Recent submissions

  • Leveraging Genome and Phenome-Wide Association Studies to Investigate Genetic Risk of Acute Lymphoblastic Leukemia. 

    Semmes, EC; Vijayakrishnan, J; Zhang, C; Hurst, JH; Houlston, RS; Walsh, KM (2020-05-28)
    BACKGROUND:Genome-wide association studies (GWAS) of childhood cancers remain limited, highlighting the need for novel analytic strategies. We describe a hybrid GWAS and phenome-wide association study (PheWAS) approach to ...
  • UKCGG Consensus Group guidelines for the management of patients with constitutional TP53 pathogenic variants. 

    Hanson, H; Brady, AF; Crawford, G; Eeles, RA; Gibson, S; Jorgensen, M; Izatt, L; Sohaib, A; Tischkowitz, M; Evans, DG; Consensus Group Members (2020-06-22)
    Constitutional pathogenic variants in TP53 are associated with Li-Fraumeni syndrome or the more recently described heritable TP53-related cancer syndrome and are associated with increased lifetime risks of a wide spectrum ...
  • A genetic risk score to personalize prostate cancer screening, applied to population data. 

    Huynh-Le, M-P; Fan, CC; Karunamuni, R; Walsh, EI; Turner, EL; Lane, JA; Martin, RM; Neal, DE; Donovan, JL; Hamdy, FC; Parsons, JKK; Eeles, RA; Easton, DF; Kote-Jarai, Z; Amin Al Olama, A; Benlloch Garcia, S; Muir, K; Grönberg, H; Wiklund, F; Aly, M; Schleutker, J; Sipeky, C; Tammela, T; Nordestgaard, BG; Key, TJ; Travis, RC; Pharoah, PDP; Pashayan, N; Khaw, K-T; Thibodeau, SN; McDonnell, SK; Schaid, DJ; Maier, C; Vogel, W; Luedeke, M; Herkommer, K; Kibel, AS; Cybulski, C; Wokolorczyk, D; Kluzniak, W; Cannon-Albright, LA; Brenner, H; Schöttker, B; Holleczek, B; Park, JY; Sellers, TA; Lin, H-Y; Slavov, CK; Kaneva, RP; Mitev, VI; Batra, J; Clements, JA; Spurdle, AB; Teixeira, MR; Paulo, P; Maia, S; Pandha, H; Michael, A; Mills, IG; Andreassen, OA; Dale, AM; Seibert, TM (2020-06-24)
    BACKGROUND:A polygenic hazard score (PHS)-the weighted sum of 54 SNP genotypes-was previously validated for association with clinically significant prostate cancer and for improved prostate cancer screening accuracy. Here, ...
  • Prostate Cancer Risk by BRCA2 Genomic Regions. 

    Nyberg, T; Frost, D; Barrowdale, D; Evans, DG; Bancroft, E; Adlard, J; Ahmed, M; Barwell, J; Brady, AF; Brewer, C; Cook, J; Davidson, R; Donaldson, A; Eason, J; Gregory, H; Henderson, A; Izatt, L; Kennedy, MJ; Miller, C; Morrison, PJ; Murray, A; Ong, K-R; Porteous, M; Pottinger, C; Rogers, MT; Side, L; Snape, K; Tripathi, V; Walker, L; Tischkowitz, M; Eeles, R; Easton, DF; Antoniou, AC (2020-06-09)
    A BRCA2 prostate cancer cluster region (PCCR) was recently proposed (c.7914 to 3') wherein pathogenic variants (PVs) are associated with higher prostate cancer (PCa) risk than PVs elsewhere in the BRCA2 gene. Using a ...
  • Prediction of outcome in newly diagnosed myeloma: a meta-analysis of the molecular profiles of 1905 trial patients. 

    Shah, V; Sherborne, AL; Walker, BA; Johnson, DC; Boyle, EM; Ellis, S; Begum, DB; Proszek, PZ; Jones, JR; Pawlyn, C; Savola, S; Jenner, MW; Drayson, MT; Owen, RG; Houlston, RS; Cairns, DA; Gregory, WM; Cook, G; Davies, FE; Jackson, GH; Morgan, GJ; Kaiser, MF (2018-01)
    Robust establishment of survival in multiple myeloma (MM) and its relationship to recurrent genetic aberrations is required as outcomes are variable despite apparent similar staging. We assayed copy number alterations (CNA) ...
  • The influence of obesity-related factors in the etiology of renal cell carcinoma-A mendelian randomization study. 

    Johansson, M; Carreras-Torres, R; Scelo, G; Purdue, MP; Mariosa, D; Muller, DC; Timpson, NJ; Haycock, PC; Brown, KM; Wang, Z; Ye, Y; Hofmann, JN; Foll, M; Gaborieau, V; Machiela, MJ; Colli, LM; Li, P; Garnier, J-G; Blanche, H; Boland, A; Burdette, L; Prokhortchouk, E; Skryabin, KG; Yeager, M; Radojevic-Skodric, S; Ognjanovic, S; Foretova, L; Holcatova, I; Janout, V; Mates, D; Mukeriya, A; Rascu, S; Zaridze, D; Bencko, V; Cybulski, C; Fabianova, E; Jinga, V; Lissowska, J; Lubinski, J; Navratilova, M; Rudnai, P; Benhamou, S; Cancel-Tassin, G; Cussenot, O; Weiderpass, E; Ljungberg, B; Tumkur Sitaram, R; Häggström, C; Bruinsma, F; Jordan, SJ; Severi, G; Winship, I; Hveem, K; Vatten, LJ; Fletcher, T; Larsson, SC; Wolk, A; Banks, RE; Selby, PJ; Easton, DF; Andreotti, G; Beane Freeman, LE; Koutros, S; Männistö, S; Weinstein, S; Clark, PE; Edwards, TL; Lipworth, L; Gapstur, SM; Stevens, VL; Carol, H; Freedman, ML; Pomerantz, MM; Cho, E; Wilson, KM; Gaziano, JM; Sesso, HD; Freedman, ND; Parker, AS; Eckel-Passow, JE; Huang, W-Y; Kahnoski, RJ; Lane, BR; Noyes, SL; Petillo, D; Teh, BT; Peters, U; White, E; Anderson, GL; Johnson, L; Luo, J; Buring, J; Lee, I-M; Chow, W-H; Moore, LE; Eisen, T; Henrion, M; Larkin, J; Barman, P; Leibovich, BC; Choueiri, TK; Lathrop, GM; Deleuze, J-F; Gunter, M; McKay, JD; Wu, X; Houlston, RS; Chanock, SJ; Relton, C; Richards, JB; Martin, RM; Davey Smith, G; Brennan, P (2019-01-03)
    BACKGROUND:Several obesity-related factors have been associated with renal cell carcinoma (RCC), but it is unclear which individual factors directly influence risk. We addressed this question using genetic markers as proxies ...
  • Genome-wide interaction and pathway-based identification of key regulators in multiple myeloma. 

    Chattopadhyay, S; Thomsen, H; Yadav, P; da Silva Filho, MI; Weinhold, N; Nöthen, MM; Hoffman, P; Bertsch, U; Huhn, S; Morgan, GJ; Goldschmidt, H; Houlston, R; Hemminki, K; Försti, A (2019-01)
    Inherited genetic susceptibility to multiple myeloma has been investigated in a number of studies. Although 23 individual risk loci have been identified, much of the genetic heritability remains unknown. Here we carried ...
  • Evaluation of Cancer-Based Criteria for Use in Mainstream BRCA1 and BRCA2 Genetic Testing in Patients With Breast Cancer. 

    Kemp, Z; Turnbull, A; Yost, S; Seal, S; Mahamdallie, S; Poyastro-Pearson, E; Warren-Perry, M; Eccleston, A; Tan, M-M; Teo, SH; Turner, N; Strydom, A; George, A; Rahman, N (2019-05-03)
    Importance:Increasing BRCA1 and BRCA2 (collectively termed herein as BRCA) gene testing is required to improve cancer management and prevent BRCA-related cancers. Objective:To evaluate mainstream genetic testing using ...
  • PhyreRisk: A Dynamic Web Application to Bridge Genomics, Proteomics and 3D Structural Data to Guide Interpretation of Human Genetic Variants. 

    Ofoegbu, TC; David, A; Kelley, LA; Mezulis, S; Islam, SA; Mersmann, SF; Strömich, L; Vakser, IA; Houlston, RS; Sternberg, MJE (2019-06)
    PhyreRisk is an open-access, publicly accessible web application for interactively bridging genomic, proteomic and structural data facilitating the mapping of human variants onto protein structures. A major advance over ...
  • Lung Cancer Risk in Never-Smokers of European Descent is Associated With Genetic Variation in the 5p15.33 TERT-CLPTM1Ll Region. 

    Hung, RJ; Spitz, MR; Houlston, RS; Schwartz, AG; Field, JK; Ying, J; Li, Y; Han, Y; Ji, X; Chen, W; Wu, X; Gorlov, IP; Na, J; de Andrade, M; Liu, G; Brhane, Y; Diao, N; Wenzlaff, A; Davies, MPA; Liloglou, T; Timofeeva, M; Muley, T; Rennert, H; Saliba, W; Ryan, BM; Bowman, E; Barros-Dios, J-M; Pérez-Ríos, M; Morgenstern, H; Zienolddiny, S; Skaug, V; Ugolini, D; Bonassi, S; van der Heijden, EHFM; Tardon, A; Bojesen, SE; Landi, MT; Johansson, M; Bickeböller, H; Arnold, S; Le Marchand, L; Melander, O; Andrew, A; Grankvist, K; Caporaso, N; Teare, MD; Schabath, MB; Aldrich, MC; Kiemeney, LA; Wichmann, H-E; Lazarus, P; Mayordomo, J; Neri, M; Haugen, A; Zhang, Z-F; Ruano-Raviña, A; Brenner, H; Harris, CC; Orlow, I; Rennert, G; Risch, A; Brennan, P; Christiani, DC; Amos, CI; Yang, P; Gorlova, OY (2019-08)
    INTRODUCTION:Inherited susceptibility to lung cancer risk in never-smokers is poorly understood. The major reason for this gap in knowledge is that this disease is relatively uncommon (except in Asians), making it difficult ...
  • Insight into genetic predisposition to chronic lymphocytic leukemia from integrative epigenomics. 

    Speedy, HE; Beekman, R; Chapaprieta, V; Orlando, G; Law, PJ; Martín-García, D; Gutiérrez-Abril, J; Catovsky, D; Beà, S; Clot, G; Puiggròs, M; Torrents, D; Puente, XS; Allan, JM; López-Otín, C; Campo, E; Houlston, RS; Martín-Subero, JI (2019-08-09)
    Genome-wide association studies have provided evidence for inherited genetic predisposition to chronic lymphocytic leukemia (CLL). To gain insight into the mechanisms underlying CLL risk we analyze chromatin accessibility, ...
  • Collateral damage: the impact on outcomes from cancer surgery of the COVID-19 pandemic. 

    Sud, A; Jones, M; Broggio, J; Loveday, C; Torr, B; Garrett, A; Nicol, DL; Jhanji, S; Boyce, SA; Gronthoud, F; Ward, P; Handy, JM; Yousaf, N; Larkin, J; Suh, Y-E; Scott, S; Pharoah, PDP; Swanton, C; Abbosh, C; Williams, M; Lyratzopoulos, G; Houlston, R; Turnbull, C (2020-05-16)
    BACKGROUND:Cancer diagnostics and surgery have been disrupted by the response of healthcare services to the COVID-19 pandemic. Progression of cancers during delay will impact on patient long-term survival. METHODS:We ...
  • Identification of four novel associations for B-cell acute lymphoblastic leukaemia risk. 

    Vijayakrishnan, J; Qian, M; Studd, JB; Yang, W; Kinnersley, B; Law, PJ; Broderick, P; Raetz, EA; Allan, J; Pui, C-H; Vora, A; Evans, WE; Moorman, A; Yeoh, A; Yang, W; Li, C; Bartram, CR; Mullighan, CG; Zimmerman, M; Hunger, SP; Schrappe, M; Relling, MV; Stanulla, M; Loh, ML; Houlston, RS; Yang, JJ (2019-11-25)
    There is increasing evidence for a strong inherited genetic basis of susceptibility to acute lymphoblastic leukaemia (ALL) in children. To identify new risk variants for B-cell ALL (B-ALL) we conducted a meta-analysis with ...
  • Combined associations of a polygenic risk score and classical risk factors with breast cancer risk. 

    Kapoor, PM; Mavaddat, N; Choudhury, PP; Wilcox, AN; Lindström, S; Behrens, S; Michailidou, K; Dennis, J; Bolla, MK; Wang, Q; Jung, A; Abu-Ful, Z; Ahearn, T; Andrulis, IL; Anton-Culver, H; Arndt, V; Aronson, KJ; Auer, PL; Freeman, LEB; Becher, H; Beckmann, MW; Beeghly-Fadiel, A; Benitez, J; Bernstein, L; Bojesen, SE; Brauch, H; Brenner, H; Brüning, T; Cai, Q; Campa, D; Canzian, F; Carracedo, A; Carter, BD; Castelao, JE; Chanock, SJ; Chatterjee, N; Chenevix-Trench, G; Clarke, CL; Couch, FJ; Cox, A; Cross, SS; Czene, K; Dai, JY; Earp, HS; Ekici, AB; Eliassen, AH; Eriksson, M; Evans, DG; Fasching, PA; Figueroa, J; Fritschi, L; Gabrielson, M; Gago-Dominguez, M; Gao, C; Gapstur, SM; Gaudet, MM; Giles, GG; González-Neira, A; Guénel, P; Haeberle, L; Haiman, CA; Håkansson, N; Hall, P; Hamann, U; Hatse, S; Heyworth, J; Holleczek, B; Hoover, RN; Hopper, JL; Howell, A; Hunter, DJ; ABCTB Investigators; kConFab/AOCS Investigators; John, EM; Jones, ME; Kaaks, R; Keeman, R; Kitahara, CM; Ko, Y-D; Koutros, S; Kurian, AW; Lambrechts, D; Marchand, LL; Lee, E; Lejbkowicz, F; Linet, M; Lissowska, J; Llaneza, A; MacInnis, RJ; Martinez, ME; Maurer, T; McLean, C; Neuhausen, SL; Newman, WG; Norman, A; O'Brien, KM; Olshan, AF; Olson, JE; Olsson, H; Orr, N; Perou, CM; Pita, G; Polley, EC; Prentice, RL; Rennert, G; Rennert, HS; Ruddy, KJ; Sandler, DP; Saunders, C; Schoemaker, MJ; Schöttker, B; Schumacher, F; Scott, C; Scott, RJ; Shu, X-O; Smeets, A; Southey, MC; Spinelli, JJ; Stone, J; Swerdlow, AJ; Tamimi, RM; Taylor, JA; Troester, MA; Vachon, CM; van Veen, EM; Wang, X; Weinberg, CR; Weltens, C; Willett, W; Winham, SJ; Wolk, A; Yang, XR; Zheng, W; Ziogas, A; Dunning, AM; Pharoah, PDP; Schmidt, MK; Kraft, P; Easton, DF; Milne, RL; García-Closas, M; Chang-Claude, J (2020-05-02)
    We evaluated the joint associations between a new 313-variant PRS (PRS313) and questionnaire-based breast cancer risk factors for women of European ancestry, using 72,284 cases and 80,354 controls from the Breast Cancer ...
  • Genomic landscape of platinum resistant and sensitive testicular cancers. 

    Loveday, C; Litchfield, K; Proszek, PZ; Cornish, AJ; Santo, F; Levy, M; Macintyre, G; Holryod, A; Broderick, P; Dudakia, D; Benton, B; Bakir, MA; Hiley, C; Grist, E; Swanton, C; Huddart, R; Powles, T; Chowdhury, S; Shipley, J; O'Connor, S; Brenton, JD; Reid, A; de Castro, DG; Houlston, RS; Turnbull, C (2020-05-04)
    While most testicular germ cell tumours (TGCTs) exhibit exquisite sensitivity to platinum chemotherapy, ~10% are platinum resistant. To gain insight into the underlying mechanisms, we undertake whole exome sequencing and ...
  • Protein-altering germline mutations implicate novel genes related to lung cancer development. 

    Ji, X; Mukherjee, S; Landi, MT; Bosse, Y; Joubert, P; Zhu, D; Gorlov, I; Xiao, X; Han, Y; Gorlova, O; Hung, RJ; Brhane, Y; Carreras-Torres, R; Christiani, DC; Caporaso, N; Johansson, M; Liu, G; Bojesen, SE; Le Marchand, L; Albanes, D; Bickeböller, H; Aldrich, MC; Bush, WS; Tardon, A; Rennert, G; Chen, C; Byun, J; Dragnev, KH; Field, JK; Kiemeney, LF; Lazarus, P; Zienolddiny, S; Lam, S; Schabath, MB; Andrew, AS; Bertazzi, PA; Pesatori, AC; Diao, N; Su, L; Song, L; Zhang, R; Leighl, N; Johansen, JS; Mellemgaard, A; Saliba, W; Haiman, C; Wilkens, L; Fernandez-Somoano, A; Fernandez-Tardon, G; Heijden, EHFMVD; Kim, JH; Davies, MPA; Marcus, MW; Brunnström, H; Manjer, J; Melander, O; Muller, DC; Overvad, K; Trichopoulou, A; Tumino, R; Goodman, GE; Cox, A; Taylor, F; Woll, P; Wichmann, E; Muley, T; Risch, A; Rosenberger, A; Grankvist, K; Johansson, M; Shepherd, F; Tsao, M-S; Arnold, SM; Haura, EB; Bolca, C; Holcatova, I; Janout, V; Kontic, M; Lissowska, J; Mukeria, A; Ognjanovic, S; Orlowski, TM; Scelo, G; Swiatkowska, B; Zaridze, D; Bakke, P; Skaug, V; Butler, LM; Offit, K; Srinivasan, P; Bandlamudi, C; Hellmann, MD; Solit, DB; Robson, ME; Rudin, CM; Stadler, ZK; Taylor, BS; Berger, MF; Houlston, R; McLaughlin, J; Stevens, V; Nickle, DC; Obeidat, M; Timens, W; Artigas, MS; Shete, S; Brenner, H; Chanock, S; Brennan, P; McKay, JD; Amos, CI (2020-05-11)
    Few germline mutations are known to affect lung cancer risk. We performed analyses of rare variants from 39,146 individuals of European ancestry and investigated gene expression levels in 7,773 samples. We find a large-effect ...
  • Transcriptome-wide association study of breast cancer risk by estrogen-receptor status. 

    Feng, H; Gusev, A; Pasaniuc, B; Wu, L; Long, J; Abu-Full, Z; Aittomäki, K; Andrulis, IL; Anton-Culver, H; Antoniou, AC; Arason, A; Arndt, V; Aronson, KJ; Arun, BK; Asseryanis, E; Auer, PL; Azzollini, J; Balmaña, J; Barkardottir, RB; Barnes, DR; Barrowdale, D; Beckmann, MW; Behrens, S; Benitez, J; Bermisheva, M; Białkowska, K; Blanco, A; Blomqvist, C; Boeckx, B; Bogdanova, NV; Bojesen, SE; Bolla, MK; Bonanni, B; Borg, A; Brauch, H; Brenner, H; Briceno, I; Broeks, A; Brüning, T; Burwinkel, B; Cai, Q; Caldés, T; Caligo, MA; Campbell, I; Canisius, S; Campa, D; Carter, BD; Carter, J; Castelao, JE; Chang-Claude, J; Chanock, SJ; Christiansen, H; Chung, WK; Claes, KBM; Clarke, CL; GEMO Study Collaborators; EMBRACE Collaborators; GC-HBOC study Collaborators; Couch, FJ; Cox, A; Cross, SS; Cybulski, C; Czene, K; Daly, MB; de la Hoya, M; De Leeneer, K; Dennis, J; Devilee, P; Diez, O; Domchek, SM; Dörk, T; Dos-Santos-Silva, I; Dunning, AM; Dwek, M; Eccles, DM; Ejlertsen, B; Ellberg, C; Engel, C; Eriksson, M; Fasching, PA; Fletcher, O; Flyger, H; Fostira, F; Friedman, E; Fritschi, L; Frost, D; Gabrielson, M; Ganz, PA; Gapstur, SM; Garber, J; García-Closas, M; García-Sáenz, JA; Gaudet, MM; Giles, GG; Glendon, G; Godwin, AK; Goldberg, MS; Goldgar, DE; González-Neira, A; Greene, MH; Gronwald, J; Guénel, P; Haiman, CA; Hall, P; Hamann, U; Hake, C; He, W; Heyworth, J; Hogervorst, FBL; Hollestelle, A; Hooning, MJ; Hoover, RN; Hopper, JL; Huang, G; Hulick, PJ; Humphreys, K; Imyanitov, EN; ABCTB Investigators; HEBON Investigators; BCFR Investigators; OCGN Investigators; Isaacs, C; Jakimovska, M; Jakubowska, A; James, P; Janavicius, R; Jankowitz, RC; John, EM; Johnson, N; Joseph, V; Jung, A; Karlan, BY; Khusnutdinova, E; Kiiski, JI; Konstantopoulou, I; Kristensen, VN; Laitman, Y; Lambrechts, D; Lazaro, C; Leroux, D; Leslie, G; Lester, J; Lesueur, F; Lindor, N; Lindström, S; Lo, W-Y; Loud, JT; Lubiński, J; Makalic, E; Mannermaa, A; Manoochehri, M; Manoukian, S; Margolin, S; Martens, JWM; Martinez, ME; Matricardi, L; Maurer, T; Mavroudis, D; McGuffog, L; Meindl, A; Menon, U; Michailidou, K; Kapoor, PM; Miller, A; Montagna, M; Moreno, F; Moserle, L; Mulligan, AM; Muranen, TA; Nathanson, KL; Neuhausen, SL; Nevanlinna, H; Nevelsteen, I; Nielsen, FC; Nikitina-Zake, L; Offit, K; Olah, E; Olopade, OI; Olsson, H; Osorio, A; Papp, J; Park-Simon, T-W; Parsons, MT; Pedersen, IS; Peixoto, A; Peterlongo, P; Peto, J; Pharoah, PDP; Phillips, K-A; Plaseska-Karanfilska, D; Poppe, B; Pradhan, N; Prajzendanc, K; Presneau, N; Punie, K; Pylkäs, K; Radice, P; Rantala, J; Rashid, MU; Rennert, G; Risch, HA; Robson, M; Romero, A; Saloustros, E; Sandler, DP; Santos, C; Sawyer, EJ; Schmidt, MK; Schmidt, DF; Schmutzler, RK; Schoemaker, MJ; Scott, RJ; Sharma, P; Shu, X-O; Simard, J; Singer, CF; Skytte, A-B; Soucy, P; Southey, MC; Spinelli, JJ; Spurdle, AB; Stone, J; Swerdlow, AJ; Tapper, WJ; Taylor, JA; Teixeira, MR; Terry, MB; Teulé, A; Thomassen, M; Thöne, K; Thull, DL; Tischkowitz, M; Toland, AE; Tollenaar, RAEM; Torres, D; Truong, T; Tung, N; Vachon, CM; van Asperen, CJ; van den Ouweland, AMW; van Rensburg, EJ; Vega, A; Viel, A; Vieiro-Balo, P; Wang, Q; Wappenschmidt, B; Weinberg, CR; Weitzel, JN; Wendt, C; Winqvist, R; Yang, XR; Yannoukakos, D; Ziogas, A; Milne, RL; Easton, DF; Chenevix-Trench, G; Zheng, W; Kraft, P; Jiang, X (2020-07)
    Previous transcriptome-wide association studies (TWAS) have identified breast cancer risk genes by integrating data from expression quantitative loci and genome-wide association studies (GWAS), but analyses of breast cancer ...
  • Genetic predisposition for multiple myeloma. 

    Pertesi, M; Went, M; Hansson, M; Hemminki, K; Houlston, RS; Nilsson, B (2020-03)
    Multiple myeloma (MM) is the second most common blood malignancy. Epidemiological family studies going back to the 1920s have provided evidence for familial aggregation, suggesting a subset of cases have an inherited genetic ...
  • Predicting ultrahigh risk multiple myeloma by molecular profiling: an analysis of newly diagnosed transplant eligible myeloma XI trial patients. 

    Shah, V; Sherborne, AL; Johnson, DC; Ellis, S; Price, A; Chowdhury, F; Kendall, J; Jenner, MW; Drayson, MT; Owen, RG; Gregory, WM; Morgan, GJ; Davies, FE; Cook, G; Cairns, DA; Houlston, RS; Jackson, G; Kaiser, MF; on behalf of NCRI Haematology Clinical Studies Group (2020-03-11)
  • Adult weight change and premenopausal breast cancer risk: A prospective pooled analysis of data from 628,463 women. 

    Schoemaker, MJ; Nichols, HB; Wright, LB; Brook, MN; Jones, ME; O'Brien, KM; Adami, H-O; Baglietto, L; Bernstein, L; Bertrand, KA; Boutron-Ruault, M-C; Chen, Y; Connor, AE; Dossus, L; Eliassen, AH; Giles, GG; Gram, IT; Hankinson, SE; Kaaks, R; Key, TJ; Kirsh, VA; Kitahara, CM; Larsson, SC; Linet, M; Ma, H; Milne, RL; Ozasa, K; Palmer, JR; Riboli, E; Rohan, TE; Sacerdote, C; Sadakane, A; Sund, M; Tamimi, RM; Trichopoulou, A; Ursin, G; Visvanathan, K; Weiderpass, E; Willett, WC; Wolk, A; Zeleniuch-Jacquotte, A; Sandler, DP; Swerdlow, AJ (2020-02-03)
    Early-adulthood body size is strongly inversely associated with risk of premenopausal breast cancer. It is unclear whether subsequent changes in weight affect risk. We pooled individual-level data from 17 prospective studies ...

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