canSAR: update to the cancer translational research and drug discovery knowledgebase.
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Date
2019-01-08Author
Coker, EA
Mitsopoulos, C
Tym, JE
Komianou, A
Kannas, C
Di Micco, P
Villasclaras Fernandez, E
Ozer, B
Antolin, AA
Workman, P
Al-Lazikani, B
Type
Journal Article
Metadata
Show full item recordAbstract
canSAR (http://cansar.icr.ac.uk) is a public, freely available, integrative translational research and drug discovery knowlegebase. canSAR informs researchers to help solve key bottlenecks in cancer translation and drug discovery. It integrates genomic, protein, pharmacological, drug and chemical data with structural biology, protein networks and unique, comprehensive and orthogonal 'druggability' assessments. canSAR is widely used internationally by academia and industry. Here we describe major enhancements to canSAR including new and expanded data. We also describe the first components of canSARblack-an advanced, responsive, multi-device compatible redesign of canSAR with a question-led interface.
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Subject
Humans
Neoplasms
Antineoplastic Agents
Protein Interaction Mapping
Protein Conformation
User-Computer Interface
Knowledge Bases
Drug Discovery
Translational Medical Research
Databases, Pharmaceutical
Research team
Computational Biology and Chemogenomics
Language
eng
Date accepted
2018-11-26
License start date
2019-01
Citation
Nucleic acids research, 2019, 47 (D1), pp. D917 - D922
Publisher
OXFORD UNIV PRESS