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Genomic Analysis of Three Metastatic Prostate Cancer Patients with Exceptional Responses to Carboplatin Indicating Different Types of DNA Repair Deficiency.

dc.contributor.authorZafeiriou, Z
dc.contributor.authorBianchini, D
dc.contributor.authorChandler, R
dc.contributor.authorRescigno, P
dc.contributor.authorYuan, W
dc.contributor.authorCarreira, S
dc.contributor.authorBarrero, M
dc.contributor.authorPetremolo, A
dc.contributor.authorMiranda, S
dc.contributor.authorRiisnaes, R
dc.contributor.authorRodrigues, DN
dc.contributor.authorGurel, B
dc.contributor.authorSumanasuriya, S
dc.contributor.authorPaschalis, A
dc.contributor.authorSharp, A
dc.contributor.authorMateo, J
dc.contributor.authorTunariu, N
dc.contributor.authorChinnaiyan, AM
dc.contributor.authorPritchard, CC
dc.contributor.authorKelly, K
dc.contributor.authorde Bono, JS
dc.date.accessioned2019-04-24T08:40:46Z
dc.date.issued2019-01-01
dc.identifier.citationEuropean urology, 2019, 75 (1), pp. 184 - 192
dc.identifier.issn0302-2838
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3201
dc.identifier.eissn1873-7560
dc.identifier.doi10.1016/j.eururo.2018.09.048
dc.description.abstractPlatinum-based regimens have not been proved to increase survival from advanced prostate cancer (PCa). Incontrovertible evidence that a proportion of prostate cancers have homologous recombination DNA (HRD) repair defects, and that such genomic aberrations are synthetically lethal with both poly(ADP)-ribose polymerase inhibition and platinum, has increased interest in the utilisation of these drugs against a subset of these diseases. Here in we report three patients with advanced castration-resistant PCa with HRD defects having exceptional responses to carboplatin.
dc.formatPrint-Electronic
dc.format.extent184 - 192
dc.languageeng
dc.language.isoeng
dc.publisherELSEVIER SCIENCE BV
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectHumans
dc.subjectAdenocarcinoma
dc.subjectCarboplatin
dc.subjectAntineoplastic Agents
dc.subjectPedigree
dc.subjectAdult
dc.subjectAged
dc.subjectMiddle Aged
dc.subjectMale
dc.subjectDNA Repair-Deficiency Disorders
dc.subjectRecombinational DNA Repair
dc.subjectProstatic Neoplasms, Castration-Resistant
dc.titleGenomic Analysis of Three Metastatic Prostate Cancer Patients with Exceptional Responses to Carboplatin Indicating Different Types of DNA Repair Deficiency.
dc.typeJournal Article
dcterms.dateAccepted2018-09-27
rioxxterms.versionofrecord10.1016/j.eururo.2018.09.048
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
rioxxterms.licenseref.startdate2019-01
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfEuropean urology
pubs.issue1
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Therapeutics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Therapeutics/Cancer Biomarkers
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Cancer Biomarkers
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Prostate Cancer Targeted Therapy Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Translational Therapeutics
pubs.organisational-group/ICR/Students
pubs.organisational-group/ICR/Students/PhD and MPhil
pubs.organisational-group/ICR/Students/PhD and MPhil/16/17 Starting Cohort
pubs.organisational-group/ICR/Students/PhD and MPhil/18/19 Starting Cohort
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Therapeutics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Therapeutics/Cancer Biomarkers
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Cancer Biomarkers
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Prostate Cancer Targeted Therapy Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Translational Therapeutics
pubs.organisational-group/ICR/Students
pubs.organisational-group/ICR/Students/PhD and MPhil
pubs.organisational-group/ICR/Students/PhD and MPhil/16/17 Starting Cohort
pubs.organisational-group/ICR/Students/PhD and MPhil/18/19 Starting Cohort
pubs.publication-statusPublished
pubs.volume75
pubs.embargo.termsNot known
icr.researchteamCancer Biomarkers
icr.researchteamProstate Cancer Targeted Therapy Group
icr.researchteamTranslational Therapeutics
dc.contributor.icrauthorRescigno, Pasquale
dc.contributor.icrauthorCarreira, Suzanne
dc.contributor.icrauthorMiranda, Susana
dc.contributor.icrauthorGurel, Bora
dc.contributor.icrauthorSumanasuriya, Semini
dc.contributor.icrauthorPaschalis, Alec
dc.contributor.icrauthorSharp, Adam
dc.contributor.icrauthorDe Bono, Johann


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