Browsing by author "Miraki-Moud, Farideh"
Now showing items 1-5 of 5
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Adipocytes disrupt the translational programme of acute lymphoblastic leukaemia to favour tumour survival and persistence.
Heydt, Q; Xintaropoulou, C; Clear, A; Austin, M; Pislariu, I; et al. (NATURE PORTFOLIO, 2021-09-17)The specific niche adaptations that facilitate primary disease and Acute Lymphoblastic Leukaemia (ALL) survival after induction chemotherapy remain unclear. Here, we show that Bone Marrow (BM) adipocytes dynamically evolve ... -
Mesenchymal niche remodeling impairs hematopoiesis via stanniocalcin 1 in acute myeloid leukemia.
Waclawiczek, A; Hamilton, A; Rouault-Pierre, K; Abarrategi, A; Albornoz, MG; et al. (AMER SOC CLINICAL INVESTIGATION INC, 2020-06-01)Acute myeloid leukemia (AML) disrupts the generation of normal blood cells, predisposing patients to hemorrhage, anemia, and infections. Differentiation and proliferation of residual normal hematopoietic stem and progenitor ... -
Quizartinib-resistant FLT3-ITD acute myeloid leukemia cells are sensitive to the FLT3-Aurora kinase inhibitor CCT241736.
Moore, AS; Faisal, A; Mak, GWY; Miraki-Moud, F; Bavetsias, V; et al. (ELSEVIER, 2020-04-14)Internal tandem duplication of FLT3 (FLT3-ITD) is one of the most common somatic mutations in acute myeloid leukemia (AML); it causes constitutive activation of FLT3 kinase and is associated with high relapse rates and ... -
Repression of sphingosine kinase (SK)-interacting protein (SKIP) in acute myeloid leukemia diminishes SK activity and its re-expression restores SK function.
Ghazaly, EA; Miraki-Moud, F; Smith, P; Gnanaranjan, C; Koniali, L; et al. (AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2020-04-17)Previous studies have shown that sphingosine kinase interacting protein (SKIP) inhibits sphingosine kinase (SK) function in fibroblasts. SK phosphorylates sphingosine producing the potent signaling molecule sphingosine-1-phosphate ... -
Single cell analysis of clonal architecture in acute myeloid leukaemia.
Potter, N; Miraki-Moud, F; Ermini, L; Titley, I; Vijayaraghavan, G; et al. (NATURE PUBLISHING GROUP, 2019-05-01)We used single cell Q-PCR on a micro-fluidic platform (Fluidigm) to analyse clonal, genetic architecture and phylogeny in acute myeloid leukaemia (AML) using selected mutations. Ten cases of NPM1c mutant AML were screened ...