The perplexing role of immuno-oncology drugs in osteosarcoma.
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Date
2021-12-01Author
Smrke, A
Tam, YB
Anderson, PM
Jones, RL
Huang, PH
Type
Journal Article
Metadata
Show full item recordAbstract
Osteosarcoma is a rare, primary tumour of bone. Curative treatment consists of multi-agent chemotherapy and complete surgical resection. Despite the use of multi-agent chemotherapy, the risk of recurrence is high. Survival outcomes for patients with osteosarcoma have not changed since the 1980's. Based on biologic rationale, there has been interest in adding immunotherapies to upfront curative intent chemotherapy, including mifamurtide (a macrophage activator) and interferon. However, results to date have been disappointing. In the metastatic setting, checkpoint inhibitors alone have not proven effective. Ongoing translational work is needed to further understand which patients may benefit from immune-oncology approaches with standard cytotoxic chemotherapy.
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Research team
Molecular and Systems Oncology
Language
eng
Date accepted
2021-10-19
Citation
Journal of bone oncology, 2021, 31 pp. 100400 - ?
Publisher
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