Is There a Special Role for Ovarian Hormones in the Pathogenesis of Lobular Carcinoma?
View/ Open
Date
2024-03-29ICR Author
Author
Flaherty, RL
Sflomos, G
Brisken, C
Type
Journal Article
Metadata
Show full item recordAbstract
Lobular carcinoma represent the most common special histological subtype of breast cancer, with the majority classed as hormone receptor positive. Rates of invasive lobular carcinoma in postmenopausal women have been seen to increase globally, while other hormone receptor-positive breast cancers proportionally have not followed the same trend. This has been linked to exposure to exogenous ovarian hormones such as hormone replacement therapy. Reproductive factors resulting in increased lifetime exposure to endogenous ovarian hormones have also been linked to an increased risk of lobular breast cancer, and taken together, these data make a case for the role of ovarian hormones in the genesis and progression of the disease. In this review, we summarize current understanding of the epidemiological associations between ovarian hormones and lobular breast cancer and highlight mechanistic links that may underpin the etiology and biology.
Collections
Subject
androgenic progestins
estrogen receptor
hormonal contraception
hormone replacement therapy
invasive lobular carcinoma
progesterone receptor
Female
Humans
Carcinoma, Lobular
Progestins
Estrogens
Breast Neoplasms
Hormone Replacement Therapy
Risk Factors
Research team
Endocrine control mechans
Language
eng
Date accepted
2024-03-29
License start date
2024-03-29
Citation
Endocrinology, 2024, 165 (5), pp. bqae031 -
Publisher
ENDOCRINE SOC