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dc.contributor.authorSzucs, Z
dc.contributor.authorThway, K
dc.contributor.authorFisher, C
dc.contributor.authorBulusu, R
dc.contributor.authorConstantinidou, A
dc.contributor.authorBenson, C
dc.contributor.authorvan der Graaf, WT
dc.contributor.authorJones, RL
dc.date.accessioned2016-09-28T11:26:21Z
dc.date.issued2017-01
dc.identifier.citationFuture oncology (London, England), 2017, 13 (2), pp. 185 - 194
dc.identifier.issn1479-6694
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/133
dc.identifier.eissn1744-8301
dc.identifier.doi10.2217/fon-2016-0194
dc.description.abstractPrimary and secondary resistance to currently available licensed tyrosine kinase inhibitors poses a real clinical challenge in the management of advanced gastrointestinal stromal tumors. Within the frame of early phase clinical trials novel systemic treatments are currently being evaluated to target both the well explored and novel emerging downstream effectors of KIT and PDGFRA signaling. Alternative therapeutic approaches also include exploring novel inhibitors of the KIT/PDGFRA receptors, immune checkpoint and cyclin-dependent kinase inhibitors. The final clinical trial outcome data for these agents are highly anticipated. Integration of new diagnostic techniques into routine clinical practice can potentially guide tailored delivery of agents in the treatment of a highly polyclonal, heterogeneous disease such as heavily pretreated advanced gastrointestinal stromal tumor.
dc.formatPrint-Electronic
dc.format.extent185 - 194
dc.languageeng
dc.language.isoeng
dc.subjectHumans
dc.subjectGastrointestinal Stromal Tumors
dc.subjectReceptor, Platelet-Derived Growth Factor alpha
dc.subjectDNA-Binding Proteins
dc.subjectTranscription Factors
dc.subjectAntineoplastic Agents
dc.subjectProtein Kinase Inhibitors
dc.subjectSignal Transduction
dc.subjectMutation
dc.subjectDisease Management
dc.subjectProto-Oncogene Proteins c-kit
dc.subjectImmunomodulation
dc.subjectMolecular Targeted Therapy
dc.titlePromising novel therapeutic approaches in the management of gastrointestinal stromal tumors.
dc.typeJournal Article
rioxxterms.versionofrecord10.2217/fon-2016-0194
rioxxterms.licenseref.startdate2017-01
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfFuture oncology (London, England)
pubs.issue2
pubs.notesNo embargo
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Clinical and Translational Sarcoma
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Sarcoma Clinical Trials (R Jones)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Sarcoma Clinical Trials (R Jones)/Sarcoma Clinical Trials (R Jones) (hon.)
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Clinical and Translational Sarcoma
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Sarcoma Clinical Trials (R Jones)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Sarcoma Clinical Trials (R Jones)/Sarcoma Clinical Trials (R Jones) (hon.)
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.publication-statusPublished
pubs.volume13
pubs.embargo.termsNo embargo
icr.researchteamClinical and Translational Sarcomaen_US
icr.researchteamSarcoma Clinical Trials (R Jones)en_US
dc.contributor.icrauthorFisher, Cyril
dc.contributor.icrauthorThway, Khin
dc.contributor.icrauthorJones, Robin
dc.contributor.icrauthorvan der Graaf, Wilhelmina
dc.contributor.icrauthorMarsden,


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