dc.contributor.author | Smrke, A | |
dc.contributor.author | Tam, YB | |
dc.contributor.author | Anderson, PM | |
dc.contributor.author | Jones, RL | |
dc.contributor.author | Huang, PH | |
dc.date.accessioned | 2022-02-18T11:20:29Z | |
dc.date.available | 2022-02-18T11:20:29Z | |
dc.date.issued | 2021-12-01 | |
dc.identifier.citation | Journal of bone oncology, 2021, 31 pp. 100400 - ? | |
dc.identifier.issn | 2212-1366 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/5026 | |
dc.identifier.eissn | 2212-1374 | |
dc.identifier.eissn | 2212-1374 | |
dc.identifier.doi | 10.1016/j.jbo.2021.100400 | |
dc.identifier.doi | 10.1016/j.jbo.2021.100400 | |
dc.description.abstract | Osteosarcoma is a rare, primary tumour of bone. Curative treatment consists of multi-agent chemotherapy and complete surgical resection. Despite the use of multi-agent chemotherapy, the risk of recurrence is high. Survival outcomes for patients with osteosarcoma have not changed since the 1980's. Based on biologic rationale, there has been interest in adding immunotherapies to upfront curative intent chemotherapy, including mifamurtide (a macrophage activator) and interferon. However, results to date have been disappointing. In the metastatic setting, checkpoint inhibitors alone have not proven effective. Ongoing translational work is needed to further understand which patients may benefit from immune-oncology approaches with standard cytotoxic chemotherapy. | |
dc.format | Electronic-eCollection | |
dc.format.extent | 100400 - ? | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | ELSEVIER | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.title | The perplexing role of immuno-oncology drugs in osteosarcoma. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2021-10-19 | |
rioxxterms.version | VoR | |
rioxxterms.versionofrecord | 10.1016/j.jbo.2021.100400 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.relation.isPartOf | Journal of bone oncology | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Molecular and Systems Oncology | |
pubs.organisational-group | /ICR/Students | |
pubs.organisational-group | /ICR/Students/PhD and MPhil | |
pubs.organisational-group | /ICR/Students/PhD and MPhil/20/21 Starting Cohort | |
pubs.publication-status | Published | |
pubs.volume | 31 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Molecular and Systems Oncology | |
dc.contributor.icrauthor | Tam, Yuen Bun | |
dc.contributor.icrauthor | Huang, Paul | |