Browsing by author "Mitsopoulos, Konstantinos"

Now showing items 1-9 of 9

    • canSAR: an updated cancer research and drug discovery knowledgebase. 

      Tym, JE; Mitsopoulos, C; Coker, EA; Razaz, P; Schierz, AC; et al. (OXFORD UNIV PRESS, 2016-01-04)
      canSAR (http://cansar.icr.ac.uk) is a publicly available, multidisciplinary, cancer-focused knowledgebase developed to support cancer translational research and drug discovery. canSAR integrates genomic, protein, ...

    • canSAR: update to the cancer translational research and drug discovery knowledgebase. 

      Mitsopoulos, C; Di Micco, P; Fernandez, EV; Dolciami, D; Holt, E; et al. (OXFORD UNIV PRESS, 2021-01-08)
      canSAR (http://cansar.icr.ac.uk) is the largest, public, freely available, integrative translational research and drug discovery knowledgebase for oncology. canSAR integrates vast multidisciplinary data from across genomic, ...

    • canSAR: update to the cancer translational research and drug discovery knowledgebase. 

      Coker, EA; Mitsopoulos, C; Tym, JE; Komianou, A; Kannas, C; et al. (OXFORD UNIV PRESS, 2019-01-08)
      canSAR (http://cansar.icr.ac.uk) is a public, freely available, integrative translational research and drug discovery knowlegebase. canSAR informs researchers to help solve key bottlenecks in cancer translation and drug ...

    • canSAR: update to the cancer translational research and drug discovery knowledgebase. 

      di Micco, P; Antolin, AA; Mitsopoulos, C; Villasclaras-Fernandez, E; Sanfelice, D; et al. (OXFORD UNIV PRESS, 2023-01-06)
      canSAR (https://cansar.ai) is the largest public cancer drug discovery and translational research knowledgebase. Now hosted in its new home at MD Anderson Cancer Center, canSAR integrates billions of experimental measurements ...

    • Characterization of the genomic features and expressed fusion genes in micropapillary carcinomas of the breast. 

      Natrajan, R; Wilkerson, PM; Marchiò, C; Piscuoglio, S; Ng, CKY; et al. (WILEY, 2014-04-01)
      Micropapillary carcinoma (MPC) is a rare histological special type of breast cancer, characterized by an aggressive clinical behaviour and a pattern of copy number aberrations (CNAs) distinct from that of grade- and oestrogen ...

    • Distinctive Behaviors of Druggable Proteins in Cellular Networks. 

      Mitsopoulos, C; Schierz, AC; Workman, P; Al-Lazikani, B (PUBLIC LIBRARY SCIENCE, 2015-12-23)
      The interaction environment of a protein in a cellular network is important in defining the role that the protein plays in the system as a whole, and thus its potential suitability as a drug target. Despite the importance ...

    • iTAG an optimized IMiD-induced degron for targeted protein degradation in human and murine cells. 

      Bouguenina, H; Nicolaou, S; Le Bihan, Y-V; Bowling, EA; Calderon, C; et al. (CELL PRESS, 2023-07-21)
      To address the limitation associated with degron based systems, we have developed iTAG, a synthetic tag based on IMiDs/CELMoDs mechanism of action that improves and addresses the limitations of both PROTAC and previous ...

    • MoKCa database--mutations of kinases in cancer. 

      Richardson, CJ; Gao, Q; Mitsopoulous, C; Zvelebil, M; Pearl, LH; et al. (OXFORD UNIV PRESS, 2009-01-01)
      Members of the protein kinase family are amongst the most commonly mutated genes in human cancer, and both mutated and activated protein kinases have proved to be tractable targets for the development of new anticancer ...

    • SiGNet: A signaling network data simulator to enable signaling network inference. 

      Coker, EA; Mitsopoulos, C; Workman, P; Al-Lazikani, B (PUBLIC LIBRARY SCIENCE, 2017-05-17)
      Network models are widely used to describe complex signaling systems. Cellular wiring varies in different cellular contexts and numerous inference techniques have been developed to infer the structure of a network from ...