Browsing by author "Smith, Myles"
Now showing items 1-13 of 13
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CT diagnosis of ilioinguinal lymph node metastases in melanoma using radiological characteristics beyond size and asymmetry.
Wilkinson, MJ; Snow, H; Downey, K; Thomas, K; Riddell, A; et al. (OXFORD UNIV PRESS, 2021-01-08)BACKGROUND: Diagnosis of lymph node (LN) metastasis in melanoma with non-invasive methods is challenging. The aim of this study was to evaluate the diagnostic accuracy of six LN characteristics on CT in detecting ... -
A Delphi consensus statement for digital surgery.
Lam, K; Abràmoff, MD; Balibrea, JM; Bishop, SM; Brady, RR; et al. (NATURE PORTFOLIO, 2022-07-19)The use of digital technology is increasing rapidly across surgical specialities, yet there is no consensus for the term 'digital surgery'. This is critical as digital health technologies present technical, governance, and ... -
Descriptive analysis of MRI functional changes occurring during reduced dose radiotherapy for myxoid liposarcomas.
Kousi, E; Messiou, C; Miah, A; Orton, M; Haas, R; et al. (BRITISH INST RADIOLOGY, 2021-10-01)OBJECTIVES: Myxoid liposarcomas (MLS) show enhanced response to radiotherapy due to their distinctive vascular pattern and therefore could be effectively treated with lower radiation doses. This is a descriptive study to ... -
Desmoid fibromatosis through the patients' eyes: time to change the focus and organisation of care?
Husson, O; Younger, E; Dunlop, A; Dean, L; Strauss, DC; et al. (SPRINGER, 2019-03-01)PURPOSE: Desmoid fibromatosis (DF) is a rare, unpredictable disease with no established, evidence-based treatments. Individual management is based on consensus algorithms. This study aimed to examine the specific health-related ... -
Development and external validation of a dynamic prognostic nomogram for primary extremity soft tissue sarcoma survivors.
Callegaro, D; Miceli, R; Bonvalot, S; Ferguson, PC; Strauss, DC; et al. (ELSEVIER, 2019-12-01)BACKGROUND: Prognostic nomograms for patients with extremity soft tissue sarcoma (eSTS) typically predict survival or the occurrence of local recurrence or distant metastasis at time of surgery. Our aim was to develop and ... -
Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies.
Arce Vargas, F; Furness, AJS; Litchfield, K; Joshi, K; Rosenthal, R; et al. (CELL PRESS, 2018-04-09)With the use of a mouse model expressing human Fc-gamma receptors (FcγRs), we demonstrated that antibodies with isotypes equivalent to ipilimumab and tremelimumab mediate intra-tumoral regulatory T (Treg) cell depletion ... -
Frailty in Very Elderly Patients is Not Associated with Adverse Surgical or Oncological Outcomes in Extremity Surgery for Soft Tissue Sarcoma.
Sivarajah, G; Davies, E; Hurley, A; Strauss, DC; Smith, MJF; et al. (SPRINGER, 2022-02-03)BACKGROUND: While surgery remains the mainstay of treatment for limb sarcoma, extreme old age is a relative contraindication to oncological surgery. METHODS: Patients >80 years referred with primary extremity soft-tissue ... -
Outcome after treatment for sebaceous carcinoma: A multicenter study.
In 't Veld, EH; Keizer, R; Post, N; Versteeg, J; Verdijk, R; et al. (WILEY, 2022-03-01)BACKGROUND: Sebaceous carcinoma (SC) is a rare malignant tumour whereby, comprehensive long-term data are scarce. This study aimed to assess the outcome of patients treated with resection for SC. METHODS: Patients treated ... -
Prostate-specific membrane antigen expression in melanoma metastases.
Snow, H; Hazell, S; Francis, N; Mohammed, K; O'Neill, S; et al. (WILEY, 2020-12-01)BACKGROUND: Prostate-specific membrane antigen (PSMA) is a prostatic epithelial protein that is used as a radiotracer (68Ga-PSMA-11) for prostate cancer staging. PSMA-PET/CT (positron emission tomography/computed tomography) ... -
Ripretinib in advanced gastrointestinal stromal tumors: an overview of current evidence and drug approval.
Goggin, C; Stansfeld, A; Mahalingam, P; Thway, K; Smith, MJ; et al. (FUTURE MEDICINE LTD, 2022-07-26)Over the past 20 years, the management of gastrointestinal stromal tumors has acted as an important model in the advancement of molecularly targeted therapies for solid tumors. The success of imatinib has established it ... -
The adequacy of tissue microarrays in the assessment of inter- and intra-tumoural heterogeneity of infiltrating lymphocyte burden in leiomyosarcoma.
Lee, ATJ; Chew, W; Wilding, CP; Guljar, N; Smith, MJ; et al. (NATURE PORTFOLIO, 2019-10-10)The characterisation and clinical relevance of tumour-infiltrating lymphocytes (TILs) in leiomyosarcoma (LMS), a subtype of soft tissue sarcoma that exhibits histological heterogeneity, is not established. The use of tissue ... -
Tumor necrosis is significantly associated with reduced recurrence-free survival after curative resection of gastrointestinal stromal tumors.
Tyler, R; Davies, E; Tan, D; Hodson, J; Taniere, P; et al. (WILEY, 2020-11-10)BACKGROUND OBJECTIVES: The impact of tumor necrosis as a prognostic factor in gastrointestinal stromal tumor (GISTs) is still debated. The objective was to determine whether tumor necrosis is an independent risk factor for ... -
Utility of Multi-Parametric Quantitative Magnetic Resonance Imaging for Characterization and Radiotherapy Response Assessment in Soft-Tissue Sarcomas and Correlation With Histopathology.
Winfield, JM; Miah, AB; Strauss, D; Thway, K; Collins, DJ; et al. (FRONTIERS MEDIA SA, 2019-04-25)Purpose: To evaluate repeatability of quantitative multi-parametric MRI in retroperitoneal sarcomas, assess parameter changes with radiotherapy, and correlate pre-operative values with histopathological findings in the ...