Recent submissions

  • Etiology of hormone receptor positive breast cancer differs by levels of histologic grade and proliferation. 

    Abubakar, M; Chang-Claude, J; Ali, HR; Chatterjee, N; Coulson, P; Daley, F; Blows, F; Benitez, J; Milne, RL; Brenner, H; Stegmaier, C; Mannermaa, A; Rudolph, A; Sinn, P; Couch, FJ; Devilee, P; Tollenaar, RAEM; Seynaeve, C; Figueroa, J; Lissowska, J; Hewitt, S; Hooning, MJ; Hollestelle, A; Foekens, R; Koppert, LB; Investigators, K; Bolla, MK; Wang, Q; Jones, ME; Schoemaker, MJ; Keeman, R; Easton, DF; Swerdlow, AJ; Sherman, ME; Schmidt, MK; Pharoah, PD; Garcia-Closas, M (2018-03-01)
    Limited epidemiological evidence suggests that the etiology of hormone receptor positive (HR+) breast cancer may differ by levels of histologic grade and proliferation. We pooled risk factor and pathology data on 5,905 HR+ ...
  • Men with a susceptibility to prostate cancer and the role of genetic based screening. 

    Eeles, R; Ni Raghallaigh, H (2018-02)
    Prostate cancer is the second most common malignancy affecting men worldwide, and the commonest affecting men of African descent. Significant diagnostic and therapeutic advances have been made in the past decade. Improvements ...
  • Two Novel Susceptibility Loci for Prostate Cancer in Men of African Ancestry. 

    Conti, DV; Wang, K; Sheng, X; Bensen, JT; Hazelett, DJ; Cook, MB; Ingles, SA; Kittles, RA; Strom, SS; Rybicki, BA; Nemesure, B; Isaacs, WB; Stanford, JL; Zheng, W; Sanderson, M; John, EM; Park, JY; Xu, J; Stevens, VL; Berndt, SI; Huff, CD; Wang, Z; Yeboah, ED; Tettey, Y; Biritwum, RB; Adjei, AA; Tay, E; Truelove, A; Niwa, S; Sellers, TA; Yamoah, K; Murphy, AB; Crawford, DC; Gapstur, SM; Bush, WS; Aldrich, MC; Cussenot, O; Petrovics, G; Cullen, J; Neslund-Dudas, C; Stern, MC; Jarai, Z-K; Govindasami, K; Chokkalingam, AP; Hsing, AW; Goodman, PJ; Hoffmann, T; Drake, BF; Hu, JJ; Clark, PE; Van Den Eeden, SK; Blanchet, P; Fowke, JH; Casey, G; Hennis, AJM; Han, Y; Lubwama, A; Thompson, IM; Leach, R; Easton, DF; Schumacher, F; Van den Berg, DJ; Gundell, SM; Stram, A; Wan, P; Xia, L; Pooler, LC; Mohler, JL; Fontham, ETH; Smith, GJ; Taylor, JA; Srivastava, S; Eeles, RA; Carpten, J; Kibel, AS; Multigner, L; Parent, M-E; Menegaux, F; Cancel-Tassin, G; Klein, EA; Brureau, L; Stram, DO; Watya, S; Chanock, SJ; Witte, JS; Blot, WJ; Henderson, BE; Haiman, CA; PRACTICAL/ELLIPSE Consortium (2017-08-01)
    Prostate cancer incidence is 1.6-fold higher in African Americans than in other populations. The risk factors that drive this disparity are unknown and potentially consist of social, environmental, and genetic influences. ...
  • Risks of breast or ovarian cancer in BRCA1 or BRCA2 predictive test negatives: findings from the EMBRACE study. 

    Girardi, F; Barnes, DR; Barrowdale, D; Frost, D; Brady, AF; Miller, C; Henderson, A; Donaldson, A; Murray, A; Brewer, C; Pottinger, C; Evans, DG; Eccles, D; EMBRACE; Lalloo, F; Gregory, H; Cook, J; Eason, J; Adlard, J; Barwell, J; Ong, KR; Walker, L; Izatt, L; Side, LE; Kennedy, MJ; Tischkowitz, M; Rogers, MT; Porteous, ME; Morrison, PJ; Eeles, R; Davidson, R; Snape, K; Easton, DF; Antoniou, AC (2018-03-22)
    PurposeBRCA1/BRCA2 predictive test negatives are proven noncarriers of a BRCA1/BRCA2 mutation that is carried by their relatives. The risk of developing breast cancer (BC) or epithelial ovarian cancer (EOC) in these women ...
  • Retrospective methods to estimate radiation dose at the site of breast cancer development after Hodgkin lymphoma radiotherapy. 

    Russell, NS; Krul, IM; van Eggermond, AM; Aleman, BMP; Cooke, R; Kuiper, S; Allen, SD; Wallis, MG; Llanas, D; Diallo, I; de Vathaire, F; Smith, SA; Hauptmann, M; Broeks, A; Swerdlow, AJ; Van Leeuwen, FE (2017-12)
    Background: An increased risk of breast cancer following radiotherapy for Hodgkin lymphoma (HL) has now been robustly established. In order to estimate the dose-response relationship more accurately, and to aid clinical ...
  • Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia 

    Vijayakrishnan, J; Studd, J; Broderick, P; Kinnersley, B; Holroyd, A; Law, P; Greaves, M; Houlston, R
  • Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia. 

    Vijayakrishnan, J; Studd, J; Broderick, P; Kinnersley, B; Holroyd, A; Law, PJ; Kumar, R; Allan, JM; Harrison, CJ; Moorman, AV; Vora, A; Roman, E; Rachakonda, S; Kinsey, SE; Sheridan, E; Thompson, PD; Irving, JA; Koehler, R; Hoffmann, P; Nöthen, MM; Heilmann-Heimbach, S; Jöckel, K-H; Easton, DF; Pharaoh, PDP; Dunning, AM; Peto, J; Canzian, F; Swerdlow, A; Eeles, RA; Kote-Jarai, Z; Muir, K; Pashayan, N; Greaves, M; Zimmerman, M; Bartram, CR; Schrappe, M; Stanulla, M; Hemminki, K; Houlston, RS; PRACTICAL Consortium (2018-04-09)
    Genome-wide association studies (GWAS) have advanced our understanding of susceptibility to B-cell precursor acute lymphoblastic leukemia (BCP-ALL); however, much of the heritable risk remains unidentified. Here, we perform ...
  • Genome-Wide Association Studies in Glioma. 

    Kinnersley, B; Houlston, RS; Bondy, ML (2018-04)
    Since the first reports in 2009, genome-wide association studies (GWAS) have been successful in identifying germline variants associated with glioma susceptibility. In this review, we describe a chronological history of ...
  • Diffuse gliomas classified by 1p/19q co-deletion, TERT promoter and IDH mutation status are associated with specific genetic risk loci. 

    Labreche, K; Kinnersley, B; Berzero, G; Di Stefano, AL; Rahimian, A; Detrait, I; Marie, Y; Grenier-Boley, B; Hoang-Xuan, K; Delattre, J-Y; Idbaih, A; Houlston, RS; Sanson, M (2018-02-19)
    Recent genome-wide association studies of glioma have led to the discovery of single nucleotide polymorphisms (SNPs) at 25 loci influencing risk. Gliomas are heterogeneous, hence to investigate the relationship between ...
  • A randomised phase III trial of carboplatin compared with docetaxel in BRCA1/2 mutated and 2 pre-specified triple negative breast cancer “BRCAness” subgroups: the TNT Trial 3 4 

    Tutt, A; Tovey, H; Cheang, M; Kernaghan, S; Kilburn, L; Gazinska, P; Owen, J; Abraham, J; Barrett, S; Barrett-Lee, P; Brown, R; Chan, S; Dowsett, M; Flanagan, J; Fox, L; Grigoriadis, A; Gutin, A; Harper-Wynne, C; Hatton, M; Hoadley, K; Parikh, J; Parker, P; Perou, C; Roylance, R; Shah, V; Shaw, A; Smith, I; Timms, K; Wardley, A; Wilson, G; Gillet, C; Lanchbury, J; Ashworth, A; Rahman, N; Harries, M; Ellis, P; Pinder, S; Bliss, J
  • Large-scale Sequencing of Testicular Germ Cell Tumour (TGCT) Cases Excludes Major TGCT Predisposition Gene. 

    Litchfield, K; Loveday, C; Levy, M; Dudakia, D; Rapley, E; Nsengimana, J; Bishop, DT; Reid, A; Huddart, R; Broderick, P; Houlston, RS; Turnbull, C (2018-02-09)
    Testicular germ cell tumour (TGCT), the most common cancer in young men, has a significant heritable basis that has long raised questions as to the existence of underlying major high-penetrance susceptibility gene(s). To ...
  • Validation of loci at 2q14.2 and 15q21.3 as risk factors for testicular cancer. 

    Loveday, C; Litchfield, K; Levy, M; Holroyd, A; Broderick, P; Kote-Jarai, Z; Dunning, AM; Muir, K; Peto, J; Eeles, R; Easton, DF; Dudakia, D; Orr, N; Pashayan, N; Reid, A; Huddart, RA; Houlston, RS; Turnbull, C (2018-02-27)
    Testicular germ cell tumor (TGCT), the most common cancer in men aged 18 to 45 years, has a strong heritable basis. Genome-wide association studies (GWAS) have proposed single nucleotide polymorphisms (SNPs) at a number ...
  • Breast cancer risk in relation to history of preeclampsia and hyperemesis gravidarum: Prospective analysis in the Generations Study. 

    Wright, LB; Schoemaker, MJ; Jones, ME; Ashworth, A; Swerdlow, AJ (2018-03-08)
    Preeclampsia and hyperemesis are pregnancy complications associated with altered sex hormone levels. Previous studies suggest preeclampsia may be associated with a decreased risk of subsequent breast cancer and hyperemesis ...
  • Breast cancer risk in relation to history of preeclampsia and hyperemesis gravidarum: Prospective analysis in the Generations Study. 

    Wright, LB; Schoemaker, MJ; Jones, ME; Ashworth, A; Swerdlow, AJ (2018-03-08)
    Preeclampsia and hyperemesis gravidarum are pregnancy complications associated with altered sex hormone levels. Previous studies suggest preeclampsia may be associated with a decreased risk of subsequent breast cancer and ...
  • Impact of atopy on risk of glioma: a Mendelian randomisation study. 

    Disney-Hogg, L; Cornish, AJ; Sud, A; Law, PJ; Kinnersley, B; Jacobs, DI; Ostrom, QT; Labreche, K; Eckel-Passow, JE; Armstrong, GN; Claus, EB; Il'yasova, D; Schildkraut, J; Barnholtz-Sloan, JS; Olson, SH; Bernstein, JL; Lai, RK; Schoemaker, MJ; Simon, M; Hoffmann, P; Nöthen, MM; Jöckel, K-H; Chanock, S; Rajaraman, P; Johansen, C; Jenkins, RB; Melin, BS; Wrensch, MR; Sanson, M; Bondy, ML; Houlston, RS
    BACKGROUND: An inverse relationship between allergies with glioma risk has been reported in several but not all epidemiological observational studies. We performed an analysis of genetic variants associated with atopy to ...
  • Influence of obesity-related risk factors in the aetiology of glioma. 

    Disney-Hogg, L; Sud, A; Law, PJ; Cornish, AJ; Kinnersley, B; Ostrom, QT; Labreche, K; Eckel-Passow, JE; Armstrong, GN; Claus, EB; Il'yasova, D; Schildkraut, J; Barnholtz-Sloan, JS; Olson, SH; Bernstein, JL; Lai, RK; Swerdlow, AJ; Simon, M; Hoffmann, P; Nöthen, MM; Jöckel, K-H; Chanock, S; Rajaraman, P; Johansen, C; Jenkins, RB; Melin, BS; Wrensch, MR; Sanson, M; Bondy, ML; Houlston, RS (2018-04)
    BACKGROUND: Obesity and related factors have been implicated as possible aetiological factors for the development of glioma in epidemiological observation studies. We used genetic markers in a Mendelian randomisation ...
  • Polygenic hazard score to guide screening for aggressive prostate cancer: development and validation in large scale cohorts. 

    Seibert, TM; Fan, CC; Wang, Y; Zuber, V; Karunamuni, R; Parsons, JK; Eeles, RA; Easton, DF; Kote-Jarai, Z; Al Olama, AA; Garcia, SB; Muir, K; Grönberg, H; Wiklund, F; Aly, M; Schleutker, J; Sipeky, C; Tammela, TL; Nordestgaard, BG; Nielsen, SF; Weischer, M; Bisbjerg, R; Røder, MA; Iversen, P; Key, TJ; Travis, RC; Neal, DE; Donovan, JL; Hamdy, FC; Pharoah, P; Pashayan, N; Khaw, K-T; Maier, C; Vogel, W; Luedeke, M; Herkommer, K; Kibel, AS; Cybulski, C; Wokolorczyk, D; Kluzniak, W; Cannon-Albright, L; Brenner, H; Cuk, K; Saum, K-U; Park, JY; Sellers, TA; Slavov, C; Kaneva, R; Mitev, V; Batra, J; Clements, JA; Spurdle, A; Teixeira, MR; Paulo, P; Maia, S; Pandha, H; Michael, A; Kierzek, A; Karow, DS; Mills, IG; Andreassen, OA; Dale, AM; PRACTICAL Consortium*
    OBJECTIVES: To develop and validate a genetic tool to predict age of onset of aggressive prostate cancer (PCa) and to guide decisions of who to screen and at what age. DESIGN: Analysis of genotype, PCa status, and age to ...
  • Mutational spectrum in a worldwide study of 29,700 families with BRCA1 or BRCA2 mutations. 

    Rebbeck, TR; Friebel, TM; Friedman, E; Hamann, U; Huo, D; Kwong, A; Olah, E; Olopade, OI; Solano, AR; Teo, S-H; Thomassen, M; Weitzel, JN; Chan, TL; Couch, FJ; Goldgar, DE; Kruse, TA; Palmero, EI; Park, SK; Torres, D; van Rensburg, EJ; McGuffog, L; Parsons, MT; Leslie, G; Aalfs, CM; Abugattas, J; Adlard, J; Agata, S; Aittomäki, K; Andrews, L; Andrulis, IL; Arason, A; Arnold, N; Arun, BK; Asseryanis, E; Auerbach, L; Azzollini, J; Balmaña, J; Barile, M; Barkardottir, RB; Barrowdale, D; Benitez, J; Berger, A; Berger, R; Blanco, AM; Blazer, KR; Blok, MJ; Bonadona, V; Bonanni, B; Bradbury, AR; Brewer, C; Buecher, B; Buys, SS; Caldes, T; Caliebe, A; Caligo, MA; Campbell, I; Caputo, SM; Chiquette, J; Chung, WK; Claes, KBM; Collée, JM; Cook, J; Davidson, R; de la Hoya, M; De Leeneer, K; de Pauw, A; Delnatte, C; Diez, O; Ding, YC; Ditsch, N; Domchek, SM; Dorfling, CM; Velazquez, C; Dworniczak, B; Eason, J; Easton, DF; Eeles, R; Ehrencrona, H; Ejlertsen, B; EMBRACE; Engel, C; Engert, S; Evans, DG; Faivre, L; Feliubadaló, L; Ferrer, SF; Foretova, L; Fowler, J; Frost, D; Galvão, HCR; Ganz, PA; Garber, J; Gauthier-Villars, M; Gehrig, A; GEMO Study Collaborators; Gerdes, A-M; Gesta, P; Giannini, G; Giraud, S; Glendon, G; Godwin, AK; Greene, MH; Gronwald, J; Gutierrez-Barrera, A; Hahnen, E; Hauke, J; HEBON; Henderson, A; Hentschel, J; Hogervorst, FBL; Honisch, E; Imyanitov, EN; Isaacs, C; Izatt, L; Izquierdo, A; Jakubowska, A; James, P; Janavicius, R; Jensen, UB; John, EM; Vijai, J; Kaczmarek, K; Karlan, BY; Kast, K; Investigators, K; Kim, S-W; Konstantopoulou, I; Korach, J; Laitman, Y; Lasa, A; Lasset, C; Lázaro, C; Lee, A; Lee, MH; Lester, J; Lesueur, F; Liljegren, A; Lindor, NM; Longy, M; Loud, JT; Lu, KH; Lubinski, J; Machackova, E; Manoukian, S; Mari, V; Martínez-Bouzas, C; Matrai, Z; Mebirouk, N; Meijers-Heijboer, HEJ; Meindl, A; Mensenkamp, AR; Mickys, U; Miller, A; Montagna, M; Moysich, KB; Mulligan, AM; Musinsky, J; Neuhausen, SL; Nevanlinna, H; Ngeow, J; Nguyen, HP; Niederacher, D; Nielsen, HR; Nielsen, FC; Nussbaum, RL; Offit, K; Öfverholm, A; Ong, K-R; Osorio, A; Papi, L; Papp, J; Pasini, B; Pedersen, IS; Peixoto, A; Peruga, N; Peterlongo, P; Pohl, E; Pradhan, N; Prajzendanc, K; Prieur, F; Pujol, P; Radice, P; Ramus, SJ; Rantala, J; Rashid, MU; Rhiem, K; Robson, M; Rodriguez, GC; Rogers, MT; Rudaitis, V; Schmidt, AY; Schmutzler, RK; Senter, L; Shah, PD; Sharma, P; Side, LE; Simard, J; Singer, CF; Skytte, A-B; Slavin, TP; Snape, K; Sobol, H; Southey, M; Steele, L; Steinemann, D; Sukiennicki, G; Sutter, C; Szabo, CI; Tan, YY; Teixeira, MR; Terry, MB; Teulé, A; Thomas, A; Thull, DL; Tischkowitz, M; Tognazzo, S; Toland, AE; Topka, S; Trainer, AH; Tung, N; van Asperen, CJ; van der Hout, AH; van der Kolk, LE; van der Luijt, RB; Van Heetvelde, M; Varesco, L; Varon-Mateeva, R; Vega, A; Villarreal-Garza, C; von Wachenfeldt, A; Walker, L; Wang-Gohrke, S; Wappenschmidt, B; Weber, BHF; Yannoukakos, D; Yoon, S-Y; Zanzottera, C; Zidan, J; Zorn, KK; Hutten Selkirk, CG; Hulick, PJ; Chenevix-Trench, G; Spurdle, AB; Antoniou, AC; Nathanson, KL (2018-02-15)
    The prevalence and spectrum of germline mutations in BRCA1 and BRCA2 have been reported in single populations, with the majority of reports focused on White in Europe and North America. The Consortium of Investigators of ...
  • Telomere structure and maintenance gene variants and risk of five cancer types. 

    Karami, S; Han, Y; Pande, M; Cheng, I; Rudd, J; Pierce, BL; Nutter, EL; Schumacher, FR; Kote-Jarai, Z; Lindstrom, S; Witte, JS; Fang, S; Han, J; Kraft, P; Hunter, D; Song, F; Hung, RJ; McKay, J; Gruber, SB; Chanock, SJ; Risch, A; Shen, H; Haiman, CA; Boardman, L; Ulrich, CM; Casey, G; Peters, U; Amin Al Olama, A; Berchuck, A; Berndt, SI; Bezieau, S; Brennan, P; Brenner, H; Brinton, L; Caporaso, N; Chan, AT; Chang-Claude, J; Christiani, DC; Cunningham, JM; Easton, D; Eeles, RA; Eisen, T; Gala, M; Gallinger, SJ; Gayther, SA; Goode, EL; Grönberg, H; Henderson, BE; Houlston, R; Joshi, AD; Küry, S; Landi, MT; Le Marchand, L; Muir, K; Newcomb, PA; Permuth-Wey, J; Pharoah, P; Phelan, C; Potter, JD; Ramus, SJ; Risch, H; Schildkraut, J; Slattery, ML; Song, H; Wentzensen, N; White, E; Wiklund, F; Zanke, BW; Sellers, TA; Zheng, W; Chatterjee, N; Amos, CI; Doherty, JA (2016-07-26)
    Telomeres cap chromosome ends, protecting them from degradation, double-strand breaks, and end-to-end fusions. Telomeres are maintained by telomerase, a reverse transcriptase encoded by TERT, and an RNA template encoded ...

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