dc.contributor.author | Howard, B | |
dc.contributor.author | Ashworth, A | |
dc.date.accessioned | 2018-06-11T11:45:27Z | |
dc.date.issued | 2006-08-01 | |
dc.identifier.citation | PLoS genetics, 2006, 2 (8), pp. e112 - ? | |
dc.identifier.issn | 1553-7390 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/1815 | |
dc.identifier.eissn | 1553-7404 | |
dc.identifier.doi | 10.1371/journal.pgen.0020112 | |
dc.description.abstract | Specification of mammary epithelial cell fate occurs during embryogenesis as cells aggregate to form the mammary anlage. Within the embryonic mammary bud, a population of epithelial cells exists that will subsequently proliferate to form a ductal tree filling the stromal compartment, and which can produce milk upon terminal differentiation after birth. Subsequently, these structures can be remodelled and returned to a basal state after weaning before regenerating in future pregnancies. The plasticity of the mammary epithelial cell, and its responsiveness to hormone receptors, facilitates this amazing biological feat, but aberrant signalling may also result in unintended consequences in the form of frequent malignancies. Reflecting this intimate connection, a considerable number of signalling pathways have been implicated in both mammary gland morphogenesis and carcinogenesis. | |
dc.format | Print | |
dc.format.extent | e112 - ? | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | PUBLIC LIBRARY SCIENCE | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject | Breast | |
dc.subject | Mammary Glands, Animal | |
dc.subject | Epithelial Cells | |
dc.subject | Stem Cells | |
dc.subject | Mesoderm | |
dc.subject | Animals | |
dc.subject | Humans | |
dc.subject | Mice | |
dc.subject | Breast Neoplasms | |
dc.subject | Mammary Neoplasms, Animal | |
dc.subject | Neuregulins | |
dc.subject | Intracellular Signaling Peptides and Proteins | |
dc.subject | T-Box Domain Proteins | |
dc.subject | Signal Transduction | |
dc.subject | Morphogenesis | |
dc.subject | Wnt Proteins | |
dc.subject | Fibroblast Growth Factor 10 | |
dc.subject | Ectodysplasins | |
dc.title | Signalling pathways implicated in early mammary gland morphogenesis and breast cancer. | |
dc.type | Journal Article | |
rioxxterms.versionofrecord | 10.1371/journal.pgen.0020112 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2006-08 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | PLoS genetics | |
pubs.issue | 8 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Endocrine control mechanisms | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Gene Function | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Gene Function | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Endocrine control mechanisms | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Gene Function | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Gene Function | |
pubs.publication-status | Published | |
pubs.volume | 2 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Endocrine control mechanisms | |
icr.researchteam | Gene Function | |
dc.contributor.icrauthor | Howard, Beatrice | |