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    • Repurposing vandetanib plus everolimus for the treatment of ACVR1-mutant diffuse intrinsic pontine glioma. 

      Carvalho, DM; Richardson, PJ; Olaciregui, N; Stankunaite, R; Lavarino, C; Molinari, V; Corley, EA; Smith, DP; Ruddle, R; Donovan, A; Pal, A; Raynaud, FI; Temelso, S; Mackay, A; Overington, JP; Phelan, A; Sheppard, D; Mackinnon, A; Zebian, B; Al-Sarraj, S; Merve, A; Pryce, J; Grill, J; Hubank, M; Cruz, O; Morales La Madrid, A; Mueller, S; Carcaboso, AM; Carceller, F; Jones, C (2021-09-22)
      Somatic mutations in ACVR1 are found in a quarter of children with diffuse intrinsic pontine glioma (DIPG), however there are no ACVR1 inhibitors licensed for the disease. Using an Artificial Intelligence-based platform ...