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dc.contributor.authorWason, JMSen_US
dc.contributor.authorBrocklehurst, Pen_US
dc.contributor.authorYap, Cen_US
dc.coverage.spatialEnglanden_US
dc.date.accessioned2019-08-08T14:40:22Z
dc.date.issued2019-08-02en_US
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/31370839en_US
dc.identifier10.1186/s12916-019-1391-9en_US
dc.identifier.citationBMC Med, 2019, 17 (1), pp. 152 - ?en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3319
dc.identifier.eissn1741-7015en_US
dc.identifier.doi10.1186/s12916-019-1391-9en_US
dc.description.abstractBACKGROUND: Adaptive designs are a wide class of methods focused on improving the power, efficiency and participant benefit of clinical trials. They do this through allowing information gathered during the trial to be used to make changes in a statistically robust manner - the changes could include which treatment arms patients are enrolled to (e.g. dropping non-promising treatment arms), the allocation ratios, the target sample size or the enrolment criteria of the trial. Generally, we are enthusiastic about adaptive designs and advocate their use in many clinical situations. However, they are not always advantageous. In some situations, they provide little efficiency advantage or are even detrimental to the quality of information provided by the trial. In our experience, factors that reduce the efficiency of adaptive designs are routinely downplayed or ignored in methodological papers, which may lead researchers into believing they are more beneficial than they actually are. MAIN TEXT: In this paper, we discuss situations where adaptive designs may not be as useful, including situations when the outcomes take a long time to observe, when dropping arms early may cause issues and when increased practical complexity eliminates theoretical efficiency gains. CONCLUSION: Adaptive designs often provide notable efficiency benefits. However, it is important for investigators to be aware that they do not always provide an advantage. There should always be careful consideration of the potential benefits and disadvantages of an adaptive design.en_US
dc.format.extent152 - ?en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.subjectAdaptive designen_US
dc.subjectClinical trialsen_US
dc.subjectEfficiencyen_US
dc.subjectPatient benefiten_US
dc.titleWhen to keep it simple - adaptive designs are not always useful.en_US
dc.typeJournal Article
dcterms.dateAccepted2019-07-15en_US
rioxxterms.versionofrecord10.1186/s12916-019-1391-9en_US
rioxxterms.licenseref.startdate2019-08-02en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfBMC Meden_US
pubs.issue1en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Clinical Trials & Statistics Unit
pubs.publication-statusPublished onlineen_US
pubs.volume17en_US
pubs.embargo.termsNot knownen_US
icr.researchteamClinical Trials & Statistics Uniten_US
dc.contributor.icrauthorYap, Christinaen_US


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