Browsing by author "Abascal Palacios, Guillermo"
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Molecular mechanisms of Bdp1 in TFIIIB assembly and RNA polymerase III transcription initiation.
Gouge, J; Guthertz, N; Kramm, K; Dergai, O; Abascal-Palacios, G; et al. (NATURE PUBLISHING GROUP, 2017-07-25)Initiation of gene transcription by RNA polymerase (Pol) III requires the activity of TFIIIB, a complex formed by Brf1 (or Brf2), TBP (TATA-binding protein), and Bdp1. TFIIIB is required for recruitment of Pol III and to ... -
RavN is a member of a previously unrecognized group of Legionella pneumophila E3 ubiquitin ligases.
Lin, Y-H; Lucas, M; Evans, TR; Abascal-Palacios, G; Doms, AG; et al. (PUBLIC LIBRARY SCIENCE, 2018-02-01)The eukaryotic ubiquitylation machinery catalyzes the covalent attachment of the small protein modifier ubiquitin to cellular target proteins in order to alter their fate. Microbial pathogens exploit this post-translational ... -
Structural basis of RNA polymerase III transcription initiation.
Abascal-Palacios, G; Ramsay, EP; Beuron, F; Morris, E; Vannini, A (NATURE PORTFOLIO, 2018-01-17)RNA polymerase (Pol) III transcribes essential non-coding RNAs, including the entire pool of transfer RNAs, the 5S ribosomal RNA and the U6 spliceosomal RNA, and is often deregulated in cancer cells. The initiation of gene ... -
Structural basis of Ty3 retrotransposon integration at RNA Polymerase III-transcribed genes.
Abascal-Palacios, G; Jochem, L; Pla-Prats, C; Beuron, F; Vannini, A (NATURE PORTFOLIO, 2021-11-30)Retrotransposons are endogenous elements that have the ability to mobilise their DNA between different locations in the host genome. The Ty3 retrotransposon integrates with an exquisite specificity in a narrow window ... -
Structure of human RNA polymerase III.
Ramsay, EP; Abascal-Palacios, G; Daiß, JL; King, H; Gouge, J; et al. (NATURE RESEARCH, 2020-12-17)In eukaryotes, RNA Polymerase (Pol) III is specialized for the transcription of tRNAs and other short, untranslated RNAs. Pol III is a determinant of cellular growth and lifespan across eukaryotes. Upregulation of Pol III ...