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Now showing items 41-60 of 5449
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Congenital alveolar rhabdomyosarcoma - Clinical and molecular distinction from alveolar rhabdomyosarcoma in older children
(2001-02-01)BACKGROUND, Congenital alveolar rhabdomyosarcoma (RMS) is extremely rare and invariably fatal with current therapy. Its clinical presentation is unusual and is distinct from RMS in older children, with > 50% of patients ... -
Genotoxins and the initiation of sporadic breast cancer
(2001-03)Breast cancer is the most frequently diagnosed female malignancy world-wide. The aetiology of the majority of cases remains obscure and the only genotoxin as yet known to initiate breast cancer is ionizing radiation, High ... -
Quantifying effects of lead shielding in electron beams: a Monte Carlo study
(IOP PUBLISHING LTD, 2001-03)Lead shielding in contact with the patient’s skin is often encountered in radiotherapy with electron beams. The influence of the lead shielding on dose distributions in the patient cannot fully be assessed using modern ... -
Mortality and cancer incidence in persons with numerical sex chromosome abnormalities: a cohort study.
(2001-03)Mortality and cancer incidence were assessed in a cohort of 1373 patients with numerical sex chromosome abnormalities diagnosed at three cytogenetics centres in Britain during 1959-90, and were compared with expectations ... -
Mortality and cancer incidence in persons with Down's syndrome, their parents and siblings.
(2001-03)A cohort study of 1425 persons with Down's syndrome (DS), and of their parents (447 mothers, 435 fathers) and siblings (1176), was set up to investigate death rates from various causes and cancer incidence patterns. In ... -
Functional phosphorylation sites in the C-terminal region of the multivalent multifunctional transcriptional factor CTCF
(2001-03)CTCF is a widely expressed and highly conserved multi-Zn-finger (ZF) nuclear factor. Binding to various CTCF target sites (CTSs) is mediated by combinatorial contributions of different ZFs. Different CTSs mediate distinct ... -
Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity
(2001-03-01)A novel sequence-selective pyrrolobenzodiazepine (PBD) dimer 5 (SJG-136) has been developed that comprises two C2-exo-methylene-substituted DC-81 (3) subunits tethered through their C8 positions via an inert propanedioxy ... -
Germline mutations in BRCA1 and BRCA2 in breast-ovarian families from a breast cancer risk evaluation clinic
(2001-04)Germline mutations in BRCA1 and BRCA2 in breast-ovarian families from a breast cancer risk evaluation clinic. Purpose: Data from the Breast Cancer Linkage Consortium suggest that the proportion of familial breast and ovarian ... -
Experimental p(wall) and p(cel) correction factors for ionization chambers in low-energy clinical proton bearras
(IOP PUBLISHING LTD, 2001-04)Current dosimetry protocols for clinical protons using ionization chambers do not take into account ionization chamber-dependent perturbation correction factors. In the present investigation, the relative response of 17 ... -
Analysis of R-Ras signalling pathways
(2001-04)Analysis of R-Ras signalling pathways. R-Ras has a high degree of sequence homology to Ras and to other members of the Ras subfamily including Rap, TC21 and ill- Ras. Activated versions of Ras and TC21 are highly transforming ... -
Impact of dose-distribution uncertainties on rectal ntcp modeling II: Uncertainty implications
(AMER INST PHYSICS, 2001-04)A trial of nonescalated conformal versus conventional radiotherapy treatment of prostate cancer has been carried out at the Royal Marsden NHS Trust (RMH) and Institute of Cancer Research (ICR), demonstrating a significant ... -
Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I
(MACMILLAN PUBLISHERS LTD, 2001-04)The execution phase of apoptosis is characterized by marked changes in cell morphology that include contraction and membrane blebbing. The actin-myosin system has been proposed to be the source of contractile force that ... -
t(2;5) associated with a histiocytic-monocytic neoplasm
(2001-04)We describe a patient with a neoplasm derived from the histiocytic-monocytic lineage associated with t(2:5) detected by FISH. The patient presented with bone marrow involvement, no organomegaly and subsequently developed ... -
Structure-based design of selective and potent G quadruplex-mediated telomerase inhibitors
(2001-04-24)The telomerase enzyme is a potential therapeutic target in many human cancers. A series of potent inhibitors has been designed by computer modeling, which exploit the unique structural features of quadruplex DNA, These ... -
Real time fluorescence imaging of PLC gamma translocation and its interaction with the epidermal growth factor receptor
(2001-04-30)The translocation of fluorescently tagged PLC gamma and requirements for this process in cells stimulated with EGF were analyzed using real time fluorescence microscopy applied for the first time to monitor growth factor ... -
Polycythemia vera: analysis of DNA from blood granulocytes using comparative genomic hybridization
(2001-05)Polycythemia vera: analysis of DNA from blood granulocytes using comparative genomic hybridization. Background and Objectives. The diagnosis of polycythemia vera (PV) is supported by the finding of an abnormal karyotype ... -
Up-regulation of WNT-4 signaling and dosage-sensitive sex reversal in humans.
(2001-05)Wnt-4, a member of the Wnt family of locally acting secreted growth factors, is the first signaling molecule shown to influence the sex-determination cascade. In mice, a targeted deletion of Wnt-4 causes the masculinization ... -
Stabilisation of TG-and AG-containing antiparrallel DNA triplexes by triplex-binding ligands
(2001-05-01)Stabilisation of TG-and AG-containing antiparrallel DNA triplexes by triplex-binding ligands. We have used DNase I footprinting to examine the interaction of several tripler-binding ligands with antiparallel TG- and AG- ... -
Modulation of both endogenous folates and thymidine enhance the therapeutic efficacy of thymidylate synthase inhibitors
(AMER ASSOC CANCER RESEARCH, 2001-05-01)Plasma levels of folates and thymidine in mice are about 10-fold higher than in humans and may influence the therapeutic efficacy of thymidylate synthase (TS) Inhibitors, such as 5-fluorouracil (5FU) and the antifolates ... -
Cancer epidemiology in the last century and the next decade
(MACMILLAN PUBLISHERS LTD, 2001-05-17)By the early 1980s, epidemiologists had identified many important causes of cancer. They had also proposed the ‘multi-stage’ model of cancer, although none of the hypothesized events in human carcinogenesis had then been ...
