Are There Specific Cancer Stem Cell Markers?
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Date
2023-01-18ICR Author
Author
Lan, L
Behrens, A
Type
Journal Article
Metadata
Show full item recordAbstract
The cancer stem cell (CSC) model states that heterogeneous tumor cell populations are organized in a hierarchical manner, with a small population of CSCs at the apex. These CSCs are capable of self-renewal and giving rise to other cancer cell populations, conceptually analogous to the function of normal adult stem cells present in almost all organs. However, there has been significant controversy regarding the existence and identification of CSCs. We argue that technical differences in experimentation and CSC assays, CSC niche-dependency and plasticity, and CSC heterogeneity itself may explain some of the differences observed.
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Subject
Humans
Neoplastic Stem Cells
Neoplasms
Research team
Convergence SC Management
Language
eng
Date accepted
2022-11-10
License start date
2023-01-18
Citation
Cancer Research, 2023, 83 (2), pp. 170 - 172
Publisher
AMER ASSOC CANCER RESEARCH