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dc.contributor.authorPerez-Lopez, Ren_US
dc.contributor.authorNava Rodrigues, Den_US
dc.contributor.authorFigueiredo, Ien_US
dc.contributor.authorMateo, Jen_US
dc.contributor.authorCollins, DJen_US
dc.contributor.authorKoh, D-Men_US
dc.contributor.authorde Bono, JSen_US
dc.contributor.authorTunariu, Nen_US
dc.coverage.spatialUnited Statesen_US
dc.date.accessioned2018-06-27T10:00:20Z
dc.date.issued2018-02en_US
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/28906339en_US
dc.identifier.citationInvest Radiol, 2018, 53 (2), pp. 96 - 102en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1947
dc.identifier.eissn1536-0210en_US
dc.identifier.doi10.1097/RLI.0000000000000415en_US
dc.description.abstractOBJECTIVES: The aim of this study was to correlate magnetic resonance imaging (MRI) of castration-resistant prostate cancer (CRPC) bone metastases with histological and molecular features of bone metastases. MATERIALS AND METHODS: Forty-three bone marrow biopsies from 33 metastatic CRPC (mCRPC) patients with multiparametric MRI and documented bone metastases were evaluated. A second cohort included 10 CRPC patients with no bone metastases. Associations of apparent diffusion coefficient (ADC), normalized b900 diffusion-weighted imaging (nDWI) signal, and signal-weighted fat fraction (swFF) with bone marrow biopsy histological parameters were evaluated using Mann-Whitney U test and Spearman correlations. Univariate and multivariate logistic regression models were analyzed. RESULTS: Median ADC and nDWI signal was significantly higher, and median swFF was significantly lower, in bone metastases than nonmetastatic bone (P < 0.001). In the metastatic cohort, 31 (72.1%) of 43 biopsies had detectable cancer cells. Median ADC and swFF were significantly lower and median nDWI signal was significantly higher in biopsies with tumor cells versus nondetectable tumor cells (898 × 10 mm/s vs 1617 × 10 mm/s; 11.5% vs 62%; 5.3 vs 2.3, respectively; P < 0.001). Tumor cellularity inversely correlated with ADC and swFF, and positively correlated with nDWI signal (P < 0.001). In serial biopsies, taken before and after treatment, changes in multiparametric MRI parameters paralleled histological changes. CONCLUSIONS: Multiparametric MRI provides valuable information about mCRPC bone metastases. These data further clinically qualify DWI as a response biomarker in mCRPC.en_US
dc.format.extent96 - 102en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.subjectAgeden_US
dc.subjectAged, 80 and overen_US
dc.subjectBiopsyen_US
dc.subjectBone Neoplasmsen_US
dc.subjectCohort Studiesen_US
dc.subjectHumansen_US
dc.subjectMagnetic Resonance Imagingen_US
dc.subjectMaleen_US
dc.subjectMiddle Ageden_US
dc.subjectProstatic Neoplasmsen_US
dc.subjectRetrospective Studiesen_US
dc.titleMultiparametric Magnetic Resonance Imaging of Prostate Cancer Bone Disease: Correlation With Bone Biopsy Histological and Molecular Features.en_US
dc.typeJournal Article
rioxxterms.versionofrecord10.1097/RLI.0000000000000415en_US
rioxxterms.licenseref.startdate2018-02en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfInvest Radiolen_US
pubs.issue2en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Prostate Cancer Targeted Therapy Group
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.publication-statusPublisheden_US
pubs.volume53en_US
pubs.embargo.termsNot knownen_US
icr.researchteamProstate Cancer Targeted Therapy Groupen_US
dc.contributor.icrauthorKoh, Dow-Muen_US
dc.contributor.icrauthorDe Bono, Johannen_US
dc.contributor.icrauthorTunariu, Ninaen_US
dc.contributor.icrauthorNava Rodrigues, Danielen_US
dc.contributor.icrauthorMateo Valderrama, Joaquinen_US


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