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dc.contributor.authorKessels, Een_US
dc.contributor.authorHusson, Oen_US
dc.contributor.authorvan der Feltz-Cornelis, CMen_US
dc.coverage.spatialNew Zealanden_US
dc.date.accessioned2019-03-04T14:52:22Z
dc.date.issued2018en_US
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/29445285en_US
dc.identifierndt-14-479en_US
dc.identifier.citationNeuropsychiatr Dis Treat, 2018, 14 pp. 479 - 494en_US
dc.identifier.issn1176-6328en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3122
dc.identifier.doi10.2147/NDT.S150464en_US
dc.description.abstractObjective: The objective of the study was to conduct systematic review and meta-analysis to establish the effect of exercise interventions on cancer-related fatigue (CRF) in cancer survivors, compared to non-exercise intervention controls. Methods: Trials published between January 1st 2000 and August 17th 2016 were included through PubMed database search and search of references. Eligible trials compared the effect of an exercise intervention on CRF compared to non-exercise intervention controls, with CRF as primary outcome and measured by validated self-report questionnaire, in cancer survivors not receiving palliative care. We evaluated risk of bias of individual trials following Cochrane Quality criteria. We performed a random-effects meta-analysis in the low risk of bias trials with intervention type, exercise intensity, adherence, and cancer type as moderators, and also performed meta-regression analyses and a sensitivity analysis including the high risk of bias trials. Results: Out of 274 trials, 11 met the inclusion criteria, of which six had low risk of bias. Exercise improved CRF with large effect size (Cohen's d 0.605, 95% CI 0.235-0.975) with no significant difference between types of cancer. Aerobic exercise (Δ=1.009, CI 0.222-1.797) showed a significantly greater effect than a combination of aerobic and resistance exercises (Δ=0.341, CI 0.129-0.552). Moderator and meta-regression analyses showed high adherence yielding best improvements. Conclusion: Exercise has a large effect on CRF in cancer survivors. Aerobic interventions with high adherence have the best result.en_US
dc.format.extent479 - 494en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.subjectcancer survivorsen_US
dc.subjectcancer-related fatigueen_US
dc.subjectexerciseen_US
dc.subjectmeta analysisen_US
dc.subjectrandomized clinical trialsen_US
dc.subjectsystematic reviewen_US
dc.titleThe effect of exercise on cancer-related fatigue in cancer survivors: a systematic review and meta-analysis.en_US
dc.typeJournal Article
rioxxterms.versionofrecord10.2147/NDT.S150464en_US
rioxxterms.licenseref.startdate2018en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfNeuropsychiatr Dis Treaten_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Clinical and Translational Sarcoma
pubs.publication-statusPublished onlineen_US
pubs.volume14en_US
pubs.embargo.termsNot knownen_US
icr.researchteamClinical and Translational Sarcomaen_US
dc.contributor.icrauthorHusson, Olgaen_US


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