Browsing by author "Calvo, Fernando"
Now showing items 1-7 of 7
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Analysis of Breast Cancer Cell Invasion Using an Organotypic Culture System.
Ranftl, RE; Calvo, F (2017-01)Metastasis is the main cause of cancer patient mortality. Local tumor invasion is a key step in metastatic dissemination whereby cancer cells dislodge from primary tumors, migrate through the peritumoral stroma and reach ... -
Characterisation of HRas local signal transduction networks using engineered site-specific exchange factors.
Herrero, A; Reis-Cardoso, M; Jiménez-Gómez, I; Doherty, C; Agudo-Ibañez, L; et al. (2020-09)Ras GTPases convey signals from different types of membranes. At these locations, different Ras isoforms, interactors and regulators generate different biochemical signals and biological outputs. The study of Ras ... -
Isolation and immortalization of fibroblasts from different tumoral stages
Calvo, F; Hooper, S; Sahai, E -
Mesenchymal Cancer Cell-Stroma Crosstalk Promotes Niche Activation, Epithelial Reversion, and Metastatic Colonization.
Del Pozo Martin, Y; Park, D; Ramachandran, A; Ombrato, L; Calvo, F; et al. (2015-12-06)During metastatic colonization, tumor cells must establish a favorable microenvironment or niche that will sustain their growth. However, both the temporal and molecular details of this process remain poorly understood. ... -
Reactivation of p53 by a Cytoskeletal Sensor to Control the Balance Between DNA Damage and Tumor Dissemination.
Herraiz, C; Calvo, F; Pandya, P; Cantelli, G; Rodriguez-Hernandez, I; et al. (OXFORD UNIV PRESS INC, 2015-10-13)BACKGROUND: Abnormal cell migration and invasion underlie metastasis, and actomyosin contractility is a key regulator of tumor invasion. The links between cancer migratory behavior and DNA damage are poorly understood. ... -
Regulation of mechanotransduction: Emerging roles for septins.
Lam, M; Calvo, F (2019-01)Cells exist in dynamic three-dimensional environments where they experience variable mechanical forces due to their interaction with the extracellular matrix, neighbouring cells and physical stresses. The ability to ... -
TGFβ-mediated suppression of CD248 in non-cancer cells via canonical Smad-dependent signaling pathways is uncoupled in cancer cells.
Suresh Babu, S; Valdez, Y; Xu, A; O'Byrne, AM; Calvo, F; et al. (2014-02-20)Background CD248 is a cell surface glycoprotein, highly expressed by stromal cells and fibroblasts of tumors and inflammatory lesions, but virtually undetectable in healthy adult tissues. CD248 promotes tumorigenesis, while ...