Browsing by author "Hubank, Michael"
Now showing items 1-13 of 13
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A genomic atlas of human adrenal and gonad development.
Del Valle, I; Buonocore, F; Duncan, AJ; Lin, L; Barenco, M; et al. (2017-04-07)Background In humans, the adrenal glands and gonads undergo distinct biological events between 6-10 weeks post conception (wpc), such as testis determination, the onset of steroidogenesis and primordial germ cell development. ... -
Clinical outcomes of COVID-19 in long-term care facilities for people with epilepsy.
Balestrini, S; Koepp, MJ; Gandhi, S; Rickman, HM; Shin, GY; et al.In this cohort study, we aim to compare outcomes from coronavirus disease 2019 (COVID-19) in people with severe epilepsy and other co-morbidities living in long-term care facilities which all implemented early preventative ... -
Deep sequencing reveals persistence of cell-associated mumps vaccine virus in chronic encephalitis.
Morfopoulou, S; Mee, ET; Connaughton, SM; Brown, JR; Gilmour, K; et al. (2017-01)Routine childhood vaccination against measles, mumps and rubella has virtually abolished virus-related morbidity and mortality. Notwithstanding this, we describe here devastating neurological complications associated with ... -
DNA methylation-based classification of glioneuronal tumours synergises with histology and radiology to refine accurate molecular stratification.
Stone, TJ; Mankad, K; Tan, AP; Jan, W; Pickles, JC; et al. (WILEY, 2023-04-01)AIMS: Glioneuronal tumours (GNTs) are poorly distinguished by their histology and lack robust diagnostic indicators. Previously, we showed that common GNTs comprise two molecularly distinct groups, correlating poorly with ... -
Eye on the B-ALL: B-cell receptor repertoires reveal persistence of numerous B-lymphoblastic leukemia subclones from diagnosis to relapse.
Bashford-Rogers, RJM; Nicolaou, KA; Bartram, J; Goulden, NJ; Loizou, L; et al. (2016-12)The strongest predictor of relapse in B-cell acute lymphoblastic leukemia (B-ALL) is the level of persistence of tumor cells after initial therapy. The high mutation rate of the B-cell receptor (BCR) locus allows high-resolution ... -
High throughput sequencing in acute lymphoblastic leukemia reveals clonal architecture of central nervous system and bone marrow compartments.
Bartram, J; Goulden, N; Wright, G; Adams, S; Brooks, T; et al. (2018-03) -
Human Coronavirus OC43 Associated with Fatal Encephalitis.
Morfopoulou, S; Brown, JR; Davies, EG; Anderson, G; Virasami, A; et al. (2016-08) -
Identification of a novel genetic locus associated with immune mediated thrombotic thrombocytopenic purpura.
Stubbs, MJ; Coppo, P; Cheshire, C; Veyradier, A; Dufek, S; et al. (2021-02-18)Not available. -
Isolation and Comparative Transcriptome Analysis of Human Fetal and iPSC-Derived Cone Photoreceptor Cells.
Welby, E; Lakowski, J; Di Foggia, V; Budinger, D; Gonzalez-Cordero, A; et al. (2017-12)Loss of cone photoreceptors, crucial for daylight vision, has the greatest impact on sight in retinal degeneration. Transplantation of stem cell-derived L/M-opsin cones, which form 90% of the human cone population, could ... -
Lineage-Independent Tumors in Bilateral Neuroblastoma.
Coorens, THH; Farndon, SJ; Mitchell, TJ; Jain, N; Lee, S; et al. (2020-11)Childhood tumors that occur synchronously in different anatomical sites usually represent metastatic disease. However, such tumors can be independent neoplasms. We investigated whether cases of bilateral neuroblastoma ... -
Recurrent FOSL1 rearrangements in desmoplastic fibroblastoma.
De Noon, S; Piggott, R; Trotman, J; Tadross, JA; Fittall, M; et al. (WILEY, 2023-02-01)The FOS gene family has been implicated in tumourigenesis across several tumour types, particularly mesenchymal tumours. The rare fibrous tumour desmoplastic fibroblastoma is characterised by overexpression of FOSL1. ... -
Targeting acute myeloid leukemia by drug-induced c-MYB degradation.
Walf-Vorderwülbecke, V; Pearce, K; Brooks, T; Hubank, M; van den Heuvel-Eibrink, MM; et al. (2018-04)Despite advances in our understanding of the molecular basis for particular subtypes of acute myeloid leukemia (AML), effective therapy remains a challenge for many individuals suffering from this disease. A significant ... -
Telomere elongation through hTERT immortalization leads to chromosome repositioning in control cells and genomic instability in Hutchinson-Gilford progeria syndrome fibroblasts, expressing a novel SUN1 isoform.
Bikkul, MU; Faragher, RGA; Worthington, G; Meinke, P; Kerr, ARW; et al. (2019-06)Immortalizing primary cells with human telomerase reverse transcriptase (hTERT) has been common practice to enable primary cells to be of extended use in the laboratory because they avoid replicative senescence. Studying ...