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dc.contributor.authorKrol, Ien_US
dc.contributor.authorCastro-Giner, Fen_US
dc.contributor.authorMaurer, Men_US
dc.contributor.authorGkountela, Sen_US
dc.contributor.authorSzczerba, BMen_US
dc.contributor.authorScherrer, Ren_US
dc.contributor.authorColeman, Nen_US
dc.contributor.authorCarreira, Sen_US
dc.contributor.authorBachmann, Fen_US
dc.contributor.authorAnderson, Sen_US
dc.contributor.authorEngelhardt, Men_US
dc.contributor.authorLane, Hen_US
dc.contributor.authorEvans, TRJen_US
dc.contributor.authorPlummer, Ren_US
dc.contributor.authorKristeleit, Ren_US
dc.contributor.authorLopez, Jen_US
dc.contributor.authorAceto, Nen_US
dc.coverage.spatialEnglanden_US
dc.date.accessioned2018-11-14T09:45:05Z
dc.date.issued2018-08en_US
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/30065256en_US
dc.identifier10.1038/s41416-018-0186-7en_US
dc.identifier.citationBr J Cancer, 2018, 119 (4), pp. 487 - 491en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2931
dc.identifier.eissn1532-1827en_US
dc.identifier.doi10.1038/s41416-018-0186-7en_US
dc.description.abstractHuman glioblastoma (GBM) is a highly aggressive, invasive and hypervascularised malignant brain cancer. Individual circulating tumour cells (CTCs) are sporadically found in GBM patients, yet it is unclear whether multicellular CTC clusters are generated in this disease and whether they can bypass the physical hurdle of the blood-brain barrier.  Here, we assessed CTC presence and composition at multiple time points in 13 patients with progressing GBM during an open-label phase 1/2a study with the microtubule inhibitor BAL101553. We observe CTC clusters ranging from 2 to 23 cells and present at multiple sampling time points in a GBM patient with pleomorphism and extensive necrosis, throughout disease progression. Exome sequencing of GBM CTC clusters highlights variants in 58 cancer-associated genes including ATM, PMS2, POLE, APC, XPO1, TFRC, JAK2, ERBB4 and ALK. Together, our findings represent the first evidence of the presence of CTC clusters in GBM.en_US
dc.format.extent487 - 491en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.titleDetection of circulating tumour cell clusters in human glioblastoma.en_US
dc.typeJournal Article
dcterms.dateAccepted2018-06-25en_US
rioxxterms.versionofrecord10.1038/s41416-018-0186-7en_US
rioxxterms.licenseref.startdate2018-08en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfBr J Canceren_US
pubs.issue4en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Therapeutics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Therapeutics/Cancer Biomarkers
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Therapeutics/Medicine (de Bono Prostate)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Cancer Biomarkers
pubs.publication-statusPublisheden_US
pubs.volume119en_US
pubs.embargo.termsNot knownen_US
icr.researchteamMedicine (de Bono Prostate)en_US
icr.researchteamCancer Biomarkersen_US
dc.contributor.icrauthorCarreira, Suzanneen_US
dc.contributor.icrauthorLopez, Juanitaen_US


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Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/