, RC; Mangel, L; Ferrero, J-M; Phillips, M; Conibear, J; Cortes, J; Foxley, A; de Bruin, EC; McEwen, R; Stetson, D; Dougherty, B; Sarker, S-J; Prendergast, A; McLaughlin-Callan, M; Burgess, M; Lawrence, C; Cartwright, H; Mousa, K; Turner, NC (2020-02)
    PURPOSE:The phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway is frequently activated in triple-negative breast cancer (TNBC). The AKT inhibitor capivasertib has shown preclinical activity in TNBC models, and drug ...
  • Adult weight change and premenopausal breast cancer risk: A prospective pooled analysis of data from 628,463 women. 

    Schoemaker, MJ; Nichols, HB; Wright, LB; Brook, MN; Jones, ME; O'Brien, KM; Adami, H-O; Baglietto, L; Bernstein, L; Bertrand, KA; Boutron-Ruault, M-C; Chen, Y; Connor, AE; Dossus, L; Eliassen, AH; Giles, GG; Gram, IT; Hankinson, SE; Kaaks, R; Key, TJ; Kirsh, VA; Kitahara, CM; Larsson, SC; Linet, M; Ma, H; Milne, RL; Ozasa, K; Palmer, JR; Riboli, E; Rohan, TE; Sacerdote, C; Sadakane, A; Sund, M; Tamimi, RM; Trichopoulou, A; Ursin, G; Visvanathan, K; Weiderpass, E; Willett, WC; Wolk, A; Zeleniuch-Jacquotte, A; Sandler, DP; Swerdlow, AJ (2020-02-03)
    Early-adulthood body size is strongly inversely associated with risk of premenopausal breast cancer. It is unclear whether subsequent changes in weight affect risk. We pooled individual-level data from 17 prospective studies ...
  • Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes. 

    Fachal, L; Aschard, H; Beesley, J; Barnes, DR; Allen, J; Kar, S; Pooley, KA; Dennis, J; Michailidou, K; Turman, C; Soucy, P; Lemaçon, A; Lush, M; Tyrer, JP; Ghoussaini, M; Moradi Marjaneh, M; Jiang, X; Agata, S; Aittomäki, K; Alonso, MR; Andrulis, IL; Anton-Culver, H; Antonenkova, NN; Arason, A; Arndt, V; Aronson, KJ; Arun, BK; Auber, B; Auer, PL; Azzollini, J; Balmaña, J; Barkardottir, RB; Barrowdale, D; Beeghly-Fadiel, A; Benitez, J; Bermisheva, M; Białkowska, K; Blanco, AM; Blomqvist, C; Blot, W; Bogdanova, NV; Bojesen, SE; Bolla, MK; Bonanni, B; Borg, A; Bosse, K; Brauch, H; Brenner, H; Briceno, I; Brock, IW; Brooks-Wilson, A; Brüning, T; Burwinkel, B; Buys, SS; Cai, Q; Caldés, T; Caligo, MA; Camp, NJ; Campbell, I; Canzian, F; Carroll, JS; Carter, BD; Castelao, JE; Chiquette, J; Christiansen, H; Chung, WK; Claes, KBM; Clarke, CL; GEMO Study Collaborators; EMBRACE Collaborators; Collée, JM; Cornelissen, S; Couch, FJ; Cox, A; Cross, SS; Cybulski, C; Czene, K; Daly, MB; de la Hoya, M; Devilee, P; Diez, O; Ding, YC; Dite, GS; Domchek, SM; Dörk, T; Dos-Santos-Silva, I; Droit, A; Dubois, S; Dumont, M; Duran, M; Durcan, L; Dwek, M; Eccles, DM; Engel, C; Eriksson, M; Evans, DG; Fasching, PA; Fletcher, O; Floris, G; Flyger, H; Foretova, L; Foulkes, WD; Friedman, E; Fritschi, L; Frost, D; Gabrielson, M; Gago-Dominguez, M; Gambino, G; Ganz, PA; Gapstur, SM; Garber, J; García-Sáenz, JA; Gaudet, MM; Georgoulias, V; Giles, GG; Glendon, G; Godwin, AK; Goldberg, MS; Goldgar, DE; González-Neira, A; Tibiletti, MG; Greene, MH; Grip, M; Gronwald, J; Grundy, A; Guénel, P; Hahnen, E; Haiman, CA; Håkansson, N; Hall, P; Hamann, U; Harrington, PA; Hartikainen, JM; Hartman, M; He, W; Healey, CS; Heemskerk-Gerritsen, BAM; Heyworth, J; Hillemanns, P; Hogervorst, FBL; Hollestelle, A; Hooning, MJ; Hopper, JL; Howell, A; Huang, G; Hulick, PJ; Imyanitov, EN; KConFab Investigators; HEBON Investigators; ABCTB Investigators; Isaacs, C; Iwasaki, M; Jager, A; Jakimovska, M; Jakubowska, A; James, PA; Janavicius, R; Jankowitz, RC; John, EM; Johnson, N; Jones, ME; Jukkola-Vuorinen, A; Jung, A; Kaaks, R; Kang, D; Kapoor, PM; Karlan, BY; Keeman, R; Kerin, MJ; Khusnutdinova, E; Kiiski, JI; Kirk, J; Kitahara, CM; Ko, Y-D; Konstantopoulou, I; Kosma, V-M; Koutros, S; Kubelka-Sabit, K; Kwong, A; Kyriacou, K; Laitman, Y; Lambrechts, D; Lee, E; Leslie, G; Lester, J; Lesueur, F; Lindblom, A; Lo, W-Y; Long, J; Lophatananon, A; Loud, JT; Lubiński, J; MacInnis, RJ; Maishman, T; Makalic, E; Mannermaa, A; Manoochehri, M; Manoukian, S; Margolin, S; Martinez, ME; Matsuo, K; Maurer, T; Mavroudis, D; Mayes, R; McGuffog, L; McLean, C; Mebirouk, N; Meindl, A; Miller, A; Miller, N; Montagna, M; Moreno, F; Muir, K; Mulligan, AM; Muñoz-Garzon, VM; Muranen, TA; Narod, SA; Nassir, R; Nathanson, KL; Neuhausen, SL; Nevanlinna, H; Neven, P; Nielsen, FC; Nikitina-Zake, L; Norman, A; Offit, K; Olah, E; Olopade, OI; Olsson, H; Orr, N; Osorio, A; Pankratz, VS; Papp, J; Park, SK; Park-Simon, T-W; Parsons, MT; Paul, J; Pedersen, IS; Peissel, B; Peshkin, B; Peterlongo, P; Peto, J; Plaseska-Karanfilska, D; Prajzendanc, K; Prentice, R; Presneau, N; Prokofyeva, D; Pujana, MA; Pylkäs, K; Radice, P; Ramus, SJ; Rantala, J; Rau-Murthy, R; Rennert, G; Risch, HA; Robson, M; Romero, A; Rossing, M; Saloustros, E; Sánchez-Herrero, E; Sandler, DP; Santamariña, M; Saunders, C; Sawyer, EJ; Scheuner, MT; Schmidt, DF; Schmutzler, RK; Schneeweiss, A; Schoemaker, MJ; Schöttker, B; Schürmann, P; Scott, C; Scott, RJ; Senter, L; Seynaeve, CM; Shah, M; Sharma, P; Shen, C-Y; Shu, X-O; Singer, CF; Slavin, TP; Smichkoska, S; Southey, MC; Spinelli, JJ; Spurdle, AB; Stone, J; Stoppa-Lyonnet, D; Sutter, C; Swerdlow, AJ; Tamimi, RM; Tan, YY; Tapper, WJ; Taylor, JA; Teixeira, MR; Tengström, M; Teo, SH; Terry, MB; Teulé, A; Thomassen, M; Thull, DL; Tischkowitz, M; Toland, AE; Tollenaar, RAEM; Tomlinson, I; Torres, D; Torres-Mejía, G; Troester, MA; Truong, T; Tung, N; Tzardi, M; Ulmer, H-U; Vachon, CM; van Asperen, CJ; van der Kolk, LE; van Rensburg, EJ; Vega, A; Viel, A; Vijai, J; Vogel, MJ; Wang, Q; Wappenschmidt, B; Weinberg, CR; Weitzel, JN; Wendt, C; Wildiers, H; Winqvist, R; Wolk, A; Wu, AH; Yannoukakos, D; Zhang, Y; Zheng, W; Hunter, D; Pharoah, PDP; Chang-Claude, J; García-Closas, M; Schmidt, MK; Milne, RL; Kristensen, VN; French, JD; Edwards, SL; Antoniou, AC; Chenevix-Trench, G; Simard, J; Easton, DF; Kraft, P; Dunning, AM (2020-01-07)
    Genome-wide association studies have identified breast cancer risk variants in over 150 genomic regions, but the mechanisms underlying risk remain largely unknown. These regions were explored by combining association ...
  • The Risk of Ovarian Cancer Increases with an Increase in the Lifetime Number of Ovulatory Cycles: An Analysis from the Ovarian Cancer Cohort Consortium (OC3). 

    Trabert, B; Tworoger, SS; O'Brien, KM; Townsend, MK; Fortner, RT; Iversen, ES; Hartge, P; White, E; Amiano, P; Arslan, AA; Bernstein, L; Brinton, LA; Buring, JE; Dossus, L; Fraser, GE; Gaudet, MM; Giles, GG; Gram, IT; Harris, HR; Bolton, JH; Idahl, A; Jones, ME; Kaaks, R; Kirsh, VA; Knutsen, SF; Kvaskoff, M; Lacey, JV; Lee, I-M; Milne, RL; Onland-Moret, NC; Overvad, K; Patel, AV; Peters, U; Poynter, JN; Riboli, E; Robien, K; Rohan, TE; Sandler, DP; Schairer, C; Schouten, LJ; Setiawan, VW; Swerdlow, AJ; Travis, RC; Trichopoulou, A; van den Brandt, PA; Visvanathan, K; Wilkens, LR; Wolk, A; Zeleniuch-Jacquotte, A; Wentzensen, N; Ovarian Cancer Cohort Consortium (OC3) (2020-03)
    Repeated exposure to the acute proinflammatory environment that follows ovulation at the ovarian surface and distal fallopian tube over a woman's reproductive years may increase ovarian cancer risk. To address this, analyses ...
  • Estrogen and Progesterone Receptor Testing in Breast Cancer: ASCO/CAP Guideline Update. 

    Allison, KH; Hammond, MEH; Dowsett, M; McKernin, SE; Carey, LA; Fitzgibbons, PL; Hayes, DF; Lakhani, SR; Chavez-MacGregor, M; Perlmutter, J; Perou, CM; Regan, MM; Rimm, DL; Symmans, WF; Torlakovic, EE; Varella, L; Viale, G; Weisberg, TF; McShane, LM; Wolff, AC (2020-01-13)
    PURPOSE:To update key recommendations of the American Society of Clinical Oncology/College of American Pathologists estrogen (ER) and progesterone receptor (PgR) testing in breast cancer guideline. METHODS:A multidisciplinary ...
  • Estrogen and Progesterone Receptor Testing in Breast Cancer: American Society of Clinical Oncology/College of American Pathologists Guideline Update. 

    Allison, KH; Hammond, MEH; Dowsett, M; McKernin, SE; Carey, LA; Fitzgibbons, PL; Hayes, DF; Lakhani, SR; Chavez-MacGregor, M; Perlmutter, J; Perou, CM; Regan, MM; Rimm, DL; Symmans, WF; Torlakovic, EE; Varella, L; Viale, G; Weisberg, TF; McShane, LM; Wolff, AC (2020-01-13)
    PURPOSE.—:To update key recommendations of the American Society of Clinical Oncology/College of American Pathologists estrogen receptor (ER) and progesterone receptor (PgR) testing in breast cancer guideline. METHODS.—:A ...
  • Associations of obesity and circulating insulin and glucose with breast cancer risk: a Mendelian randomization analysis. 

    Shu, X; Wu, L; Khankari, NK; Shu, X-O; Wang, TJ; Michailidou, K; Bolla, MK; Wang, Q; Dennis, J; Milne, RL; Schmidt, MK; Pharoah, PDP; Andrulis, IL; Hunter, DJ; Simard, J; Easton, DF; Zheng, W; Breast Cancer Association Consortium (2019-06)
    BACKGROUND:In addition to the established association between general obesity and breast cancer risk, central obesity and circulating fasting insulin and glucose have been linked to the development of this common malignancy. ...
  • Ubiquitin-mediated regulation of necroptosis 

    Ramos Garcia, L (2020-01-31)
    Regulated cell death is a fundamental cellular process that is critical for the development and survival of multicellular organisms. Cell death and inflammation are essential to restore tissue homeostasis following tissue ...
  • Menstrual cycle associated changes in hormone-related gene expression in oestrogen receptor positive breast cancer. 

    Haynes, BP; Ginsburg, O; Gao, Q; Folkerd, E; Afentakis, M; Buus, R; Quang, LH; Thi Han, P; Khoa, PH; Dinh, NV; To, TV; Clemons, M; Holcombe, C; Osborne, C; Evans, A; Skene, A; Sibbering, M; Rogers, C; Laws, S; Noor, L; Smith, IE; Dowsett, M (2019-01)
    The major changes in hormone levels that occur through the menstrual cycle have been postulated to affect the expression of hormone-regulated and proliferation-associated genes (PAGs) in premenopausal ER+ breast cancer. ...
  • Use of anastrozole for breast cancer prevention (IBIS-II): long-term results of a randomised controlled trial. 

    Cuzick, J; Sestak, I; Forbes, JF; Dowsett, M; Cawthorn, S; Mansel, RE; Loibl, S; Bonanni, B; Evans, DG; Howell, A; IBIS-II investigators (2020-01)
    BACKGROUND:Two large clinical trials have shown a reduced rate of breast cancer development in high-risk women in the initial 5 years of follow-up after use of aromatase inhibitors (MAP.3 and International Breast Cancer ...
  • Assessment of molecular relapse detection in early-stage breast cancer 

    Garcia-Murillas, I; Chopra, N; Comino-Mendez, I; Beany, M; Tovey, H; Cutts, R; Swift, C; Kriplani, D; Afentakis, M; Hrebien, S; Walsh-Crestani, G; Barry, P; Johnston, S; Ring, A; Bliss, J; Russell, S; Evans, A; Skene, A; Wheatley, D; Dowsett, M; Smith, I; Turner, N
  • Real-time ex vivo perfusion of human lymph nodes invaded by cancer (REPLICANT): a feasibility study. 

    Barrow-McGee, R; Procter, J; Owen, J; Woodman, N; Lombardelli, C; Kothari, A; Kovacs, T; Douek, M; George, S; Barry, PA; Ramsey, K; Gibson, A; Buus, R; Holgersen, E; Natrajan, R; Haider, S; Shattock, MJ; Gillett, C; Tutt, AN; Pinder, SE; Naidoo, K (2020-03)
    Understanding how breast cancer (BC) grows in axillary lymph nodes (ALNs), and refining how therapies might halt that process, is clinically important. However, modelling the complex ALN microenvironment is difficult, and ...
  • Combination of mTORC1/2 inhibitor vistusertib plus fulvestrant in vitro and in vivo targets oestrogen receptor-positive endocrine-resistant breast cancer. 

    Pancholi, S; Leal, MF; Ribas, R; Simigdala, N; Schuster, E; Chateau-Joubert, S; Zabaglo, L; Hills, M; Dodson, A; Gao, Q; Johnston, SR; Dowsett, M; Cosulich, SC; Maragoni, E; Martin, L-A (2019-12-04)
    BACKGROUND:Endocrine therapies are still the main strategy for the treatment of oestrogen receptor-positive (ER+) breast cancers (BC), but resistance remains problematic. Cross-talk between ER and PI3K/AKT/mTORC has been ...
  • Modulation of the tumour immune microenvironment by cancer-associated fibroblasts 

    Jenkins, L (2019-11-30)
    The breast tumour microenvironment (TME) consists of a variety of non-cancerous cell types that can promote or inhibit cancer progression. Cancer-associated fibroblasts (CAFs) represent a major component of the breast TME ...
  • Targeting RIPK1 ubiquitylation to promote anti-tumour immunity 

    Jamal, K (2019-11-30)
    Cancer heterogeneity is a key problem of current therapies leading to resistance. The way cancer cells die can lead to anti-cancer immunity, which is frequently referred to as "immunogenic" cell death. The aim of the project ...

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