Signalling pathways implicated in early mammary gland morphogenesis and breast cancer.
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Date
2006-08-01ICR Author
Author
Howard, B
Ashworth, A
Type
Journal Article
Metadata
Show full item recordAbstract
Specification of mammary epithelial cell fate occurs during embryogenesis as cells aggregate to form the mammary anlage. Within the embryonic mammary bud, a population of epithelial cells exists that will subsequently proliferate to form a ductal tree filling the stromal compartment, and which can produce milk upon terminal differentiation after birth. Subsequently, these structures can be remodelled and returned to a basal state after weaning before regenerating in future pregnancies. The plasticity of the mammary epithelial cell, and its responsiveness to hormone receptors, facilitates this amazing biological feat, but aberrant signalling may also result in unintended consequences in the form of frequent malignancies. Reflecting this intimate connection, a considerable number of signalling pathways have been implicated in both mammary gland morphogenesis and carcinogenesis.
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Subject
Breast
Mammary Glands, Animal
Epithelial Cells
Stem Cells
Mesoderm
Animals
Humans
Mice
Breast Neoplasms
Mammary Neoplasms, Animal
Neuregulins
Intracellular Signaling Peptides and Proteins
T-Box Domain Proteins
Signal Transduction
Morphogenesis
Wnt Proteins
Fibroblast Growth Factor 10
Ectodysplasins
Research team
Endocrine control mechanisms
Gene Function
Language
eng
License start date
2006-08
Citation
PLoS genetics, 2006, 2 (8), pp. e112 - ?
Publisher
PUBLIC LIBRARY SCIENCE