Browsing by author "Behrens, Axel"
Now showing items 1-20 of 25
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Antibodies against endogenous retroviruses promote lung cancer immunotherapy.
Ng, KW; Boumelha, J; Enfield, KSS; Almagro, J; Cha, H; et al. (NATURE PORTFOLIO, 2023-04-20)B cells are frequently found in the margins of solid tumours as organized follicles in ectopic lymphoid organs called tertiary lymphoid structures (TLS)1,2. Although TLS have been found to correlate with improved patient ... -
Antigen retrieval and clearing for whole-organ immunofluorescence by FLASH.
Messal, HA; Almagro, J; Zaw Thin, M; Tedeschi, A; Ciccarelli, A; et al. (NATURE RESEARCH, 2020-11-27)Advances in light-sheet and confocal microscopy now allow imaging of cleared large biological tissue samples and enable the 3D appreciation of cell and protein localization in their native organ environment. However, the ... -
Are There Specific Cancer Stem Cell Markers?
Lan, L; Behrens, A (AMER ASSOC CANCER RESEARCH, 2023-01-18)The cancer stem cell (CSC) model states that heterogeneous tumor cell populations are organized in a hierarchical manner, with a small population of CSCs at the apex. These CSCs are capable of self-renewal and giving rise ... -
ATMIN Is a Tumor Suppressor Gene in Lung Adenocarcinoma.
Foster, H; Ruiz, EJ; Moore, C; Stamp, GWH; Nye, EL; et al. (AMER ASSOC CANCER RESEARCH, 2019-10-15)Tumor cells proliferate rapidly and thus are frequently subjected to replication stress and the risk of incomplete duplication of the genome. Fragile sites are replicated late, making them more vulnerable to damage when ... -
Cep55 promotes cytokinesis of neural progenitors but is dispensable for most mammalian cell divisions.
Tedeschi, A; Almagro, J; Renshaw, MJ; Messal, HA; Behrens, A; et al. (NATURE PUBLISHING GROUP, 2020-04-08)In mammalian cell lines, the endosomal sorting complex required for transport (ESCRT)-III mediates abscission, the process that physically separates daughter cells and completes cell division. Cep55 protein is regarded as ... -
Deficient adaptation to centrosome duplication defects in neural progenitors causes microcephaly and subcortical heterotopias.
González-Martínez, J; Cwetsch, AW; Martínez-Alonso, D; López-Sainz, LR; Almagro, J; et al. (AMER SOC CLINICAL INVESTIGATION INC, 2021-08-23)Congenital microcephaly (MCPH) is a neurodevelopmental disease associated with mutations in genes encoding proteins involved in centrosomal and chromosomal dynamics during mitosis. Detailed MCPH pathogenesis at the cellular ... -
Dual-view oblique plane microscopy (dOPM).
Sparks, H; Dent, L; Bakal, C; Behrens, A; Salbreux, G; et al. (OPTICAL SOC AMER, 2020-12-01)We present a new folded dual-view oblique plane microscopy (OPM) technique termed dOPM that enables two orthogonal views of the sample to be obtained by translating a pair of tilted mirrors in refocussing space. Using a ... -
Ductal Ngn3-expressing progenitors contribute to adult β cell neogenesis in the pancreas.
Gribben, C; Lambert, C; Messal, HA; Hubber, E-L; Rackham, C; et al. (CELL PRESS, 2021-11-04)Ductal cells have been proposed as a source of adult β cell neogenesis, but this has remained controversial. By combining lineage tracing, 3D imaging, and single-cell RNA sequencing (scRNA-seq) approaches, we show that ... -
High expression of vinculin predicts poor prognosis and distant metastasis and associates with influencing tumor-associated NK cell infiltration and epithelial-mesenchymal transition in gastric cancer.
Li, H; Wang, C; Lan, L; Behrens, A; Tomaschko, M; et al. (IMPACT JOURNALS LLC, 2021-02-01)In the process of epithelial-mesenchymal transition (EMT), epithelial cancer cells transdifferentiate into mesenchymal-like cells with high motility and aggressiveness, resulting in the spread of tumor cells. Immune cells ... -
An intrinsic temporal order of c-JUN N-terminal phosphorylation regulates its activity by orchestrating co-factor recruitment.
Waudby, CA; Alvarez-Teijeiro, S; Josue Ruiz, E; Suppinger, S; Pinotsis, N; et al. (Springer Science and Business Media LLC, 2022-10-17)Protein phosphorylation is a major regulatory mechanism of cellular signalling. The c-JUN proto-oncoprotein is phosphorylated at four residues within its transactivation domain (TAD) by the JNK family kinases, but the ... -
JunD, not c-Jun, is the AP-1 transcription factor required for Ras-induced lung cancer.
Ruiz, EJ; Lan, L; Diefenbacher, ME; Riising, EM; Da Costa, C; et al. (AMER SOC CLINICAL INVESTIGATION INC, 2021-07-08)The AP-1 transcription factor c-Jun is required for Ras-driven tumorigenesis in many tissues and is considered as a classical proto-oncogene. To determine the requirement for c-Jun in a mouse model of K-RasG12D-induced ... -
LUBAC determines chemotherapy resistance in squamous cell lung cancer.
Ruiz, EJ; Diefenbacher, ME; Nelson, JK; Sancho, R; Pucci, F; et al. (ROCKEFELLER UNIV PRESS, 2019-02-04)Lung squamous cell carcinoma (LSCC) and adenocarcinoma (LADC) are the most common lung cancer subtypes. Molecular targeted treatments have improved LADC patient survival but are largely ineffective in LSCC. The tumor ... -
MEKK3 coordinates with FBW7 to regulate WDR62 stability and neurogenesis.
Xu, D; Yao, M; Wang, Y; Yuan, L; Hoeck, JD; et al. (PUBLIC LIBRARY SCIENCE, 2018-12-01)Mutations of WD repeat domain 62 (WDR62) lead to autosomal recessive primary microcephaly (MCPH), and down-regulation of WDR62 expression causes the loss of neural progenitor cells (NPCs). However, how WDR62 is regulated ... -
Micro-CT acquisition and image processing to track and characterize pulmonary nodules in mice.
Zaw Thin, M; Moore, C; Snoeks, T; Kalber, T; Downward, J; et al. (NATURE PORTFOLIO, 2022-12-09)X-ray computed tomography is a reliable technique for the detection and longitudinal monitoring of pulmonary nodules. In preclinical stages of diagnostic or therapeutic development, the miniaturized versions of the clinical ... -
PARP1 Inhibitor Combined With Oxaliplatin Efficiently Suppresses Oxaliplatin Resistance in Gastric Cancer-Derived Organoids via Homologous Recombination and the Base Excision Repair Pathway.
Li, H; Wang, C; Lan, L; Wu, W; Evans, I; et al. (FRONTIERS MEDIA SA, 2021-08-23)Oxaliplatin (OXA) resistance in the treatment of different types of cancer is an important and complex problem. The culture of tumor organoids derived from gastric cancer can help us to provide a deeper understanding of ... -
Proteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12.
Khan, OM; Almagro, J; Nelson, JK; Horswell, S; Encheva, V; et al. (NATURE RESEARCH, 2021-04-06)The tumour suppressor FBW7 is a substrate adaptor for the E3 ubiquitin ligase complex SKP1-CUL1-F-box (SCF), that targets several oncoproteins for proteasomal degradation. FBW7 is widely mutated and FBW7 protein levels are ... -
The deubiquitinase USP9X regulates FBW7 stability and suppresses colorectal cancer.
Khan, OM; Carvalho, J; Spencer-Dene, B; Mitter, R; Frith, D; et al. (AMER SOC CLINICAL INVESTIGATION INC, 2018-04-02)The tumor suppressor FBW7 targets oncoproteins such as c-MYC for ubiquitylation and is mutated in several human cancers. We noted that in a substantial percentage of colon cancers, FBW7 protein is undetectable despite the ... -
The deubiquitylase USP9X controls ribosomal stalling.
Clancy, A; Heride, C; Pinto-Fernández, A; Elcocks, H; Kallinos, A; et al. (ROCKEFELLER UNIV PRESS, 2021-03-01)When a ribosome stalls during translation, it runs the risk of collision with a trailing ribosome. Such an encounter leads to the formation of a stable di-ribosome complex, which needs to be resolved by a dedicated machinery. ... -
The Jun-dependent axon regeneration gene program: Jun promotes regeneration over plasticity.
Mason, MRJ; van Erp, S; Wolzak, K; Behrens, A; Raivich, G; et al. (OXFORD UNIV PRESS, 2022-04-22)The regeneration-associated gene (RAG) expression program is activated in injured peripheral neurons after axotomy and enables long-distance axon re-growth. Over 1000 genes are regulated, and many transcription factors are ... -
The roles of intratumour heterogeneity in the biology and treatment of pancreatic ductal adenocarcinoma.
Evan, T; Wang, VM-Y; Behrens, A (SPRINGERNATURE, 2022-10-14)Intratumour heterogeneity (ITH) has become an important focus of cancer research in recent years. ITH describes the cellular variation that enables tumour evolution, including tumour progression, metastasis and resistance ...