Browsing by author "Tam, Yuen Bun"

Now showing items 1-5 of 5

    • Bcar1/p130Cas is essential for ventricular development and neural crest cell remodelling of the cardiac outflow tract. 

      Mahmoud, M; Evans, I; Wisniewski, L; Tam, Y; Walsh, C; et al. (OXFORD UNIV PRESS, 2022-06-29)
      AIMS: The adapter protein p130Cas, encoded by the Bcar1 gene, is a key regulator of cell movement, adhesion, and cell cycle control in diverse cell types. Bcar1 constitutive knockout mice are embryonic lethal by embryonic ...

    • Molecular profiling in desmoplastic small round cell tumours. 

      Tam, YB; Jones, RL; Huang, PH (PERGAMON-ELSEVIER SCIENCE LTD, 2023-04-01)
      Desmoplastic small round cell tumour (DSRCT) is an ultra-rare soft tissue sarcoma that is characterised by aggressive disease and dismal patient outcomes. Despite multi-modal therapy, prognosis remains poor and there are ...

    • The perplexing role of immuno-oncology drugs in osteosarcoma. 

      Smrke, A; Tam, YB; Anderson, PM; Jones, RL; Huang, PH (ELSEVIER, 2021-12-01)
      Osteosarcoma is a rare, primary tumour of bone. Curative treatment consists of multi-agent chemotherapy and complete surgical resection. Despite the use of multi-agent chemotherapy, the risk of recurrence is high. Survival ...

    • The proteomic landscape of soft tissue sarcomas. 

      Burns, J; Wilding, CP; Krasny, L; Zhu, X; Chadha, M; et al. (NATURE PORTFOLIO, 2023-06-29)
      Soft tissue sarcomas (STS) are rare and diverse mesenchymal cancers with limited treatment options. Here we undertake comprehensive proteomic profiling of tumour specimens from 321 STS patients representing 11 histological ...

    • Translational Aspects of Epithelioid Sarcoma: Current Consensus. 

      Grünewald, TGP; Postel-Vinay, S; Nakayama, RT; Berlow, NE; Bolzicco, A; et al. (AMER ASSOC CANCER RESEARCH, 2024-03-15)
      Epithelioid sarcoma (EpS) is an ultra-rare malignant soft-tissue cancer mostly affecting adolescents and young adults. EpS often exhibits an unfavorable clinical course with fatal outcome in ∼50% of cases despite aggressive ...