Now showing items 1-12 of 12

    • Cep55 promotes cytokinesis of neural progenitors but is dispensable for most mammalian cell divisions. 

      Tedeschi, A; Almagro, J; Renshaw, MJ; Messal, HA; Behrens, A; Petronczki, M (2020-04-08)
      In mammalian cell lines, the endosomal sorting complex required for transport (ESCRT)-III mediates abscission, the process that physically separates daughter cells and completes cell division. Cep55 protein is regarded as ...
    • Deficient adaptation to centrosome duplication defects in neural progenitors causes microcephaly and subcortical heterotopias. 

      González-Martínez, J; Cwetsch, AW; Martínez-Alonso, D; López-Sainz, LR; Almagro, J; Melati, A; Gómez, J; Pérez-Martínez, M; Megías, D; Boskovic, J; Gilabert-Juan, J; Graña-Castro, O; Pierani, A; Behrens, A; Ortega, S; Malumbres, M (2021-08-23)
      Congenital microcephaly (MCPH) is a neurodevelopmental disease associated with mutations in genes encoding proteins involved in centrosomal and chromosomal dynamics during mitosis. Detailed MCPH pathogenesis at the cellular ...
    • Dual-view oblique plane microscopy (dOPM). 

      Sparks, H; Dent, L; Bakal, C; Behrens, A; Salbreux, G; Dunsby, C (2020-12)
      We present a new folded dual-view oblique plane microscopy (OPM) technique termed dOPM that enables two orthogonal views of the sample to be obtained by translating a pair of tilted mirrors in refocussing space. Using a ...
    • High expression of vinculin predicts poor prognosis and distant metastasis and associates with influencing tumor-associated NK cell infiltration and epithelial-mesenchymal transition in gastric cancer. 

      Li, H; Wang, C; Lan, L; Behrens, A; Tomaschko, M; Ruiz, J; Su, Q; Zhao, G; Yuan, C; Xiao, X; Li, B; Yan, L; Wu, W; Li, W; Chen, J; He, Y; Zhang, C
      In the process of epithelial-mesenchymal transition (EMT), epithelial cancer cells transdifferentiate into mesenchymal-like cells with high motility and aggressiveness, resulting in the spread of tumor cells. Immune cells ...
    • <i>ATMIN</i> Is a Tumor Suppressor Gene in Lung Adenocarcinoma. 

      Foster, H; Ruiz, EJ; Moore, C; Stamp, GWH; Nye, EL; Li, N; Pan, Y; He, Y; Downward, J; Behrens, A (2019-10)
      Tumor cells proliferate rapidly and thus are frequently subjected to replication stress and the risk of incomplete duplication of the genome. Fragile sites are replicated late, making them more vulnerable to damage when ...
    • JunD, not c-Jun, is the AP-1 transcription factor required for Ras-induced lung cancer. 

      Ruiz, EJ; Lan, L; Diefenbacher, ME; Riising, EM; Da Costa, C; Chakraborty, A; Hoeck, JD; Spencer-Dene, B; Kelly, G; David, J-P; Nye, E; Downward, J; Behrens, A (2021-07-08)
      The AP-1 transcription factor c-Jun is required for Ras-driven tumorigenesis in many tissues and is considered as a classical proto-oncogene. To determine the requirement for c-Jun in a mouse model of K-RasG12D-induced ...
    • LUBAC determines chemotherapy resistance in squamous cell lung cancer. 

      Ruiz, EJ; Diefenbacher, ME; Nelson, JK; Sancho, R; Pucci, F; Chakraborty, A; Moreno, P; Annibaldi, A; Liccardi, G; Encheva, V; Mitter, R; Rosenfeldt, M; Snijders, AP; Meier, P; Calzado, MA; Behrens, A (2019-02)
      Lung squamous cell carcinoma (LSCC) and adenocarcinoma (LADC) are the most common lung cancer subtypes. Molecular targeted treatments have improved LADC patient survival but are largely ineffective in LSCC. The tumor ...
    • MEKK3 coordinates with FBW7 to regulate WDR62 stability and neurogenesis. 

      Xu, D; Yao, M; Wang, Y; Yuan, L; Hoeck, JD; Yu, J; Liu, L; Yeap, YYC; Zhang, W; Zhang, F; Feng, Y; Ma, T; Wang, Y; Ng, DCH; Niu, X; Su, B; Behrens, A; Xu, Z (2018-12-19)
      Mutations of WD repeat domain 62 (WDR62) lead to autosomal recessive primary microcephaly (MCPH), and down-regulation of WDR62 expression causes the loss of neural progenitor cells (NPCs). However, how WDR62 is regulated ...
    • Proteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12. 

      Khan, OM; Almagro, J; Nelson, JK; Horswell, S; Encheva, V; Keyan, KS; Clurman, BE; Snijders, AP; Behrens, A (2021-04-06)
      The tumour suppressor FBW7 is a substrate adaptor for the E3 ubiquitin ligase complex SKP1-CUL1-F-box (SCF), that targets several oncoproteins for proteasomal degradation. FBW7 is widely mutated and FBW7 protein levels are ...
    • The deubiquitinase USP9X regulates FBW7 stability and suppresses colorectal cancer. 

      Khan, OM; Carvalho, J; Spencer-Dene, B; Mitter, R; Frith, D; Snijders, AP; Wood, SA; Behrens, A (2018-04)
      The tumor suppressor FBW7 targets oncoproteins such as c-MYC for ubiquitylation and is mutated in several human cancers. We noted that in a substantial percentage of colon cancers, FBW7 protein is undetectable despite the ...
    • The deubiquitylase USP9X controls ribosomal stalling. 

      Clancy, A; Heride, C; Pinto-Fernández, A; Elcocks, H; Kallinos, A; Kayser-Bricker, KJ; Wang, W; Smith, V; Davis, S; Fessler, S; McKinnon, C; Katz, M; Hammonds, T; Jones, NP; O'Connell, J; Follows, B; Mischke, S; Caravella, JA; Ioannidis, S; Dinsmore, C; Kim, S; Behrens, A; Komander, D; Kessler, BM; Urbé, S; Clague, MJ
      When a ribosome stalls during translation, it runs the risk of collision with a trailing ribosome. Such an encounter leads to the formation of a stable di-ribosome complex, which needs to be resolved by a dedicated machinery. ...
    • Tissue curvature and apicobasal mechanical tension imbalance instruct cancer morphogenesis. 

      Messal, HA; Alt, S; Ferreira, RMM; Gribben, C; Wang, VM-Y; Cotoi, CG; Salbreux, G; Behrens, A (2019-02)
      Tubular epithelia are a basic building block of organs and a common site of cancer occurrence<sup>1-4</sup>. During tumorigenesis, transformed cells overproliferate and epithelial architecture is disrupted. However, the ...