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dc.contributor.authorTaylor, AI
dc.contributor.authorBeuron, F
dc.contributor.authorPeak-Chew, S-Y
dc.contributor.authorMorris, EP
dc.contributor.authorHerdewijn, P
dc.contributor.authorHolliger, P
dc.date.accessioned2016-11-24T10:54:26Z
dc.date.issued2016-06-16
dc.identifier.citationChembiochem : a European journal of chemical biology, 2016, 17 (12), pp. 1107 - 1110
dc.identifier.issn1439-4227
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/275
dc.identifier.eissn1439-7633
dc.identifier.doi10.1002/cbic.201600136
dc.description.abstractNanoscale objects of increasing complexity can be constructed from DNA or RNA. However, the scope of potential applications could be enhanced by expanding beyond the moderate chemical diversity of natural nucleic acids. Here, we explore the construction of nano-objects made entirely from alternative building blocks: synthetic genetic polymers not found in nature, also called xeno nucleic acids (XNAs). Specifically, we describe assembly of 70 kDa tetrahedra elaborated in four different XNA chemistries (2'-fluro-2'-deoxy-ribofuranose nucleic acid (2'F-RNA), 2'-fluoroarabino nucleic acids (FANA), hexitol nucleic acids (HNA), and cyclohexene nucleic acids (CeNA)), as well as mixed designs, and a ∼600 kDa all-FANA octahedron, visualised by electron microscopy. Our results extend the chemical scope for programmable nanostructure assembly, with implications for the design of nano-objects and materials with an expanded range of structural and physicochemical properties, including enhanced biostability.
dc.formatPrint-Electronic
dc.format.extent1107 - 1110
dc.languageeng
dc.language.isoeng
dc.publisherWILEY-V C H VERLAG GMBH
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectPolymers
dc.subjectNucleic Acids
dc.subjectMicroscopy, Electron, Transmission
dc.subjectElectrophoretic Mobility Shift Assay
dc.subjectNanostructures
dc.titleNanostructures from Synthetic Genetic Polymers.
dc.typeJournal Article
rioxxterms.versionofrecord10.1002/cbic.201600136
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2016-06
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfChembiochem : a European journal of chemical biology
pubs.issue12
pubs.notesNo embargo
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Structural Biology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Structural Biology/Structural Electron Microscopy
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Structural Biology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Structural Biology/Structural Electron Microscopy
pubs.publication-statusPublished
pubs.volume17
pubs.embargo.termsNo embargo
icr.researchteamStructural Electron Microscopy
dc.contributor.icrauthorBeuron, Fabienne
dc.contributor.icrauthorMorris, Edward


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