Browsing by author "Stratton, Michael"
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Actin-myosin-based contraction is responsible for apoptotic nuclear disintegration.
Croft, DR; Coleman, ML; Li, S; Robertson, D; Sullivan, T; et al. (2005-01)Membrane blebbing during the apoptotic execution phase results from caspase-mediated cleavage and activation of ROCK I. Here, we show that ROCK activity, myosin light chain (MLC) phosphorylation, MLC ATPase activity, and ... -
Recurrent KRAS Codon 146 mutations in human colorectal cancer
Stratton, M (2006-08)Recurrent KRAS Codon 146 mutations in human colorectal cancer An activating point mutation in codon 12 of the HRAS gene was the first somatic point mutation identified in a human cancer and established the role of somatic ... -
RNA editing of human microRNAs
Stratton, M (2006)BACKGROUND: MicroRNAs (miRNAs) are short RNAs of around 22 nucleotides that regulate gene expression. The primary transcripts of miRNAs contain double-stranded RNA and are therefore potential substrates for adenosine to ...