Genetic predisposition to mosaic Y chromosome loss in blood.
Date
2019-11-28Author
Thompson, DJ
Genovese, G
Halvardson, J
Ulirsch, JC
Wright, DJ
Terao, C
Davidsson, OB
Day, FR
Sulem, P
Jiang, Y
Danielsson, M
Davies, H
Dennis, J
Dunlop, MG
Easton, DF
Fisher, VA
Zink, F
Houlston, RS
Ingelsson, M
Kar, S
Kerrison, ND
Kinnersley, B
Kristjansson, RP
Law, PJ
Li, R
Loveday, C
Mattisson, J
McCarroll, SA
Murakami, Y
Murray, A
Olszewski, P
Rychlicka-Buniowska, E
Scott, RA
Thorsteinsdottir, U
Tomlinson, I
Moghadam, BT
Turnbull, C
Wareham, NJ
Gudbjartsson, DF
International Lung Cancer Consortium (INTEGRAL-ILCCO),
Breast Cancer Association Consortium,
Consortium of Investigators of Modifiers of BRCA1/2,
Endometrial Cancer Association Consortium,
Ovarian Cancer Association Consortium,
Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) Consortium,
Kidney Cancer GWAS Meta-Analysis Project,
eQTLGen Consortium,
Biobank-based Integrative Omics Study (BIOS) Consortium,
23andMe Research Team,
Kamatani, Y
Hoffmann, ER
Jackson, SP
Stefansson, K
Auton, A
Ong, KK
Machiela, MJ
Loh, P-R
Dumanski, JP
Chanock, SJ
Forsberg, LA
Perry, JRB
Type
Journal Article
Metadata
Show full item recordAbstract
Mosaic loss of chromosome Y (LOY) in circulating white blood cells is the most common form of clonal mosaicism1-5, yet our knowledge of the causes and consequences of this is limited. Here, using a computational approach, we estimate that 20% of the male population represented in the UK Biobank study (n = 205,011) has detectable LOY. We identify 156 autosomal genetic determinants of LOY, which we replicate in 757,114 men of European and Japanese ancestry. These loci highlight genes that are involved in cell-cycle regulation and cancer susceptibility, as well as somatic drivers of tumour growth and targets of cancer therapy. We demonstrate that genetic susceptibility to LOY is associated with non-haematological effects on health in both men and women, which supports the hypothesis that clonal haematopoiesis is a biomarker of genomic instability in other tissues. Single-cell RNA sequencing identifies dysregulated expression of autosomal genes in leukocytes with LOY and provides insights into why clonal expansion of these cells may occur. Collectively, these data highlight the value of studying clonal mosaicism to uncover fundamental mechanisms that underlie cancer and other ageing-related diseases.
Collections
Subject
Adult
Aged
Chromosome Deletion
Chromosomes, Human, Y
Computational Biology
Databases, Genetic
Female
Genetic Markers
Genetic Predisposition to Disease
Genomic Instability
Humans
Leukocytes
Male
Middle Aged
Mosaicism
Neoplasms
United Kingdom
Research team
Cancer Genomics
Translational Genetics
Language
eng
Date accepted
2019-10-04
License start date
2019-11-28
Citation
Nature, 2019, 575 (7784), pp. 652 - 657
Publisher
NATURE PORTFOLIO
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