Browsing by author "Gabbutt, Calum"

Now showing items 1-3 of 3

    • Crypt fusion as a homeostatic mechanism in the human colon. 

      Baker, A-M; Gabbutt, C; Williams, MJ; Cereser, B; Jawad, N; et al. (BMJ PUBLISHING GROUP, 2019-11-01)
      OBJECTIVE: The crypt population in the human intestine is dynamic: crypts can divide to produce two new daughter crypts through a process termed crypt fission, but whether this is balanced by a second process to remove ...

    • Lineage tracing in human tissues. 

      Gabbutt, C; Wright, NA; Baker, A-M; Shibata, D; Graham, TA (WILEY, 2022-05-05)
      The dynamical process of cell division that underpins homeostasis in the human body cannot be directly observed in vivo, but instead is measurable from the pattern of somatic genetic or epigenetic mutations that accrue in ...

    • Phenotypic plasticity and genetic control in colorectal cancer evolution. 

      Househam, J; Heide, T; Cresswell, GD; Spiteri, I; Kimberley, C; et al. (NATURE PORTFOLIO, 2022-11-24)
      Genetic and epigenetic variation, together with transcriptional plasticity, contribute to intratumour heterogeneity1. The interplay of these biological processes and their respective contributions to tumour evolution remain ...