Prevalence of Cardiovascular Disease in Patients With Potentially Curable Malignancies: A National Registry Dataset Analysis.
Date
2022-06-01ICR Author
Author
Battisti, NML
Welch, CA
Sweeting, M
de Belder, M
Deanfield, J
Weston, C
Peake, MD
Adlam, D
Ring, A
Type
Journal Article
Metadata
Show full item recordAbstract
BACKGROUND: Although a common challenge for patients and clinicians, there is little population-level evidence on the prevalence of cardiovascular disease (CVD) in individuals diagnosed with potentially curable cancer. OBJECTIVES: We investigated CVD rates in patients with common potentially curable malignancies and evaluated the associations between patient and disease characteristics and CVD prevalence. METHODS: The study included cancer registry patients diagnosed in England with stage I to III breast cancer, stage I to III colon or rectal cancer, stage I to III prostate cancer, stage I to IIIA non-small-cell lung cancer, stage I to IV diffuse large B-cell lymphoma, and stage I to IV Hodgkin lymphoma from 2013 to 2018. Linked hospital records and national CVD databases were used to identify CVD. The rates of CVD were investigated according to tumor type, and associations between patient and disease characteristics and CVD prevalence were determined. RESULTS: Among the 634,240 patients included, 102,834 (16.2%) had prior CVD. Men, older patients, and those living in deprived areas had higher CVD rates. Prevalence was highest for non-small-cell lung cancer (36.1%) and lowest for breast cancer (7.7%). After adjustment for age, sex, the income domain of the Index of Multiple Deprivation, and Charlson comorbidity index, CVD remained higher in other tumor types compared to breast cancer patients. CONCLUSIONS: There is a significant overlap between cancer and CVD burden. It is essential to consider CVD when evaluating national and international treatment patterns and cancer outcomes.
Collections
Subject
CVD, cardiovascular disease
DLBCL, diffuse large B-cell lymphoma
HES, Hospital Episode Statistics
ICD-10, International Statistical Classification of Diseases and Related Health Problems-10th Revision
NCRD, National Cancer Registration Dataset
NICOR, National Institute for Cardiovascular Outcomes Research
NSCLC, non-small-cell lung cancer
breast cancer
colorectal cancer
lung cancer
lymphoma
prostate cancer
Research team
Breast Cancer Clin Res
Language
eng
Date accepted
2022-03-10
License start date
2022-06-01
Citation
JACC: CardioOncology, 2022, 4 (2), pp. 238 - 253
Publisher
ELSEVIER
Except where otherwise noted, this item's license is described
as
http://creativecommons.org/licenses/by/4.0/
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