Recent submissions

  • Evaluation of Polygenic Risk Scores for Breast and Ovarian Cancer Risk Prediction in BRCA1 and BRCA2 Mutation Carriers. 

    Kuchenbaecker, KB; McGuffog, L; Barrowdale, D; Lee, A; Soucy, P; Dennis, J; Domchek, SM; Robson, M; Spurdle, AB; Ramus, SJ; Mavaddat, N; Terry, MB; Neuhausen, SL; Schmutzler, RK; Simard, J; Pharoah, PDP; Offit, K; Couch, FJ; Chenevix-Trench, G; Easton, DF; Antoniou, AC (2017-07-01)
    Background: Genome-wide association studies (GWAS) have identified 94 common single-nucleotide polymorphisms (SNPs) associated with breast cancer (BC) risk and 18 associated with ovarian cancer (OC) risk. Several of these ...
  • Prostate Cancer Risks for Male BRCA1 and BRCA2 Mutation Carriers: A Prospective Cohort Study. 

    Nyberg, T; Frost, D; Barrowdale, D; Evans, DG; Bancroft, E; Adlard, J; Ahmed, M; Barwell, J; Brady, AF; Brewer, C; Cook, J; Davidson, R; Donaldson, A; Eason, J; Gregory, H; Henderson, A; Izatt, L; Kennedy, MJ; Miller, C; Morrison, PJ; Murray, A; Ong, K-R; Porteous, M; Pottinger, C; Rogers, MT; Side, L; Snape, K; Walker, L; Tischkowitz, M; Eeles, R; Easton, DF; Antoniou, AC (2019-09-05)
    BACKGROUND: BRCA1 and BRCA2 mutations have been associated with prostate cancer (PCa) risk but a wide range of risk estimates have been reported that are based on retrospective studies. OBJECTIVE: To estimate relative and ...
  • Oral Contraceptive Use and Breast Cancer Risk: Retrospective and Prospective Analyses From a BRCA1 and BRCA2 Mutation Carrier Cohort Study. 

    Schrijver, LH; Olsson, H; Phillips, K-A; Terry, MB; Goldgar, DE; Kast, K; Engel, C; Mooij, TM; Adlard, J; Barrowdale, D; Davidson, R; Eeles, R; Ellis, S; Evans, DG; Frost, D; Izatt, L; Porteous, ME; Side, LE; Walker, L; Berthet, P; Bonadona, V; Leroux, D; Mouret-Fourme, E; Venat-Bouvet, L; Buys, SS; Southey, MC; John, EM; Chung, WK; Daly, MB; Bane, A; van Asperen, CJ; Gómez Garcia, EB; Mourits, MJE; van Os, TAM; Roos-Blom, M-J; Friedlander, ML; McLachlan, S-A; Singer, CF; Tan, YY; Foretova, L; Navratilova, M; Gerdes, A-M; Caldes, T; Simard, J; Olah, E; Jakubowska, A; Arver, B; Osorio, A; Noguès, C; Andrieu, N; Easton, DF; van Leeuwen, FE; Hopper, JL; Milne, RL; Antoniou, AC; Rookus, MA; EMBRACE, GENEPSO, BCFR, HEBON, kConFab, and IBCCS (2018-04)
    Background: For BRCA1 and BRCA2 mutation carriers, the association between oral contraceptive preparation (OCP) use and breast cancer (BC) risk is still unclear. Methods: Breast camcer risk associations were estimated from ...
  • Mendelian randomisation study of height and body mass index as modifiers of ovarian cancer risk in 22,588 BRCA1 and BRCA2 mutation carriers. 

    Qian, F; Rookus, MA; Leslie, G; Risch, HA; Greene, MH; Aalfs, CM; Adank, MA; Adlard, J; Agnarsson, BA; Ahmed, M; Aittomäki, K; Andrulis, IL; Arnold, N; Arun, BK; Ausems, MGEM; Azzollini, J; Barrowdale, D; Barwell, J; Benitez, J; Białkowska, K; Bonadona, V; Borde, J; Borg, A; Bradbury, AR; Brunet, J; Buys, SS; Caldés, T; Caligo, MA; Campbell, I; Carter, J; Chiquette, J; Chung, WK; Claes, KBM; Collée, JM; Collonge-Rame, M-A; Couch, FJ; Daly, MB; Delnatte, C; Diez, O; Domchek, SM; Dorfling, CM; Eason, J; Easton, DF; Eeles, R; Engel, C; Evans, DG; Faivre, L; Feliubadaló, L; Foretova, L; Friedman, E; Frost, D; Ganz, PA; Garber, J; Garcia-Barberan, V; Gehrig, A; Glendon, G; Godwin, AK; Gómez Garcia, EB; Hamann, U; Hauke, J; Hopper, JL; Hulick, PJ; Imyanitov, EN; Isaacs, C; Izatt, L; Jakubowska, A; Janavicius, R; John, EM; Karlan, BY; Kets, CM; Laitman, Y; Lázaro, C; Leroux, D; Lester, J; Lesueur, F; Loud, JT; Lubiński, J; Łukomska, A; McGuffog, L; Mebirouk, N; Meijers-Heijboer, HEJ; Meindl, A; Miller, A; Montagna, M; Mooij, TM; Mouret-Fourme, E; Nathanson, KL; Nehoray, B; Neuhausen, SL; Nevanlinna, H; Nielsen, FC; Offit, K; Olah, E; Ong, K-R; Oosterwijk, JC; Ottini, L; Parsons, MT; Peterlongo, P; Pfeiler, G; Pradhan, N; Radice, P; Ramus, SJ; Rantala, J; Rennert, G; Robson, M; Rodriguez, GC; Salani, R; Scheuner, MT; Schmutzler, RK; Shah, PD; Side, LE; Simard, J; Singer, CF; Steinemann, D; Stoppa-Lyonnet, D; Tan, YY; Teixeira, MR; Terry, MB; Thomassen, M; Tischkowitz, M; Tognazzo, S; Toland, AE; Tung, N; van Asperen, CJ; van Engelen, K; van Rensburg, EJ; Venat-Bouvet, L; Vierstraete, J; Wagner, G; Walker, L; Weitzel, JN; Yannoukakos, D; KConFab Investigators; HEBON Investigators; GEMO Study Collaborators; EMBRACE Collaborators; Antoniou, AC; Goldgar, DE; Olopade, OI; Chenevix-Trench, G; Rebbeck, TR; Huo, D; CIMBA (2019-07)
    BACKGROUND: Height and body mass index (BMI) are associated with higher ovarian cancer risk in the general population, but whether such associations exist among BRCA1/2 mutation carriers is unknown. METHODS: We applied a ...
  • Runs of homozygosity and testicular cancer risk. 

    Loveday, C; Sud, A; Litchfield, K; Levy, M; Holroyd, A; Broderick, P; Kote-Jarai, Z; Dunning, AM; Muir, K; Peto, J; Eeles, R; Easton, DF; Dudakia, D; Orr, N; Pashayan, N; UK Testicular Cancer Collaboration; PRACTICAL Consortium; Reid, A; Huddart, RA; Houlston, RS; Turnbull, C (2019-07)
    BACKGROUND: Testicular germ cell tumour (TGCT) is highly heritable but > 50% of the genetic risk remains unexplained. Epidemiological observation of greater relative risk to brothers of men with TGCT compared to sons has ...
  • Mutational processes contributing to the development of multiple myeloma. 

    Hoang, PH; Cornish, AJ; Dobbins, SE; Kaiser, M; Houlston, RS (2019-08-06)
    To gain insight into multiple myeloma (MM) tumorigenesis, we analyzed the mutational signatures in 874 whole-exome and 850 whole-genome data from the CoMMpass Study. We identified that coding and non-coding regions are ...
  • Transcriptome-wide association study of multiple myeloma identifies candidate susceptibility genes. 

    Went, M; Kinnersley, B; Sud, A; Johnson, DC; Weinhold, N; Försti, A; van Duin, M; Orlando, G; Mitchell, JS; Kuiper, R; Walker, BA; Gregory, WM; Hoffmann, P; Jackson, GH; Nöthen, MM; da Silva Filho, MI; Thomsen, H; Broyl, A; Davies, FE; Thorsteinsdottir, U; Hansson, M; Kaiser, M; Sonneveld, P; Goldschmidt, H; Stefansson, K; Hemminki, K; Nilsson, B; Morgan, GJ; Houlston, RS (2019-08-20)
    BACKGROUND: While genome-wide association studies (GWAS) of multiple myeloma (MM) have identified variants at 23 regions influencing risk, the genes underlying these associations are largely unknown. To identify candidate ...
  • Analysis of Over 140,000 European Descendants Identifies Genetically Predicted Blood Protein Biomarkers Associated with Prostate Cancer Risk. 

    Wu, L; Shu, X; Bao, J; Guo, X; Kote-Jarai, Z; Haiman, CA; Eeles, RA; Zheng, W; PRACTICAL, CRUK, BPC3, CAPS, PEGASUS Consortia (2019-09-15)
    Several blood protein biomarkers have been associated with prostate cancer risk. However, most studies assessed only a small number of biomarkers and/or included a small sample size. To identify novel protein biomarkers ...
  • AA9int: SNP interaction pattern search using non-hierarchical additive model set. 

    Lin, H-Y; Huang, P-Y; Chen, D-T; Tung, H-Y; Sellers, TA; Pow-Sang, JM; Eeles, R; Easton, D; Kote-Jarai, Z; Amin Al Olama, A; Benlloch, S; Muir, K; Giles, GG; Wiklund, F; Gronberg, H; Haiman, CA; Schleutker, J; Nordestgaard, BG; Travis, RC; Hamdy, F; Neal, DE; Pashayan, N; Khaw, K-T; Stanford, JL; Blot, WJ; Thibodeau, SN; Maier, C; Kibel, AS; Cybulski, C; Cannon-Albright, L; Brenner, H; Kaneva, R; Batra, J; Teixeira, MR; Pandha, H; Lu, Y-J; PRACTICAL Consortium; Park, JY (2018-12-15)
    Motivation: The use of single nucleotide polymorphism (SNP) interactions to predict complex diseases is getting more attention during the past decade, but related statistical methods are still immature. We previously ...
  • Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170. 

    Dunning, AM; Michailidou, K; Kuchenbaecker, KB; Thompson, D; French, JD; Beesley, J; Healey, CS; Kar, S; Pooley, KA; Lopez-Knowles, E; Dicks, E; Barrowdale, D; Sinnott-Armstrong, NA; Sallari, RC; Hillman, KM; Kaufmann, S; Sivakumaran, H; Moradi Marjaneh, M; Lee, JS; Hills, M; Jarosz, M; Drury, S; Canisius, S; Bolla, MK; Dennis, J; Wang, Q; Hopper, JL; Southey, MC; Broeks, A; Schmidt, MK; Lophatananon, A; Muir, K; Beckmann, MW; Fasching, PA; Dos-Santos-Silva, I; Peto, J; Sawyer, EJ; Tomlinson, I; Burwinkel, B; Marme, F; Guénel, P; Truong, T; Bojesen, SE; Flyger, H; González-Neira, A; Perez, JI; Anton-Culver, H; Eunjung, L; Arndt, V; Brenner, H; Meindl, A; Schmutzler, RK; Brauch, H; Hamann, U; Aittomäki, K; Blomqvist, C; Ito, H; Matsuo, K; Bogdanova, N; Dörk, T; Lindblom, A; Margolin, S; Kosma, VM; Mannermaa, A; Tseng, CC; Wu, AH; Lambrechts, D; Wildiers, H; Chang-Claude, J; Rudolph, A; Peterlongo, P; Radice, P; Olson, JE; Giles, GG; Milne, RL; Haiman, CA; Henderson, BE; Goldberg, MS; Teo, SH; Yip, CH; Nord, S; Borresen-Dale, AL; Kristensen, V; Long, J; Zheng, W; Pylkäs, K; Winqvist, R; Andrulis, IL; Knight, JA; Devilee, P; Seynaeve, C; Figueroa, J; Sherman, ME; Czene, K; Darabi, H; Hollestelle, A; van den Ouweland, AM; Humphreys, K; Gao, YT; Shu, XO; Cox, A; Cross, SS; Blot, W; Cai, Q; Ghoussaini, M; Perkins, BJ; Shah, M; Choi, JY; Kang, D; Lee, SC; Hartman, M; Kabisch, M; Torres, D; Jakubowska, A; Lubinski, J; Brennan, P; Sangrajrang, S; Ambrosone, CB; Toland, AE; Shen, CY; Wu, PE; Orr, N; Swerdlow, A; McGuffog, L; Healey, S; Lee, A; Kapuscinski, M; John, EM; Terry, MB; Daly, MB; Goldgar, DE; Buys, SS; Janavicius, R; Tihomirova, L; Tung, N; Dorfling, CM; van Rensburg, EJ; Neuhausen, SL; Ejlertsen, B; Hansen, TV; Osorio, A; Benitez, J; Rando, R; Weitzel, JN; Bonanni, B; Peissel, B; Manoukian, S; Papi, L; Ottini, L; Konstantopoulou, I; Apostolou, P; Garber, J; Rashid, MU; Frost, D; Izatt, L; Ellis, S; Godwin, AK; Arnold, N; Niederacher, D; Rhiem, K; Bogdanova-Markov, N; Sagne, C; Stoppa-Lyonnet, D; Damiola, F; Sinilnikova, OM; Mazoyer, S; Isaacs, C; Claes, KB; De Leeneer, K; de la Hoya, M; Caldes, T; Nevanlinna, H; Khan, S; Mensenkamp, AR; Hooning, MJ; Rookus, MA; Kwong, A; Olah, E; Diez, O; Brunet, J; Pujana, MA; Gronwald, J; Huzarski, T; Barkardottir, RB; Laframboise, R; Soucy, P; Montagna, M; Agata, S; Teixeira, MR; Park, SK; Lindor, N; Couch, FJ; Tischkowitz, M; Foretova, L; Vijai, J; Offit, K; Singer, CF; Rappaport, C; Phelan, CM; Greene, MH; Mai, PL; Rennert, G; Imyanitov, EN; Hulick, PJ; Phillips, KA; Piedmonte, M; Mulligan, AM; Glendon, G; Bojesen, A; Thomassen, M; Caligo, MA; Yoon, SY; Friedman, E; Laitman, Y; Borg, A; von Wachenfeldt, A; Ehrencrona, H; Rantala, J; Olopade, OI; Ganz, PA; Nussbaum, RL; Gayther, SA; Nathanson, KL; Domchek, SM; Arun, BK; Mitchell, G; Karlan, BY; Lester, J; Maskarinec, G; Woolcott, C; Scott, C; Stone, J; Apicella, C; Tamimi, R; Luben, R; Khaw, KT; Helland, Å; Haakensen, V; Dowsett, M; Pharoah, PD; Simard, J; Hall, P; García-Closas, M; Vachon, C; Chenevix-Trench, G; Antoniou, AC; Easton, DF; Edwards, SL (2016-04)
    We analyzed 3,872 common genetic variants across the ESR1 locus (encoding estrogen receptor α) in 118,816 subjects from three international consortia. We found evidence for at least five independent causal variants, each ...
  • Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer. 

    Ferreira, MA; Gamazon, ER; Al-Ejeh, F; Aittomäki, K; Andrulis, IL; Anton-Culver, H; Arason, A; Arndt, V; Aronson, KJ; Arun, BK; Asseryanis, E; Azzollini, J; Balmaña, J; Barnes, DR; Barrowdale, D; Beckmann, MW; Behrens, S; Benitez, J; Bermisheva, M; Białkowska, K; Blomqvist, C; Bogdanova, NV; Bojesen, SE; Bolla, MK; Borg, A; Brauch, H; Brenner, H; Broeks, A; Burwinkel, B; Caldés, T; Caligo, MA; Campa, D; Campbell, I; Canzian, F; Carter, J; Carter, BD; Castelao, JE; Chang-Claude, J; Chanock, SJ; Christiansen, H; Chung, WK; Claes, KBM; Clarke, CL; EMBRACE Collaborators; GC-HBOC Study Collaborators; GEMO Study Collaborators; Couch, FJ; Cox, A; Cross, SS; Czene, K; Daly, MB; de la Hoya, M; Dennis, J; Devilee, P; Diez, O; Dörk, T; Dunning, AM; Dwek, M; Eccles, DM; Ejlertsen, B; Ellberg, C; Engel, C; Eriksson, M; Fasching, PA; Fletcher, O; Flyger, H; Friedman, E; Frost, D; Gabrielson, M; Gago-Dominguez, M; Ganz, PA; Gapstur, SM; Garber, J; García-Closas, M; García-Sáenz, JA; Gaudet, MM; Giles, GG; Glendon, G; Godwin, AK; Goldberg, MS; Goldgar, DE; González-Neira, A; Greene, MH; Gronwald, J; Guénel, P; Haiman, CA; Hall, P; Hamann, U; He, W; Heyworth, J; Hogervorst, FBL; Hollestelle, A; Hoover, RN; Hopper, JL; Hulick, PJ; Humphreys, K; Imyanitov, EN; ABCTB Investigators; HEBON Investigators; BCFR Investigators; Isaacs, C; Jakimovska, M; Jakubowska, A; James, PA; Janavicius, R; Jankowitz, RC; John, EM; Johnson, N; Joseph, V; Karlan, BY; Khusnutdinova, E; Kiiski, JI; Ko, Y-D; Jones, ME; Konstantopoulou, I; Kristensen, VN; Laitman, Y; Lambrechts, D; Lazaro, C; Leslie, G; Lester, J; Lesueur, F; Lindström, S; Long, J; Loud, JT; Lubiński, J; Makalic, E; Mannermaa, A; Manoochehri, M; Margolin, S; Maurer, T; Mavroudis, D; McGuffog, L; Meindl, A; Menon, U; Michailidou, K; Miller, A; Montagna, M; Moreno, F; Moserle, L; Mulligan, AM; Nathanson, KL; Neuhausen, SL; Nevanlinna, H; Nevelsteen, I; Nielsen, FC; Nikitina-Zake, L; Nussbaum, RL; Offit, K; Olah, E; Olopade, OI; Olsson, H; Osorio, A; Papp, J; Park-Simon, T-W; Parsons, MT; Pedersen, IS; Peixoto, A; Peterlongo, P; Pharoah, PDP; Plaseska-Karanfilska, D; Poppe, B; Presneau, N; Radice, P; Rantala, J; Rennert, G; Risch, HA; Saloustros, E; Sanden, K; Sawyer, EJ; Schmidt, MK; Schmutzler, RK; Sharma, P; Shu, X-O; Simard, J; Singer, CF; Soucy, P; Southey, MC; Spinelli, JJ; Spurdle, AB; Stone, J; Swerdlow, AJ; Tapper, WJ; Taylor, JA; Teixeira, MR; Terry, MB; Teulé, A; Thomassen, M; Thöne, K; Thull, DL; Tischkowitz, M; Toland, AE; Torres, D; Truong, T; Tung, N; Vachon, CM; van Asperen, CJ; van den Ouweland, AMW; van Rensburg, EJ; Vega, A; Viel, A; Wang, Q; Wappenschmidt, B; Weitzel, JN; Wendt, C; Winqvist, R; Yang, XR; Yannoukakos, D; Ziogas, A; Kraft, P; Antoniou, AC; Zheng, W; Easton, DF; Milne, RL; Beesley, J; Chenevix-Trench, G (2019-04-15)
    Genome-wide association studies (GWAS) have identified more than 170 breast cancer susceptibility loci. Here we hypothesize that some risk-associated variants might act in non-breast tissues, specifically adipose tissue ...
  • No evidence that protein truncating variants in BRIP1 are associated with breast cancer risk: implications for gene panel testing. 

    Easton, DF; Lesueur, F; Decker, B; Michailidou, K; Li, J; Allen, J; Luccarini, C; Pooley, KA; Shah, M; Bolla, MK; Wang, Q; Dennis, J; Ahmad, J; Thompson, ER; Damiola, F; Pertesi, M; Voegele, C; Mebirouk, N; Robinot, N; Durand, G; Forey, N; Luben, RN; Ahmed, S; Aittomäki, K; Anton-Culver, H; Arndt, V; Baynes, C; Beckman, MW; Benitez, J; Van Den Berg, D; Blot, WJ; Bogdanova, NV; Bojesen, SE; Brenner, H; Chang-Claude, J; Chia, KS; Choi, JY; Conroy, DM; Cox, A; Cross, SS; Czene, K; Darabi, H; Devilee, P; Eriksson, M; Fasching, PA; Figueroa, J; Flyger, H; Fostira, F; García-Closas, M; Giles, GG; Glendon, G; González-Neira, A; Guénel, P; Haiman, CA; Hall, P; Hart, SN; Hartman, M; Hooning, MJ; Hsiung, CN; Ito, H; Jakubowska, A; James, PA; John, EM; Johnson, N; Jones, M; Kabisch, M; Kang, D; Kosma, VM; Kristensen, V; Lambrechts, D; Li, N; Lindblom, A; Long, J; Lophatananon, A; Lubinski, J; Mannermaa, A; Manoukian, S; Margolin, S; Matsuo, K; Meindl, A; Mitchell, G; Muir, K; Nevelsteen, I; van den Ouweland, A; Peterlongo, P; Phuah, SY; Pylkäs, K; Rowley, SM; Sangrajrang, S; Schmutzler, RK; Shen, CY; Shu, XO; Southey, MC; Surowy, H; Swerdlow, A; Teo, SH; Tollenaar, RA; Tomlinson, I; Torres, D; Truong, T; Vachon, C; Verhoef, S; Wong-Brown, M; Zheng, W; Zheng, Y; Nevanlinna, H; Scott, RJ; Andrulis, IL; Wu, AH; Hopper, JL; Couch, FJ; Winqvist, R; Burwinkel, B; Sawyer, EJ; Schmidt, MK; Rudolph, A; Dörk, T; Brauch, H; Hamann, U; Neuhausen, SL; Milne, RL; Fletcher, O; Pharoah, PD; Campbell, IG; Dunning, AM; Le Calvez-Kelm, F; Goldgar, DE; Tavtigian, SV; Chenevix-Trench, G (2016-05)
    BRCA1 interacting protein C-terminal helicase 1 (BRIP1) is one of the Fanconi Anaemia Complementation (FANC) group family of DNA repair proteins. Biallelic mutations in BRIP1 are responsible for FANC group J, and previous ...
  • Analysis of 153 115 patients with hematological malignancies refines the spectrum of familial risk. 

    Sud, A; Chattopadhyay, S; Thomsen, H; Sundquist, K; Sundquist, J; Houlston, RS; Hemminki, K (2019-09-19)
    Estimating familial cancer risks is clinically important in being able to discriminate between individuals in the population at differing risk for malignancy. To gain insight into the familial risk for the different ...
  • Radiogenomics Consortium Genome-Wide Association Study Meta-analysis of Late Toxicity after Prostate Cancer Radiotherapy. 

    Kerns, SL; Fachal, L; Dorling, L; Barnett, GC; Baran, A; Peterson, DR; Hollenberg, M; Hao, K; Narzo, AD; Ahsen, ME; Pandey, G; Bentzen, SM; Janelsins, M; Elliott, RM; Pharoah, PDP; Burnet, NG; Dearnaley, DP; Gulliford, SL; Hall, E; Sydes, MR; Aguado-Barrera, ME; Gómez-Caamaño, A; Carballo, AM; Peleteiro, P; Lobato-Busto, R; Stock, R; Stone, NN; Ostrer, H; Usmani, N; Singhal, S; Tsuji, H; Imai, T; Saito, S; Eeles, R; DeRuyck, K; Parliament, M; Dunning, AM; Vega, A; Rosenstein, BS; West, CML (2019-05-16)
    BACKGROUND: 10-20% of patients develop long-term toxicity following radiotherapy for prostate cancer. Identification of common genetic variants associated with susceptibility to radiotoxicity might improve risk prediction ...
  • Night shift work and risk of breast cancer in women: the Generations Study cohort. 

    Jones, ME; Schoemaker, MJ; McFadden, EC; Wright, LB; Johns, LE; Swerdlow, AJ (2019-07)
    BACKGROUND: It is plausible that night shift work could affect breast cancer risk, possibly by melatonin suppression or circadian clock disruption, but epidemiological evidence is inconclusive. METHODS: Using serial ...
  • Identification of Novel Susceptibility Loci and Genes for Prostate Cancer Risk: A Transcriptome-Wide Association Study in Over 140,000 European Descendants. 

    Wu, L; Wang, J; Cai, Q; Cavazos, TB; Emami, NC; Long, J; Shu, X-O; Lu, Y; Guo, X; Bauer, JA; Pasaniuc, B; Penney, KL; Freedman, ML; Kote-Jarai, Z; Witte, JS; Haiman, CA; Eeles, RA; Zheng, W; and the PRACTICAL, CRUK, BPC3, CAPS, PEGASUS Consortia (2019-07-01)
    Genome-wide association study-identified prostate cancer risk variants explain only a relatively small fraction of its familial relative risk, and the genes responsible for many of these identified associations remain ...
  • Second primary cancers in patients with acute lymphoblastic, chronic lymphocytic and hairy cell leukaemia. 

    Zheng, G; Chattopadhyay, S; Sud, A; Sundquist, K; Sundquist, J; Försti, A; Houlston, R; Hemminki, A; Hemminki, K (2019-04)
    Improvement of survival in lymphocytic leukaemia has been accompanied by the occurrence of second primary cancer (SPCs). Based on Swedish Family Cancer Database, we applied bi-directional analyses in which relative risks ...
  • Association analyses identify 31 new risk loci for colorectal cancer susceptibility. 

    Law, PJ; Timofeeva, M; Fernandez-Rozadilla, C; Broderick, P; Studd, J; Fernandez-Tajes, J; Farrington, S; Svinti, V; Palles, C; Orlando, G; Sud, A; Holroyd, A; Penegar, S; Theodoratou, E; Vaughan-Shaw, P; Campbell, H; Zgaga, L; Hayward, C; Campbell, A; Harris, S; Deary, IJ; Starr, J; Gatcombe, L; Pinna, M; Briggs, S; Martin, L; Jaeger, E; Sharma-Oates, A; East, J; Leedham, S; Arnold, R; Johnstone, E; Wang, H; Kerr, D; Kerr, R; Maughan, T; Kaplan, R; Al-Tassan, N; Palin, K; Hänninen, UA; Cajuso, T; Tanskanen, T; Kondelin, J; Kaasinen, E; Sarin, A-P; Eriksson, JG; Rissanen, H; Knekt, P; Pukkala, E; Jousilahti, P; Salomaa, V; Ripatti, S; Palotie, A; Renkonen-Sinisalo, L; Lepistö, A; Böhm, J; Mecklin, J-P; Buchanan, DD; Win, A-K; Hopper, J; Jenkins, ME; Lindor, NM; Newcomb, PA; Gallinger, S; Duggan, D; Casey, G; Hoffmann, P; Nöthen, MM; Jöckel, K-H; Easton, DF; Pharoah, PDP; Peto, J; Canzian, F; Swerdlow, A; Eeles, RA; Kote-Jarai, Z; Muir, K; Pashayan, N; PRACTICAL consortium; Harkin, A; Allan, K; McQueen, J; Paul, J; Iveson, T; Saunders, M; Butterbach, K; Chang-Claude, J; Hoffmeister, M; Brenner, H; Kirac, I; Matošević, P; Hofer, P; Brezina, S; Gsur, A; Cheadle, JP; Aaltonen, LA; Tomlinson, I; Houlston, RS; Dunlop, MG (2019-05-14)
    Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a strong heritable basis. We report a genome-wide association analysis of 34,627 CRC cases and 71,379 controls of European ancestry that ...

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