Now showing items 1-20 of 25

    • Assessing the effect of obesity-related traits on multiple myeloma using a Mendelian randomisation approach. 

      Went, M; Sud, A; Law, PJ; Johnson, DC; Weinhold, N; Försti, A; van Duin, M; Mitchell, JS; Chen, B; Kuiper, R; Stephens, OW; Bertsch, U; Campo, C; Einsele, H; Gregory, WM; Henrion, M; Hillengass, J; Hoffmann, P; Jackson, GH; Lenive, O; Nickel, J; Nöthen, MM; da Silva Filho, MI; Thomsen, H; Walker, BA; Broyl, A; Davies, FE; Langer, C; Hansson, M; Kaiser, M; Sonneveld, P; Goldschmidt, H; Hemminki, K; Nilsson, B; Morgan, GJ; Houlston, RS (2017-06-16)
    • Genetic correlation between multiple myeloma and chronic lymphocytic leukaemia provides evidence for shared aetiology. 

      Went, M; Sud, A; Speedy, H; Sunter, NJ; Försti, A; Law, PJ; Johnson, DC; Mirabella, F; Holroyd, A; Li, N; Orlando, G; Weinhold, N; van Duin, M; Chen, B; Mitchell, JS; Mansouri, L; Juliusson, G; Smedby, KE; Jayne, S; Majid, A; Dearden, C; Allsup, DJ; Bailey, JR; Pratt, G; Pepper, C; Fegan, C; Rosenquist, R; Kuiper, R; Stephens, OW; Bertsch, U; Broderick, P; Einsele, H; Gregory, WM; Hillengass, J; Hoffmann, P; Jackson, GH; Jöckel, K-H; Nickel, J; Nöthen, MM; da Silva Filho, MI; Thomsen, H; Walker, BA; Broyl, A; Davies, FE; Hansson, M; Goldschmidt, H; Dyer, MJS; Kaiser, M; Sonneveld, P; Morgan, GJ; Hemminki, K; Nilsson, B; Catovsky, D; Allan, JM; Houlston, RS (2018-12-21)
      The clustering of different types of B-cell malignancies in families raises the possibility of shared aetiology. To examine this, we performed cross-trait linkage disequilibrium (LD)-score regression of multiple myeloma ...
    • Genetic Predisposition to Chronic Lymphocytic Leukemia Is Mediated by a BMF Super-Enhancer Polymorphism. 

      Kandaswamy, R; Sava, GP; Speedy, HE; Beà, S; Martín-Subero, JI; Studd, JB; Migliorini, G; Law, PJ; Puente, XS; Martín-García, D; Salaverria, I; Gutiérrez-Abril, J; López-Otín, C; Catovsky, D; Allan, JM; Campo, E; Houlston, RS (2016-08-10)
      Chronic lymphocytic leukemia (CLL) is an adult B cell malignancy. Genome-wide association studies show that variation at 15q15.1 influences CLL risk. We deciphered the causal variant at 15q15.1 and the mechanism by which ...
    • Genetic Predisposition to Multiple Myeloma at 5q15 Is Mediated by an ELL2 Enhancer Polymorphism. 

      Li, N; Johnson, DC; Weinhold, N; Kimber, S; Dobbins, SE; Mitchell, JS; Kinnersley, B; Sud, A; Law, PJ; Orlando, G; Scales, M; Wardell, CP; Försti, A; Hoang, PH; Went, M; Holroyd, A; Hariri, F; Pastinen, T; Meissner, T; Goldschmidt, H; Hemminki, K; Morgan, GJ; Kaiser, M; Houlston, RS (2017-09-12)
      Multiple myeloma (MM) is a malignancy of plasma cells. Genome-wide association studies have shown that variation at 5q15 influences MM risk. Here, we have sought to decipher the causal variant at 5q15 and the mechanism by ...
    • Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia. 

      Law, PJ; Berndt, SI; Speedy, HE; Camp, NJ; Sava, GP; Skibola, CF; Holroyd, A; Joseph, V; Sunter, NJ; Nieters, A; Bea, S; Monnereau, A; Martin-Garcia, D; Goldin, LR; Clot, G; Teras, LR; Quintela, I; Birmann, BM; Jayne, S; Cozen, W; Majid, A; Smedby, KE; Lan, Q; Dearden, C; Brooks-Wilson, AR; Hall, AG; Purdue, MP; Mainou-Fowler, T; Vajdic, CM; Jackson, GH; Cocco, P; Marr, H; Zhang, Y; Zheng, T; Giles, GG; Lawrence, C; Call, TG; Liebow, M; Melbye, M; Glimelius, B; Mansouri, L; Glenn, M; Curtin, K; Diver, WR; Link, BK; Conde, L; Bracci, PM; Holly, EA; Jackson, RD; Tinker, LF; Benavente, Y; Boffetta, P; Brennan, P; Maynadie, M; McKay, J; Albanes, D; Weinstein, S; Wang, Z; Caporaso, NE; Morton, LM; Severson, RK; Riboli, E; Vineis, P; Vermeulen, RCH; Southey, MC; Milne, RL; Clavel, J; Topka, S; Spinelli, JJ; Kraft, P; Ennas, MG; Summerfield, G; Ferri, GM; Harris, RJ; Miligi, L; Pettitt, AR; North, KE; Allsup, DJ; Fraumeni, JF; Bailey, JR; Offit, K; Pratt, G; Hjalgrim, H; Pepper, C; Chanock, SJ; Fegan, C; Rosenquist, R; de Sanjose, S; Carracedo, A; Dyer, MJS; Catovsky, D; Campo, E; Cerhan, JR; Allan, JM; Rothman, N; Houlston, R; Slager, S (2017-02-06)
      Several chronic lymphocytic leukaemia (CLL) susceptibility loci have been reported; however, much of the heritable risk remains unidentified. Here we perform a meta-analysis of six genome-wide association studies, imputed ...
    • Genome-wide association analysis of chronic lymphocytic leukaemia, Hodgkin lymphoma and multiple myeloma identifies pleiotropic risk loci. 

      Law, PJ; Sud, A; Mitchell, JS; Henrion, M; Orlando, G; Lenive, O; Broderick, P; Speedy, HE; Johnson, DC; Kaiser, M; Weinhold, N; Cooke, R; Sunter, NJ; Jackson, GH; Summerfield, G; Harris, RJ; Pettitt, AR; Allsup, DJ; Carmichael, J; Bailey, JR; Pratt, G; Rahman, T; Pepper, C; Fegan, C; von Strandmann, EP; Engert, A; Försti, A; Chen, B; Filho, MIDS; Thomsen, H; Hoffmann, P; Noethen, MM; Eisele, L; Jöckel, K-H; Allan, JM; Swerdlow, AJ; Goldschmidt, H; Catovsky, D; Morgan, GJ; Hemminki, K; Houlston, RS (2017-01-23)
      B-cell malignancies (BCM) originate from the same cell of origin, but at different maturation stages and have distinct clinical phenotypes. Although genetic risk variants for individual BCMs have been identified, an agnostic, ...
    • Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia 

      Vijayakrishnan, J; Studd, J; Broderick, P; Kinnersley, B; Holroyd, A; Law, P; Greaves, M; Houlston, R
    • Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia. 

      Vijayakrishnan, J; Studd, J; Broderick, P; Kinnersley, B; Holroyd, A; Law, PJ; Kumar, R; Allan, JM; Harrison, CJ; Moorman, AV; Vora, A; Roman, E; Rachakonda, S; Kinsey, SE; Sheridan, E; Thompson, PD; Irving, JA; Koehler, R; Hoffmann, P; Nöthen, MM; Heilmann-Heimbach, S; Jöckel, K-H; Easton, DF; Pharaoh, PDP; Dunning, AM; Peto, J; Canzian, F; Swerdlow, A; Eeles, RA; Kote-Jarai, Z; Muir, K; Pashayan, N; Greaves, M; Zimmerman, M; Bartram, CR; Schrappe, M; Stanulla, M; Hemminki, K; Houlston, RS; PRACTICAL Consortium (2018-04-09)
      Genome-wide association studies (GWAS) have advanced our understanding of susceptibility to B-cell precursor acute lymphoblastic leukemia (BCP-ALL); however, much of the heritable risk remains unidentified. Here, we perform ...
    • Genome-wide association study implicates immune dysfunction in the development of Hodgkin lymphoma. 

      Sud, A; Thomsen, H; Orlando, G; Försti, A; Law, PJ; Broderick, P; Cooke, R; Hariri, F; Pastinen, T; Easton, DF; Pharoah, PDP; Dunning, AM; Peto, J; Canzian, F; Eeles, R; Kote-Jarai, Z; Muir, K; Pashayan, N; Campa, D; PRACTICAL Consortium; Hoffmann, P; Nöthen, MM; Jöckel, K-H; von Strandmann, EP; Swerdlow, AJ; Engert, A; Orr, N; Hemminki, K; Houlston, RS (2018-11-08)
      To further our understanding of inherited susceptibility to Hodgkin lymphoma (HL), we performed a meta-analysis of 7 genome-wide association studies totaling 5325 HL cases and 22 423 control patients. We identify 5 new HL ...
    • Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility. 

      Sud, A; Thomsen, H; Law, PJ; Försti, A; Filho, MIDS; Holroyd, A; Broderick, P; Orlando, G; Lenive, O; Wright, L; Cooke, R; Easton, D; Pharoah, P; Dunning, A; Peto, J; Canzian, F; Eeles, R; Kote-Jarai, Z; Muir, K; Pashayan, N; PRACTICAL consortium; Hoffmann, P; Nöthen, MM; Jöckel, K-H; Strandmann, EPV; Lightfoot, T; Kane, E; Roman, E; Lake, A; Montgomery, D; Jarrett, RF; Swerdlow, AJ; Engert, A; Orr, N; Hemminki, K; Houlston, RS (2017-12-01)
      Several susceptibility loci for classical Hodgkin lymphoma have been reported. However, much of the heritable risk is unknown. Here, we perform a meta-analysis of two existing genome-wide association studies, a new genome-wide ...
    • Germline mutations in shelterin complex genes are associated with familial chronic lymphocytic leukemia. 

      Speedy, HE; Kinnersley, B; Chubb, D; Broderick, P; Law, PJ; Litchfield, K; Jayne, S; Dyer, MJ; Dearden, C; Follows, GA; Catovsky, D; Houlston, RS (2016-08-15)
      Chronic lymphocytic leukemia (CLL) can be familial, however thus far no rare germline disruptive alleles for CLL have been identified. We performed whole-exome sequencing of 66 CLL families, identifying four families where ...
    • Identification of 19 new risk loci and potential regulatory mechanisms influencing susceptibility to testicular germ cell tumor. 

      Litchfield, K; Levy, M; Orlando, G; Loveday, C; Law, PJ; Migliorini, G; Holroyd, A; Broderick, P; Karlsson, R; Haugen, TB; Kristiansen, W; Nsengimana, J; Fenwick, K; Assiotis, I; Kote-Jarai, Z; Dunning, AM; Muir, K; Peto, J; Eeles, R; Easton, DF; Dudakia, D; Orr, N; Pashayan, N; UK Testicular Cancer Collaboration; PRACTICAL Consortium; Bishop, DT; Reid, A; Huddart, RA; Shipley, J; Grotmol, T; Wiklund, F; Houlston, RS; Turnbull, C (2017-07)
      Genome-wide association studies (GWAS) have transformed understanding of susceptibility to testicular germ cell tumors (TGCTs), but much of the heritability remains unexplained. Here we report a new GWAS, a meta-analysis ...
    • Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma. 

      Went, M; Sud, A; Försti, A; Halvarsson, B-M; Weinhold, N; Kimber, S; van Duin, M; Thorleifsson, G; Holroyd, A; Johnson, DC; Li, N; Orlando, G; Law, PJ; Ali, M; Chen, B; Mitchell, JS; Gudbjartsson, DF; Kuiper, R; Stephens, OW; Bertsch, U; Broderick, P; Campo, C; Bandapalli, OR; Einsele, H; Gregory, WA; Gullberg, U; Hillengass, J; Hoffmann, P; Jackson, GH; Jöckel, K-H; Johnsson, E; Kristinsson, SY; Mellqvist, U-H; Nahi, H; Easton, D; Pharoah, P; Dunning, A; Peto, J; Canzian, F; Swerdlow, A; Eeles, RA; Kote-Jarai, Z; Muir, K; Pashayan, N; Nickel, J; Nöthen, MM; Rafnar, T; Ross, FM; da Silva Filho, MI; Thomsen, H; Turesson, I; Vangsted, A; Andersen, NF; Waage, A; Walker, BA; Wihlborg, A-K; Broyl, A; Davies, FE; Thorsteinsdottir, U; Langer, C; Hansson, M; Goldschmidt, H; Kaiser, M; Sonneveld, P; Stefansson, K; Morgan, GJ; Hemminki, K; Nilsson, B; Houlston, RS; PRACTICAL consortium (2018-09-13)
      Genome-wide association studies (GWAS) have transformed our understanding of susceptibility to multiple myeloma (MM), but much of the heritability remains unexplained. We report a new GWAS, a meta-analysis with previous ...
    • Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma. 

      Went, M; Sud, A; Försti, A; Halvarsson, B-M; Weinhold, N; Kimber, S; van Duin, M; Thorleifsson, G; Holroyd, A; Johnson, DC; Li, N; Orlando, G; Law, PJ; Ali, M; Chen, B; Mitchell, JS; Gudbjartsson, DF; Kuiper, R; Stephens, OW; Bertsch, U; Broderick, P; Campo, C; Bandapalli, OR; Einsele, H; Gregory, WA; Gullberg, U; Hillengass, J; Hoffmann, P; Jackson, GH; Jöckel, K-H; Johnsson, E; Kristinsson, SY; Mellqvist, U-H; Nahi, H; Easton, D; Pharoah, P; Dunning, A; Peto, J; Canzian, F; Swerdlow, A; Eeles, RA; Kote-Jarai, Z; Muir, K; Pashayan, N; Nickel, J; Nöthen, MM; Rafnar, T; Ross, FM; da Silva Filho, MI; Thomsen, H; Turesson, I; Vangsted, A; Andersen, NF; Waage, A; Walker, BA; Wihlborg, A-K; Broyl, A; Davies, FE; Thorsteinsdottir, U; Langer, C; Hansson, M; Goldschmidt, H; Kaiser, M; Sonneveld, P; Stefansson, K; Morgan, GJ; Hemminki, K; Nilsson, B; Houlston, RS; PRACTICAL consortium (2018-09-13)
      Genome-wide association studies (GWAS) have transformed our understanding of susceptibility to multiple myeloma (MM), but much of the heritability remains unexplained. We report a new GWAS, a meta-analysis with previous ...
    • Identification of recurrent noncoding mutations in B-cell lymphoma using capture Hi-C. 

      Cornish, AJ; Hoang, PH; Dobbins, SE; Law, PJ; Chubb, D; Orlando, G; Houlston, RS (2019-01-08)
      The identification of driver mutations is fundamental to understanding oncogenesis. Although genes frequently mutated in B-cell lymphoma have been identified, the search for driver mutations has largely focused on the ...
    • Impact of atopy on risk of glioma: a Mendelian randomisation study. 

      Disney-Hogg, L; Cornish, AJ; Sud, A; Law, PJ; Kinnersley, B; Jacobs, DI; Ostrom, QT; Labreche, K; Eckel-Passow, JE; Armstrong, GN; Claus, EB; Il'yasova, D; Schildkraut, J; Barnholtz-Sloan, JS; Olson, SH; Bernstein, JL; Lai, RK; Schoemaker, MJ; Simon, M; Hoffmann, P; Nöthen, MM; Jöckel, K-H; Chanock, S; Rajaraman, P; Johansen, C; Jenkins, RB; Melin, BS; Wrensch, MR; Sanson, M; Bondy, ML; Houlston, RS (2018-03-15)
      BACKGROUND: An inverse relationship between allergies with glioma risk has been reported in several but not all epidemiological observational studies. We performed an analysis of genetic variants associated with atopy to ...
    • Influence of obesity-related risk factors in the aetiology of glioma. 

      Disney-Hogg, L; Sud, A; Law, PJ; Cornish, AJ; Kinnersley, B; Ostrom, QT; Labreche, K; Eckel-Passow, JE; Armstrong, GN; Claus, EB; Il'yasova, D; Schildkraut, J; Barnholtz-Sloan, JS; Olson, SH; Bernstein, JL; Lai, RK; Swerdlow, AJ; Simon, M; Hoffmann, P; Nöthen, MM; Jöckel, K-H; Chanock, S; Rajaraman, P; Johansen, C; Jenkins, RB; Melin, BS; Wrensch, MR; Sanson, M; Bondy, ML; Houlston, RS (2018-04)
      BACKGROUND: Obesity and related factors have been implicated as possible aetiological factors for the development of glioma in epidemiological observation studies. We used genetic markers in a Mendelian randomisation ...
    • Large-scale Analysis Demonstrates Familial Testicular Cancer to have Polygenic Aetiology. 

      Loveday, C; Law, P; Litchfield, K; Levy, M; Holroyd, A; Broderick, P; Kote-Jarai, Z; Dunning, AM; Muir, K; Peto, J; Eeles, R; Easton, DF; Dudakia, D; Orr, N; Pashayan, N; UK Testicular Cancer Collaboration, The PRACTICAL Consortium; Reid, A; Huddart, RA; Houlston, RS; Turnbull, C (2018-09)
      Testicular germ cell tumour (TGCT) is the most common cancer in young men. Multiplex TGCT families have been well reported and analyses of population cancer registries have demonstrated a four- to eightfold risk to male ...
    • Mendelian randomisation analysis provides no evidence for a relationship between adult height and testicular cancer risk. 

      Levy, M; Hall, D; Sud, A; Law, P; Litchfield, K; Dudakia, D; Haugen, TB; Karlsson, R; Reid, A; Huddart, RA; Grotmol, T; Wiklund, F; Houlston, RS; Turnbull, C (2017-09)
      Observational studies have suggested anthropometric traits, particularly increased height are associated with an elevated risk of testicular cancer (testicular germ cell tumour). However, there is an inconsistency between ...
    • Mendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancer. 

      Jarvis, D; Mitchell, JS; Law, PJ; Palin, K; Tuupanen, S; Gylfe, A; Hänninen, UA; Cajuso, T; Tanskanen, T; Kondelin, J; Kaasinen, E; Sarin, AP; Kaprio, J; Eriksson, JG; Rissanen, H; Knekt, P; Pukkala, E; Jousilahti, P; Salomaa, V; Ripatti, S; Palotie, A; Järvinen, H; Renkonen-Sinisalo, L; Lepistö, A; Böhm, J; Meklin, JP; Al-Tassan, NA; Palles, C; Martin, L; Barclay, E; Farrington, SM; Timofeeva, MN; Meyer, BF; Wakil, SM; Campbell, H; Smith, CG; Idziaszczyk, S; Maughan, TS; Kaplan, R; Kerr, R; Kerr, D; Buchanan, DD; Win, AK; Hopper, JL; Jenkins, MA; Lindor, NM; Newcomb, PA; Gallinger, S; Conti, D; Schumacher, F; Casey, G; Taipale, J; Aaltonen, LA; Cheadle, JP; Dunlop, MG; Tomlinson, IP; Houlston, RS (2016-07)
      Observational studies have associated adiposity with an increased risk of colorectal cancer (CRC). However, such studies do not establish a causal relationship. To minimise bias from confounding we performed a Mendelian ...