dc.contributor.author | Meyers, J | |
dc.contributor.author | Chessum, NEA | |
dc.contributor.author | Ali, S | |
dc.contributor.author | Mok, NY | |
dc.contributor.author | Wilding, B | |
dc.contributor.author | Pasqua, AE | |
dc.contributor.author | Rowlands, M | |
dc.contributor.author | Tucker, MJ | |
dc.contributor.author | Evans, LE | |
dc.contributor.author | Rye, CS | |
dc.contributor.author | O'Fee, L | |
dc.contributor.author | Le Bihan, Y-V | |
dc.contributor.author | Burke, R | |
dc.contributor.author | Carter, M | |
dc.contributor.author | Workman, P | |
dc.contributor.author | Blagg, J | |
dc.contributor.author | Brown, N | |
dc.contributor.author | van Montfort, RLM | |
dc.contributor.author | Jones, K | |
dc.contributor.author | Cheeseman, MD | |
dc.date.accessioned | 2018-11-19T12:37:00Z | |
dc.date.issued | 2018-12-13 | |
dc.identifier.citation | ACS medicinal chemistry letters, 2018, 9 (12), pp. 1199 - 1204 | |
dc.identifier.issn | 1948-5875 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/2946 | |
dc.identifier.eissn | 1948-5875 | |
dc.identifier.doi | 10.1021/acsmedchemlett.8b00364 | |
dc.description.abstract | Polypharmacology is often a key contributor to the efficacy of a drug, but is also a potential risk. We investigated two hits discovered via a cell-based phenotypic screen, the CDK9 inhibitor CCT250006 (1) and the pirin ligand CCT245232 (2), to establish methodology to elucidate their secondary protein targets. Using computational pocket-based analysis, we discovered intrafamily polypharmacology for our kinase inhibitor, despite little overall sequence identity. The interfamily polypharmacology of 2 with B-Raf was used to discover a novel pirin ligand from a very small but privileged compound library despite no apparent ligand or binding site similarity. Our data demonstrates that in areas of drug discovery where intrafamily polypharmacology is often an issue, ligand dissimilarity cannot necessarily be used to assume different off-target profiles and that understanding interfamily polypharmacology will be important in the future to reduce the risk of idiopathic toxicity and in the design of screening libraries. | |
dc.format | Electronic-eCollection | |
dc.format.extent | 1199 - 1204 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | AMER CHEMICAL SOC | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.title | Privileged Structures and Polypharmacology within and between Protein Families. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2018-11-16 | |
rioxxterms.versionofrecord | 10.1021/acsmedchemlett.8b00364 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2018-12 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | ACS medicinal chemistry letters | |
pubs.issue | 12 | |
pubs.notes | No embargo | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Therapeutics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Therapeutics/Hit Discovery & Structural Design | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Therapeutics/Medicinal Chemistry 1 | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Therapeutics/Medicinal Chemistry 3 | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Structural Biology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Structural Biology/Hit Discovery & Structural Design | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Therapeutics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Therapeutics/Hit Discovery & Structural Design | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Therapeutics/Medicinal Chemistry 1 | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Therapeutics/Medicinal Chemistry 3 | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Structural Biology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Structural Biology/Hit Discovery & Structural Design | |
pubs.publication-status | Published | |
pubs.volume | 9 | |
pubs.embargo.terms | No embargo | |
icr.researchteam | Medicinal Chemistry 1 | |
icr.researchteam | Medicinal Chemistry 3 | |
icr.researchteam | Hit Discovery & Structural Design | |
dc.contributor.icrauthor | Le Bihan, Yann-Vai | |
dc.contributor.icrauthor | Burke, Rosemary | |
dc.contributor.icrauthor | Workman, Paul | |
dc.contributor.icrauthor | Van Montfort, Robert | |
dc.contributor.icrauthor | Jones, Keith | |
dc.contributor.icrauthor | Cheeseman, Matthew | |